Patents Assigned to CNRS
  • Patent number: 11608315
    Abstract: The invention relates to a process for preparing methyl mercaptan from a mixture of carbon oxide, hydrogen sulfide and hydrogen, in the presence of a catalyst based on molybdenum and potassium supported on zirconia, said catalyst not comprising any promoter.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: March 21, 2023
    Assignees: Arkema France, Universite Lille 1-Sciences et Technologies, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Georges Frémy, Hélori Salembier, Carole Lamonier, Pascal Blanchard
  • Patent number: 11608589
    Abstract: A method for coating a textile material, said method includes the following steps: a) incorporating activated carbon in powder form into a coating composition including an aqueous solvent and at least one organosilicon precursor, wherein the organosilicon precursor represents from 5 to 50% by volume relative to the whole of the aqueous solvent and organosilicon precursor, b) impregnating the textile material with the coating composition by padding and c) drying the impregnated textile material, characterised in that the coating composition contains no polycarboxylic acid or catalyst.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: March 21, 2023
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS-, SAFRAN ELECTRONICS & DEFENSE, EUROPROTECT FRANCE SA
    Inventors: Thu-Hoa Tran-Thi, Philippe Charton, Franck Tirard, Eva Grinenval, Sébastien Chatard
  • Patent number: 11610647
    Abstract: The invention relates to a method for generating a unique identifier of a subject from a genotyped DNA sample from said subject, the method comprising the steps of: obtaining a number N?2 of genomic positions of interest, said obtained genomic positions being such that, in a population of M subjects, these genomic positions exhibit a polymorphism of at least one nucleotide having an allelic frequency of between 25% and 35%, for the minority allele; combining in pairs the obtained genomic positions by means of logical functions so as to obtain a binary code bc.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: March 21, 2023
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PAUL SABATIER TOULOUSE III
    Inventors: Denis Pierron, Thierry Letellier, Margit Heiske, Veronica Pereda
  • Patent number: 11608509
    Abstract: The present invention relates to pseudotyped retrovirus-like particles or retroviral vectors comprising both engineered envelope glycoproteins derived from a virus of the Paramyxoviridae family fused to a cell targeting domain and fused to a functional domain. The present invention also relates to the use of said pseudotyped retrovirus-like particles or retroviral vectors to selectively modulate the activity of specific subsets of cells, in particular of specific immune cells. These pseudotyped retrovirus-like particles or retroviral vectors are particularly useful for gene therapy, immune therapy and/or vaccination.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: March 21, 2023
    Assignees: Ecole Normale Superieure de Lyon, Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard Lyon 1, Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Caroline Costa Fejoz, Els Verhoeyen, François-Loïc Cosset, Ruben Bender, Christian Buchholz, Qi Zhou
  • Patent number: 11609124
    Abstract: A method for determining wavefront shapes of N angular channels CL of different propagation directions PL, said propagation directions PL being determined by a mean propagation direction vector , from a single signal image acquisition I(x,y) of a multi-angular signal light beam containing said angular channels, each angular channel Ci being separated from other angular channels Cj by an angular separation ??ij defined by ??ij=arccos, where “·” stands for the inner product between and .
    Type: Grant
    Filed: September 28, 2021
    Date of Patent: March 21, 2023
    Assignees: UNIVERSITE DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), SORBONNE UNIVERSITE
    Inventors: Marc Guillon, Gilles Tessier, Tengfei Wu, Pascal Berto
  • Patent number: 11606530
    Abstract: Disclosed is a display device including, from a front face towards a rear face, a panel, a ground plane, and a processing unit connected to the panel and including an antenna for receiving and/or emitting a wave for connection to a wireless network. The display device further includes a plurality of adjustable elements connected to the processing unit, each adjustable element having an impedance which can be modified by the processing unit in order to change the manner in which the wave is reflected and/or transmitted by the adjustable elements, these adjustable elements being located on the rear side of the ground plane.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: March 14, 2023
    Assignees: GREENEWAVE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS
    Inventor: Geoffroy Lerosey
  • Publication number: 20230066255
    Abstract: A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.
    Type: Application
    Filed: January 15, 2021
    Publication date: March 2, 2023
    Applicants: HORIBA ABX SAS, UNIVERSITE DE MONTPELLIER, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Pierre TARACONAT, Damien ISEBE, Simon MENDEZ, Franck NICOUD
  • Publication number: 20230057033
    Abstract: Probes for the detection of ?-lactamase-type enzymatic activity. In particular, novel fluorogenic substrates for detecting the presence of a catalytically active ?-lactamase and a detection method using such substrates.
    Type: Application
    Filed: November 30, 2020
    Publication date: February 23, 2023
    Applicants: MOLSID, ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Jens HASSERODT, Mathieu BORDY, Quentin GLENADEL, Charlie VERRIER
  • Publication number: 20230054300
    Abstract: The present application relates to a double-stranded DNA molecule comprising a first double-stranded DNA molecule (1) connected to a second double-stranded DNA molecule (2) by at least one covalent bond which is not a phosphodiester, phosphorothioate, phosphoramidate or phosphorodiamidate bond, preferably by a tether, said tether preferably being a double-stranded DNA molecule.
