Patents Assigned to College
  • Publication number: 20210340597
    Abstract: The present invention generally relates to droplet-based microfluidic devices, including systems, methods, and kits for amplifying or cloning within droplets. In some embodiments, the present invention is generally directed to systems, methods, or kits for amplifying a plurality of nucleic acids, e.g., without substantially selectively amplifying some nucleic acids over others. The nucleic acids may be contained within the droplets. In addition, in some embodiments, a plurality of microfluidic droplet containing a species of interest, such as a nucleic acid, may be mixed with microfluidic droplets free of the species, then pipetted or otherwise transferred such that, on average, a predetermined number of droplets containing species of interest is transferred.
    Type: Application
    Filed: May 13, 2021
    Publication date: November 4, 2021
    Applicant: President and Fellows of Harvard College
    Inventors: David A. Weitz, John Heyman, Huidan Zhang, Linas Mazutis
  • Patent number: 11161824
    Abstract: The present invention relates to a compound of formula (I): wherein L is an optionally substituted heterocyclic group excluding unsubstituted monocyclic pyridine groups; wherein a is 0, 1 or 2; wherein R1 is H or with R2 is a bond; wherein R2 is an optionally substituted alkoxy or aryloxy group, or with R1 forms a bond; wherein R3 is an optionally substituted alkyl group; and wherein R4 is CH2, CMe2 or O. Such compounds may be used in the treatment or prophylaxis of a disease or condition in which inhibition of acute inflammation and/or promotion of its resolution and/or suppression of fibrosis.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: November 2, 2021
    Assignee: University College Dublin, National University of Ireland, Dublin
    Inventors: Patrick Guiry, Catherine Godson, Monica De Gaetano, Eibhlin Butler, Claire Wilson, Catherine Tighe, Denise Moran, Andrea Zanetti, Kevin Gahan
  • Patent number: 11162141
    Abstract: The invention relates, in part, to compounds, compositions, and methods to assess molecular characteristics papillary microcarcinoma (PMC) of the thyroid and indicators of indolent compared to aggressive PMC of the thyroid. In addition, the invention relates, in part, to methods of assessing characteristics of microRNAs associated with PMC of the thyroid.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: November 2, 2021
    Assignee: University of Vermont and State Agricultural College
    Inventors: Frances Carr, Nikoletta Sidiropoulos
  • Patent number: 11161910
    Abstract: The present invention provides glycated Amadori products of the CD59 peptide and fragments thereof to be used as tools and among methods for the diagnosis and prognosis of pre-diabetes and diabetes. Certain aspects of the invention include glycated Amadori products of CD59 and fragments thereof to be used for the generation of antibodies and antibody fragments. Still other aspects of the invention include methodologies for the preparation of glycated Amadori products of CD59, fragments thereof, the inventive antibodies, and antibody fragments.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: November 2, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Jose A. Halperin, Michael Chorev
  • Patent number: 11162078
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: November 2, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey R. Millman, Michael Saris Segel, Mads Gurtler
  • Patent number: 11164721
    Abstract: A system and method is provided for rapidly collecting high quality images of a specimen through controlling a re-focusable beam of an electron microscope. An intelligent acquisition system instructs the electron microscope to perform an initial low-resolution scan of a sample. A low-resolution image of the sample is received by the intelligent acquisition system as scanned image information from the electron microscope. The intelligent acquisition system then determines regions of interest within the low-resolution image and instructs the electron microscope to perform a high-resolution scan of the sample, only in areas of the sample corresponding to the determined regions of interest or portions of the determined regions of interest, so that other regions within the sample are not scanned at high-resolution. The intelligent acquisition system then reconstructs an image using the collected high-resolution scan pixels and pixels in the received low-resolution image.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: November 2, 2021
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Nir Shavit, Aravinathan Samuel, Jeff Lichtman, Lu Mi
  • Patent number: 11161958
    Abstract: Disclosed is a macroporous polymeric hydrogel microsphere that contains polyacrylamide and chitosan. The hydrogel microsphere, having a diameter of 50-250 ?m and an average pore size of 1-60 nm, is capable of transporting biomolecules conjugated to it. Also disclosed is a method of fabricating the microsphere based on a micromolding technique utilizing surface tension-induced droplet formation followed by photo-induced polymerization.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: November 2, 2021
    Assignee: Trustees of Tufts College
    Inventors: Hyunmin Yi, Sukwon Jung, John H. Abel
