Patents Assigned to Ciba-Geigy AG
-
Patent number: 5948898Abstract: Compositions and methods are provided for modulating the expression of protein kinase C. Oligonucleotides are provided which are targeted to nucleic acids encoding PKC. The oligonucleotides contain a methoxyethoxy (--O--CH.sub.2 CH.sub.2 OCH.sub.3) modification at the 2' position of at least one nucleotide. Methods of inhibiting PKC expression and methods of treating conditions associated with expression of PKC using oligonucleotides of the invention are disclosed.Type: GrantFiled: February 14, 1996Date of Patent: September 7, 1999Assignees: ISIS Pharmaceuticals, Inc., Ciba-Geigy AGInventors: Nicholas M. Dean, Pierre Martin, Karl-Heinz Altmann
-
Patent number: 5863620Abstract: A process for coating printed circuit boards with a coating composition that is crosslinkable by electromagnetic radiation, especially UV radiation, using the roll coating process, is distinguished by the following process steps:a photopolymerisable, meltable, low-molecular-weight coating composition that is highly viscous to solid at room temperature and has an average molecular weight of preferably from 500 to 1500 is melted and fed to the applicator roll of a roll coating apparatus;the coating composition is coated at a temperature of approximately from 60.degree. to 110.degree. C. and a viscosity of approximately from 1000 to 20000 mPas on to the surface(s) of a printed circuit board in a thickness of approximately from 10 to 200 .mu.m,the surface of the printed circuit board to be coated being pre-heated, prior to coating, to a temperature that is approximately from 10.degree. to 50.degree. C. higher than the application temperature of the coating composition.Type: GrantFiled: December 29, 1995Date of Patent: January 26, 1999Assignee: Ciba-Geigy AGInventor: Hans-Jurgen Schafer
-
Patent number: 5843621Abstract: A process for coating printed circuit boards is described, comprising the following process steps:the printed circuit boards on the coating side are kept at room temperature and, as appropriate, are heated to approximately 120.degree. C.; thenin a first step, a preferably photopolymerisable, meltable, low-molecular-weight coating composition that preferably has an average molecular weight of from 500 to 1500 and that is highly viscous to solid at room temperature is coated in a thickness of approximately from 10 .mu.m to 200 .mu.m on to the surface(s) of the printed circuit board to be coated;in a second step, a second, high-molecular-weight, photopolymerisable coating composition preferably having an average molecular weight of from 2000 to 10000 is applied in a thickness of from 2 .mu.m to 20 .mu.Type: GrantFiled: February 27, 1996Date of Patent: December 1, 1998Assignee: Ciba-Geigy AGInventor: Hans-Jurgen Schafer
-
Patent number: 5677331Abstract: The invention relates to a synergistic antimalarial composition which comprises the antimalarial agent benflumetol and also an antimalarial agent from the artemisinine group such as artemether. The composition can be formulated into solid dosage forms such as tablets and is useful for the treatment of drug resistant malaria.Type: GrantFiled: March 23, 1994Date of Patent: October 14, 1997Assignees: Ciba-Geigy AG, Institute of Microbiology and Epidemiology, Academy of Military Medical SciencesInventors: Yiqing Zhou, Dianxi Ning, Shufen Wang, Deben Ding, Guofu Li, Chengqi Shan, Guangyu Liu
-
