Patents Assigned to College
  • Gas-phase homogeneous oxidative dehydrogenation and coupling of organic molecules
    Patent number: 12202795
    Abstract: Disclosed are gas-phase ODH and OCP processes for converting alkanes (e.g., C2H6 and C3H8) to alkenes (e.g., C2H4 and C3H6) or oxygenates (e.g., methanol, ethanol, isopropanol, or propylene oxide) or converting alkenes (e.g., ethylene and propene) and oxygenates (e.g., methanol, ethanol, isopropanol or propylene oxide) to longer carbon-chain alkenes or longer carbon-chain alkanes with or without solid catalysts.
    Type: Grant
    Filed: November 1, 2019
    Date of Patent: January 21, 2025
    Assignee: Trustees of Tufts College
    Inventors: Prashant Deshlahra, Leelavathi Annamalai
  • Quantum system and method of measuring states of qubits of quantum processor
    Patent number: 12204998
    Abstract: A method of measuring states of qubits of a quantum processor, the method includes providing, to the qubits, a control signal to control states of n qubits in the quantum processor, where n is a natural number; performing a bit-flip to invert a state of at least one qubit of the qubits; reading out output qubit values of bit-flipped qubits based on the performing of the bit-flip; and generating an error model indicating a probability of occurrence of measurement errors in the output qubit values based on a result of the reading-out of the output qubit values.
    Type: Grant
    Filed: February 9, 2022
    Date of Patent: January 21, 2025
    Assignees: Samsung Electronics Co., Ltd., Imperial College Innovations Limited
    Inventors: Alistair Smith, Myungshik Kim, Chris Self, Kiran Khosla
  • DEVELOPMENT OF MICROBIAL BIOSENSORS FOR INTESTINAL INFLAMMATION
    Publication number: 20250020667
    Abstract: Embodiments of the disclosure include systems, methods, and compositions for detection of imminent onset of a symptom of a gut inflammation medical condition. The disclosure also concerns microbial biosensors that detect a marker in the gut that is predictive of onset of at least one symptom of inflammatory bowel disease (IBD), for example, and such a sensor may include a promoter sensitive to the marker that is linked to expression of a detectable readout, such as in the feces of the individual with IBD.
    Type: Application
    Filed: August 19, 2024
    Publication date: January 16, 2025
    Applicant: Baylor College of Medicine
    Inventors: Robert Allen Britton, Jeffrey David Galley
  • COMPOSITIONS AND METHODS FOR REDUCING TACTILE DYSFUNCTION, ANXIETY, AND SOCIAL IMPAIRMENT
    Publication number: 20250019351
    Abstract: The present invention provides novel peripherally-restricted benzodiazepines with reduced blood brain barrier permeability and methods of use thereof for reducing tactile dysfunction, social impairment, and anxiety in a subject diagnosed with Autism Spectrum Disorder, Rett syndrome, Phelan McDermid syndrome, or Fragile X syndrome.
    Type: Application
    Filed: July 24, 2024
    Publication date: January 16, 2025
    Applicant: President and Fellows of Harvard College
    Inventors: David D. Ginty, Lauren L. Orefice, Jinbo Lee
  • VHH POLYPEPTIDES THAT BIND TO CLOSTRIDIUM DIFFICILE TOXIN B AND METHODS OF USE THEREOF
    Publication number: 20250019424
    Abstract: Polypeptide products, methods, pharmaceutical compositions, and kits are provided for treating a subject exposed to, or at risk for exposure to, C. difficile microbial pathogens and toxin B produced by C. difficile (TcdB) pathogens. The methods, compositions and kits include a single domain, anti-TcdB VHH polypeptide (antibody), or toxin B binding portion thereof, that specifically binds to and/or neutralizes TcdB and treats or prevents illness and disease associated with C. difficile infection and TcdB intoxication. The anti-TcdB VHHs, or toxin B binding portion thereof, may be recombinantly produced.
    Type: Application
    Filed: July 29, 2024
    Publication date: January 16, 2025
    Applicant: Trustees of Tufts College
    Inventor: Charles B. SHOEMAKER
  • ENZYME-FREE ISOTHERMAL EXPONENTIAL AMPLIFICATION
    Publication number: 20250019750
    Abstract: Provided herein, in some embodiments, are methods, compositions and kits for controlling nucleation and assembly of molecular nanostructures, microstructures and macrostructures.
