Patents Assigned to College
  • COMPOSITIONS OF TOEHOLD PRIMER DUPLEXES AND METHODS OF USE
    Publication number: 20210388430
    Abstract: Provided herein are primers and primer systems having improved specificity and kinetics over existing primers, and methods of use thereof.
    Type: Application
    Filed: February 5, 2021
    Publication date: December 16, 2021
    Applicant: President and Fellows of Harvard College
    Inventors: David Yu Zhang, Peng Yin
  • Trans-tympanic membrane delivery platform and uses thereof
    Patent number: 11197820
    Abstract: Provided herein are methods and composition for trans-tympanic membrane delivery of therapeutic agents such as antimicrobial agents, anti-inflammatory agents, and anti-biofilm agents to the middle ear for rapid, localized treatment and prevention of diseases and conditions associated with a middle ear infection. In particular, provided herein are cationic, anionic, and polymer-based nanoparticles that provide a platform for delivery of therapeutic cargo, as well as cationic, anionic, and polymer-based nanoparticles compositions for rapid, localized delivery of therapeutic agents to the middle ear.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: December 14, 2021
    Assignee: The Medical College of Wisconsin, Inc.
    Inventors: Amit Joshi, Joseph Edward Kerschner, Wenzhou Hong, Gayatri Sharma
  • Two-layer nanofiltration membranes
    Patent number: 11198103
    Abstract: A two-layer membrane including a polymer layer and a support layer, the polymer layer being disposed on a surface of the support layer. The polymer layer, having a pore size of at most 50 nm and a thickness of 5 nm to 10 ?m, is formed of an amphiphilic copolymer that contains both charged groups and hydrophobic groups. The support layer has a pore size of 3 nm to 10 ?m, which is larger than the pore size of the polymer layer. Also disclosed is a process of filtering a liquid using the two-layer membrane described above.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: December 14, 2021
    Assignee: Trustees of Tufts College
    Inventors: Ayse Asatekin Alexiou, Ilin Sadeghi
  • Compositions and methods of mechanically inducing tissue regeneration
    Patent number: 11197944
    Abstract: The present invention provides methods and compositions for promoting regeneration of a tissue, methods for preventing or reducing inflammation of a tissue, methods for preventing or reducing fibrosis of a tissue, methods for increasing a mass of a tissue, methods for increasing a level of oxygen available to a tissue, methods for increasing a rate of metabolic waste removal from a tissue, methods for increasing blood perfusion to a tissue, and methods of treating severe muscle tissue damage in a subject in need thereof by contacting the tissue with a composition that is suitable for applying cyclic mechanical compression to the tissue.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: December 14, 2021
    Assignees: President and Fellows of Harvard College, CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN
    Inventors: Christine A. Cezar, Conor J. Walsh, David J. Mooney, Ellen T. Roche, Herman H. Vandenburgh, Georg N. Duda
  • Bifurcated flow diverter systems
    Patent number: 11197770
    Abstract: One aspect of the invention provides a flow-diverting system including: a first stent having a proximal end, a distal end and a first sidewall opening; and a second stent having a proximal end, a distal end and a second sidewall opening. The first sidewall opening is of sufficient size for the distal end of the second stent to pass from inside the first stent through the first sidewall opening. The second sidewall opening is of sufficient size for fluid flow from inside the second stent through the second sidewall opening into the first stent.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: December 14, 2021
    Assignee: Baylor College of Medicine
    Inventors: Stephen P. Chen, Peter Tze Man Kan
  • Antimicrobial compounds from the genus
    Patent number: 11197907
    Abstract: Cultures of Delftia bacteria are disclosed. Antimicrobial agents derived therefrom are also disclosed.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: December 14, 2021
    Assignees: Ministry of Health, State of Israel, Sami Shamoon College of Engineeing (R.A), Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Israel Nissan, Noa Lea Tejman-Yarden, Chaim Rubinovitz, Yakov Davidov, Galia Rahav, Ari Robinson, Yoram Shotland
  • Nucleic acid-based linkers for detecting and measuring interactions
    Patent number: 11198900
    Abstract: The invention provides compositions comprising nucleic acid complexes for use in monitoring binding interactions and in measuring association and/or dissociation kinetics, detecting analytes including low concentration analytes, and screening library members. In some instances, the nucleic acid complexes are double-stranded nicked nucleic acids comprising a scaffold nucleic acid hybridized to one or more oligonucleotides. In some instances, a first, a second, a third, and optionally a fourth oligonucleotide are linked to moieties that are known to interact with each other or which are suspected of interacting with each other or of interacting with a common moiety such as an analyte. Changes in topology of the complex are used to determine the binding interactions of the various binding partners.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: December 14, 2021
    Assignees: Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Mounir Ahmad Koussa, Kenneth Anders Halvorsen, Andrew Ward, Wesley Philip Wong
  • Methods of lowering blink reflex for the treatment of dry eye disease
    Patent number: 11197906