  • Patent number: 11161857
    Abstract: Compounds are synthesized with bicyclic amidinate ligands attached to one or more metal atoms. These compounds are useful for the synthesis of materials containing metals. Examples include pure metals, metal alloys, metal oxides, metal nitrides, metal phosphides, metal sulfides, metal selenides, metal tellurides, metal borides, metal carbides, metal silicides and metal germanides. Techniques for materials synthesis include vapor deposition (chemical vapor deposition and atomic layer deposition), liquid solution methods (sol-gel and precipitation) and solid-state pyrolysis. Copper metal films are formed on heated substrates by the reaction of copper(I) bicyclic amidinate vapor and hydrogen gas, whereas reaction with water vapor produces copper oxide. Silver and gold films were deposited on surfaces by reaction of their respective bicyclic amidinate vapors with hydrogen gas.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: November 2, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Roy Gerald Gordon, Eugene Beh, Liuchuan Tong
  • Patent number: 11161831
    Abstract: Embodiments of the invention include methods of treating, preventing, and/or reduce the risk or severity of a condition selected from the group consisting of muscle wasting, muscle weakness, cachexia, and a combination thereof in an individual in need thereof. In some embodiments, particular small molecules are employed for treatment, prevention, and/or reduction in the risk of muscle wasting. In at least particular cases, the small molecules are inhibitors of STAT3.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: November 2, 2021
    Assignee: Baylor College of Medicine
    Inventors: David J. Tweardy, Moses M. Kasembeli, Marvin X. Xu, Thomas Kristian Eckols
  • Patent number: 11161827
    Abstract: In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on sequential combination of enantiodifferentiative H-atom abstraction and stereoretentive radical substitution. Also disclosed is an asymmetric system for stereoselective synthesis of strained 5-membered cyclic sulfamides via radical 1,5-C—H amination of sulfamoyl azides. The disclosed metalloradical system can control the degree and sense of asymmetric induction in the catalytic radical C—H amination in a systematic manner. The disclosed system is applicable to a broad scope of substrates with different types of C(sp3)—H bonds and exhibits reactivity and selectivity, providing access to both enantiomers of useful 5-membered cyclic sulfamides in a highly enantioenriched form. Also disclosed are catalysts useful in these processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: November 2, 2021
    Assignee: The Trustees of Boston College
    Inventors: Xiao-Xiang Zhang, Kai Lang
  • Patent number: 11165562
    Abstract: The invention discloses a sequential encryption method based on multi-key stream ciphers, comprising the following steps of: acquiring plaintext data, and storing the acquired plaintext data in the form of a circular linked list; storing a plurality of key sequences in the form of a circular linked list, respectively; performing a bitwise operation on the key sequences according to a specified starting bit to generate a stream random sequence; and, reconstructing the plaintext data according to the stream random sequence to generate encrypted ciphertext data. The method of the invention is simple in encryption and decryption, difficult to decipher, easy to implement by a computer without auxiliary hardware devices, fast in encryption and decryption speed, strong in the diffusion property of the generated ciphertext, and good in anti-interception performance and the like.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: November 2, 2021
    Assignee: Zhuhai College of Jilin University
    Inventors: Yujuan Si, Liuqi Lang, Guanghui Feng, Jialiang Chen
  • Patent number: 11162134
    Abstract: Embodiments of the disclosure encompass highly sensitive and quantitative methods for single-cell sequencing of total RNA. In particular cases, methods utilize annealing of multiple primers to RNA, polytailing of single stranded DNA reverse transcribed therefrom, and utilization of bar codes in primers for amplification of amplicons produced from second strand synthesis.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: November 2, 2021
    Assignee: Baylor College of Medicine
    Inventor: Chenghang Zong
  • Publication number: 20210330240
    Abstract: Provided is a method for mapping a neural area involved in speech processing, including applying a plurality of recording electrodes to a surface of a cortex of a human subject, presenting a plurality of auditory stimuli to the subject wherein some of the plurality of stimuli are speech sounds and others of the plurality of auditory stimuli are non-speech sounds, recording brain activity during the presenting of the plurality of auditory stimuli, and identifying one or more brain areas wherein activity changes more after presentation of speech sounds than it does after presentation of non-speech sounds, wherein the human subject does not speak during the presenting and the recording. Also provided is a method for mapping a neural area involved in speech production wherein the human subject does not speak during presenting speech stimuli and recording neural activity.
