Abstract: A package assembly or kit can be used in conjunction with storing and dispensing adhesive materials. The package assembly can include an enclosure in which an applicator and a container may be positioned. The container contains adhesive material. The enclosure may include a base and a cover. The base preferably includes one or more cavities, with at least one applicator disposed in one of the cavities. Further, the container may be disposed in another of the cavities. The cover may be provided with a plurality of wells. The container may include a restrictor positioned within a neck of the container. The restrictor is provided to limit the volume of adhesive material retained in an absorbent end of an applicator such as a swab. The package assembly can be provided in a sterilized condition.

Abstract: A medical procedure kit includes a saleable package including: an outer wrap defining at least one sealed and sterile interior portion; at least one sterilized surgical tool located within the at least one interior portion and sterilized after insertion into the at least one interior portion by a sterilization process that sterilizes both the at least one interior portion and the at least one sterilized surgical tool; a container having a medical adhesive therein, wherein the adhesive is also sterilized; and a medical adhesive applicator for applying the medical adhesive, wherein the at least one sterilized surgical tool forms part of a wound closure system.

Abstract: A method of treating or preventing skin yeast infections, such as cutaneous candidiasis, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to a skin yeast infection, optionally with at least one of an additional anti-fungal agent or a skin care additive, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.

Abstract: A tissue bonding article includes a flexible material, an adhesive substance applied over at least a portion of a bottom side of the flexible material, and a polymerizable adhesive composition permeated throughout at least a portion of the flexible material.

Abstract: An applicator/dispenser assembly for dispensing and/or applying an adhesive material comprises: a first body portion and a second body portion, at least one of the first and second body portions being movable relative to the other of the first and second body portions; a cavity in at least one of the first and second body portions; and a piercing or breaking member arranged on one of the first and second body portions. Movement of one of the first and second body portions relative to the other of the first and second body portions moves the piercing or breaking member into the cavity. When a container of adhesive material is at least partially disposed within the cavity, movement of one of the first and second body portions relative to the other moves the piercing or breaking member to rupture the container for dispensing and/or applying the adhesive material.

Abstract: A container made without employing a mold release agent, comprised of halogenated polymeric material provides an extended shelf-life for 1,1-disubstituted ethylene adhesive monomer compositions.

Abstract: A single use applicator for applying an adhesive material, particularly for medical use, includes a semi-rigid base strip having a longitudinal direction, and a reservoir containing an adhesive material, the reservoir being secured to one side of the base strip. The base strip is arranged to be folded about an axis substantially perpendicular to the longitudinal direction such that a portion of the reservoir is ruptured and pressure is applied on the reservoir to expel the adhesive material from the ruptured reservoir. In embodiments, the base strip has a hole formed therethrough and a projection corresponding to the hole formed on one side thereof. The reservoir is disposed over the hole on a side of the base strip opposite the one side on which the projection is formed. When the base strip is folded, the projection extends into the hole to apply pressure on the reservoir.

Abstract: A monomeric adhesive composition includes a polymerizable monomer, such as a 1,1-disubstituted monomer such as a cyanoacrylate, and an antimicrobial agent, wherein the antimicrobial agent is a phenolic active compound. Examples of suitable phenolic active compounds include halogenated phenol compounds such as chlorinated phenol compounds (such as triclosan) and brominated phenol compounds.

Abstract: A medical procedure kit incorporates one or more surgical tools necessary to perform at least part of a medical procedure, along with a container having a quantity of a medical adhesive. Medical adhesives are useful as an alternate or an adjunct to surgical sutures and/or staples in wound closure, as well as for covering and protecting surface wounds such as lacerations, abrasions, burns, stomatitis, sores, minor cuts and scrapes, and other wounds. As such, the inclusion of such an adhesive into a composite medical procedure kit can be of great assistance to a medical doctor or surgeon by providing in single kit form, tools necessary to complete many medical procedures, without having to use multiple procedure kits. The adhesive may be independently sterilized and wrapped from the other surgical tools of the resultant kit, and then associated into kit form, or assembled and sterilized together as a unitary kit.

Abstract: A method of treating acne includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with acne, optionally with at least one of an additional anti-acne agent or other active agent, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.

Abstract: A method of treating insect bites includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with an insect bite, optionally with at least one of an additional active agent, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.

Abstract: A device for use in combining components to form a compound and for applying the compound to a substrate includes a first housing having a first-housing receptacle with a proximal end, a plunger including a proximal end and a distal end, the distal end being disposed in the proximal end of the first-housing receptacle, at least one penetrable barrier sealing the receptacle, and a first component of the compound disposed in the first-housing receptacle, where one of the first housing and the plunger includes an applicator tip retaining a second component of the compound and being separated from the first component by the at least one penetrable barrier.

Abstract: A package assembly or kit can be used in conjunction with storing and dispensing adhesive materials. The package assembly can include an enclosure in which an applicator and a container may be positioned. The container contains adhesive material. The enclosure may include a base and a cover. The base preferably includes one or more cavities, with at least one applicator disposed in one of the cavities. Further, the container may be disposed in another of the cavities. The cover may be provided with a plurality of wells. The container may include a restrictor positioned within a neck of the container. The restrictor is provided to limit the volume of adhesive material retained in an absorbent end of an applicator such as a swab. The package assembly can be provided in a sterilized condition.

Abstract: An applicator/dispenser assembly for dispensing and/or applying an adhesive material comprises: a first body portion and a second body portion, at least one of the first and second body portions being movable relative to the other of the first and second body portions; a cavity in at least one of the first and second body portions; and a piercing or breaking member arranged on one of the first and second body portions. Movement of one of the first and second body portions relative to the other of the first and second body portions moves the piercing or breaking member into the cavity. When a container of adhesive material is at least partially disposed within the cavity, movement of one of the first and second body portions relative to the other moves the piercing or breaking member to rupture the container for dispensing and/or applying the adhesive material.

Abstract: A single-use applicator assembly for dispensing and applying a polymerizable monomeric adhesive material includes: a base portion having at least one sealed compartment; a polymerizable monomeric adhesive material contained in the compartment; an applicator at least partially disposed in the compartment such that a tip of the applicator is proximate the adhesive material. The at least one sealed compartment may comprise first and second sealed compartments that are separated with the polymerizable monomeric adhesive material contained in the first compartment and the applicator at least partially disposed in the second compartment. Alternatively, the first and second compartments may be open to each other. In such case, the applicator assembly may further comprise a plunger that defines the second compartment and that is movable into the first compartment to displace the adhesive material into the second compartment. A kit can include multiple applicator assemblies that are separate or frangibly connected.

Abstract: A method of treating or preventing epistaxis includes applying a synthetic or semi-synthetic polymerizable monomer polymerizable monomer adhesive composition to a nasal area afflicted with or prone or susceptible to epistaxis, optionally with at least one of an additional anti-microbial or therapeutic agent, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the nasal area.

Abstract: A method of treating or preventing oral fungal infection includes applying a polymerizable monomer adhesive composition to an area afflicted with or susceptible to oral fungal infection, optionally with at least one of an additional anti-fungal agent, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area.

Abstract: An applicator tip for an applicator for applying a polymerizable monomeric adhesive composition can include a bioactive material, a flavorant, a polymerization initiator, and/or a polymerization rate modifier.

Abstract: Adhesive compositions, particularly medical adhesive compositions, often include several components that may react differently to different sterilization processes, particularly when combined with one another. The present invention is directed to methods of sterilizing different components or groups of components of a final adhesive composition. The different components or groups of components may be sterilized in separate containers before packaging the components or groups of components within a kit, and thereafter sterilizing the kit.