Patents Assigned to Chiba University
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Publication number: 20140194683Abstract: Problem: To provide a trocar equipped with a retractable camera, with which the security is enhanced as compared with the related art. Means for Solution: An opening portion 13 is provided at a position of a pipe portion 11. The position of opening portion 13 is reliably within the body of the patient. A shaft 14 is arranged along the interior of the trocar, along an edge of the opening portion 13. Several bearings 15 are fixed to the inter wall of the pipe portion 11, with the shaft 14 being rotatably mounted in the bearings 15. The end portion of the shaft 14 extends to the exterior of the trocar, outside the body of the patient. A selection lever 16 is provided at the outer end portion of the shaft 14. The selection lever 16 can be changed over between a stored position and a deployed position, and can be fixed in each of these positions. A camera 17 is rigidly and integrally attached to the shaft 14 at a position that corresponds to the opening portion 13.Type: ApplicationFiled: August 23, 2013Publication date: July 10, 2014Applicants: National University Corporation Chiba University, Advanced Healthcare Co., Ltd.Inventor: Toshiya NAKAGUCHI
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Patent number: 8771749Abstract: The invention relates to a stable bicarbonate ion-containing drug solution, particularly a bicarbonate-containing drug solution for dialysis in which the stability has been improved by the presence of a phosphate ion. Further, the invention relates to a drug solution for acute blood purification, particularly a dialysate and a substitution liquid for acute blood purification to be mixed before use containing the drug solution. Still further, the invention relates to a dialysate and a substitution liquid for acute blood purification to be mixed before use in which the formation of insoluble fine particles or precipitates is prevented for a long time after mixing and with which hypokalemeia and hypophosphatemia are not caused.Type: GrantFiled: October 6, 2008Date of Patent: July 8, 2014Assignees: National University Corporation Chiba University, Fuso Pharmaceutical Industries, Ltd.Inventors: Shigeto Oda, Tomohito Sadahiro, Masataka Nakamura, Syuichi Tanaka, Shogo Tokuoka, Hiroya Otani
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Publication number: 20140170700Abstract: The present invention provides a method of producing a carotenoid having 50 carbon atoms which comprises culturing, in a medium, a cell transformed with a mutant phytoene desaturase gene and obtaining the carotenoid having 50 carbon atoms from the culture. The mutant phytoene desaturase gene has an introduced mutation to encode a mutant phytoene desaturase having an enhanced activity to desaturate a carotenoid backbone compound of 50 carbon atoms.Type: ApplicationFiled: June 8, 2012Publication date: June 19, 2014Applicant: National University Corporation Chiba UniversityInventors: Daisuke Umeno, Maiko Furubayashi, Norihiko Misawa, Shinichi Takaichi
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Patent number: 8741583Abstract: A method of identifying compounds that inhibit fertilization is provided. The method can include selecting compounds that bind to equatorin protein. Two types of equatorin protein, a long form and a short form, can be present in the testis. The amino acid sequence of mouse equatorin from positions 101 to 146 including the 138th O-glycosylated threonine residue contains an epitope recognized by anti-equatorin antibody MN9 that has an effect of inhibiting fertilization. In addition, the MN9 antibody also binds to human sperm. Compounds that bind to the epitope can inhibit fertilization. Both forms of mouse equatorin can be used as well as human equatorin to identify compounds that inhibit fertilization.Type: GrantFiled: March 31, 2010Date of Patent: June 3, 2014Assignee: National University Corporation Chiba UniversityInventors: Kiyotaka Toshimori, Chizuru Ito, Kenji Yamatoya, Keiichi Yoshida
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Patent number: 8663947Abstract: A method for quantitatively evaluating chromatin structural changes using pixel imaging of the nucleus is provided. Pixel imaging of the nucleus can include capturing one or more images of a nucleus of one or more nucleic acid stain treated cells. The stain intensity can be measured by quantitating the intensity. The mean and/or standard deviation of stain intensity per pixel can be used to determine chromatin condensation levels or chromatin structural change.Type: GrantFiled: February 18, 2010Date of Patent: March 4, 2014Assignee: National University Corporation Chiba UniversityInventor: Naoto Yamaguchi
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Patent number: 8648090Abstract: Indole alkaloid derivatives having an opioid receptor agonistic effect, their synthesis, and therapeutic compositions containing these derivatives, and methods of treating conditions with these compounds and therapeutic compositions, are provided.Type: GrantFiled: July 16, 2012Date of Patent: February 11, 2014Assignees: National University Corporation Chiba University, Josai University CorporationInventors: Hiromitsu Takayama, Mariko Kitajima, Kenjiro Matsumoto, Syunji Horie
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Patent number: 8629225Abstract: A poly(N-alkylcarbazole) columnar structure having electroconductivity is provided. The poly(N-alkylcarbazole) columnar structure having electroconductivity may be produced by electrolytically polymerizing an N-alkylcarbazole in a particular solvent.Type: GrantFiled: March 4, 2011Date of Patent: January 14, 2014Assignees: National University Corporation Chiba University, JNC CorporationInventors: Katsuyoshi Hoshino, Kazuki Takizawa, Katsuyuki Murashiro, Toshiki Komatsu
