Patents Assigned to CNRS
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Publication number: 20230159447Abstract: Chemoenzymatic process for coproducing a disulfide and a sulfoxide or a sulfone The present invention relates to a chemoenzymatic process for coproducing disulfide and sulfoxide or sulfone from a composition M comprising: 1) a sulfide, 2) optionally an oxidizing agent, 3) an organic compound bearing at least one thiol group, 4) an enzyme E catalyzing the oxidation of said sulfide to sulfoxide or to sulfone, 5) an enzyme D catalyzing the formation of a disulfide bridge between two equivalents of said organic compound bearing at least one thiol group to form a dimer, and 6) a cofactor common to the two enzymes E and D; and also to a composition enabling especially the implementation of this process. The present invention also relates to the use of a mercaptan for reducing a disulfide bridge formed between two equivalents of an organic compound bearing at least one thiol group, and more particularly to the use thereof as regeneration substrate of the process described above.Type: ApplicationFiled: March 3, 2021Publication date: May 25, 2023Applicants: Arkema France, Centre National De La Recherche Scientifique - CNRS, Universite d'AIX-MarseilleInventors: Georges Fremy, Hugo Brasselet, Jean-Christophe Lec, Véronique Alphand, Katia Duquesne
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Patent number: 11655158Abstract: The present disclosure relates to a novel staged-synthesis method for introduction of various metals in the structure of zeolite frameworks by isomorphous substitution. This new method is based on a hydrothermal synthesis in which the metal addition to the precursor suspensions (gel) is delayed. This so-called “staged-synthesis method” allows to obtain nanosized silanol highly homo-geneous crystalline zeolite structures with a control of the metal location.Type: GrantFiled: October 13, 2020Date of Patent: May 23, 2023Assignees: TOTALENERGIES ONETECH, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Svetlana Mintova, Jean-Pierre Gilson, Nikolai Nesterenko, Delphine Minoux, Cindy Aquino, Julien Grand, Florent Dubray
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Patent number: 11654055Abstract: The sensory substitution system includes a portable matrix of exciters that can be worn by a user in such a way that the exciters are placed against the skin of a user, as well as a control circuit for the exciters of the matrix. An asynchronous signal source provides the control circuit with an asynchronous signal representative of visual information organised according to a matrix of pixels. This asynchronous signal includes, for each pixel, successive events associated in an asynchronous manner with the pixel.Type: GrantFiled: December 7, 2017Date of Patent: May 23, 2023Assignees: SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Guillaume Chenegros, Ryad Benosman, Kevin Arth, Sio-Hoi Ieng
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Patent number: 11648319Abstract: The invention is directed to the field of gene therapy, i.e. gene delivery into target cells, tissue, organ and organism, and more particularly to gene delivery via viral vectors. The inventors showed that it is possible by chemical coupling to modulate the coupling of a ligand in the surface of the capsid of AAV, for example AAV2 and AAV3b. In particular, the present invention relates to a recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L, wherein coupling of said ligand L is implemented through a bond comprising a —CSNH— bond and an optionally substituted aromatic moiety. Particularly, the inventors tested the chemical coupling of mannose ligand on AAV2 for subretinally injection to rats.Type: GrantFiled: May 26, 2021Date of Patent: May 16, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Nantes Universitè, CENTRE HOSPITALIER UNIVERSITAIRE DE NANTESInventors: Mathieu Mevel, David Deniaud, Eduard Ayuso
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Patent number: 11649264Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.Type: GrantFiled: February 12, 2021Date of Patent: May 16, 2023Assignees: Institut National De La Sante Et De La Recherche Medicale (INSERM), Centre National De La Recherche Scientifique (CNRS), Ecole Normale Superieure De Lyon, Universite De Claude Bernard Lyon 1Inventors: Théophile Ohlmann, Philippe Mangeot, Emiliano Ricci
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Patent number: 11644422Abstract: A calibration standard for determining an intensity decay related to an evanescent field generated close to the interface between a sample to be tested and a substrate on which the sample is to be deposited, preparation and analysis methods and use thereof.Type: GrantFiled: September 12, 2019Date of Patent: May 9, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE PARIS, UNIVERSITE BAR-ILANInventors: Martin Oheim, Adi Salomon
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Publication number: 20230136949Abstract: A method for growing a III-V material may include forming at least one layer on a stack including a crystalline layer made of III-V material, a first masking layer surmounting the germination layer, the first masking layer having at least one first opening; depositing a second masking layer covering an upper face of the sacrificial layer; forming at least one second opening in the second masking layer; removing the sacrificial layer selectively at the first masking layer and at the second masking layer; epitaxially growing a material made of the III-V material from the germination layer; forming al least one third opening in the second masking layer; and epitaxially growing at least one material made of the III-V material from the first epitaxial layer.Type: ApplicationFiled: November 2, 2022Publication date: May 4, 2023Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CNRSInventors: Matthew CHARLES, Yvon CORDIER
