Abstract: Disclosed is a compound of Formula I or a pharmaceutically acceptable salt thereof, and pharmaceutical composition comprising the same, and use thereof in the treatment of diseases benefiting from the inhibition of autophagic flux and/or chromatin ubiquitination, especially in the treatment of breast cancer.

Abstract: Provided is a data security sharing method for multiple edge nodes to operate in a collaboration mode under an industrial cloud environment. The method includes: firstly, edge nodes that need collaborative computing separately applying for a shared key to an authority center; secondly, the authority center generating a shared key and issuing the key to each of the edge nodes applying for participation in the collaborative computing; again, the edge nodes combining industrial characteristics to generate an interference factor set, and adding different interference factors for different types of data; then, the data of the edge nodes is implemented with improved homomorphic encryption and is uploaded to an industrial cloud platform; and finally, the industrial cloud platform performing homomorphic analysis and computing on the data uploaded by each of the edge nodes, and issuing the data back to each of the edge nodes.

Abstract: The present invention relates to a ball picking robot, comprising a walking mechanism, a ball picking mechanism, a ball pushing mechanism and a ball storage mechanism. The ball picking mechanism comprises a ball picking basket, an air cylinder used for driving the ball picking basket to move up and down, an air storage tank used for providing an air source for the air cylinder, a solenoid valve arranged at the air outlet of the air storage tank, a micro air pump connected to the air storage tank, and a shielding assembly arranged at an opening in the rear end of the ball picking basket. A first gear is mounted at the input end of the micro air pump. The ball pushing mechanism comprises a rotary ball discharging assembly, comprising an either-rotation motor, a rotary impeller connected to a first output shaft of the either-rotation motor through a belt assembly.

Abstract: The disclosure provides a milling system and method under different lubrication conditions. The system uses a tool to mill the workpiece, a force measuring system to measure the milling force, a tool change system to replace the tools, a tool storage to store the tools. It can store the tools, provide the lubricating oil to the milling surface, select different tools according to different processing conditions, select the best angle differences of the unequal spiral angle tools according to different conditions comprising dry cutting, casting-type lubrication, minimal quantities of lubrication or minimal quantities of nanofluid lubrication, and/or choose the optimal tool according to different cutting parameters in order to obtain the minimum milling force.

Abstract: The disclosure provides a method and system for injecting cutting fluid during milling under different working conditions. By analyzing influence of an airflow field in a milling area under different working conditions on injection of cutting fluid, an influence rule of a helical angle and a rotation speed of a cutter on the flow field is quantitatively analyzed, an optimal target distance of a nozzle, an angle between the nozzle and a milling cutter feeding direction and an angle between the nozzle and the surface of a workpiece are comprehensively determined, the nozzle is set according to a determined setting manner, and lubricating oil is sprayed to the milling area by utilizing the nozzle.

Abstract: Provided are a copper-containing, high-toughness and rapidly degradable magnesium alloy, a preparation method therefor and the use thereof, wherein same relate to the field of materials for oil and gas exploitation. When the magnesium alloy is in an as-cast state, an extrusion state or an aging state, a strengthening phase thereof mainly includes an Mg12CuRE-type long-period phase and an Mg5RE phase and an Mg2Cu phase, the Mg12CuRE-type long-period phase has a volume fraction of 3-60%, the Mg5RE phase has a volume fraction of 0.5-20%, and the Mg2Cu phase has a volume fraction of 0.5-15%, wherein RE is a rare-earth metal element.

Abstract: The present invention relates to an improved KNN-based 6LoWPAN network intrusion detection method. The present invention selects quantifiable security features which can reflect a self-security state of network elements of a 6LoWPAN network for training, and establishes a 6LoWPAN network feature space. The present invention assigns the weights to the features and transfers zero points, to alleviate the bias caused by large and small impact factors and simplify calculation; realizes construction and update of a state data table of network elements by extracting the feature data of network elements in real time, thus forming a normal contour updated according to the real-time state of the network in the feature space of the 6LoWPAN network based on the clustering effect of a KNN algorithm; and the present invention improves the KNN algorithm and redefines a basis for judging the invasion, to meet the requirements for 6LoWPAN network intrusion detection.

