Abstract: An applicator for dispensing compositions includes a crushable ampoule covered with a barrier material that serves as a protective barrier. The applicator can also include a body made of a flexible material that holds at least one crushable ampoule. The protective barrier protects the user's fingers from puncture by shards created during breakage of the crushable ampoule.

Abstract: An adhesive composition includes a polymerizable adhesive monomer and at least one dual function stabilizer. The stabilizer provides superior stabilization and shelf-life of the composition, and enhances wound healing properties of the monomer composition.

Abstract: A microapplicator for dispensing and applying an adhesive or sealant material comprises a handle portion, an applicator tip connected to the handle portion, and a microreservoir at the applicator tip arranged to hold a small amount, about 20 microliters or less, of an adhesive/sealant material until dispensing. In embodiments, the applicator tip has a width of about 1 mm. The microapplicator may include a second reservoir, containing the adhesive/sealant material, that is arranged to supply the adhesive/sealant material to the microreservoir at the applicator tip. The second reservoir may comprise a frangible ampoule disposed in the handle portion, a container, such as a syringe, connected to the handle portion, or the handle portion itself. The applicator tip may comprise one of a polymer loop, a spatula, a rolling ball, a grate, a porous material, such as a swab, a foam pad or a mesh, and a brush.

Abstract: An article of manufacture for dispensing a synthetic or semi-synthetic polymerizable or cross-linkable adhesive monomer material includes a pipette-shaped applicator, and a synthetic or semi-synthetic adhesive monomer material sealed in the pipette-shaped applicator prior to dispensing the material.

Abstract: An adhesive remover composition and methods for removing medical grade and other adhesive compositions including, but not limited to, cyanoacrylate adhesive compositions from surfaces including, but not limited to, areas of tissue, including areas of compromised skin. The composition, which is preferably bio-compatible, includes a suitable remover compound such as an alkylester plasticizer combined with an antimicrobial preservative to protect the composition from microorganisms. A method of removing adhesive compositions includes applying the remover composition to the adhesive composition using an applicator, such as a spray applicator or a towelette, allowing the remover to interact with the adhesive composition and then removing the remover and the adhesive composition.

Abstract: A microapplicator for dispensing and applying an adhesive or sealant material comprises a handle portion, an applicator tip connected to the handle portion, and a microreservoir at the applicator tip arranged to hold a small amount, about 20 microliters or less, of an adhesive/sealant material until dispensing. In embodiments, the applicator tip has a width of about 1 mm. The microapplicator may include a second reservoir, containing the adhesive/sealant material, that is arranged to supply the adhesive/sealant material to the microreservoir at the applicator tip. The second reservoir may comprise a frangible ampoule disposed in the handle portion, a container, such as a syringe, connected to the handle portion, or the handle portion itself. The applicator tip may comprise one of a polymer loop, a spatula, a rolling ball, a grate, a porous material, such as a swab, a foam or a mesh, and a brush.

Abstract: A combination includes a pipette-shaped container formed from a polymeric material selected from polyethylene terephthalate, high density polyethylene, low density polyethylene, and mixtures thereof, and a 1,1 -disubstituted ethylene monomer adhesive composition sealed in the pipette-shaped container prior to dispensing the material.

Abstract: An applicator for dispensing adhesive material includes a quenched foam material, provided so that the adhesive material comes in contact with the quenched foam material. Thus, polymerization of the adhesive material is initiated in the absence of additional polymerization initiators. In addition, the applicator is configured to permit improved control and economy in application of the adhesive.

Abstract: Continuous processes for forming cyanoacrylate from polycyanoacrylate include stripping a solvent from a reaction mass; cracking a polymer in the reaction mass to form a cracked cyanoacrylate monomer and residue substances; and distilling the cracked cyanoacrylate monomer to produce a cyanoacrylate monomer product. These steps can be performed in short-path, wiped-film evaporators. Polycyanoacrylate used in the processes can be formed using cyanoacetate produced by processes for continuously producing cyanoacetate by forming a higher homologue cyanoacetate from a lower homologue cyanoacetate. The cyanoacetate can be formed in short-path, wiped-film evaporators.

Abstract: An adhesive composition includes a polymerizable adhesive monomer, at least one vapor phase stabilizer, and at least one liquid phase stabilizer. The combination of at least one vapor phase stabilizer and at least one liquid phase stabilizer provides superior stabilization and shelf-life for the monomer composition. The stabilized adhesive composition provides superior performance and shelf-life and can be sterilized without significant polymerization of the monomer.