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Patent number: 11635367Abstract: A contrast-amplifying carrier for observing a sample, includes a transparent substrate bearing at least one absorbent coating suitable for behaving as an antireflection coating when it is illuminated at normal incidence at an illumination wavelength ? through the substrate and when the face of the coating opposite the substrate is in contact with a medium referred to as a transparent ambient medium, the refractive index n3 of which is lower than that of the refractive index n0 of the substrate. The absorbent coating comprises: an absorbent sublayer referred to as the contrast sublayer, deposited on the surface of the transparent substrate; and an absorbent layer referred to as the sensitive layer, distinct from the contrast sublayer and comprising between 1 and 5 sheets of a graphene-type material. Methods for producing and for using such a contrast-amplifying carrier are also provided.Type: GrantFiled: December 16, 2016Date of Patent: April 25, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DU MANS, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Stéphane Campidelli, Renaud Cornut, Vincent Derycke, Dominique Ausserre, Manuel Ausserre
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Patent number: 11634452Abstract: The invention relates to compounds of formula (I), their method of synthesis as well as their use to treat neurodegenerative disorders.Type: GrantFiled: December 11, 2017Date of Patent: April 25, 2023Assignees: ETHNODYNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Chérif Rabhi, Léon Cariel, Christian Da Costa Noble, Jamal Ouazzani, Guillaume Arcile, Géraldine Le Goff
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Patent number: 11633728Abstract: Nanoparticles that can be used as hydrosilylation and dehydrogenative silylation catalysts. The nanoparticles have at least one transition metal with an oxidation state of 0, chosen from the metals of columns 8, 9 and 10 of the periodic table, and at least one carbonyl ligand, preferably a silicide.Type: GrantFiled: January 11, 2019Date of Patent: April 25, 2023Assignees: ELKEM SILICONES FRANCE SAS, UNIVERSITE CLAUDE BERNARD LYON I, CPE LYON FORMATION CONTINUE ET RECHERCHE—CPE LYON CFR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRSInventors: Valerie Meille, Chloe Thieuleux, Laurent Veyre, Iurii Suleimanov, Thomas Galeandro-Diamant, Magali Bousquie
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Patent number: 11634405Abstract: The present invention relates to the Compound of following formula (I): or a pharmaceutically acceptable salt thereof. The present invention also relates to a pharmaceutical composition containing such a compound and a method for preparing such a compound.Type: GrantFiled: April 26, 2019Date of Patent: April 25, 2023Assignees: UNIVERSITE PARIS-SACLAY PARC TECHNOLOGIQUE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT GUSTAVE-ROUSSY, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Mouad Alami, Olivier Provot, Abdallah Hamze, Ilhem Khelifi, Timothée Naret, Sébastien Apcher, Romain Darrigrand
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Publication number: 20230121377Abstract: A method for preparing a nanoporous silica sol-gel matrix containing at least one amine reactant selected from hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, tetraethylenepentamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof, said method including the following steps: a) synthesising a gel from tetramethoxysilane or from a mixture of tetramethoxysilane and another organosilicon precursor selected from among phenyltrimethoxysilane, phenyltriethoxysilane, a fluoroalkyltrimethoxysilane, a fluoroalkyltriethoxysilane, a chloroalkylmethoxysilane, a chloroalkylethoxysilane, an alkyltrimethoxysilane, an alkyltriethoxysilane, an aminopropyltriethoxysilane and the mixtures thereof, the synthesis being performed in an aqueous medium at a temperature ranging from 10 to 70° C.Type: ApplicationFiled: December 16, 2022Publication date: April 20, 2023Applicants: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -Inventors: Thu-Hoa TRAN-THI, Ana BORTA, Mickael GINEYS, Marie-Pierre SOM, Frédéric HAMMEL
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Patent number: 11630066Abstract: Optical device for optical fluorescence microscopy, comprising a spatial modulator (1), a microscope objective (2), a beamsplitter (3) and a camera (4), wherein the beamsplitter (3) is placed between the spatial modulator (1) and the microscope objective (2), wherein the beamsplitter (3) is placed between the camera (4) and the microscope objective (2), and wherein a prism (5) is placed between the beamsplitter (3) and the camera (4).Type: GrantFiled: December 14, 2018Date of Patent: April 18, 2023Assignees: ALVEOLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITÉ DE BORDEAUXInventors: Vincent Studer, Rémi Galland