Abstract: The disclosure provides a method and system for milling injected cutting fluid under different working conditions. By analyzing influence of airflow fields in a milling area under different working conditions on injection of cutting fluid, an influence rule of a helical angle and a rotation speed of a cutter on the flow field is quantitatively analyzed, an optimal target distance of a nozzle, an angle between the nozzle and a milling cutter feeding direction and an angle between the nozzle and the surface of a workpiece are comprehensively determined, the nozzle is set according to a determined setting manner, and lubricating oil is sprayed to the milling area by utilizing the nozzle.

Abstract: The present invention discloses a preparation method of a biomedical titanium implant with a function of eliminating a surface biomembrane. The method includes the following steps: firstly synthesizing mesoporous polydopamine (MPDA) nanoparticles by a “one-pot method”, constituting a surface-aminated titanium material through diacid corrosion and modification of a 3-aminopropyltriethoxysilane (APTES) coupling agent, and integrating the MPDA nanoparticles into the surface of the titanium material through Michael addition reaction; secondly, taking MPDA anchored on the surface of the titanium material as a photothermal material and a photosensitizer carrier, where MPDA contains abundant aromatic rings capable of facilitating abundant loading of a photosensitizer (indocyanine green, ICG) through ?-? stacking interaction; and finally further modifying biocompatible RGD polypeptides on the surface of MPDA by Michael addition reaction, where a modified titanium material is referred to as Ti-M/I/RGD.

Abstract: The present disclosure discloses an experimental system and method capable of simulating a non-inertial system of gear transmission, and relates to the field of aviation power transmission. The experimental system includes a gear transmission experiment table, a linear motion platform and an electric vibration table. The linear motion platform drives the gear transmission experiment table to perform horizontal linear acceleration motion to simulate a non-inertial system for linear acceleration of gear transmission. The electric vibration table drives the gear transmission experiment table to rotate back and forth around a horizontal shaft to simulate a non-inertial system for pitching of gear transmission. The electric vibration table drives the gear transmission experiment table to rotate back and forth around a vertical shaft to simulate a non-inertial system for yawing of gear transmission.

Abstract: The present invention belongs to the field of computer visual detection, and relates to a binocular automatic gear pitting detection device based on deep learning, comprising a gearbox system, a data acquisition system, an image processing system, a tooth surface positioning system, a control system and a motor, wherein the gearbox is used for installing paired meshing gears; the data acquisition system is arranged on the side wall of the gearbox, and a CCD industrial camera is arranged on the data acquisition system; the image processing system completes quantitative evaluation of gear pitting and target detection based on a deep learning technology; both ends of the tooth surface positioning system are respectively connected with the motor and the gearbox, and the torque of the motor is transmitted to an input shaft of the gearbox.

Abstract: Implementations of the disclosure provide for methods, systems, and media for image reconstruction using metal artifacts reductions techniques. In some embodiments, a method for image reconstruction is provided, the method comprising: receiving a first computed tomography (CT) image and a second CT image; generating, by a processing device, a prior image based on the second CT image; generating a noise image based on the first CT image, wherein the noise image corresponds to metal artifacts in the first CT image; and reconstructing, by the processing device, the first CT image based at least in part on the prior image. In some embodiments, generating the prior image comprises: registering the first CT image and the second CT image to generate a registered image; and reducing noise artifacts in the registered image.

Abstract: The present disclosure discloses a piezoelectric self-powered combination beam vibration damper and a control method thereof. An upper guiding component is installed inside an upper rigid frame, a lower guiding component is installed inside a lower rigid component, a guide rod is nested inside the upper guiding component and the lower guiding component, an upper elastic component is sleeved outside the upper idler wheel mechanism, a lower elastic component is sleeved outside the lower idler wheel mechanism, one end of each piezoelectric cantilever beam is fixed between the upper rigid frame and the lower rigid frame, the other end of each piezoelectric cantilever beam is arranged between the upper idler wheel mechanism and the lower idler wheel mechanism, at least one piezoelectric cantilever beam is connected with the input end of a circuit system, and other piezoelectric cantilever beams are connected with the output end of the circuit system.

Abstract: The present invention relates to a DDoS attack detection and mitigation method for an industrial SDN network, and belongs to the field of network security. According to the method, by means of the cooperation between an east-west interface of an SDN controller in an industrial backhaul network and a system manager of an industrial access network, in conjunction with the features of the industrial backhaul network and an industrial access network data packet, a flow entry matching field of an OpenFlow switch is extended, and a flow table 0 is set to be a “flow table dedicated to DDoS attack mitigation” for defending against an attacking data flow in a timely manner. By using the SDN controller of an industrial backhaul network and a DDoS attack detection and mitigation system, an attacking data flow is identified and a DDoS attack source is found, and the policy of mitigating a DDoS attack is implemented by means of scheduling a system manager of the industrial access network.

