Patents Assigned to Cima Labs Inc.
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Publication number: 20110223115Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.Type: ApplicationFiled: May 2, 2011Publication date: September 15, 2011Applicant: CIMA LABS INC.Inventors: Sathasivan Indiran Pather, Rajendra K. Khankari, Jonathan D. Eichman, Joseph R. Robinson, John Hontz
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Publication number: 20110212034Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.Type: ApplicationFiled: May 2, 2011Publication date: September 1, 2011Applicant: CIMA LABS INC.Inventors: Sathasivan Indiran Pather, Rajendra K. Khankari, Jonathan D. Eichman, Joseph R. Robinson, John Hontz
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Publication number: 20110206621Abstract: The invention described herein relates to an oral transmucosal solid dosage form useful in treating nicotine addiction or as a nicotine substitute or replacement. By virtue of the formulation in combination with nicotine, the invention transmucosally delivers an effective amount of nicotine to the recipient while permitting the accomplishing of such, and manufacture of such, using a relatively small, convenient and orally comfortable dosage form (e.g., tablet) size.Type: ApplicationFiled: January 11, 2011Publication date: August 25, 2011Applicants: Cephalon, Inc., CIMA LABS INC.Inventors: Vikas Agarwal, Brian I. Hague, Rajendra K. Khankari
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Publication number: 20110200681Abstract: A pharmaceutical composition may include a granulate which may include at least one active pharmaceutical ingredient susceptible to abuse by an individual mixed with at least two materials, a first material that is substantially water insoluble and at least partially alcohol soluble and a second material that is substantially alcohol insoluble and at least partially water soluble, wherein the active pharmaceutical ingredient and the two materials are granulated in the presence of water and alcohol. The composition may also include a coating on the granulate exhibiting crush resistance which may have a material that is deposited on the granulate using an alcohol based solvent. The composition further comprises a second particle comprising a fat/wax. The present invention also includes a coated granulate, various dosage forms of the composition, as well as methods of production and tableting.Type: ApplicationFiled: April 27, 2011Publication date: August 18, 2011Applicant: CIMA LABS INC.Inventors: Walid Habib, Ehab Hamed, Derek Moe, Carrie Kraling, Lisa Hillman
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Publication number: 20110073518Abstract: Fentanyl containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than know oral formulation and have advantages in terms of cost and side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.Type: ApplicationFiled: November 29, 2010Publication date: March 31, 2011Applicant: CIMA LABS INC.Inventors: Derek Moe, Vikas Agarwal, Walid Habib
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Publication number: 20110070169Abstract: Fentanyl-containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than known oral formulation and have advantages in terms of reduced cost and reduced side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.Type: ApplicationFiled: November 29, 2010Publication date: March 24, 2011Applicant: CIMA LABS INC.Inventors: Derek Moe, Vikas Agarwal, Walib Habib
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Publication number: 20110071181Abstract: Opiate containing dosage forms and methods using same are described. These dosage forms include substantially less opiates by weight than known oral formulations. These dosage forms are intended for oral administration across the oral mucosa.Type: ApplicationFiled: November 29, 2010Publication date: March 24, 2011Applicant: CIMA LABS INC.Inventor: Derek Moe
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Patent number: 7862832Abstract: Fentanyl containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than know oral formulation and have advantages in terms of cost and side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.Type: GrantFiled: December 30, 2004Date of Patent: January 4, 2011Assignee: Cima Labs, Inc.Inventors: Derek Moe, Vikas Agarwal, Walid Habib
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Patent number: 7862833Abstract: Opiate containing dosage forms and methods using same are described. These dosage forms include substantially less opiates by weight than known oral formulations. These dosage forms are intended for oral administration across the oral mucosa.Type: GrantFiled: December 30, 2004Date of Patent: January 4, 2011Assignee: Cima Labs, Inc.Inventor: Derek Moe
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Patent number: 7858121Abstract: Fentanyl-containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than known oral formulation and have advantages in terms of reduced cost and reduced side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.Type: GrantFiled: December 30, 2004Date of Patent: December 28, 2010Assignee: Cima Labs, Inc.Inventors: Derek Moe, Vikas Agarwal, Walid Habib
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Patent number: 7793784Abstract: A child resistant package for tablets is disclosed. The package includes an outer sleeve and a blister package. The blister package is designed to fit within the outer sleeve, and is capable of being slid from a closed position to an open position. The blister package includes a blister sheet and a lidding material sheet that is peeled from the blister sheet to access the tablets.Type: GrantFiled: January 13, 2006Date of Patent: September 14, 2010Assignee: Cima Labs, Inc.Inventor: Michelle Nivala
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Patent number: 7670617Abstract: The invention relates to methods and composition for improving absorption and dissolution of active ingredients of drugs. The invention provides a method of administration of an active ingredient to a mammal through a transmucosal route that includes delivering the active ingredient to a desired site in a body of the mammal, and, sequentially, at the desired site, promoting dissolution and absorption of the active ingredient. In a preferred embodiment, the pH of the localized environment of the active ingredient is sequentially modified to promote dissolution and absorption.Type: GrantFiled: September 8, 2004Date of Patent: March 2, 2010Assignee: CIMA Labs Inc.Inventors: S. Indiran Pather, John Hontz, John M. Siebert
