Patents Assigned to Closure Medical Corporation
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Patent number: 6372313Abstract: A package assembly or kit can be used in conjunction with storing and dispensing adhesive materials. The package assembly includes an enclosure in which an applicator and a container may be positioned. The container contains adhesive material. The enclosure may include a base and a cover. The base preferably includes one or more cavities, with at least one applicator disposed in one of the cavities. Further, the container may be disposed in another of the cavities. The cover may be provided with a plurality of wells. The container may include a restrictor positioned within a neck of the container. The restrictor is provided to limit the volume of adhesive material retained in an absorbent end of an applicator such as a swab.Type: GrantFiled: September 1, 1998Date of Patent: April 16, 2002Assignee: Closure Medical CorporationInventors: Keith R. D'Alessio, Gary F. Prokop, Leonard F. Czuba, Carl E. Behrend, Peter J. Kopec
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Publication number: 20020037310Abstract: A method of treating living tissue includes applying to living tissue a biocompatible adhesive composition, where the adhesive composition contains at least one alkyl ester cyanoacrylate monomer and a polymerization initiator or accelerator, wherein the polymerization initiator or accelerator is a quaternary amine, or where the adhesive composition contains a mixture of two monomer species having different absorption rates.Type: ApplicationFiled: August 2, 2001Publication date: March 28, 2002Applicant: Closure Medical CorporationInventors: Jerry Y. Jonn, John Bobo, Julian Quintero, Jon P. Moseley, Dennis D. Burns
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Patent number: 6352704Abstract: A sterile or non-sterile flavored monomeric adhesive composition includes a flavoring additive and a monomer. The composition can be applied, for example, to skin or the inside of the mouth. A method of making a sterile, flavored adhesive composition includes placing a mixture of a polymerizable adhesive monomer and a flavoring additive in a container, sealing the container, and sterilizing the mixture and the container. The flavored adhesive composition is particularly useful as a medical adhesive and can include 1,1 -disubstituted ethylene monomers, such as &agr;-cyanoacrylates.Type: GrantFiled: June 30, 1999Date of Patent: March 5, 2002Assignee: Closure Medical CorporationInventors: William S. C. Nicholson, Upvan Narang
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Publication number: 20020012678Abstract: An adhesive composition that contains cyanoacrylate monomers and cyclic or alkyl- or phenyl-terminated linear polydimethylsiloxane is particularly useful in applications requiring flexibility and elasticity. A method of removing, reducing or preventing scar tissue including applying an adhesive composition that contains cyanoacrylate monomer and cyclic or alkyl- or phenyl-terminated linear polydimethylsiloxane.Type: ApplicationFiled: December 22, 2000Publication date: January 31, 2002Applicant: CLOSURE MEDICAL CORPORATIONInventor: Upvan Narang
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Patent number: 6340097Abstract: An applicator for dispensing compositions includes a crushable ampoule covered with a barrier material that serves as a protective barrier. The applicator can also include a body made of a flexible material that holds at least one crushable ampoule. The protective barrier protects the user's fingers from puncture by shards created during breakage of the crushable ampoule.Type: GrantFiled: November 23, 1999Date of Patent: January 22, 2002Assignee: Closure Medical CorporationInventors: Keith R. D'Alessio, Andres Rivera, Anthony S. Voiers, Joe B. Barefoot
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Patent number: 6322852Abstract: An applicator tip for dispensing a polymerizable and/or cross-linkable material which is porous, absorbent or adsorbent and includes a polymerization or cross-linking initiator. The initiator initiates polymerization or cross-linking when the polymerizable and/or cross-linkable material is dispensed through the applicator tip. The polymerizable and/or cross-linkable material may be applied to a variety of substrates.Type: GrantFiled: February 17, 2000Date of Patent: November 27, 2001Assignee: Closure Medical CorporationInventor: Jeffrey C. Leung