    Abstract: The present disclosure relates to, among other things, compositions and methods for treating an inflammatory condition including, but not limited to, ocular inflammation, dry eye disease, and ocular neuropathic pain. One aspect of the present disclosure relates to a composition comprising (a) chemerin or a fragment or analog thereof and (b) a lipid entity linked to the chemerin or fragment or analog thereof.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: December 14, 2021
    Assignees: On Target Therapeutics LLC, Trustees of Tufts College, Tufts Medical Center
    Inventors: Charles Cohen, Krishna Kumar, Alan S. Kopin, Benjamin N. Harwood, Venkata S. Raman, Pedram Hamrah
  • Image processing
    Patent number: 11200693
    Abstract: Imaging methods, imaging apparatus and computer program products are disclosed. An imaging method comprises: receiving image data of a 3-dimensional object; and allocating a confidence level to at least a portion of an image frame of the image data using a machine-learning algorithm, the confidence level indicating a likelihood of that image frame having a specified element imaged on a specified plane through the 3-dimensional object. In this way, particular elements when imaged in a desired way can be identified from image data of the 3-dimensional object.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: December 14, 2021
    Assignee: King's College London
    Inventors: Christian Baumgartner, Daniel Rueckert
  • THERAPEUTICS AND METHODS OF TREATMENT OF ANGIOTENSIN-CONVERTING ENZYME 2 ASSOCIATED CONDITIONS
    Publication number: 20210379016
    Abstract: Therapeutics and methods of treating one of an angiotensin-converting enzyme 2 (ACE2) associated condition and an ACE2 associated pre-condition patient comprising administering to the patient a pharmaceutically therapeutic dose of a therapeutic, wherein the therapeutic includes either a Sigmar1 antagonist or any pharmaceutically acceptable salt, solvate, or prodrug thereof, or a Sigmar1 enhancer, or any pharmaceutically acceptable salt, solvate, or prodrug thereof. A method of treating coronavirus disease 2019 (COVID-19) patient comprising administering to the patient a pharmaceutically therapeutic dose of a therapeutic, wherein the therapeutic includes a Sigmar1 enhancer, or any pharmaceutically acceptable salt, solvate, or prodrug thereof.
    Type: Application
    Filed: June 7, 2021
    Publication date: December 9, 2021
    Applicant: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Shenuarin BHUIYAN, Christopher KEVIL, Anthony Wayne ORR, Chowdhury S ABDULLAH, Richa Aishwarya
  • SYSTEMS AND METHODS FOR BARCODING NUCLEIC ACIDS
    Publication number: 20210379555
    Abstract: The present invention generally relates to microfluidics and labeled nucleic acids. For example, certain aspects are generally directed to systems and methods for labeling nucleic acids within microfluidic droplets. In one set of embodiments, the nucleic acids may include “barcodes” or unique sequences that can be used to distinguish nucleic acids in a droplet from those in another droplet, for instance, even after the nucleic acids are pooled together. In some cases, the unique sequences may be incorporated into individual droplets using particles and attached to nucleic acids contained within the droplets (for example, released from lysed cells). In some cases, the barcodes may be used to distinguish tens, hundreds, or even thousands of nucleic acids, e.g., arising from different cells or other sources.
    Type: Application
    Filed: May 18, 2021
    Publication date: December 9, 2021
    Applicants: President and Fellows of Harvard College, Vilnius University
    Inventors: David A. Weitz, Allon Moshe Klein, Ilke Akartuna, Linas Mazutis, Marc W. Kirschner
  • Programmable nucleic acid synthesis cascade
    Patent number: 11193153
    Abstract: The present disclosure provides, in some embodiments, methods and compositions for exponential amplification of single- and double-stranded DNA under isothermal conditions.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: December 7, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Feng Xuan, Jocelyn Yoshiko Kishi, Peng Yin
  • Methods of treatment for bacterial infections
    Patent number: 11191773
    Abstract: This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, including certain combinations that exhibit synergistic effects. Furthermore, aminocoumarin compounds are described having altered inhibition of DNA gyrase in Gram-negative bacteria and/or the ability to target the transport proteins responsible for assembling lipopolysaccharide in the outer membrane of Gram-negative bacteria.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: December 7, 2021
    Assignees: President and Fellows of Harvard College, The Ohio State University
    Inventors: Daniel E. Kahne, Michael D. Mandler, Vadim Baidin, Natividad Ruiz
  • Synthesis of tetracyclines and analogues thereof
    Patent number: 11192866
    Abstract: The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: December 7, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Andrew G. Myers, Mark G. Charest, Christian D. Lerner, Jason D. Brubaker, Dionicio R. Siegel
  • Formation of high quality titania, alumina and other metal oxide templated materials through coassembly
    Patent number: 11192796
    Abstract: A co-assembly method for synthesizing inverse photonic structures is described. The method includes combining an onium compound with a sol-gel precursor to form metal oxide (MO) nanocrystals, where each MO nanocrystal has crystalline and amorphous content. The MO nanocrystals are combined with templating particles to form a suspension. A solvent is evaporated from the suspension to form an intermediate or compound product, which then undergoes calcination to produce an inverse structure.
