Patents Assigned to CNRS
  • Isomorphous substitution of metals on synthesized zeolite framework
    Patent number: 11485643
    Abstract: The present disclosure relates to a novel method for introducing various metals in the structure of zeolite frameworks by isomorphous substitution. This new method is based on a hydrothermal reaction of the metal with the zeolite. This method allows obtaining zeolite with a structure and with control of the metal location.
    Type: Grant
    Filed: October 13, 2020
    Date of Patent: November 1, 2022
    Assignees: TOTALENERGIES ONETECH, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Cindy Aquino, Svetlana Mintova, Jean-Pierre Gilson, Florent Dubray, Delphine Minoux, Julien Grand, Nikolai Nesterenko
  • SURGERY-ASSISTANCE DEVICE
    Publication number: 20220338954
    Abstract: A device for assisting surgery includes means for offsetting a rotation of a first type and a second type, a mechanism for transmitting a rotation of a third type, and a mechanism for transforming the rotation of a third type into a translation. An elastic element is connected at one end to the mechanism for transmitting the rotation of a third type. The mechanism for transmitting the rotation of a third type is connected to a rotary motor, the rotation of the motor in a first direction causing the lowering of a tool and an elongation of the elastic element, the rotation of the motor in a second direction causing the raising of the tool and a contraction of the elastic element, and, when the tool is lowered and the rotary motor is not exerting any torque, the elastic element returns to an initial shape causing the raising of the tool.
    Type: Application
    Filed: September 22, 2020
    Publication date: October 27, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, CHU DE NANTES
    Inventors: Damien CHABLAT, Guillaume MICHEL, Philippe BORDURE
  • Polypeptide expressed in the stratum corneum and use thereof
    Patent number: 11479580
    Abstract: Polypeptides belonging to the family of late proteins of the cornified envelope (LCE), fragments of the polypeptide, isolated nucleotide sequences encoding the polypeptides, and cosmetic and/or pharmaceutical compositions containing such polypeptides are described. The polypeptides have cosmetic and/or therapeutic use to reinforce the barrier function of the epidermis, prevent and/or treat the signs of skin dryness and prevent and/or treat disorders of the barrier function or the weakening of the epidermis.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: October 25, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE PAUL SABATIER TOULOUSE III
    Inventors: Nathalie Jonca, Eve Toulza, Gaelle Saintigny, Guy Serre, Marina Weber Vivat
  • DIGITAL BIOMOLECULES DETECTION AND/OR QUANTIFICATION USING ISOTHERMAL AMPLIFICATION
    Publication number: 20220333177
    Abstract: The present invention relates to a digital method for detecting and/or quantifying at least one target biomolecules in a sample, said biomolecules being selected from DNA, RNA, and proteins based on isothermal amplification. The present invention further relates to different applications of the digital method and to a kit.
    Type: Application
    Filed: May 27, 2020
    Publication date: October 20, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS, PARIS SCIENCES ET LETTRES, UNIVERSITE DE PARIS
    Inventors: Yannick RONDELEZ, Guillaume GINES, Roberta LIMA DE CASTRO MENEZES, Valérie TALY
  • Methods for determining whether a patient suffering from rhabdomyolysis achieves a response with a TLR9 antagonist
    Patent number: 11473145
    Abstract: The inventors initially participated to the identification of LPIN1 mutations as a cause for massive rhabdomyolysis episodes in children, triggered by febrile illness. The inventors have suggested that TLR9 antagonists would be suitable for the treatment of rhabdomyolysis (WO2017085115). The inventors thus treated 2 patients with lipin-1 disease by a TRL9 antagonist (hydroxychloroquine). They showed that the accumulation of mtDNA in plasma of the two patients before treatment decreases under treatment. When the treatment was stopped, the accumulation of mtDNA reappeared, then normalized when treatment was resumed. Accordingly, the present invention relates to a method for determining whether a patient suffering from rhabdomyolysis achieves a response with a TLR9 antagonist comprising determining the amount of mitochondrial DNA (mtDNA) in a blood sample obtained from the patient (e.g. by PCR).