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Publication number: 20090214442Abstract: Described herein are oral transmucosal solid dosage forms useful in treating nicotine addiction or as a nicotine substitute or replacement. By virtue of the formulation in combination with nicotine, the dosage forms transmucosally delivers an effective amount of nicotine to the recipient while permitting the accomplishing of such, and manufacture of such, using a relatively small, convenient and orally comfortable dosage form (e.g., tablet) size.Type: ApplicationFiled: October 6, 2008Publication date: August 27, 2009Applicants: Cephalon, Inc., CIMA LABS INC.Inventors: Vikas Agarwal, Brian I. Hague, Rajendra K. Khankari
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Publication number: 20090202632Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administerable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of additional pH adjusting substance in combination with the effervescent for promoting the absorption of drugs is also disclosed.Type: ApplicationFiled: April 24, 2009Publication date: August 13, 2009Applicant: CIMA LABS INC.Inventors: Sathasivan Indiran Pather, Rajendra K. Khankari, Jonathan D. Eichman, Joseph R. Robinson, John Hontz
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Publication number: 20080311205Abstract: A pharmaceutical composition may include a coated particulate which may include at least one active pharmaceutical ingredient, particularly one susceptible to abuse by an individual. The coated particles may include a fat/wax and have improved controlled release and/or crush resistance. Method of making these coated particulate and dosage forms therewith are also described.Type: ApplicationFiled: March 12, 2008Publication date: December 18, 2008Applicant: CIMA LABS, Inc.Inventors: Walid A. Habib, Ehab Hamed, Manuel A. Vega Zepeda
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Publication number: 20080131508Abstract: The invention described herein relates to an oral transmucosal solid dosage form useful in treating nicotine addiction or as a nicotine substitute or replacement. By virtue of the formulation in combination with nicotine, the invention transmucosally delivers an effective amount of nicotine to the recipient while permitting the accomplishing of such, and manufacture of such, using a relatively small, convenient and orally comfortable dosage form (e.g., tablet) size.Type: ApplicationFiled: November 20, 2007Publication date: June 5, 2008Applicants: Cephalon, Inc, CIMA LABS INC.Inventors: Vikas Agarwal, Brian I. Hague, Rajendra K. Khankari
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Publication number: 20080069891Abstract: A pharmaceutical composition may include a granulate which may include at least one active pharmaceutical ingredient susceptible to abuse by an individual mixed with at least two materials, a first material that is substantially water insoluble and at least partially alcohol soluble and a second material that is substantially alcohol insoluble and at least partially water soluble, wherein the active pharmaceutical ingredient and the two materials are granulated in the presence of water and alcohol. The composition may also include a coating on the granulate exhibiting crush resistance which may have a material that is deposited on the granulate using an alcohol based solvent. The composition further comprises a second particle comprising a fat/wax. The present invention also includes a coated granulate, various dosage forms of the composition, as well as methods of production and tableting.Type: ApplicationFiled: September 13, 2007Publication date: March 20, 2008Applicant: CIMA LABS, Inc.Inventors: Walid Habib, Ehab Hamed, Derek Moe
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Publication number: 20080031947Abstract: The present invention provides an orally dissolvable/disintegrable, lyophilized, dosage form adapted for direct oral dosing, including an active pharmaceutical ingredient (“API”) containing particle which is coated with a lyophilizing solvent protective coating, which protects the form and/or attributes of the particle and/or API, and a matrix. There is also provided a method of making an orally dissolvable/disintegrable lyophilized dosage form in accordance with the present invention, and a method of treating a patient with a dosage form in accordance with the present invention.Type: ApplicationFiled: July 23, 2007Publication date: February 7, 2008Applicants: CIMA LABS INC., Cephalon FranceInventors: Ehab Hamed, Lisa Hillman, Rajendra Khankari, Derek Moe, Thanh-Tam Nguyen
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Publication number: 20080031944Abstract: This invention relates to orally disintegrable, lorazepam-containing dosage forms which are storage stable and disintegrable within about 90 seconds or less. In one embodiment, there is provided a storage stable, orally disintegrable dosage form comprising: protected lorazepam particles comprising lorazepam and polymeric material having a glass transition temperature of about 65° C. or above. Also disclosed is a method of producing a storage stable lorazepam containing tablet.Type: ApplicationFiled: August 2, 2007Publication date: February 7, 2008Applicant: CIMA LABS INC.Inventors: Larry Bereuter, David K. Brown, Derek Moe
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Publication number: 20080031949Abstract: The present invention provides an orally dissolvable/disintegrable, lyophilized dosage form including a protected granulate comprising an active ingredient and a protective granulation binder, which substantially protects the form and/or attributes of a granulate and/or active ingredient, and participates in masking bad tasting active ingredients, such as sulfur-containing materials, and a matrix, and a method for making same. There is also provided a method of treating a patient using any orally dissolvable/disintegrable lyophilized dosage form comprising the steps of placing the dosage form in the mouth of a patient in need of treatment, allowing the dosage form to disintegrate/dissolve sufficiently to allow it, and in particular, the protected granulate, to be swallowed as a solution, suspension or slurry, and swallowing the at least partially disintegrated/dissolved dosage form.Type: ApplicationFiled: July 23, 2007Publication date: February 7, 2008Applicants: CIMA LABS INC., Cephalon FranceInventors: Ehab Hamed, Rajendra Khankari, Derek Moe, Thanh-Tam Nguyen