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Patent number: 8609796Abstract: A novel nanosized or microsized material having electroconductivity that can be produced simply and in a large amount is provided. A method for producing a poly(N-alkylcarbazole) columnar structure having electroconductivity obtained by chemically polymerizing N-alkylcarbazole including alkyl having 1 to 4 carbons by adding an oxidizing agent to a solution obtained by dissolving the N-alkylcarbazole in a solvent is provided.Type: GrantFiled: June 14, 2012Date of Patent: December 17, 2013Assignees: National University Corporation Chiba University, JNC CorporationInventors: Katsuyoshi Hoshino, Takuya Tokuda, Katsuyuki Murashiro, Toshiki Komatsu
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Publication number: 20130324572Abstract: A medicinal preparation for preventing and/or treating psychoneurotic diseases such as integration dysfunction and Alzheimer's disease which contains tropisetron or its pharmaceutically acceptable salt as the active ingredient.Type: ApplicationFiled: May 22, 2013Publication date: December 5, 2013Applicant: National University Corporation Chiba UniversityInventors: Kenji Hashimoto, Masaomi Iyo, Kaori Koike
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Publication number: 20130324877Abstract: An apparatus for determining a respiratory condition, the apparatus includes: a signal acquirer which is configured to acquire a signal waveform corresponding to a respiratory flow of a subject; a differential calculator which is configured to acquire a differential waveform which is obtained by performing differentiation of the signal waveform; and a first determiner which is configured to determine that inspiratory flow to limitation occurs in the subject, when the differential waveform satisfies a predetermined condition in a portion of the signal waveform, which corresponds to inspiration of the subject.Type: ApplicationFiled: May 23, 2013Publication date: December 5, 2013Applicants: National University Corporation Chiba University, NIHON KOHDEN CORPORATIONInventors: Yukio NONAKA, Shiroh ISONO, Tsuyoshi Shimizu
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Patent number: 8581022Abstract: A method of identifying a compound for preventing and/or treating an autoimmune disease is described which comprises obtaining a (BTLA?/?) NKT cell from a non-human animal, contacting the (BTLA?/?) NKT cell ex vivo with a test compound, in the presence of an antigen, measuring a response of the (BTLA?/?) NKT cell to the antigen, comparing the response of the (BTLA?/?) NKT cell to the antigen with a response of a (BTLA?/?) NKT cell in control assay, and selecting the compound that reduces the response of the (BTLA?/?) NKT cell in the presence of an antigen compared to a response of a (BTLA?/?) NKT cell in the control assay. Other methods of identifying a compound for preventing and/or treating an autoimmune disease are also described.Type: GrantFiled: March 30, 2010Date of Patent: November 12, 2013Assignee: National University Corporation Chiba UniversityInventors: Norihiko Watanabe, Yoshihiro Oya
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Publication number: 20130288914Abstract: Provided is a method of determining a therapeutic effect of cancer chemotherapy with an anticancer drug obtained by blending three ingredients, i.e., tegafur, gimeracil, and oteracil potassium as active ingredients (hereinafter abbreviated as S-1) quickly, simply, and accurately before carrying out the cancer chemotherapy. Specifically, provided is a method of determining an administration effect in chemotherapy with S-1, the method comprising: a step (a) of measuring expression level of a decorin gene in a biological sample collected from a subject to be diagnosed; and a step (b) of determining an administration effect of S-1 based on the expression level of the gene obtained from the measurement.Type: ApplicationFiled: March 29, 2013Publication date: October 31, 2013Applicants: Koshinchemical Co., Ltd., National University Corporation Chiba UniversityInventors: Hideki Tanzawa, Atsushi Kasamatsu, Katsuhito Uzawa
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Patent number: 8570639Abstract: An electrophoretic liquid includes a first electrophoretic particle, a second electrophoretic particle having a polarity opposite to that of the first electrophoretic particle, a non-electrophoretic particle, and a transparent dispersion medium. In the electrophoretic liquid, the first, second, and non-electrophoretic particles are dispersed in the transparent dispersion medium.Type: GrantFiled: November 26, 2009Date of Patent: October 29, 2013Assignees: Ricoh Company, Ltd., Chiba UniversityInventors: Masahiro Masuzawa, Takashi Kitamura, Yoshitaku Yoshimatsu
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Patent number: 8563235Abstract: A method of detecting an abnormal amount of a biomarker associated with biliary tract cancer in a subject can comprise: a) quantitating an amount of a fragment of prothrombin having an m/z value of about 4204 m/z in a biological sample from the subject; and b) comparing the quantitated value obtained in (a) with a threshold value.Type: GrantFiled: November 2, 2010Date of Patent: October 22, 2013Assignee: National University Corporation Chiba UniversityInventors: Shintaro Kikkawa, Kazuyuki Sogawa, Osamu Yokosuka, Fumio Nomura
