Patents Assigned to Cima Labs Inc.
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Publication number: 20070281013Abstract: The present invention relates to tablets containing prednisolone salts and in particular prednisolone sodium phosphates. The dosage forms include ODTs and non-ODTs, effervescent tablets and noneffervescent tablets and tablets meeting certain performance criteria.Type: ApplicationFiled: December 13, 2006Publication date: December 6, 2007Applicant: Cima Labs, Inc.Inventors: Walid Habib, Bhaveshkumar Kothari
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Publication number: 20070281014Abstract: The present invention relates to tablets containing prednisolone salts and in particular prednisolone sodium phosphates. The tablets include ODTs and non-ODTs, effervescent tablets and noneffervescent tablets and tablets meeting certain performance criteria.Type: ApplicationFiled: December 13, 2006Publication date: December 6, 2007Applicant: Cima Labs, Inc.Inventors: Walid Habib, Bhaveshkumar Kothari
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Publication number: 20070048373Abstract: The present invention relates to a method of producing a dried wet granulate having a desirable average particle size and particle size distribution and dosage forms made from that granulate.Type: ApplicationFiled: August 21, 2006Publication date: March 1, 2007Applicant: CIMA LABS INC.Inventors: Sara Chastain, Walid Habib, Derek Moe
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Publication number: 20070036853Abstract: Fentanyl containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than know oral formulation and have advantages in terms of cost and side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.Type: ApplicationFiled: September 15, 2006Publication date: February 15, 2007Applicant: CIMA LABS INC.Inventors: Vikas Agarwal, Walid Habib, Derek Moe
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Publication number: 20060292219Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.Type: ApplicationFiled: August 28, 2006Publication date: December 28, 2006Applicant: CIMA LABS INC.Inventors: Sathasivan Pather, Rajendra Khankari, Jonathan Eichman, Joseph Robinson, John Hontz
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Publication number: 20060283760Abstract: A child resistant package for tablets is disclosed. The package includes an outer sleeve and a blister package. The blister package is designed to fit within the outer sleeve, and is capable of being slid from a closed position to an open position. The blister package includes a blister sheet and a lidding material sheet that is peeled from the blister sheet to access the tablets.Type: ApplicationFiled: January 13, 2006Publication date: December 21, 2006Applicant: CIMA LABS INC.Inventor: Michelle Nivala
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Publication number: 20060147517Abstract: The present invention relates to taste masking system, taste masked formulations, dosage forms made from those formulations and methods of making those formulations that involve dissolving or dispersing a pH dependant polymer and a non-plasticizing active pharmaceutical ingredient in a solvent, granulating using that material or forming layers over a solid support therewith. This can be followed with the use of a taste masking overcoating layer.Type: ApplicationFiled: January 4, 2006Publication date: July 6, 2006Applicant: CIMA LABS INC.Inventors: Walid Habib, Derek Moe
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Publication number: 20060147516Abstract: The present invention relates to taste masking system, taste masked formulations, dosage forms made from those formulations and methods of making those formulations that involve dissolving or dispersing a pH dependant polymer and alprazolam in a solvent, granulating using that material or forming layers over a solid support therewith. This can be followed with the use of an overcoating layer.Type: ApplicationFiled: January 4, 2006Publication date: July 6, 2006Applicant: CIMA LABS INC.Inventors: Walid Habib, Derek Moe
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Publication number: 20060062833Abstract: The present invention relates to a wound dressing that can be applied as a solid to a wound area and can assist in stopping blood flow and promoting clot formation.Type: ApplicationFiled: September 15, 2005Publication date: March 23, 2006Applicant: CIMA LABS INC.Inventor: Derek Moe
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Patent number: 6974590Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administerable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.Type: GrantFiled: February 20, 2002Date of Patent: December 13, 2005Assignee: Cima Labs Inc.Inventors: Sathasivan Indiran Pather, Rajendra K. Khankari, Jonathan D. Eichman, Joseph R. Robinson, John Hontz
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Publication number: 20050169989Abstract: Fentanyl containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than know oral formulation and have advantages in terms of cost and side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.Type: ApplicationFiled: December 30, 2004Publication date: August 4, 2005Applicant: CIMA LABS INC.Inventors: Derek Moe, Vikas Agarwal, Walid Habib
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Publication number: 20050163838Abstract: Opiate containing dosage forms and methods using same are described. These dosage forms include substantially less opiates by weight than known oral formulations. These dosage forms are intended for oral administration across the oral mucosa.Type: ApplicationFiled: December 30, 2004Publication date: July 28, 2005Applicant: CIMA LABS INC.Inventor: Derek Moe
