Patents Assigned to CNRS
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Patent number: 11608315Abstract: The invention relates to a process for preparing methyl mercaptan from a mixture of carbon oxide, hydrogen sulfide and hydrogen, in the presence of a catalyst based on molybdenum and potassium supported on zirconia, said catalyst not comprising any promoter.Type: GrantFiled: December 20, 2018Date of Patent: March 21, 2023Assignees: Arkema France, Universite Lille 1-Sciences et Technologies, Centre National de la Recherche Scientifique (CNRS)Inventors: Georges Frémy, Hélori Salembier, Carole Lamonier, Pascal Blanchard
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Patent number: 11608589Abstract: A method for coating a textile material, said method includes the following steps: a) incorporating activated carbon in powder form into a coating composition including an aqueous solvent and at least one organosilicon precursor, wherein the organosilicon precursor represents from 5 to 50% by volume relative to the whole of the aqueous solvent and organosilicon precursor, b) impregnating the textile material with the coating composition by padding and c) drying the impregnated textile material, characterised in that the coating composition contains no polycarboxylic acid or catalyst.Type: GrantFiled: January 8, 2018Date of Patent: March 21, 2023Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS-, SAFRAN ELECTRONICS & DEFENSE, EUROPROTECT FRANCE SAInventors: Thu-Hoa Tran-Thi, Philippe Charton, Franck Tirard, Eva Grinenval, Sébastien Chatard
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Patent number: 11610647Abstract: The invention relates to a method for generating a unique identifier of a subject from a genotyped DNA sample from said subject, the method comprising the steps of: obtaining a number N?2 of genomic positions of interest, said obtained genomic positions being such that, in a population of M subjects, these genomic positions exhibit a polymorphism of at least one nucleotide having an allelic frequency of between 25% and 35%, for the minority allele; combining in pairs the obtained genomic positions by means of logical functions so as to obtain a binary code bc.Type: GrantFiled: October 18, 2018Date of Patent: March 21, 2023Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PAUL SABATIER TOULOUSE IIIInventors: Denis Pierron, Thierry Letellier, Margit Heiske, Veronica Pereda
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Patent number: 11608509Abstract: The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.Type: GrantFiled: April 20, 2017Date of Patent: March 21, 2023Assignees: Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1, Institut National de la Sante et de la Recherche Medicale (INSERM)Inventors: Caroline Costa Fejoz, Els Verhoeyen, François-Loïc Cosset, Ruben Bender, Christian Buchholz, Qi Zhou
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Patent number: 11609124Abstract: A method for determining wavefront shapes of N angular channels CL of different propagation directions PL, said propagation directions PL being determined by a mean propagation direction vector , from a single signal image acquisition I(x,y) of a multi-angular signal light beam containing said angular channels, each angular channel Ci being separated from other angular channels Cj by an angular separation ??ij defined by ??ij=arccos, where “·” stands for the inner product between and .Type: GrantFiled: September 28, 2021Date of Patent: March 21, 2023Assignees: UNIVERSITE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), SORBONNE UNIVERSITEInventors: Marc Guillon, Gilles Tessier, Tengfei Wu, Pascal Berto
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Patent number: 11606530Abstract: Disclosed is a display device including, from a front face towards a rear face, a panel, a ground plane, and a processing unit connected to the panel and including an antenna for receiving and/or emitting a wave for connection to a wireless network. The display device further includes a plurality of adjustable elements connected to the processing unit, each adjustable element having an impedance which can be modified by the processing unit in order to change the manner in which the wave is reflected and/or transmitted by the adjustable elements, these adjustable elements being located on the rear side of the ground plane.Type: GrantFiled: October 19, 2018Date of Patent: March 14, 2023Assignees: GREENEWAVE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARISInventor: Geoffroy Lerosey
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Publication number: 20230066255Abstract: A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.Type: ApplicationFiled: January 15, 2021Publication date: March 2, 2023Applicants: HORIBA ABX SAS, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Pierre TARACONAT, Damien ISEBE, Simon MENDEZ, Franck NICOUD
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Publication number: 20230057033Abstract: Probes for the detection of ?-lactamase-type enzymatic activity. In particular, novel fluorogenic substrates for detecting the presence of a catalytically active ?-lactamase and a detection method using such substrates.Type: ApplicationFiled: November 30, 2020Publication date: February 23, 2023Applicants: MOLSID, ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: Jens HASSERODT, Mathieu BORDY, Quentin GLENADEL, Charlie VERRIER