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Patent number: 6310166Abstract: A method of making a sterile adhesive composition includes placing a mixture of a polymerizable adhesive monomer and a thickening agent in a container, sealing the container, and sterilizing the mixture and the container. The method provides superior viscosity for the monomer composition. The sterile adhesive composition is particularly useful as a medical adhesive and can comprise 1,1-disubstituted ethylene monomers, such as &agr;-cyanoacrylates.Type: GrantFiled: August 12, 1999Date of Patent: October 30, 2001Assignee: Closure Medical CorporationInventors: Timothy Hickey, Ubonwan A. Stewart
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Patent number: 6306243Abstract: The pH-modified monomer and polymer compositions are useful as biomedical and surgical adhesives, sealants, implants and bioactive agent release carriers or matrices. They comprise a monomer or polymer; and an effective amount of an acidic or basic pH modifier effective to modify the pH of an immediate in vivo environment of the composition to a pH range at which the polymer biodegrades at a different rate than at physiologic pH. The invention also relates to in vivo applications in which surfaces are joined or treated with such pH-modified biocompatible compositions.Type: GrantFiled: June 7, 2000Date of Patent: October 23, 2001Assignee: Closure Medical CorporationInventors: Jeffrey G. Clark, Jeffrey C. Leung
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Patent number: 6283933Abstract: A disposable applicator includes a generally tubular applicator body having a closed proximal end and an open distal end and a frangible vial inside. The proximal end is covered by a drying swab while the distal end is covered by an applicator swab that is in open communication with the interior of the applicator body. Within the applicator body is a frangible vial containing a biomedically useful liquid composition, such as an &agr;-cyanoacrylate adhesive, a medicament, or both. The applicator is useful for applying liquid compositions to target sites such as tissue, particularly sites of topical pathology, such as stomatitis lesions.Type: GrantFiled: December 23, 1998Date of Patent: September 4, 2001Assignee: Closure Medical CorporationInventors: Keith R. D'Alessio, William M. Cotter
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Patent number: 6245933Abstract: An &agr;-cyanoacrylate may be formed by first condensing a cyanoacetate with paraformaldehyde or formaldehyde; reacting the polymer formed with an alcohol to transesterify the polymer; and depolymerizing the polymer to form &agr;-cyanoacrylate monomers.Type: GrantFiled: November 19, 1999Date of Patent: June 12, 2001Assignee: Closure Medical CorporationInventors: Bernard Malofsky, Ibraheem T. Badejo
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Patent number: 6217603Abstract: A method of joining together in vivo living tissue surfaces includes (a) holding together at least two tissue surfaces to form abutted tissue surfaces, (b) applying across the abutted tissue surfaces an excessive amount of an adhesive composition comprising at least one monomer that forms a medically acceptable polymer with an applicator having a porous applicator tip; and (c) maintaining the tissue surfaces in contact in vivo until the composition polymerizes to form a thick film of polymerized composition on the abutted tissue surface.Type: GrantFiled: August 29, 1997Date of Patent: April 17, 2001Assignee: Closure Medical CorporationInventors: Jeffrey G. Clark, Jeffrey C. Leung
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Patent number: 6183593Abstract: An adhesive composition that contains cyanoacrylate monomers and cyclic or alkyl- or phenyl-terminated linear polydimethylsiloxane is particularly useful in applications requiring flexibility and elasticity.Type: GrantFiled: December 23, 1999Date of Patent: February 6, 2001Assignee: Closure Medical CorporationInventors: Upvan Narang, William S. C. Nicholson
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Patent number: 6174919Abstract: An adhesive composition includes compounds having the following formula: wherein R1 is alkyl, alkoxy alkyl, anhydride, ether, ester, or amide, and R2 and R3 are hydrogen, alkyl, alkoxy alkyl, hydroxy, alkenyl, ester, carboxylic acid or ether and wherein R1 is optionally omitted where R2 and R3 are not both hydrogen.Type: GrantFiled: February 18, 1998Date of Patent: January 16, 2001Assignee: Closure Medical CorporationInventor: Timothy P. Hickey
