Patents Assigned to Ciba-Geigy Corporation
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Patent number: 5622979Abstract: The invention relates to compounds of the following general formula I ##STR1## especially the compound of formula Ia referred to as thiangazole ##STR2## their pharmaceutically acceptable acid addition salts, processes for their preparation and therapeutic compositions and compositions that can be used in crop-protection.Type: GrantFiled: June 7, 1995Date of Patent: April 22, 1997Assignees: Ciba-Geigy Corporation, Gesellschaft fur Biotechnologische Forschung mbHInventors: Gerhard H ofle, Norbert Bedorf, Edgar Forche, Klaus Gerth, Herbert Irschik, Rolf Jansen, Brigitte Kunze, Hans Reichenbach, Florenz Sasse, Heinrich Steinmetz, Wolfram Trowitzsch-Kienast, Johannes P. Pachlatko
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Patent number: 5621018Abstract: Compounds of formula I: ##STR1## are disclosed. The compounds are photoinitiators which can be functionalized by means of ethylenic groups or can be bonded to H-active substances, in order, for example, to modify surfaces by means of photopolymerizable substances. The compounds are especially useful in the manufacture of contact lenses.Type: GrantFiled: June 6, 1995Date of Patent: April 15, 1997Assignee: CIBA GEIGY CorporationInventors: Peter Chabrecek, Dieter Lohmann
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Patent number: 5620553Abstract: A liquid composition which on exposure to actinic radiation polymerizes to form a heat-curable solid film adhesive, said composition comprising (A) a heat-curable phenol-aldehyde resol resin, (B) a photopolymerizable polyurethane or polyester having, on average, more than one polymerizable acrylic group per molecule, or a mixture of said polyurethane and said polyester, (C) a photopolymerization initiator for (B) and (D) a polyvinylacetal. The heat-curable solid film adhesive is used for bonding friction materials, such as brake linings, to metal.Type: GrantFiled: May 18, 1995Date of Patent: April 15, 1997Assignee: Ciba-Geigy CorporationInventors: Margaret R. Haddon, Terence J. Smith, Stuart Mansfield
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Patent number: 5620998Abstract: The invention relates to N-acyl-N-heterocyclylalkylamino acids of the formula ##STR1## wherein Y.sub.1 is O, S or N(R) and R is hydrogen or C.sub.1 -C.sub.7 alkyl;X.sub.1 is --CO-- or --S(O).sub.m -- and the index m is 0, 1 or 2;one of the variables X.sub.2 and X.sub.4 is C.sub.1 -C.sub.4 alkylene and the other of the variables X.sub.2 and X.sub.4 is a bond; or each of the variables X.sub.2 and X.sub.4 is a bond;X.sub.3 is C.sub.3 -C.sub.7 cycloalkylidene or the structural element --C(X.sub.a)(X.sub.b)-- and X.sub.a is hydrogen or C.sub.1 -C.sub.7 alkyl and X.sub.b is C.sub.1 -C.sub.7 alkyl;and the rings A, B and C, with the exception of the substituents indicated in the formula, and also aromatic substituents are, independently of one another, unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of halogen, C.sub.1 -C.sub.7 alkyl, C.sub.1 -C.sub.7 alkoxy, C.sub.2 -C.sub.7 alkenyloxy, phenoxy, benzyloxy, trifluoromethyl and S(O).sub.Type: GrantFiled: June 7, 1995Date of Patent: April 15, 1997Assignee: Ciba-Geigy CorporationInventors: Tibur Schmidlin, Paul Zbinden, Peter B uhlmayer
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Patent number: 5618963Abstract: A process is described for the preparation of hydroxybenzylphosphonates of the formula I ##STR1## which involves A) reacting a phenol of the formula II ##STR2## with an amine of the formula III ##STR3## formaldehyde or paraformaldehyde and a protonic acid H.sub.n A to give a salt of the formula IV ##STR4## B) distilling off the water of reaction which forms, and C) reacting the reaction mixture, or the salt IV isolated therefrom, with a trialkyl phosphite of the formula ##STR5## in which H.sub.n A is an organic or inorganic acid having n protons,n is 1, 2, 3 or 4,R.sub.1 and R.sub.2 independently of one another are C.sub.1 -C.sub.12 alkyl or C.sub.5 -C.sub.7 cycloalkyl,R.sub.3 and R.sub.4 independently of one another are C.sub.1 -C.sub.12 alkyl or form, together with the nitrogen atom attached to them, a piperidyl or morpholinyl radical, and R.sub.5, R.sub.6 and R.sub.7 independently of one another are C.sub.1 -C.sub.Type: GrantFiled: June 22, 1995Date of Patent: April 8, 1997Assignee: Ciba-Geigy CorporationInventors: Thomas Engert, Hans Stephan, Walter Wolf