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Publication number: 20230054300Abstract: The present application relates to a double-stranded DNA molecule comprising a first double-stranded DNA molecule (1) connected to a second double-stranded DNA molecule (2) by at least one covalent bond which is not a phosphodiester, phosphorothioate, phosphoramidate or phosphorodiamidate bond, preferably by a tether, said tether preferably being a double-stranded DNA molecule.Type: ApplicationFiled: December 21, 2018Publication date: February 23, 2023Applicants: PARIS SCIENCES ET LETTRES - QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE, UNIVERSITÉ DE PARISInventors: Térence STRICK, Charlie GOSSE, Dorota KOSTRZ, Jinglong WANG, Marc NADAL
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Patent number: 11579068Abstract: The invention relates to a system (10) adapted to measure multiple biophysical characteristics of cells, the system (10) comprising: a microfluidic chip (12) provided with a microfluidic channel (14) which allows cells to flow through, the microfluidic channel (14) having an inlet (14a), an outlet (14b), and a lateral opening (14c) situated between the inlet (14a) and the outlet (14b); and a capacitive sensor (30) integrated in the microfluidic chip, adapted to obtain biophysical characteristics of a single cell in the microfluidic channel (14) by directly manipulating the single cell by sensor elements (31, 32) through the lateral opening (14c) of the microfluidic channel (14), the sensor (30) comprising a stationary part and an electrostatically driven movable part which is movable relative to the stationary part, the stationary part being fixed to the microfluidic chip (12), the movable part being arranged in the lateral opening (14c) of the microfluidic channel (14), wherein a portion of the sensor elemenType: GrantFiled: December 12, 2017Date of Patent: February 14, 2023Assignees: Centre National de la Recherche Scientifique (CNRS), Neuroindx, Inc., The Foundation for the Promotion of Industrial ScienceInventors: Dominique Collard, Hiroyuki Fujita, Stanislav Karsten
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Patent number: 11579147Abstract: Sarcomas are rare malignant tumors arising from the mesenchymal tissues at all body sites. The inventors show that in a mouse model of p16/p19 deficiency prone to tumor development, the absence of the mouse pantetheinase Vnn1 enhances the frequency of aggressive fibrosarcomas. They also show that reintroduction of a catalytically active form of the Vnn1 pantetheinase limits tumor growth in vivo. Interestingly, VNN1 expression in human sarcomas is associated with reduced aggressiveness and lower risk of metastatic relapse in patients. In conclusion, Vnn1 represents a novel marker of sarcoma and may modulate tumor aggressiveness by sustaining myofibroblast cell differentiation, thereby limiting evolution towards undifferentiated tumors. The present invention relates to the use of Vnn1 as a biomarker and a therapeutic target in sarcomas.Type: GrantFiled: September 25, 2018Date of Patent: February 14, 2023Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université d'Aix Marseille, Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard, Centre Leon BernardInventors: Philippe Naquet, Franck Galland, Virginie Millet, Jean-Yves Blay, Caroline Giessner
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Patent number: 11573241Abstract: The present invention relates to a novel use of total cellular iron, preferably under the form of ferrous iron (Fe2+), as a marker of cancer stem cells (CSCs). The invention also relates to methods using said iron marker, in particular for metastatic cancer diagnosis or treatment, for screening for compounds of interest, as well as for killing CSCs.Type: GrantFiled: March 8, 2017Date of Patent: February 7, 2023Assignees: Institute National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université de ParisInventors: Maryam Mehrpour, Raphael Rodriguez, Ahmed Hamai, Trang Mai
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Patent number: 11572409Abstract: The present invention relates to antibodies having specificity for BTN2 and uses thereof, in particular for the treatment of cancer.Type: GrantFiled: September 21, 2018Date of Patent: February 7, 2023Assignees: IMCHECK THERAPEUTICS SAS, INSERM, INSTITUT JEAN PAOLI & IRENE CALMETTES, UNIVERSITÉ D'AIX-MARSEILLE, CNRSInventors: Daniel Olive, Christine Pasero
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Patent number: 11571650Abstract: A method for preparing a nanoporous silica sol-gel matrix containing at least one amine reactant selected from hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, tetraethylenepentamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof, said method including the following steps: a) synthesising a gel from tetramethoxysilane or from a mixture of tetramethoxysilane and another organosilicon precursor selected from among phenyltrimethoxysilane, phenyltriethoxysilane, a fluoroalkyltrimethoxysilane, a fluoroalkyltriethoxysilane, a chloroalkylmethoxysilane, a chloroalkylethoxysilane, an alkyltrimethoxysilane, an alkyltriethoxysilane, an aminopropyltriethoxysilane and the mixtures thereof, the synthesis being performed in an aqueous medium at a temperature ranging from 10 to 70° C.Type: GrantFiled: July 27, 2018Date of Patent: February 7, 2023Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—Inventors: Thu-Hoa Tran-Thi, Ana Borta, Mickael Gineys, Marie-Pierre Som, Frédéric Hammel