    Type: Application
    Filed: December 21, 2018
    Publication date: February 23, 2023
    Applicants: PARIS SCIENCES ET LETTRES - QUARTIER LATIN, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE, UNIVERSITÉ DE PARIS
    Inventors: Térence STRICK, Charlie GOSSE, Dorota KOSTRZ, Jinglong WANG, Marc NADAL
  • Patent number: 11579068
    Abstract: The invention relates to a system (10) adapted to measure multiple biophysical characteristics of cells, the system (10) comprising: a microfluidic chip (12) provided with a microfluidic channel (14) which allows cells to flow through, the microfluidic channel (14) having an inlet (14a), an outlet (14b), and a lateral opening (14c) situated between the inlet (14a) and the outlet (14b); and a capacitive sensor (30) integrated in the microfluidic chip, adapted to obtain biophysical characteristics of a single cell in the microfluidic channel (14) by directly manipulating the single cell by sensor elements (31, 32) through the lateral opening (14c) of the microfluidic channel (14), the sensor (30) comprising a stationary part and an electrostatically driven movable part which is movable relative to the stationary part, the stationary part being fixed to the microfluidic chip (12), the movable part being arranged in the lateral opening (14c) of the microfluidic channel (14), wherein a portion of the sensor elemen
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: February 14, 2023
    Assignees: Centre National de la Recherche Scientifique (CNRS), Neuroindx, Inc., The Foundation for the Promotion of Industrial Science
    Inventors: Dominique Collard, Hiroyuki Fujita, Stanislav Karsten
  • Patent number: 11579147
    Abstract: Sarcomas are rare malignant tumors arising from the mesenchymal tissues at all body sites. The inventors show that in a mouse model of p16/p19 deficiency prone to tumor development, the absence of the mouse pantetheinase Vnn1 enhances the frequency of aggressive fibrosarcomas. They also show that reintroduction of a catalytically active form of the Vnn1 pantetheinase limits tumor growth in vivo. Interestingly, VNN1 expression in human sarcomas is associated with reduced aggressiveness and lower risk of metastatic relapse in patients. In conclusion, Vnn1 represents a novel marker of sarcoma and may modulate tumor aggressiveness by sustaining myofibroblast cell differentiation, thereby limiting evolution towards undifferentiated tumors. The present invention relates to the use of Vnn1 as a biomarker and a therapeutic target in sarcomas.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: February 14, 2023
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université d'Aix Marseille, Centre National de la Recherche Scientifique (CNRS), Université Claude Bernard, Centre Leon Bernard
    Inventors: Philippe Naquet, Franck Galland, Virginie Millet, Jean-Yves Blay, Caroline Giessner
  • Patent number: 11573241
    Abstract: The present invention relates to a novel use of total cellular iron, preferably under the form of ferrous iron (Fe2+), as a marker of cancer stem cells (CSCs). The invention also relates to methods using said iron marker, in particular for metastatic cancer diagnosis or treatment, for screening for compounds of interest, as well as for killing CSCs.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: February 7, 2023
    Assignees: Institute National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Université de Paris
    Inventors: Maryam Mehrpour, Raphael Rodriguez, Ahmed Hamai, Trang Mai
  • Patent number: 11572409
    Abstract: The present invention relates to antibodies having specificity for BTN2 and uses thereof, in particular for the treatment of cancer.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: February 7, 2023
    Assignees: IMCHECK THERAPEUTICS SAS, INSERM, INSTITUT JEAN PAOLI & IRENE CALMETTES, UNIVERSITÉ D'AIX-MARSEILLE, CNRS
    Inventors: Daniel Olive, Christine Pasero
  • Patent number: 11571650
    Abstract: A method for preparing a nanoporous silica sol-gel matrix containing at least one amine reactant selected from hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, tetraethylenepentamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof, said method including the following steps: a) synthesising a gel from tetramethoxysilane or from a mixture of tetramethoxysilane and another organosilicon precursor selected from among phenyltrimethoxysilane, phenyltriethoxysilane, a fluoroalkyltrimethoxysilane, a fluoroalkyltriethoxysilane, a chloroalkylmethoxysilane, a chloroalkylethoxysilane, an alkyltrimethoxysilane, an alkyltriethoxysilane, an aminopropyltriethoxysilane and the mixtures thereof, the synthesis being performed in an aqueous medium at a temperature ranging from 10 to 70° C.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: February 7, 2023
    Assignees: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—
    Inventors: Thu-Hoa Tran-Thi, Ana Borta, Mickael Gineys, Marie-Pierre Som, Frédéric Hammel
  • Patent number: 11571659
    Abstract: A method for producing electrical energy. An electrolyte solution having a first concentration CA of a solute is placed in a first vessel having an electrode arranged so the electrode is contacted with the electrolyte solution of concentration CA. An electrolyte solution having a concentration CB of the same solute is placed in a second vessel having an electrode arranged so the electrode comes in contact with the electrolyte solution of concentration CB, the concentration CB being lower than the concentration CA. The first and the second vessels are separated by a membrane, the membrane having at least one nanochannel arranged to allow diffusion of the electrolyte solution from the first vessel to the second vessel through the at least one nanochannel. An inner surface of the at least one nanochannel is formed of at least one titanium oxide. Electrical energy generated by a potential difference existing between the electrodes is captured using a device having the first and second vessels.