Abstract: The present disclosure provides a multi-carrier time-division multiplexing (MC-TDMA) modulation and demodulation method and system. Before multi-carrier modulation is performed on an input symbol, an interleaving allocation and an FFT may be performed, a time domain symbol may be transformed into a frequency domain symbol signal to perform a MDFT treatment. A sending end may adopt an analyzing filter bank structure, and pre-filtering and an IFFT may be performed on a signal successively. A pre-filter may be positioned between an NM point FFT and an M point IFFT, a PAPR value of the system may be reduced using the symmetry of a coefficient of a filter, and a frequency domain symbol signal may be allocated to different sub-bands for multi-carrier modulation.

Abstract: The present disclosure provides a nickel-containing high-toughness controllably degradable magnesium alloy material, a preparation method therefor and use thereof, and relates to the technical field of magnesium alloys. The magnesium alloy material comprises the following components in percentage by mass: 0.3 to 8.5% of Ni, 0.5 to 28% of RE, with the balance being Mg and unavoidable impurities. RE represents rare earth elements. By adding Ni and RE elements to introduce an Mg12RENi-type long-period phase, an Mg2Ni phase and an MgxREy phase, the magnesium alloy material provided by the present disclosure significantly improves mechanical properties of the alloy material, the tensile strength being up to 510 MPa. At the same time, the presence of the Mg12RENi-type long-period phase and Mg2Ni phase enables the alloy material to be controllably degradable, and enables the degradation rate to be adjustable between 360 and 2400 mm/a.

Abstract: The present invention discloses a device and method for measuring the softening and melting performances of iron ore in blast furnace under a reducing condition. The device includes a high temperature furnace, a gas supply system, a loading system and a weighing system, where the high temperature furnace is provided with a hearth, which is provided therein with a graphite crucible and a temperature acquisition device; the gas supply system is used to inject a reducing gas including N2, H2, CO2 and CO into the hearth; the gas supply system includes a gas storage device and a gas mixing device; the loading system includes a loading rod; an upper end of the loading rod is connected with a loading device and a displacement sensor, and a lower end of the loading rod is provided with a loading head; the weighing system is used to weigh a droplet and iron ore specimen.

Abstract: The present disclosure discloses an automated dispensing machine adopting local coverage type sucker array and a control method thereof. The automated dispensing machine adopting local coverage type sucker array comprises a rack. A medicine obtaining device and a medicine weighing and discharging device are arranged on the rack. The control method comprises: (1), after receiving medicine grasping and discharging commands, a single-chip microprocessor firstly selects a current medicine obtaining station according to a medicine obtaining station circulation sequence, and then controls the first linear driver to push the slide to move forwards to the selected medicine obtaining station; (2), the single-chip microprocessor transmits the control signal to a fifth relay to control the second linear driver to drive the vacuum medicine sucking mechanical arm to move downwards.

Abstract: The disclosure relates to a method for preparing Ti(C,N)-based superhard metal composite materials, with Ti(C,N) powder and (W,Mo,Ta)(C,N) powder as main raw materials and Co powder as binding phase for preparation, thereby obtaining a material in which a microstructure is a double-core rim structure that has both a black core rim and a white core rim. The material has a complete and evenly distributed double-core rim structure. In the condition that the ensured hardness of the material is not reduced and even slightly increased, the toughness of the material is significantly improved, wherein the fracture toughness of the material is in the range of 11.3 to 12.5 MPa·m1/2.

Abstract: The present disclosure relates to systems and methods for a handover. The methods may include establishing a connection between a vehicle terminal and a first macro evolved Node B (MeNB) and a connection between the vehicle terminal and a secondary evolved Node B (SeNB), the vehicle terminal in a dual connectivity mode with the first MeNB and the SeNB; receiving, by the vehicle terminal, a handover command from the first MeNB; and disconnecting, based on the handover command, the vehicle terminal from the first MeNB and establishing synchronization between the vehicle terminal and a second MeNB, wherein the connection between the vehicle terminal and the SeNB is maintained. The SeNB is a secondary vehicle terminal meeting a preset condition or an SeNB installed at a fixed location.