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Patent number: 11571659Abstract: A method for producing electrical energy. An electrolyte solution having a first concentration CA of a solute is placed in a first vessel having an electrode arranged so the electrode is contacted with the electrolyte solution of concentration CA. An electrolyte solution having a concentration CB of the same solute is placed in a second vessel having an electrode arranged so the electrode comes in contact with the electrolyte solution of concentration CB, the concentration CB being lower than the concentration CA. The first and the second vessels are separated by a membrane, the membrane having at least one nanochannel arranged to allow diffusion of the electrolyte solution from the first vessel to the second vessel through the at least one nanochannel. An inner surface of the at least one nanochannel is formed of at least one titanium oxide. Electrical energy generated by a potential difference existing between the electrodes is captured using a device having the first and second vessels.Type: GrantFiled: February 24, 2021Date of Patent: February 7, 2023Assignees: Centre National de la Recherche Scientifique (CNRS), Sweetch EnergyInventors: Bruno Mottet, Lyderic Bocquet, Alessandro Siria, Mikhael Bechelany
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Publication number: 20230032722Abstract: A full-field optical coherence tomography imaging method, FFOCT, using a system comprising an FFOCT device and a sample, the sample comprising a layer of interest to be imaged, the FFOCT device comprising an incoherent light source, an imager, a beam splitter defining a sample arm and a reference arm, the method comprising-generating sample light containing interest light originating from the layer of interest and reference light traveling from the reference arm, —acquiring an image from reference light and sample light combined in the beam splitter; wherein at least one of the sample arm and the reference arm comprises an optical curvature compensator that modifies a transverse variation distribution of an optical path length to match the transverse variation distributions of the optical path lengths travelled by the reference light and the interest light incident on the imager.Type: ApplicationFiled: December 18, 2020Publication date: February 2, 2023Applicants: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De ParisInventors: Viacheslav Mazlin, Pedro Francisco Baracal De Mece, Albert Claude Boccara
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Patent number: 11563128Abstract: A shielding element comprises a rigid substrate and at least one electrically conductive two-dimensional structure which is placed on one of the faces of the substrate. The substrate and the electrically conductive two-dimensional structure are such that the shielding element has optical-transmission and shielding-efficiency values at least one of which varies between two zones of the shielding element. Such a shielding element enables easier assembly of a detection system comprising multiple optical sensors.Type: GrantFiled: January 19, 2021Date of Patent: January 24, 2023Assignees: SAFRAN ELECTRONICS & DEFENSE Boulogne, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE DE RENNES 1Inventors: Cyril Dupeyrat, Patrice Foutrel, Philippe Besnier, Xavier Castel, Yonathan Corredores
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Patent number: 11559244Abstract: Disclosed is a method for the generation of a consciousness indicator for a non-communicating subject, including the steps of generating an auditory stimulation, receiving an electrocardiographic signal of the subject obtained from a recording during the generation of the auditory stimulation, extracting at least one feature from the electrocardiographic signal and deducing a consciousness indicator from an analysis of the electrocardiographic feature.Type: GrantFiled: September 11, 2018Date of Patent: January 24, 2023Assignees: ICM—INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE), APHP, SORBONNE UNIVERSITÉInventors: Federico Raimondo, Jacobo D Sitt, Lionel Naccache, Diego Fernandez Slezak
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Publication number: 20230016226Abstract: The present invention relates to a selective process for preparing sulfones from sulfides by enzymatic catalysis, and to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of said symmetrical sulfide to symmetrical sulfone; optionally at least one cofactor C of said enzyme E; and an oxidant, which allows in particular the implementation of said process.Type: ApplicationFiled: June 12, 2020Publication date: January 19, 2023Applicants: Arkema France, Centre National de la Recherche Scientifique (CNRS), Universite d'Aix-MarseilleInventors: Georges Fremy, Hugo Brasselet, Véronique Alphand, Katia Duquesne
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Publication number: 20230003652Abstract: A method for identifying a microorganism to be identified, which includes the following steps: obtaining an Excitation-Emission EEM of the microorganism to be identified, analysing the main components of the EEM matrix using at least one reference EEMr matrix, projecting the result of the analysis onto a plane defined by two main components, and identifying the microorganism to be identified.Type: ApplicationFiled: November 27, 2020Publication date: January 5, 2023Applicants: UNIVERSITE DU MANS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE D'ANGERS, CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERSInventors: Jean-François BARDEAU, Jean-Philippe BOUCHARA