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Patent number: 11629192Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of diseases mediated by the NRP-1/OBR complex signaling pathway. In particular, the present invention relates to a method for treating a disease selected from the group consisting of cancers, obesity and obesity related diseases, anorexia, autoimmune diseases and infectious diseases in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an antagonist of the NRP-1/OBR signaling pathway.Type: GrantFiled: September 4, 2018Date of Patent: April 18, 2023Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITÉ PARIS CITÉ, FONDATION IMAGINE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE GRENOBLE ALPES, COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, UNIVERSITE DE BOURGOGNEInventors: Zakia Belaid-Choucair, Olivier Hermine, Carmen Garrido-Fleury, Claude Cochet, Odile Filhol-Cochet, Renaud Seigneuric
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Patent number: 11622978Abstract: The present invention relates to an engineered immune cell defective for Suv39h1. Preferably, said engineered immune cell further comprises a genetically engineered antigen receptor that specifically binds a target antigen. The present invention also relates to a method for obtaining a genetically engineered immune cell comprising a step consisting in inhibiting the expression and/or activity of Suv39h1 in the immune cell; and further optionally comprising a step consisting in introducing in the said immune cell a genetically engineered antigen receptor that specifically binds to a target antigen. The invention also encompasses said engineered immune cell for their use in adoptive therapy, notably for the treatment of cancer.Type: GrantFiled: January 20, 2020Date of Patent: April 11, 2023Assignees: INSTITUT CURIE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Sebastian Amigorena, Eliane Piaggio, Christel Goudot, Luigia Pace, Genevieve Almouzni, Leticia Niborski
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Patent number: 11618829Abstract: The present invention concerns a solid nanocomposite material consisting of a polymer-matrix in which are dispersed alkali metal, hydronium or ammonium salts of polyanionic components, wherein the polymer-matrix comprises at least a linear or branched polymer or copolymer containing one or several poly(ethylene oxide) (PEO) chains, said polymer or copolymer being optionally crosslinked and each PEO chain having at least 4 ethylene oxide monomer units. The present invention relates also to a photonic, e.g. optoelectronic, device comprising such a nanocomposite material. Such material and device can be used as phosphorescence emitter, for crop growth lighting or for generating singlet oxygen.Type: GrantFiled: October 30, 2018Date of Patent: April 4, 2023Assignees: Universite de Rennes 1, Centre National de la Recherche Scientifique (CNRS), Universidade de Franca—UNIFRANInventors: Yann Molard, Maria De Los Angeles Amela-Cortes, Malo Robin, Stephane Cordier, Eduardo Ferreira Molina
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Patent number: 11618884Abstract: The present invention relates to regulatory T cell and uses thereof. By their immunosuppressive and anti-inflammatory activities, regulatory T cells play a central role in peripheral tolerance and thus critically prevent the development of autoimmune and inflammatory disorders. The inventors showed that Foxp3+CD4+ Tregs express high levels of LT?, which negatively regulates their immunosuppressive signature. They demonstrated that the adoptive transfer of LT??/? Tregs in mice protects from dextran sodium sulfate (DSS)-induced colitis and attenuates inflammatory bowel disease (IBD), multi-organ autoimmunity and the development of CAC. The inventors also showed that by mixed bone marrow chimeras that LT? expression specifically in hematopoietic cells negatively controls the immunosuppressive signature of Tregs. In particular, the present invention relates to regulatory T cell characterized in that it does not express or expresses reduced levels of lymphotoxin alpha.Type: GrantFiled: November 13, 2018Date of Patent: April 4, 2023Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), UNIVERSITE D'AIX MARSEILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventor: Magali Irla
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Patent number: 11612743Abstract: The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.Type: GrantFiled: January 24, 2020Date of Patent: March 28, 2023Assignees: ICM (INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE, APHP (ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA ECHERCHE MEDICALE), SORBONNE UNIVERSITEInventors: Michel Le Van Quyen, Stéphane Charpier, Séverine Mahon
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Patent number: 11614460Abstract: An electronic device for measuring a speed of flow of a fluid that includes at least two electroacoustic transducers adapted for emitting and/or receiving acoustic signals through the flow of the fluid, the electronic device being adapted for determining a measurement of the speed of flow of the fluid from the characteristics of an acoustic signal emitted and one or more acoustic signals received, these received acoustic signals corresponding to reflections of the emitted acoustic signal.Type: GrantFiled: April 19, 2019Date of Patent: March 28, 2023Assignees: UNIVERSITE DU MANS, ASSOC TRANSFERTS TECHNOLOGIES MANS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Jacques Emery, Mohammed Tabellout, Charfeddine Mechri
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Patent number: 11613513Abstract: The present invention relates to a compound of the following formula (I). The invention also relates to uses thereof as a chromophore as such or for building pigments displaying special optical effects, including metal-like reflection.Type: GrantFiled: December 28, 2017Date of Patent: March 28, 2023Assignees: Centre National de la Recherche Scientifique (CNRS), Université Paris CitéInventors: Philippe Laine, Laurélie Poulard, Grégory Dupeyre