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: October 18, 2022
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), FOUNDATION IMAGING, ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE PARIS
    Inventors: Pascale De Lonlay-Debeney, Peter Van Endert, Marine Madrange, Yamina Hamel, François-Xavier Mauvais
  • Method for transposing the frequency of an optical signal by mixing a plurality of waves
    Patent number: 11474413
    Abstract: A method for frequency-converting a source optical signal in order to produce a useful optical signal, by mixing a plurality of waves, implements a plurality of waveguides that are coupled together. Individual parameter values of the waveguides, as well as at least one coupling parameter, are selected so as to obtain the useful signal with a high intensity. Such a method for producing the useful signal is suitable for a spectroscopic application, in particular a molecular spectroscopy application.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: October 18, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—, UNIVERSITE DE BOURGOGNE
    Inventors: Pierre Colman, Alexandre Parriaux, Kamal Hammani, Guy Millot
  • Turbine engine part coated in a thermal barrier, and a method of obtaining it
    Patent number: 11466370
    Abstract: A turbine engine part coated in at least a first ceramic layer forming a thermal barrier and including a ceramic material with first ceramic fibers dispersed in the first layer. The first layer may have a chemical composition gradient between a material for forming a thermal barrier and a material for providing protection against calcium and magnesium aluminosilicates, which is present at a greater content in an outer zone of the first layer, and/or the first layer may be porous and may present a porosity gradient such that an outer portion of the first layer presents lower porosity.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: October 11, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PAUL SABATIER—TOULOUSE III, SAFRAN AIRCRAFT ENGINES, SAFRAN
    Inventors: Aurélien Joulia, André Hubert Louis Malie, Florence Ansart, Elodie Marie Delon, Sandrine Duluard
  • SOLVENT TRANSFER PRINTING METHOD
    Publication number: 20220314686
    Abstract: Solvent transfer printing method for applying a pattern (1) made of a non-soluble material and non-dispersible (10) on the surface of an object (2), the method comprising the following steps: m1/forming a pattern (1) on a surface of a solvent-soluble substrate (3), m2/depositing the solvent-soluble substrate (3) on the surface of a solvent bath (5), on the side of the substrate opposed to the side on which the pattern is applied, in order to dissolve partially the substrate (3), m3/dipping the object (2) in the bath (5), so that the surface of the object (2) comes into contact with the pattern (1), m4/getting the object (2), on which the pattern (1) is applied, out of the bath (5), m5/drying the object (2).
    Type: Application
    Filed: May 23, 2022
    Publication date: October 6, 2022
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE DE RENNES 1
    Inventors: Maxime HARNOIS, Jacques EMMANUEL, Brice LE BORGNE
  • Methods and devices for full-field ocular blood flow imaging
    Patent number: 11457806
    Abstract: According to a first aspect, the present disclosure relates to a digital holography device (100) for full-field blood flow imaging of ocular vessels of a field of view of a layer (11) of the eye (10). The device comprises an optical source (101) configured for the generation of an illuminating beam (Eobj) and a reference beam (ELO), and a detector (135) configured to acquire a plurality of interferograms (I(x,y,t)) wherein an interferogram is defined as the signal resulting from the interference between the said reference beam (ELO) and a part of said illuminating beam (Eobj) that is backscattered from said layer (11).