    Type: Application
    Filed: November 18, 2022
    Publication date: January 16, 2025
    Applicants: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: William M. Shih, Dionis Minev, Anastasia Ershova
  • Preparation method of zaleplon
    Patent number: 12195474
    Abstract: A preparation method of zaleplon is provided and belongs to the technical field of pharmaceutical chemistry. The preparation method adopts simple and cheap m-nitrobenzaldehyde and triethylamine as raw materials, and constructs a core structure of zaleplon with high efficiency and high selectivity through a one-pot series reaction without transition metal catalysis, thereby avoiding the formation of isomers, reducing the generation of by-products, increasing the yield of target products and reducing the synthesis cost; and after simple nitro reduction modification, zaleplon is prepared. The method has the advantages of short preparation route, mild reaction conditions and simple operation, so the method is suitable for industrial production.
    Type: Grant
    Filed: January 5, 2022
    Date of Patent: January 14, 2025
    Assignees: Xinxiang Medical College, Anhui University of Technology
    Inventors: Qinghe Gao, Xinya Han, Yongtao Xu, Yingchao Duan, Jieli Lv, Lizhen Fang, Yan Zhang, Jufen Yan, Yingying Li
  • Systems, methods, and devices for health monitoring of an energy storage device
    Patent number: 12196715
    Abstract: A monitoring device for a battery pack, which includes a plurality of battery cells, has at least one ultrasound source and at least one ultrasound sensor. The ultrasound source can be configured to generate and direct ultrasound at one or more battery cells of the battery pack. The ultrasound sensor can be configured to detect ultrasound reflected from or transmitted through one or more cells of the battery pack. A battery management unit receives one or more signals from the ultrasound sensor responsive to the detected ultrasound. The battery management unit can be configured to determine a state of the battery pack based at least in part on the detected ultrasound.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: January 14, 2025
    Assignee: University of Maryland, College Park
    Inventors: Bhanu Sood, Michael G. Pecht, Michael D. Osterman
  • Monocyte compositions and methods for the treatment of infectious disease
    Patent number: 12193996
    Abstract: Described herein are compositions comprising subsets of monocyte having distinct functional properties and methods for using the same to treat infectious disease.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: January 14, 2025
    Assignees: The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Catherine Rhee, David T. Scadden
  • Pueraria lobata nano-silver composite hydrosol, preparation method and application thereof
    Patent number: 12193445
    Abstract: A preparation method of a Pueraria lobata nano-silver composite hydrosol includes: dispersing Pueraria lobata powder in water, then heating to perform gelatinization, then adjusting a pH value, then sequentially adding an alkyl polyglucoside solution, a silver nitrate solution, and a sodium chloride solution, and performing a reaction by microwave heating to obtain the Pueraria lobata nano-silver composite hydrosol. The Pueraria lobata nano-silver composite hydrosol promotes seed germination of a Polygonatum Mill genus, and is applied in antibiotic detection and agricultural sterilization used as a fungicide.
    Type: Grant
    Filed: June 11, 2024
    Date of Patent: January 14, 2025
    Assignees: Jiangsu Vocational College of Agriculture and Forestry, Zhenjiang Zhaolong Agricultural Science and Technology Co., Ltd.
    Inventors: DaXiang Gao, FengTing Liu, GangJun Xi, Jun Shi, JiuLing Ding, HeTong Yang
  • Silk fibroin-based microneedles and methods of making the same
    Patent number: 12194200
    Abstract: A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: January 14, 2025
    Assignee: Trustees of Tufts College
    Inventors: David L. Kaplan, Konstantinos Tsioris, Fiorenzo G. Omenetto, Eleanor M. Pritchard
  • Universal early cancer diagnostics
    Patent number: 12195802
    Abstract: Methods for quantifying DNA methylation that may be utilized for screening for diseases (e.g., cancer), diagnosing diseases (e.g., cancer type), monitoring progression of a disease, and monitoring response to a therapeutic treatment.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: January 14, 2025
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Alexander Meissner, Zachary D. Smith, Franziska Michor, Jiantao Shi
  • Methods and compositions for the production of oligodendrocyte progenitor cells
    Patent number: 12195756
    Abstract: Provided herein are pluripotent stem cells comprising particular combinations of transcription factor for the production of oligodendrocyte progenitor cells (OPCs). Also provided herein are methods of producing the pluripotent stem cells and methods of using the pluripotent stem cells to produce (OPCs) and oligodendrocytes.