Patent number: 5646116Abstract: A composition for the treatment of osteoporosis and the method of treatment of osteoporosis therewith in mammals is disclosed. The method comprises administering Insulin-Like Growth Factor I (IGF-I) to a mammal in need thereof. Need is determined by bone mineral density levels, whether by single measurement (as compared to the population generally) or by a series of measurements evidencing a loss of bone mineral density, or due to a genetic or familial or other predisposition to bone mineral density loss.Type: GrantFiled: March 1, 1995Date of Patent: July 8, 1997Assignee: Ciba-Geigy AGInventor: Robert Roland Burk
-
Patent number: 5632936Abstract: A lens mold cavity is formed and then evacuated via a vacuum channel contained within a mold member. A fluid valve is opened to expose the lens mold cavity to liquid lens material, whereby a vacuum of the lens mold cavity draws the liquid lens material to fill the lens mold cavity. The fluid valve is then closed and the liquid lens material within the lens mold cavity is cured to obtain an opthalmic lens such as a contact lens.Type: GrantFiled: May 4, 1994Date of Patent: May 27, 1997Assignee: Ciba-Geigy AGInventors: Kai C. Su, Jack C. White, Hans U. Schlapfer
-
Patent number: 5602240Abstract: Oligonucleotide analogs are provided wherein phosphodiester inter-sugar linkages are replaced with four atom linking groups. Such linking groups include NR--C(O)--CH.sub.2 --CH.sub.2, NR--C(S)--CH.sub.2 --CH.sub.2, CH.sub.2 --NR--C(O)--CH.sub.2, CH.sub.2 --NR--C(S)--CH.sub.2, CH.sub.2 --CH.sub.2 --NR--C(O)--R--CH.sub.2, and CH.sub.2 --C(S)--NR--CH.sub.2. Methods for preparing and using these oligonucleotide analogs are also provided.Type: GrantFiled: April 25, 1994Date of Patent: February 11, 1997Assignees: Ciba Geigy AG., Isis Pharmaceuticals, Inc.Inventors: Alain De Mesmaeker, Jacques Lebreton, Adrian Waldner, Phillip D. Cook
-
Patent number: 5574554Abstract: Collimated white light is transmitted through a transparent lens mold having a molded lens resting on a curved surface thereof. A telecentric lens and a camera having a digital output are used to view the illuminated lens to obtain pixel image data of the lens. The pixel image data is analyzed by a computer to detect deformities in the molded lens.Type: GrantFiled: June 2, 1995Date of Patent: November 12, 1996Assignee: Ciba-Geigy AGInventors: Kai C. Su, Jack C. White, Mushir Siddiqui
-
Patent number: 5500437Abstract: A disinfectant composition comprising as active ingredients 4-(2,2-difluoro-1,3-benzo-dioxol-4-yl)pyrrole-3-carbonitrile and penta-4-enyl-N-furfuryl-N-imidazol-1-ylcarbonyl-DL-homoalaninate exhibits high synergistic effect by the joint use of the two active ingredients and has remarkably high effect in a low amount against Bakanae disease, blast, leaf spot, loose smut, Septoria leaf blight, snow mold on cereals such as rice, wheat, barley etc.Type: GrantFiled: April 24, 1995Date of Patent: March 19, 1996Assignees: Ciba-Geigy, AG, Ube Industries Limited, Hokko Chemical Industry Co., Ltd.Inventors: Yasuhiko Saitoh, Yasuo Iwata, Seiichi Kuzuma, Yoshihide Nakajima, Kanji Yokomizo
-
Patent number: 5470689Abstract: Photopolymerisable compositions comprising(a) a tetraacrylate of formula I or II ##STR1## wherein R.sub.1 is a hydrogen atom or methyl,X.sub.1 and X.sub.2 are each independently of the other --O-- or --CO--O--,R.sub.2 is a divalent aliphatic, cycloaliphatic or aromatic radical of a diglycidyl compound that contains no more glycidyl ether or ester groups,A is a divalent aliphatic, cycloaliphatic or aromatic radical of a diisocyanate compound that contains no more isocyanate groups,n is an integer from 1 to 8, andR.sub.3 is a tetravalent cycloaliphatic radical of a diepoxide compound that contains no more 1,2-epoxide groups at the cycloaliphatischen ring,(b) at least one liquid radically polymerisable compound that differs from component a), and(c) a radical photoinitiator, are suitable preferably for the production of three-dimensional objects by the stereolithographic technique.Type: GrantFiled: February 24, 1994Date of Patent: November 28, 1995Assignee: Ciba-Geigy AGInventors: Jean-Pierre Wolf, Adrian Schulthess, Bettina Steinmann, Max Hunziker