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: October 4, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventors: Léo Puyo, Michael Atlan
  • Movement amplifying actuation device
    Patent number: 11463020
    Abstract: A movement amplifying actuation device may include two piezoelectric beams, one beam being attached at a fixed point, and a hinge connecting a first beam and a second beam between them. Each hinge may include a first flexible portion connected to the first beam, a second flexible portion connected to the second beam, a first rigid portion connecting the first and second flexible portions, a second rigid portion capable of being positioned against a fixed point, and a third flexible portion connecting the second beam to the second rigid portion at a pivot point of the second beam such that the assembly formed by the second rigid portion and the second beam forms a lever around the pivot point. The flexible and rigid portions may form a single piece.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: October 4, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE FRANCHE-COMTE, ECOLE NATIONALE SUPERIEURE DE MECANIQUE ET DES MICROTECHNIQUES
    Inventors: Sergio Lescano, Nicolas Andreff, Micky Rakotondrabe, Kanty Rabenorosoa, Brahim Tamadazte, Clément Bouderlique
  • Compositions useful in the diagnostic of latently infected
    Patent number: 11448656
    Abstract: The present invention concerns a composition comprising at least three peptides derived from Mycobacterium tuberculosis antigen Rv2626c, its use in the diagnostic of latently infected Mycobacterium tuberculosis (LTBI) subjects, corresponding methods of use and kits.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: September 20, 2022
    Assignees: CNRS, CONICET, INSTITUT JEAN PAOLI & IRENE CALMETES, UNIVERSITE D' AIX-MARSEILLE, INSERM
    Inventors: Juan Iovanna, Virginia Pasquinelli, Maria Madgalena Gherardi, Hector Eduardo Chuluyan, Ana Inès Rovetta, Delfina Pena, Véronica Edith Garcia
  • ELASTOMER COMPOSITION
    Publication number: 20220280683
    Abstract: A composition based on triblock copolymers of the ABA type, including two styrene thermoplastic terminal blocks A, and an elastomer central block B which is a saturated olefin, and at least one polyisobutene having a very low molecular weight and optionally a diblock copolymer of AB. The present composition exhibits advantageous properties which are similar to those of silicone elastomers. Also, a dressing including such an elastomeric composition.
    Type: Application
    Filed: July 30, 2020
    Publication date: September 8, 2022
    Applicants: URGO RECHERCHE INNOVATION ET DEVELOPPEMENT, UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -
    Inventors: Christophe DERAIL, Armelle RONCIN, Xavier CALLIES, Christelle Marie Aline GUILLAMAUD, Anne-Sophie DANEROL, Marie DAUX
  • PROTEIN HYDROLYSATE DERIVED FROM BLUE-BACKED FISH
    Publication number: 20220279814
    Abstract: A protein hydrolysate obtained from at least one protein source from bluefish having (i) a degree of hydrolysis (DH) of at least 10%, (ii) at least 80% water-soluble protein with a molecular weight of less than 1000 Da, (iii) at least 0.3% phospholipids, and (iv) at least 0.5% DHA and EPA.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 8, 2022
    Applicants: SPECIALITES PET FOOD, UNIVERSITE DE BORDEAUX, UNIVERSITÉ DE BRETAGNE OCCIDENTALE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD), INSTITUT POLYTECHNIQUE DE BORDEAUX, ABYSS INGREDIENTS, INSTITUT FRANCAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER - IFREMER, INSTITUT NATIONAL DE LA RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
    Inventors: Fabienne GUERARD, Cloé OROY, Anne LEPOUDERE, Mathilde CHATAIGNER, Patrick ALLAUME, Anne-Laure DINEL, Corinne JOFFRE, Véronique PALLET, Fabienne LE GRAND
  • NOVEL DIZOCILPINE DERIVATIVES AS PERIPHERAL NMDA RECEPTOR ANTAGONISTS
    Publication number: 20220280498
    Abstract: The present invention relates to compounds of formula (I): for use as peripheral NMDA receptor antagonists.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 8, 2022
    Applicants: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS SUD, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (APHP), HOPITAL MARIE LANNELONGUE
    Inventors: Sylvia COHEN-KAMINSKY, Marc HUMBERT, Sebastien DUMAS, Gilles BRU-MERCIER, Samir MESSAOUDI, Jean-Daniel BRION, Mouad ALAMI, Gilles GALVANI
  • ENZYMATIC BIOCATHODE, METHOD FOR PRODUCING IT AND FUEL BIOCELL AND BIOSENSOR COMPRISING THIS ENZYMATIC BIOCATHODE
    Publication number: 20220275420
    Abstract: A biomass-based enzymatic biocathode based on glucose, monosaccharide, ketone or aldehyde includes a collector conductor support, conductive particles disposed on and bound to said collector conductor support, and an aldose reductase disposed on said conductive particles, being bound thereto by adsorption and accessible at the surface of the monosaccharide, ketone or aldehyde reagent that is to be reduced when the biocathode is operational.