Abstract: An applicator for dispensing adhesive material, includes a container body, and an applicator tip, where the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing said adhesive material. The applicator tip has a proximal open end open toward said container body for attachment to the container body, a distal end having at least one orifice, a restrictive flow portion located between the proximal end and the distal end, and a flow reducing portion located between the restrictive flow portion and the distal end. The applicator tip defines a fluid flow channel from the proximal end to the distal end and through the restrictive flow portion and the flow reducing portion, where the applicator tip permits the adhesive material to pass through the applicator tip and exit the applicator tip at the at least one orifice.

Abstract: A method of treating or preventing tinea cruris, commonly known as Jock Itch, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to tinea cruris, optionally with at least one of an additional anti-fungal agent or a skin care additive, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.

Abstract: A method of treating or preventing oral fungal infection includes applying a polymerizable monomer adhesive composition to an area afflicted with or susceptible to oral fungal infection, optionally with at least one of an additional anti-fungal agent, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area.

Abstract: A method of treating or preventing tinea corporis, commonly known as ringworm of the skin, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to tinea corporis, optionally with at least one of an additional anti-fungal agent or a skin care additive, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.

Abstract: A method of treating or preventing skin yeast infections, such as cutaneous candidiasis, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to a skin yeast infection, optionally with at least one of an additional anti-fungal agent or a skin care additive, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.

Abstract: A method of treating or preventing tinea pedis, commonly known as Athlete's Foot, includes applying a polymerizable monomer adhesive composition to an area of skin afflicted with or susceptible to tinea pedis, optionally with at least one of an additional anti-fungal agent or a foot care additive, and allowing the polymerizable monomer composition to polymerize to form a polymer film over the area of skin.

Abstract: An article of manufacture for dispensing an adhesive material, such as a synthetic or semi-synthetic polymerizable or cross-linkable monomer material, includes a container body, and a porous applicator tip having a proximal end that is attached to the container body, and a distal end located away from the container body, wherein the adhesive material is located in the container body in a non-contacting relationship with the applicator tip prior to dispensing the material. A flow pattern of the adhesive material within or on the applicator tip is controlled by providing one or more cuts in the applicator tip to alter flow properties of the adhesive material through the applicator tip.

Abstract: A medical procedure kit incorporates one or more surgical tools necessary to perform at least part of a medical procedure, along with a container having a quantity of a medical adhesive. Medical adhesives are useful as an alternate or an adjunct to surgical sutures and/or staples in wound closure, as well as for covering and protecting surface wounds such as lacerations, abrasions, burns, stomatitis, sores, minor cuts and scrapes, and other wounds. As such, the inclusion of such an adhesive into a composite medical procedure kit can be of great assistance to a medical doctor or surgeon by providing in single kit form, tools necessary to complete many medical procedures, without having to use multiple procedure kits. The adhesive may be independently sterilized and wrapped from the other surgical tools of the resultant kit, and then associated into kit form, or assembled and sterilized together as a unitary kit.

Abstract: A hand-held applicator delivers liquid or semi-liquid compositions, such as adhesives, to an internal tissue or organ in an even and controlled manner. The applicator includes a pump, a tubular extension that is thin enough to pass through an endoscopic pathway or trocar, a proximal end of the tubular extension being sealingly connected to the pump, and an applicator tip that attaches to the distal end of the tubular extension. The tip includes the liquid and the pump pumps the liquid to the internal tissue in an even and controlled manner without contact of the liquid by the pump. The pump is preferably a micropipetter that includes a hand-held portion having a hand-actuatable plunger that does not come in direct, physical contact with the liquid to be dispensed. The composition may be an adhesive such as an alpha-cyanoacrylate. The device may further include a wound closure device including at least two closure pins extending from the distal end of the tubular extension.

Abstract: A single-use applicator assembly for dispensing and applying a polymerizable monomeric adhesive material includes: a base portion having at least one sealed compartment; a polymerizable monomeric adhesive material contained in the compartment; an applicator at least partially disposed in the compartment such that a tip of the applicator is proximate the adhesive material. The at least one sealed compartment may comprise first and second sealed compartments that are separated with the polymerizable monomeric adhesive material contained in the first compartment and the applicator at least partially disposed in the second compartment. Alternatively, the first and second compartments may be open to each other. In such case, the applicator assembly may further comprise a plunger that defines the second compartment and that is movable into the first compartment to displace the adhesive material into the second compartment. A kit can include multiple applicator assemblies that are separate or frangibly connected.