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Patent number: 5618690Abstract: The invention concerns novel DNA molecules encoding a modified, endoplasmic reticulum-located "dibasic processing endoprotease" and the use of said endoplasmic reticulum-located "dibasic processing endoprotease" for the correct processing of heterologous polypeptides in transformed hosts.Type: GrantFiled: June 5, 1995Date of Patent: April 8, 1997Assignee: CIBA-Geigy CorporationInventors: Bhabatosh Chaudhuri, Christine Stephan, Peter Seeboth, Howard Riezman
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Patent number: 5618774Abstract: A selective herbicidal composition for controlling grasses and weeds in crops of cultivated plants, comprising, in addition to inert carriers and adjuvants, as active component a mixture ofa) a herbicidally effective mount of a N-phenylsulfonyl-N'-triazinylurea of formula I ##STR1## wherein the substituents are as defined in claim 1, and b) to antagonise the herbicide, an antidotally effective mount of a quinoline derivative of formula IIa ##STR2## wherein R.sub.10 is hydrogen, C.sub.1 -C.sub.8 alkyl or C.sub.1 -C.sub.8 alkyl which is substituted by C.sub.1 -C.sub.6 alkoxy or C.sub.3 -C.sub.6 alkenyloxy; andX.sub.2 is hydrogen or chloro; or of a 1-phenylazole-3-carboxylic acid derivative of formula IIb ##STR3## wherein E is nitrogen or methine;R.sub.11 is --CCl.sub.3, phenyl or halogen-substituted phenyl;R.sub.12 and R.sub.13 are each independently of the other hydrogen or halogen; and R.sub.14 is C.sub.1 -C.sub.4 alkyl.Type: GrantFiled: December 21, 1995Date of Patent: April 8, 1997Assignee: Ciba-Geigy CorporationInventors: Jutta Glock, Manfred Hudetz, Elmar Kerber
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Patent number: 5618778Abstract: The present invention relates to a composition containing a lubricant or hydraulic fluid and in an effective amount to improve extreme pressure and anti-wear properties of said lubricant or hydraulic fluid of at least one compound of the formula II ##STR1## R.sup.1, R.sup.2, and R.sup.3 together with the C atom to which they are bound are tert-C.sub.4 -C.sub.14 -alkyl. R.sup.4 is phenyl, --CH.sub.2 --CH.sub.2 --NH.sub.2, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH(OH)--CH.sub.2 --OH, tert-C.sub.4 -C.sub.14 alkyl, --(CH.sub.2).sub.2 --S--CH(OH)--CH.sub.2 --S-(tert-C.sub.8 -C.sub.12 alkyl), --CH.sub.2 --COOH, --CH.sub.2 --COO--(i-C.sub.8 H.sub.17), --CH.sub.2 --CO--OH.H.sub.2 N-(tert-C.sub.10 -C.sub.16 -alkyl), --P(S)--[O--(i-C.sub.3 H.sub.7)].sub.2, --P(S)--[O--(i-C.sub.8 H.sub.17)].sub.2, .alpha.-naphthyl, benzothiazolyl, benzimidazolyl, thiazolyl, --CH.sub.2 --CH--(OH)--CH.sub.2 --S--R.sup.10 wherein R.sup.10 is tertiary C.sub.4 -C.sub.14 -alkyl, or R.sup.4 is radical ##STR2## R.sup.1, R.sup.2 and R.sup.Type: GrantFiled: April 12, 1995Date of Patent: April 8, 1997Assignee: Ciba-Geigy CorporationInventors: Hermann O. Wirth, Hans-Helmut Friedrich
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Patent number: 5618343Abstract: The present invention relates to pigment and coating compositions that are used to prepare pigmented coatings that exhibit geometric metamerism or metallic flop. The pigment compositions comprise a small particle size pigment and a flop-enhancing agent, which flop-enhancing agent is a copper phthalocyanine, an indanthrone or a carbazole dioxazine compound. A method of enhancing the flop of a pigmented polymeric coating by incorporating one or more flop-enhancing agents into the composition is also disclosed.Type: GrantFiled: December 27, 1994Date of Patent: April 8, 1997Assignee: Ciba-Geigy CorporationInventors: Shivakumar B. Hendi, Edward E. Jaffe