    Type: Application
    Filed: July 27, 2020
    Publication date: September 1, 2022
    Applicants: UNIVERSITÉ GRENOBLE ALPES, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MEDICALE - INSERM, GRENOBLE INP (INSTITUT NATIONAL POLYTECHNIQUE), CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Abdelkader ZEBDA, Philippe CINQUIN, Donald MARTIN, Thomas SORANZO
  • PROCESS FOR POLYMERIZING A COMPOSITION IN THE PRESENCE OF A BLOCK COPOLYMER
    Publication number: 20220275136
    Abstract: The present invention relates to a process for the polymerization of a composition in the presence of at least one block copolymer, and also to the products obtained by this polymerization process. The present invention also relates to the use of the products obtained using the polymerization process which is a subject matter of the invention.
    Type: Application
    Filed: May 19, 2020
    Publication date: September 1, 2022
    Applicants: Arkema France, Centre National De La Recherche Scientifique - CNRS, UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR
    Inventors: Sylvain Bourrigaud, Anne-Laure Brocas, Sylvie Cazaumayou, Laura Garcia Andujar, Maud Save, Christophe Derail, Laurent Rubatat
  • Devices and methods for conveying and controlling light beams for lensless endo-microscopic imagery
    Patent number: 11428924
    Abstract: According to one aspect, the invention relates to a device for transporting and controlling light beams for endo-microscopic imaging without a lens on the distal side comprising a single-mode optical fibre bundle (40) on the distal side, wherein each single-mode optical fibre is intended to receive an elementary light source and to emit a light beam at a distal end; a single-mode optical fibre section (50) arranged at the distal end of the optical fibre bundle and intended to receive the light beams emitted by the single-mode optical fibres of the optical fibre bundle; an optical phase control device arranged on the side of the proximal end of the single-mode optical fibres.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: August 30, 2022
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Ecole Centrale de Marseille (ECM), Université d'Aix-Marseille (AMU)
    Inventors: Hervé Rigneault, Esben Ravn Andresen, Siddarth Sivankutty
  • Neuronal viability factor and use thereof in Alzheimer's disease
    Patent number: 11428698
    Abstract: The present invention concerns a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected in the group comprising (i) a polypeptide comprising an amino acid sequence selected in the group comprising the amino acid sequence of the long isoform in Homo sapiens of the RdCVF2 gene (SEQ ID NO: 10), orthologs, derivatives and fragments thereof, (ii) a polynucleotide coding for said polypeptide, (iii) a vector comprising said polynucleotide, and (iv) a host cell genetically engineered expressing said polypeptide; the use of such a composition for the manufacture of a medicament for treating and/or preventing a neurodegenerative disorder in a subject; and a method of testing a subject thought to have or be predisposed to having a neurodegenerative disorder.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: August 30, 2022
    Assignees: Institut National de la Santé et de la Recherche Médicale, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQU—CNRS
    Inventors: Thierry Leveillard, Jose-Alain Sahel, Celine Jaillard, Olivier Poch
  • SELECTIVE BCRP/ABCG2 TRANSPORTER INHIBITORS AS AGENTS TO ABOLISH RESISTANCE TO ANTI-CANCER AGENTS
    Publication number: 20220267289
    Abstract: A compound of formula (I): or pharmaceutically acceptable enantiomer, salt or solvate thereof, or a mixture thereof, the ring A, and the substituents Z, Y and R1 being as defined herein.
    Type: Application
    Filed: June 1, 2020
    Publication date: August 25, 2022
    Applicants: UNIVERSITE GRENOBLE ALPES, CNRS - CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Ahcène BOUMENDJEL, Pierre FALSON, Alexis MORENO, Basile PERES, Emile ROUSSEL
  • Process For Preparation Of Bioorganic Nylon Polymers And Their Use As Antibacterial Material
    Publication number: 20220267522
    Abstract: The present invention relates to new biopolymer, i.e. bioorganic nylons incorporating peptidic blocks obtained by a process of polymerization of amino peptidic blocks. The process of the invention comprises the steps of mixing amino peptidic blocks with or without a diaminoalcane and reacting the mixture according to polycondensation with a diacyl chloride in homogeneous or heterogeneous media.
    Type: Application
    Filed: March 8, 2022
    Publication date: August 25, 2022
    Applicants: Universite De Montpellier, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Jean Martinez, Ahmad Mehdi, Gilles Subra, Saïd Jebors