    Type: Grant
    Filed: February 24, 2021
    Date of Patent: February 7, 2023
    Assignees: Centre National de la Recherche Scientifique (CNRS), Sweetch Energy
    Inventors: Bruno Mottet, Lyderic Bocquet, Alessandro Siria, Mikhael Bechelany
  • Publication number: 20230032722
    Abstract: A full-field optical coherence tomography imaging method, FFOCT, using a system comprising an FFOCT device and a sample, the sample comprising a layer of interest to be imaged, the FFOCT device comprising an incoherent light source, an imager, a beam splitter defining a sample arm and a reference arm, the method comprising-generating sample light containing interest light originating from the layer of interest and reference light traveling from the reference arm, —acquiring an image from reference light and sample light combined in the beam splitter; wherein at least one of the sample arm and the reference arm comprises an optical curvature compensator that modifies a transverse variation distribution of an optical path length to match the transverse variation distributions of the optical path lengths travelled by the reference light and the interest light incident on the imager.
    Type: Application
    Filed: December 18, 2020
    Publication date: February 2, 2023
    Applicants: Paris Sciences et Lettres, Centre National de la Recherche Scientifique (CNRS), Ecole Superieure De Physique Et De Chimie Industrielles De La Ville De Paris
    Inventors: Viacheslav Mazlin, Pedro Francisco Baracal De Mece, Albert Claude Boccara
  • Patent number: 11563128
    Abstract: A shielding element comprises a rigid substrate and at least one electrically conductive two-dimensional structure which is placed on one of the faces of the substrate. The substrate and the electrically conductive two-dimensional structure are such that the shielding element has optical-transmission and shielding-efficiency values at least one of which varies between two zones of the shielding element. Such a shielding element enables easier assembly of a detection system comprising multiple optical sensors.
    Type: Grant
    Filed: January 19, 2021
    Date of Patent: January 24, 2023
    Assignees: SAFRAN ELECTRONICS & DEFENSE Boulogne, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, UNIVERSITE DE RENNES 1
    Inventors: Cyril Dupeyrat, Patrice Foutrel, Philippe Besnier, Xavier Castel, Yonathan Corredores
  • Patent number: 11559244
    Abstract: Disclosed is a method for the generation of a consciousness indicator for a non-communicating subject, including the steps of generating an auditory stimulation, receiving an electrocardiographic signal of the subject obtained from a recording during the generation of the auditory stimulation, extracting at least one feature from the electrocardiographic signal and deducing a consciousness indicator from an analysis of the electrocardiographic feature.
    Type: Grant
    Filed: September 11, 2018
    Date of Patent: January 24, 2023
    Assignees: ICM—INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE, INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), CNRS (CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE), APHP, SORBONNE UNIVERSITÉ
    Inventors: Federico Raimondo, Jacobo D Sitt, Lionel Naccache, Diego Fernandez Slezak
  • Publication number: 20230016226
    Abstract: The present invention relates to a selective process for preparing sulfones from sulfides by enzymatic catalysis, and to a composition comprising a symmetrical sulfide, an oxidoreductase enzyme catalyzing the oxidation of said symmetrical sulfide to symmetrical sulfone; optionally at least one cofactor C of said enzyme E; and an oxidant, which allows in particular the implementation of said process.
    Type: Application
    Filed: June 12, 2020
    Publication date: January 19, 2023
    Applicants: Arkema France, Centre National de la Recherche Scientifique (CNRS), Universite d'Aix-Marseille
    Inventors: Georges Fremy, Hugo Brasselet, Véronique Alphand, Katia Duquesne
  • Publication number: 20230003652
    Abstract: A method for identifying a microorganism to be identified, which includes the following steps: obtaining an Excitation-Emission EEM of the microorganism to be identified, analysing the main components of the EEM matrix using at least one reference EEMr matrix, projecting the result of the analysis onto a plane defined by two main components, and identifying the microorganism to be identified.
    Type: Application
    Filed: November 27, 2020
    Publication date: January 5, 2023
    Applicants: UNIVERSITE DU MANS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS -, UNIVERSITE D'ANGERS, CENTRE HOSPITALIER UNIVERSITAIRE D'ANGERS
    Inventors: Jean-François BARDEAU, Jean-Philippe BOUCHARA