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Patent number: 5618965Abstract: Process for preparing a nitrile of the formula (I) ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 are for example hydrogen, halogen, cyano, hydroxyl, carboxyl, alkyl, alkoxy, alkylthio, alkylamino, dialkylamino, aryl, aryloxy, arylthio or arylamino, or R.sub.2 and R.sub.3 together form a substituted or unsubstituted 4-membered carbon bridge,by reacting an aldehyde of the formula (II) ##STR2## with a hydroxylammonium salt followed by dehydration by heating to an elevated temperature, wherein the reaction takes place in the presence of an anhydrous inorganic sulfate and in the absence of diluents from the group consisting of carboxylic acids, strongly polar aprotic solvents, sulfur compounds and heteroaromatic basic nitrogen compounds.The nitriles obtainable by the process of the invention are valuable intermediates for, in particular, the preparation of diketopyrrolopyrrole pigments.Type: GrantFiled: March 4, 1996Date of Patent: April 8, 1997Assignee: CIBA-GEIGY CorporationInventor: Martin Kudschus
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Patent number: 5618871Abstract: Novel compounds of the formula I and formula II ##STR1## in which R and R.sub.1, independently of one another, are hydrogen or C.sub.1 -C.sub.4 alkyl or together with the carbon atom to which they are attached form a 3,4-dehydrocyclohexylidene ring,R.sub.2 is hydrogen, C.sub.1 -C.sub.8 alkyl or C.sub.5 -C.sub.6 cycloalkyl,R.sub.3 is C.sub.1 -C.sub.8 alkyl or C.sub.5-C.sub.6 cycloalkyl,R.sub.4, R.sub.5 and R.sub.6, independently of one another, are hydrogen or C.sub.1-C.sub.4 alkyl, R.sub.4, R.sub.5 and R.sub.6 together containing 1 to 4 carbon atoms, andR.sub.7 and R.sub.8 are hydrogen or together an additional direct bond, are described for use as stabilizers for organic materials against thermal, oxidative or light-induced degradation.Type: GrantFiled: February 3, 1995Date of Patent: April 8, 1997Assignee: Ciba-Geigy CorporationInventor: Peter Nesvadba
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Patent number: 5616602Abstract: A topically administrable pharmaceutical composition comprising (A) zinc phthalocyanine complex, (B) as carrier for the complex, (i) a N-alkylpyrrolidone together with a pharmaceutically acceptable co-solvent for the complex, (ii) dimethyl sulphoxide or a mixture thereof with a pharmaceutically acceptable co-solvent for the complex, (iii) a liposome, or (iv) a N,N-dialkylbenzamide or a mixture thereof with a pharmaceutically acceptable co-solvent for the complex, and (C) a gelling agent.Type: GrantFiled: June 30, 1994Date of Patent: April 1, 1997Assignee: Ciba-Geigy CorporationInventors: Peter W. Taylor, William G. Love, Brigitte C. H. van der Zanden
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Patent number: 5616695Abstract: The invention relates to azo dyes of formula ##STR1## wherein R.sub.1 is acryloyl, .alpha.-haloacryloyl, .alpha.-methylacryloyl or .alpha.,.beta.-dihalopropionyl, R.sub.2 is C.sub.1 -C.sub.5 alkyl which is unsubstituted or substituted by halogen, cyano, hydroxy, sulfo, sulfato or C.sub.1 -C.sub.4 alkoxy, n is 0 or 1 and m is 1;or wherein R.sub.1 is acryloyl, .alpha.-haloacryloyl, .alpha.-methylacryloyl or .alpha., .beta.-dihalopropionyl, R.sub.2 is C.sub.2 -C.sub.8 alkylene which is unsubstituted or substituted by hydroxy, halogen, C.sub.1 -C.sub.4 alkoxy, n is 0 or 1 and m is 2.The dyes are suitable for dyeing nitrogen-containing or hydroxyl group-containing fibre materials.Type: GrantFiled: August 25, 1995Date of Patent: April 1, 1997Assignee: Ciba-Geigy CorporationInventor: Peter Aeschlimann
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Patent number: 5616774Abstract: Ethylenically unsaturated monomers are protected from premature polymerization during manufacture and storage by the incorporation therein of an effective stabilizing amount of a 7-aryl quinone methide compound.Type: GrantFiled: April 14, 1995Date of Patent: April 1, 1997Assignee: Ciba-Geigy CorporationInventors: Samuel Evans, Matthew E. Gande, Peter Nesvadba, Volker H. von Ahn, Roland A. E. Winter
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Patent number: 5616725Abstract: Pyrrolo[3,4-c]pyrroles of formula ##STR1## wherein D and E are each independently of the other a group of formula ##STR2## The symbols Q, R.sub.8, R.sub.9, R.sub.10, R.sub.11, X, Y, Z, m and n are as defined in claim 1.These pyrrolo[3,4-c]pyrroles are distinguished by outstanding solid state fluorescence in the UV range as well as by the ease with which they can be converted to pyrrolopyrrole pigments even in the substrate in which they are incorporated.Type: GrantFiled: October 11, 1995Date of Patent: April 1, 1997Assignee: Ciba-Geigy CorporationInventors: John S. Zambounis, Zhimin Hao, Abul Iqbal