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Patent number: 6143805Abstract: A method for sterilizing a liquid adhesive composition includes subjecting the composition to electron beam irradiation while it is enclosed in a container.Type: GrantFiled: February 18, 1998Date of Patent: November 7, 2000Assignee: Closure Medical CorporationInventors: Timothy Hickey, Ubonwan A. Stewart
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Patent number: 6143352Abstract: The pH-modified monomer and polymer compositions are useful as biomedical and surgical adhesives, sealants, implants and bioactive agent release carriers or matrices. They comprise a monomer or polymer; and an effective amount of an acidic or basic pH modifier effective to modify the pH of an immediate in vivo environment of the composition to a pH range at which the polymer biodegrades at a different rate than at physiologic pH. The invention also relates to in vivo applications in which surfaces are joined or treated with such pH-modified biocompatible compositions.Type: GrantFiled: September 18, 1996Date of Patent: November 7, 2000Assignee: Closure Medical CorporationInventors: Jeffrey G. Clark, Jeffrey C. Leung
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Patent number: 6099807Abstract: An applicator tip for dispensing a polymerizable and/or cross-linkable material which is porous, absorbent or adsorbent and includes a polymerization or cross-linking initiator. The initiator initiates polymerization or cross-linking when the polymerizable and/or cross-linkable material is dispensed through the applicator tip. The polymerizable and/or cross-linkable material may be applied to a variety of substrates.Type: GrantFiled: December 29, 1998Date of Patent: August 8, 2000Assignee: Closure Medical CorporationInventor: Jeffrey C. Leung
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Patent number: 6055828Abstract: Treatment methods for glass medical adhesive applicators in which a glass applicator is exposed to ammonium sulfate, an acidic gas, a plasma or a silanizing agent in order to remove or coat alkalide materials trapped in the glass.Type: GrantFiled: December 30, 1997Date of Patent: May 2, 2000Assignee: Closure Medical CorporationInventors: Andres Rivera, Upvan Narang, Ubonwan A. Stewart
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Patent number: 6010714Abstract: A biocompatible monomer composition includes at least one monomer, which forms a medically acceptable polymer, and an effective amount of at least one heat dissipating agent sufficient to reduce exothermic polymerization temperature increase of the composition. The heat dissipating agent enhances patient comfort and prevents necrosis of living tissue normally encountered with such medical adhesives.Type: GrantFiled: November 22, 1996Date of Patent: January 4, 2000Assignee: Closure Medical CorporationInventors: Jeffrey C. Leung, Jeffrey G. Clark
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Patent number: 5981621Abstract: A biocompatible monomer composition includes: (A) at least one monomer, which forms a medically acceptable polymer; (B) at least one plasticizing agent present in the composition in an amount of from 0.5 wt. % to 15 wt. % of the composition; and (C) at least one acidic stabilizing agent having a pK.sub.a ionization constant of from about 1 to about 7. The composition can be applied to a variety of materials and is particularly suitable as in vivo tissue adhesive. A method of joining together in vivo two surfaces, e.g.Type: GrantFiled: February 29, 1996Date of Patent: November 9, 1999Assignee: Closure Medical CorporationInventors: Jeffrey G. Clark, Jeffrey C. Leung
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Patent number: 5928611Abstract: An applicator tip for dispensing a polymerizable and/or cross-linkable material which is porous, absorbent or adsorbent and includes a polymerization or cross-linking initiator. The initiator initiates polymerization or cross-linking when the polymerizable and/or cross-linkable material is dispensed through the applicator tip. The polymerizable and/or cross-linkable material may be applied to a variety of substrates.Type: GrantFiled: June 7, 1995Date of Patent: July 27, 1999Assignee: Closure Medical CorporationInventor: Jeffrey C. Leung