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Publication number: 20130267011Abstract: Provided are: a selection method for a gene switch and a gene circuit, including using, as a selector, an expression vector containing at least a gene sequence whose expression is controlled by a transcription regulatory factor to be expressed when a genetic switch and a genetic circuit including the genetic switch operate, and a promoter sequence operably linked to the gene sequence upstream thereof; and an expression vector to be used in the selection method. This enables an effective selection method for a genetic switch and a genetic circuit, the selection method being able to be conducted within a short time period and with high selection efficiency and less leakiness.Type: ApplicationFiled: November 2, 2011Publication date: October 10, 2013Applicant: National University Corporation Chiba UniversityInventors: Daisuke Umeno, Hiroki Fukutomi, Kyoichi Saito
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Publication number: 20130260458Abstract: The present invention relates to a differentiation inducing method comprising: introducing, into human induced pluripotent stem cells, a combination of genes of transcription factors which are possessed by fetal and adult hepatic cells, but are not possessed by human induced pluripotent stem cells; and adhering the human induced pluripotent stem cells to a substrate for monolayer culture in a medium containing a combination of growth-promoting agents for proliferation and differentiation, thereby enabling induction of the differentiation of the human induced pluripotent stem cells in large amounts in a short term, a hepatic progenitor cell produced by the method, and a cell composition for transplantation into the liver comprising the cell. The transcription factors include FOXA2, GATA4, HEX and C/EBP?, and the growth-promoting agents include oncostatin M, an epidermal growth factor, retinoic acid, dexamethasone, insulin, transferrin and a selenite ion.Type: ApplicationFiled: March 28, 2013Publication date: October 3, 2013Applicant: National University Corporation Chiba UniversityInventor: Minoru TOMIZAWA
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Publication number: 20130224111Abstract: A method of treating or reducing at least one inflammatory condition or the susceptibility to at least one inflammatory condition is provided involving administering at least one CD69 antagonist to a subject, wherein the subject has been diagnosed with at least one inflammatory condition, or a susceptibility to the same. CD69 antagonists can include one or more of an anti-CD69 antibody, an anti-CD69 aptamer, a CD69 mRNA antagonist, and a small molecule pharmaceutical.Type: ApplicationFiled: April 16, 2013Publication date: August 29, 2013Applicants: National University Corporation Yamaguchi University, National University Corporation Chiba UniversityInventors: National University Corporation Chiba University, National University Corporation Yamaguchi
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Patent number: 8507270Abstract: An object of the present invention is to achieve a method capable of increasing transfection efficiency of polyethyleneimine (PEI) and reducing toxicity thereof, to provide a PEI with high transfection efficiency, and to provide a method of introducing nucleic acids into cells comprising using the PEI. There are provided a method of introducing nucleic acids into cells comprising mixing acidified PEI with nucleic acids under acidic conditions and applying the resulting mixture to cells, a reagent for introducing nucleic acids into cells comprising an acidified PEI solution, and a reagent kit including the solution.Type: GrantFiled: April 1, 2010Date of Patent: August 13, 2013Assignee: National University Corporation Chiba UniversityInventors: Naoto Yamaguchi, Yasunori Fukumoto
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Publication number: 20130203064Abstract: [PROBLEM TO BE SOLVED] An object of the present invention is to provide a novel tumor marker and use thereof. In more detail, the present invention provides a novel tumor marker, a method for measuring said tumor marker and a measurement kit, a method for detecting cancer using the same, a kit for detecting cancer, a method for screening a preventive and/or therapeutic agent for cancer, as well as a medicament such as cancer vaccine. [SOLUTION] According to the present invention, a method for measuring an alternative splicing variant of OATP1B3 mRNA in a sample to be examined is provided. Said measurement method comprises measuring mRNA comprising a nucleotide sequence represented by SEQ ID NO: 1 in the sequence listing table in a sample to be examined isolated from living organism with differentiation from a mRNA comprising a nucleotide sequence represented by SEQ ID NO: 2. Said measurement method is useful for detecting cancer or screening a preventive and/or therapeutic agent.Type: ApplicationFiled: February 5, 2013Publication date: August 8, 2013Applicant: National University Corporation Chiba UniversityInventor: National University Corporation Chiba University
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Patent number: 8476258Abstract: A novel compound having NMDA receptor channel blocking activity, is provided. A pharmaceutical agent comprising the compound is also provided. The pharmaceutical agent can be used for the treatment or prevention of a disease caused by overexcitation of an NMDA receptor, and can comprise a compound having NMDA receptor channel blocking activity and represented by the formula (1), or a pharmaceutically acceptable salt thereof.Type: GrantFiled: April 26, 2007Date of Patent: July 2, 2013Assignee: National University Corporation Chiba UniversityInventors: Kazuei Igarashi, Hiromitsu Takayama