-
Patent number: 5397680Abstract: Polymers having a molecular weight (weight average) M.sub.w from 10.sup.3 to 10.sup.6, comprising recurring structural units of the formulae (I), (IIa) and (IIb) ##STR1## in which R.sub.1 is hydrogen or methyl, Y is a direct bond or a divalent radical of the formula (III) ##STR2## in which Z is a C.sub.1 -C.sub.6 alkylene group bound to the phenyl nucleus,OR.sub.2 is an acid-cleavable radical,in which R.sub.2 is C.sub.4 -C.sub.10 tert-alkyl, allyl, cyclohex-2-enyl, C.sub.6 -C.sub.14 aryl or C.sub.7 -C.sub.16 aralkyl which are unsubstituted or mono- or poly-substituted by C.sub.1 -C.sub.6 alkyl groups, C.sub.1 -C.sub.6 alkoxy groups or halogen atoms, trialkylsilyl or a group of the formulae (IV)-(VII) ##STR3## in which R.sub.8 is C.sub.1 -C.sub.6 alkyl, or C.sub.6 -C.sub.14 aryl or C.sub.7 -C.sub.16 aralkyl which are unsubstituted or mono- or poly-substituted by C.sub.1 -C.sub.6 alkyl groups, C.sub.1 -C.sub.6 alkoxy groups or halogen atoms,R.sub.3 and R.sub.4 independently of one another are hydrogen, C.sub.Type: GrantFiled: May 27, 1994Date of Patent: March 14, 1995Assignees: Ciba-Geigy AG, QCG MicroelectronicsInventors: Ulrich Schadeli, Norbert Munzel
-
Patent number: 5369200Abstract: Polymers having a molecular weight (weight average) M.sub.w from 10.sup.3 to 10.sup.6, comprising recurring structural units of the formulae (I), (IIa) and (IIb) ##STR1## in which R.sub.1 is hydrogen or methyl, Y is a direct bond or a divalent radical of the formula (III) ##STR2## in which Z is a C.sub.1 -C.sub.6 alkylene group bound to the phenyl nucleus,OR.sub.2 is an acid-cleavable radical,in which R.sub.2 is C.sub.4 -C.sub.10 tert-alkyl, allyl, cyclohex-2-enyl, C.sub.6 -C.sub.14 aryl or C.sub.7 -C.sub.16 aralkyl which are unsubstituted or mono- or poly-substituted by C.sub.1 -C.sub.6 alkyl groups, C.sub.1 -C.sub.6 alkoxy groups or halogen atoms, trialkylsilyl or a group of the formulae (IV)-(VII) ##STR3## in which R.sub.8 is C.sub.1 -C.sub.6 alkyl, or C.sub.6 -C.sub.14 aryl or C.sub.7 -C.sub.16 aralkyl which are unsubstituted or mono- or poly-substituted by C.sub.1 -C.sub.6 alkyl groups, C.sub.1 -C.sub.6 alkoxy groups or halogen atoms,R.sub.3 and R.sub.4 independently of one another are hydrogen, C.sub.Type: GrantFiled: December 3, 1993Date of Patent: November 29, 1994Assignees: Ciba-Geigy AG, OCG Microelectronics, Inc.Inventors: Ulrich Schadeli, Norbert Munzel
-
Patent number: 5212312Abstract: Dyes of the formula ##STR1## in which F is the radical of an indigoid dye, of a benzothioxanthene or of an aromatic dye which contains at least 4 alicyclic and/or heterocyclic, fused six-membered rings and at least two ring keto groups and is not water-soluble, R.sub.1 is a substituted or unsubstituted C.sub.1-4 -alkyl radical, a substituted or unsubstituted cycloalkyl radical, a substituted or unsubstituted aryl radical or a radical of the formula--A--Qwhere A is a substituted or unsubstituted C.sub.1-4 -alkylene radical and Q is a basic radical, which may be quaternised, and R.sub.2 is hydrogen or a substituted or unsubstituted C.sub.1-4 -alkyl radical, or in which R.sub.1 and R.sub.2 together with the ##STR2## group are a phthalimide radical, and R.sub.3 is hydrogen, a substituted or unsubstituted C.sub.1-4 -alkyl radical, a substituted or unsubstituted aryl radical, a C.sub.1-4 -alkoxycarbonyl radical or a N,N-di-C.sub.1-4 -alkylcarboxamide radical and n is 1, 2, 3 or 4.Type: GrantFiled: September 22, 1986Date of Patent: May 18, 1993Assignee: Ciba-Geigy AGInventors: Jean-Marie Adam, Athanassios Tzikas