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Publication number: 20050142197Abstract: Fentanyl containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than know oral formulation and have advantages in terms of cost and side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.Type: ApplicationFiled: December 30, 2004Publication date: June 30, 2005Applicant: CIMA LABS INC.Inventors: Derek Moe, Vikas Agarwal, Walid Habib
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Publication number: 20050142198Abstract: Fentanyl-containing dosage forms and methods using same are described. These dosage forms include substantially less fentanyl by weight than known oral formulation and have advantages in terms of reduced cost and reduced side effects. These dosage forms are intended for oral administration of fentanyl across the oral mucosa.Type: ApplicationFiled: December 30, 2004Publication date: June 30, 2005Applicant: CIMA LABS INC.Inventors: Derek Moe, Vikas Agarwal, Walid Habib
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Publication number: 20050064030Abstract: A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administrable medicament in combination with an effervescent for use in promoting absorption of the medicament in the oral cavity. The use of an additional pH adjusting substance in combination with the effervescent for promoting the absorption drugs is also disclosed.Type: ApplicationFiled: October 29, 2004Publication date: March 24, 2005Applicant: CIMA LABS INC.Inventors: Sathasivan Pather, Rajendra Khankari, Jonathan Eichman, Joseph Robinson, John Hontz
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Publication number: 20050037072Abstract: The pharmaceutical compositions of the present invention comprise rectally and vaginally administerable dosage forms that contain effervescent agents as penetration enhancers for drugs. Effervescence occurs in the rectum or vagina, once the dosage form is administered or at a predetermined time following administration. The effervescent agents can be used alone or in combination with pH adjusting substance, which further promote dissolution and absorption of the active ingredient.Type: ApplicationFiled: September 21, 2004Publication date: February 17, 2005Applicant: CIMA LABS INC.Inventors: S. Pather, Joseph Robinson, Jonathan Eichman, Rajendra Khankari, John Hontz
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Publication number: 20050031677Abstract: The invention relates to methods and composition for improving absorption and dissolution of active ingredients of drugs. The invention provides a method of administration of an active ingredient to a mammal through a transmucosal route that includes delivering the active ingredient to a desired site in a body of the mammal, and, sequentially, at the desired site, promoting dissolution and absorption of the active ingredient. In a preferred embodiment, the pH of the localized environment of the active ingredient is sequentially modified to promote dissolution and absorption.Type: ApplicationFiled: September 8, 2004Publication date: February 10, 2005Applicant: CIMA LABS INC.Inventors: S. Pather, John Hontz, John Siebert
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Patent number: 6764696Abstract: The pharmaceutical compositions of the present invention comprise orally administerable dosage forms that use effervescence as a penetration enhancer for drugs known, or suspected, of having poor bioavailability. Effervescence can occur in the stomach, once the tablet or other dosage form is ingested. In addition to effervescence in the stomach, or as alternative technique, by the use of appropriate coatings and other techniques, the effervescence can occur in other parts of the gastrointestinal tract, including, but not limited to, the esophagus, duodenum, and colon. The site of effervescence and drug release is chosen to correspond with the segment of the gastrointestinal tract displaying maximal absorption of the formulated drug, or to gain some other therapeutic advantage.Type: GrantFiled: March 18, 2003Date of Patent: July 20, 2004Assignee: Cima Labs Inc.Inventors: S. Indiran Pather, Joseph R. Robinson, Jonathan D. Eichman, Rajendra K. Khankari, John Hontz, Sangeeta V. Gupte
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Patent number: 6740341Abstract: The present invention relates to a core containing a drug encased in a spacing layer and a taste masking layer which provides effective taste masking for in-mouth disintegrable dosage forms containing highly objectionable tasting drugs, as well as dosage forms containing these cores.Type: GrantFiled: November 24, 1999Date of Patent: May 25, 2004Assignee: Cima Labs Inc.Inventors: Kris E. Holt, Rajendra K. Khankari, John Hontz
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Patent number: 6692771Abstract: Novel emulsion compositions which improve the rate and/or extent of absorption of drugs are disclosed. The novel emulsion compositions of the present invention include drug-containing emulsions adsorbed onto solid particles which may be further formulated into solid dosage forms, methods of preparing such emulsion compositions and their uses thereof. The emulsion compositions and their dosage forms improve the drug-load and the bioavailability of a wide range of drugs including drugs that are known or suspected of having poor bioavailability by the utilization of several different mechanisms.Type: GrantFiled: February 23, 2001Date of Patent: February 17, 2004Assignee: CIMA Labs Inc.Inventors: S. Indiran Pather, Sangeeta V. Gupte, Rajendra K. Khankari, John Hontz, Ramya Kumbale