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Patent number: 5616637Abstract: The invention relates to polyethers of the formula I ##STR1## in which m is 0 or 1; n is an integer in the range from 3 to 100; R.sup.1, in the case where m is 0 or 1, is C.sub.1 -C.sub.36 alkyl or C.sub.7 -C.sub.36 aralkyl, each of which is unsubstituted or substituted by C.sub.5 -C.sub.8 cycloalkyl, is interrupted in the aliphatic part by C.sub.5 -C.sub.8 cycloalkylene or by oxygen or sulfur or --NR.sup.11 -- or is substituted in the aromatic part by 1 to 3 C.sub.1 -C.sub.4 alkyl and/or C.sub.1 -C.sub.4 alkoxy radicals; C.sub.3 -C.sub.36 alkenyl; C.sub.5 -C.sub.12 cycloalkyl which is unsubstituted or substituted by 1 to 4 C.sub.1 -C.sub.4 alkyl and/or C.sub.1 -C.sub.4 alkoxy radicals; C.sub.6 -C.sub.10 aryl which is unsubstituted or substituted by 1 to 4 C.sub.1 -C.sub.4 alkyl and/or C.sub.1 -C.sub.4 alkoxy radicals; and R.sup.1, in the case where m is 0, can alternatively be hydrogen; C.sub.1 -C.sub.36 alkoxy or C.sub.7 -C.sub.36 aralkoxy, each of which is unsubstituted or substituted by C.sub.5 -C.sub.Type: GrantFiled: March 13, 1996Date of Patent: April 1, 1997Assignee: Ciba-Geigy CorporationInventor: Alfred Steinmann
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Patent number: 5616787Abstract: The invention relates to a process for the preparation of polyalkylated aromatic carboxylic acids of formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each independently of one another hydrogen, C.sub.1 -C.sub.20 alkyl, halogen or C.sub.5 -C.sub.8 cycloalkyl, with the proviso that at least two of the substituents R.sub.1, R.sub.2, R.sub.3, R.sub.4 or R.sub.5 are alkyl and/or cycloalkyl, by reacting corresponding aromatic hydrocarbons with carbon dioxide, which reaction is carried out observing special ratios of temperature and pressure. The invention furthermore relates to a one-pot process for the preparation of the corresponding acyl halides.Type: GrantFiled: October 11, 1995Date of Patent: April 1, 1997Assignee: Ciba-Geigy CorporationInventors: Rinaldo Husler, Ivan Orban, Martin Holer
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Patent number: 5616590Abstract: Compounds of the formula I ##STR1## in which a) X is CH and Y is N; orb) X is N and Y is CH; and in whichZ is a C.sub.1 group to which there are bonded 1-3 halogen atoms or 1-3 substituted or unsubstituted hetero atoms O, S and/or N are suitable for controlling and preventing microbial attack on plants.Type: GrantFiled: June 7, 1995Date of Patent: April 1, 1997Assignee: Ciba-Geigy CorporationInventor: Thomas Maetzke
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Patent number: 5616780Abstract: The novel compounds of the formula I ##STR1## in which A is a group of the formula IIa or IIb, ##STR2## Y is oxygen, methylene, ethylidene or a >C.dbd.C(CH.sub.3).sub.2 group, Z is nitrogen, ##STR3## R.sub.1 and R.sub.2 are, for example C.sub.1 -C.sub.5 alkyl, R.sub.3 and R.sub.4 are, for example, hydrogen or methyl, and R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13 and R.sub.14 are, for example, hydrogen, are suitable for stabilizing organic material against oxidative, thermal or light-induced degradation.Type: GrantFiled: January 31, 1996Date of Patent: April 1, 1997Assignee: Ciba-Geigy CorporationInventors: Rita Pitteloud, Bernard Gilg
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Patent number: 5616633Abstract: The present invention provides a liquid epoxy resin composition that includes an epoxy resin, at least one filler and an inorganic thixotropic agent in an amount effective to reduce settling of said filler at ambient temperatures. The composition further includes a polymer powder that dissolves in and thickens the composition when the composition is heated. The polymer powder is added in an amount effective to reduce settling of said filler at temperatures up to the gelling temperature of the composition. The thixotropic agent is added in an amount that the resulting epoxy resin composition is a free-flowing liquid. The composition may optionally further include a curing agent.Type: GrantFiled: September 9, 1994Date of Patent: April 1, 1997Assignee: Ciba-Geigy CorporationInventors: Paul T. Wombwell, Philip D. Willis, Christopher H. Bull