-
Patent number: 5202458Abstract: Compounds of the formula I or II ##STR1## in which R, R.sup.0, R.sup.1 and R.sup.2 are as defined in claim 1. The compounds, some of which are novel, are light stabilizers for color photographic recording materials.Type: GrantFiled: August 5, 1991Date of Patent: April 13, 1993Assignee: Ciba-Geigy AGInventor: David G. Leppard
-
Patent number: 5149828Abstract: Tetrahydrothiopyran compound of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, X and n are as defined in claim 1, are effective stabilizers for dyes and dye couplers in photographic layers. In particular, they provide protection from damage by light. They are preferably used in combination with a phenolic antioxidant.Type: GrantFiled: March 21, 1990Date of Patent: September 22, 1992Assignee: Ciba-Geigy AGInventors: Jean Rody, David G. Leppard
-
Patent number: 5071982Abstract: A process for producing a 4,6-bis(difluoromethoxy)-2-alkylthiopyrimidine, which comprises reacting a 2-alkylthiobarbituric acid and monochlorodifluoromethane in the presence of a base in an inert solvent, wherein, for a first reaction, after charging a part of the base, the rest of the base and the monochlorodifluoromethane are simultaneously introduced to obtain a mixture of a 4-difluoromethoxy-6-hydroxy-2-alkylthiopyrimidine and a 4,6-bis(difluoromethoxy)-2-alkylthiopyrimidine, and then, for a second reaction, to this mixture, the base and the monochlorodifluoromethane are again simultaneously introduced, or the base is charged first and then the monochlorodifluoromethane is introduced.Type: GrantFiled: July 26, 1990Date of Patent: December 10, 1991Assignees: Asahi Glass Co., Ltd., Ciba-Geigy AG, Kawaguchi Chemical Industry Company, Ltd.Inventors: Sumio Yoshino, Kazuyuki Watanabe, Mikio Akazawa
-
Patent number: 5070007Abstract: Phenolic thiane derivatives of the formula I or II ##STR1## in which n is 0, 1 or 2 and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, T and Z are as defined in claim 1, are effective stabilizers for color photography recording materials, in particular for the yellow layer. They act not only as light stabilizers but also as stabilizers against thermal oxidation.Type: GrantFiled: February 6, 1991Date of Patent: December 3, 1991Assignee: Ciba-Geigy AGInventors: Jean Rody, David G. Leppard
-
Patent number: 5059515Abstract: Compounds of the formula I or II ##STR1## in which R, R.sup.0, R.sup.1 and R.sup.2 are as defined in claim 1. The compounds, some of which are novel, are light stabilizers for color photographic recording materials.Type: GrantFiled: September 28, 1990Date of Patent: October 22, 1991Assignee: Ciba-Geigy AGInventor: David G. Leppard
-
Patent number: 5006665Abstract: Phenolic thiane derivatives of the formula I or II ##STR1## in which n is 0, 1 or 2 and R.sup.2, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, T and Z are as defined in claim 1, are effective stabilizers for color photography recording materials, in particular for the yellow layer. They act not only as light stabilizers but also as stabilizers against thermal oxidation.Type: GrantFiled: September 29, 1988Date of Patent: April 9, 1991Assignee: Ciba-Geigy AGInventors: Jean Rody, David G. Leppard
-
Patent number: D329595Type: GrantFiled: July 20, 1989Date of Patent: September 22, 1992Assignee: Ciba-Geigy AGInventor: Eduard R. Kung