    Type: Application
    Filed: July 1, 2021
    Publication date: October 28, 2021
    Applicants: Health Research, Inc., Albany Medical College
    Inventors: Gerwin SCHALK, Anthony L. RITACCIO, Adriana DE PESTERS, AmiLyn TAPLIN
  • Publication number: 20210330206
    Abstract: An apparatus for estimating bio-information of a user may include a first sensor configured to measure a first signal from the user; a second sensor configured to measure a second signal from the user; and a processor configured to obtain a first characteristic point from the first signal; obtain a second characteristic point from the second signal based on the first characteristic point and a pre-defined probability distribution function; and estimate the bio-information of the user based on the second characteristic point.
    Type: Application
    Filed: April 12, 2021
    Publication date: October 28, 2021
    Applicants: SAMSUNG ELECTRONICS CO., LTD., University of Maryland, College Park
    Inventors: Dae Geun JANG, Sungtae SHIN, Jin-Oh HAHN, Ui Kun KWON, Youn Ho KIM, Peyman YOUSEFIAN
  • Publication number: 20210332350
    Abstract: A method of altering a target nucleic acid sequence within a cell is provided including providing the cell with a donor nucleic acid, providing the cell with a single strand annealing protein, and providing the cell with a single strand DNA binding protein, wherein one or more or both of the single strand annealing protein and the single strand DNA binding protein is foreign to the cell, and wherein the donor nucleic acid is recombined into the target nucleic acid.
    Type: Application
    Filed: February 2, 2017
    Publication date: October 28, 2021
    Applicants: President and Fellows of Harvard College, President and Fellows of Harvard College
    Inventors: George M. Church, Christopher J. Gregg, Marc J. Lajoie, Xavier Rios Villanueva
  • Patent number: 11154212
    Abstract: Systems and methods for estimating quantitative histological features of a subject's tissue based on medical images of the subject are provided. For instance, quantitative histological features of a tissue are estimated by comparing medical images of the subject to a trained model that relates histological features to multiple different medical image contrast types, whether from one medical imaging modality or multiple different medical imaging modalities. In general, the trained model is generated based on medical images of ex vivo samples, in vitro samples, in vivo samples or combinations thereof, and is based on histological features extracted from those samples. A machine learning algorithm, or other suitable learning algorithm, is used to generate the trained model. The trained model is not patient-specific and thus, once generated, can be applied to any number of different individual subjects.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: October 26, 2021
    Assignee: The Medical College of Wisconsin, Inc.
    Inventor: Peter Sherman Laviolette
  • Patent number: 11155801
    Abstract: Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: October 26, 2021
    Assignee: Trustees of Dartmouth College
    Inventors: Karl E. Griswold, Hongliang Zhao
  • Patent number: 11155787
    Abstract: Disclosed herein are methods for generating SC-? cells, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: October 26, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: Douglas A. Melton, Mads Gurtler
  • Patent number: 11155784
    Abstract: The present disclosure relates to a novel process for expanding T cells, such as autologous T cells, cell populations therefrom, pharmaceutical compositions comprising the said cell populations and use of the cells and compositions for treatment, particular the treatment or prophylaxis of virus infection and/or cancer, for example in immune compromised or immune competent human patients.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: October 26, 2021
    Assignees: Baylor College of Medicine, Cell Medica Inc.
    Inventors: Cliona M Rooney, Rainer Ludwig Knaus
  • Patent number: 11158091
    Abstract: The present disclosure includes systems and methods for color transfer. The method includes receiving a target image, and determining dominant source colors. The method further includes transforming the target image into a color model including a target luminance component and a target color information component. Additionally, the method includes segmenting the target image into a plurality of target segments based on the target color information component or the target luminance component and extracting dominant target colors from the target image by extracting information for at least one of the dominant target colors from each target segment of the plurality of target segments. Further, the method includes generating a color mapping relationship between the dominant target colors and the dominant source colors, and creating a recolored target image using the color mapping relationship.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: October 26, 2021
    Assignees: Trustees of Tufts College, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Karen Panetta, Long Bao, Sos Agaian