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: December 7, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Joanna Aizenberg, Tanya Shirman, Katherine Reece Phillips, Elijah Shirman, Theresa M. Kay
  • Method of performing magnetic resonance imaging and a magnetic resonance apparatus
    Patent number: 11194001
    Abstract: In a method and apparatus for performing magnetic resonance (MR) imaging for generating multiple T1 maps of separate regions of interest of a subject along a first spatial axis, multiple MR pulse sequences are generated, each MR pulse sequence being for imaging a respective one of the separate regions of interest of the subject. In order to generate each of the plurality of MR pulse sequences, a spatially selective preparation pulse is generated exciting the region of interest of the subject and a number of imaging sequences that follow the application of the spatially selective preparation pulse are generated. MR imaging data are acquired during the generation of the multiple imaging sequences. The multiple MR pulse sequences are generated during a period not exceeding 30 seconds.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: December 7, 2021
    Assignees: Siemens Healthcare GmbH, King's College, London
    Inventors: Li Huang, Radhouene Neji, Sebastien Roujol
  • Methods for generation of cell-derived microfilament network
    Patent number: 11185568
    Abstract: This invention provides for a network of cell-derived microfilaments. Also provided are methods of producing a network of microfilaments via culturing cells in a matrix support and cell culture medium wherein the cells proliferate and form aggregated cell masses, which produce microfilaments external to and surrounding the cell masses, and wherein the extracellular microfilaments connect and form a continuous extracellular microfilament network, and methods for treating a medical condition as well as facilitating wound repair and tissue regeneration comprising applying the microfilament network to an area in need of treatment.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: November 30, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Tingfang Yi, Gerhard Wagner
  • Multi-linear dynamical model reduction
    Patent number: 11188616
    Abstract: An illustrative embodiment includes a method for solving a dynamical system. The method comprises: obtaining multidimensional snapshots representing respective discrete solutions of the dynamical system; storing the multidimensional snapshots within a snapshot tensor having an order of at least three; generating a basis for at least a subspace of a state space of the dynamical system at least in part by performing a decomposition of the snapshot tensor; deriving a reduced order model at least in part by using the basis to project the dynamical system from the state space onto the subspace; and solving the reduced order model of the dynamical system.
    Type: Grant
    Filed: February 25, 2020
    Date of Patent: November 30, 2021
    Assignees: International Business Machines Corporation, Trustees of Tufts College, Ramot at Tel Aviv University Ltd.
    Inventors: Lior Horesh, Misha Elena Kilmer, Haim Avron, Jiani Zhang
  • Treatment of helicobacter pylori infections
    Patent number: 11186575
    Abstract: Methods of treating infections due to Helicobacter pylori (H. pylori), in particular in subjects having a peptic ulcer, are disclosed where the methods comprise administering to the subject an inhibitor of H.
    Type: Grant
    Filed: August 7, 2013
    Date of Patent: November 30, 2021
    Assignees: Alber Einslein College of Medicine, Victoria Link Limited
    Inventors: Vern L. Schramm, Shanzhi Wang, Antti Marko Haapalainen, Gary Brian Evans, Richard Hubert Furneaux, Keith Clinch, Peter Charles Tyler, Shivali Ashwin Gulab
  • Controlled excitation and saturation of magnetisation transfer systems
    Patent number: 11187768
    Abstract: The present invention relate to a system and associate method of MRI and MR spectroscopy which provide stable measurements of the relaxation times, T1 and T2, by using tailored multi-band RF pulses that direct control of the saturation conditions in the background pool of macro-molecular protons, and hence provide a flexible means to induce constant Magnetisation Transfer (MT) effects. In doing this, equal saturation of the background pool is obtained for all measurements independent of the parameters that may be changed, for example, the rotation rate used to obtain a desired flip angle, that is, the degree of change in the magnetisation of the free pool of protons.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: November 30, 2021
    Assignee: King's College London
    Inventors: Rui Pedro Azeredo Gomes Teixeira, Joseph Vilmos Hajnal, Shaihan Jalal Malik, Daniel John West