    Type: Grant
    Filed: February 9, 2024
    Date of Patent: January 14, 2025
    Assignee: President and Fellows of Harvard College
    Inventors: Parastoo Khoshakhlagh, Hon Man Alex Ng, George M. Church
  • System and methods for sealing a channel in tissue
    Patent number: 12193654
    Abstract: A system for performing a minimally invasive percutaneous procedure comprises a medical device comprising a hydrogel delivery needle (4) with a tip and a hydrogel outlet (6), an injectable, shear-thinning, self-healing viscoelastic hydrogel that exhibits a storage modulus (G?) of at least 600 Pa, and a tan ? (G?/G?) from 0.1 to 0.6 in dynamic viscoelasticity measured by a rheometer at 1 Hz and 1% strain rate at 25° C. The system may also comprise a coaxial cannula (2) having a lumen configured for receipt of the hydrogel delivery needle (4), wherein the hydrogel delivery needle comprises an adjustable positioning mechanism (8) configured to limit the advancement depth of the hydrogel delivery needle through the coaxial cannula to a predetermined depth distal to a distal-most end of the coaxial cannula.
    Type: Grant
    Filed: June 27, 2022
    Date of Patent: January 14, 2025
    Assignee: The Provost, Fellows, Scholars and Other Members of Board of Trinity College Dublin
    Inventors: Garrett Ryan, Colm McGarvey
  • Oral drug delivery devices and methods using iontophoresis
    Patent number: 12194294
    Abstract: Disclosed herein are methods, systems, and devices for oral drug delivery. The method generally involves orally administering a drug delivery device to the subject in need of treatment and triggering iontophoresis. The drug delivery device includes one or more active agents for delivery to the subject. The method can include the step of delivering the active agent to the intestinal mucosa after iontophoresis is triggered at the site, or simultaneously as iontophoresis is applied at the site. After the active agent(s) are delivered, the drug delivery device can be released from the intestinal mucosa. The iontophoresis can be performed for a period of time and at an electrical current that is effective to improve permeability of the one or more active agents across the intestine compared to orally administering the same drug delivery device in the absence of iontophoresis.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: January 14, 2025
    Assignees: The Regents of the University of California, President and Fellows of Harvard College
    Inventors: Amrita Banerjee, Renwei Chen, Shamsul Arafin, Samir Mitragotri
  • Spin memory encryption
    Patent number: 12201029
    Abstract: A topological spin memory effect, defined as the recovery of magnetic skyrmions or magnetic bubble skyrmions in magnetic thin films after a transition to a dramatically different spin texture, is used for encrypted non-volatile information storage. The storage strategy is based on magnetic skyrmions, that is, topologically protected spin textures comprising chiral domain walls surrounding small (e.g., nanometers to microns in diameter), typically circular, single-domain cores. Systems and methods are described for encrypted non-volatile information storage based on a spin memory effect in magnetic thin films that support skyrmions. Systems and methods encrypt and recover information stored in the form of magnetic skyrmions.
    Type: Grant
    Filed: January 19, 2022
    Date of Patent: January 14, 2025
    Assignees: Colorado State University Research Foundation, Bryn Mawr College
    Inventors: Kristen Buchanan, Xiao Wang, Xuemei Cheng
  • Deaminase-based RNA sensors
    Patent number: 12195734
    Abstract: RNA editing tools for use in systems designed to measure RNA in vivo and manipulate specific cell types are disclosed herein. An RNA sensor system comprising a) a single-stranded RNA (ssRNA) sensor comprising a stop codon and a payload; optionally wherein the ssRNA sensor further comprises a normalizing gene; and b) an adenosine deaminase acting on RNA (ADAR) deaminase; wherein the sensor is capable of binding to a ssRNA target to form a double-stranded RNA (dsRNA) duplex that becomes a substrate for the ADAR deaminase; wherein the substrate comprises a mispairing within the stop codon; and wherein the mispairing is editable by the ADAR deaminase, which editing can effectively remove the stop codon so as to enable translation and expression of the payload. A method of quantifying ribonucleic acid (RNA) levels using the RNA sensor system is also disclosed.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: January 14, 2025
    Assignees: Massachusetts Institute of Technology, The Broad Institute, Inc., President and Fellows of Harvard College
    Inventors: Kaiyi Jiang, Rohan Neil Krajeski, Omar Osama Abudayyeh, Jonathan S. Gootenberg, Yifan Zhang, Fei Chen, Xi Chen, Jeremy G. Koob
  • NOCICEPTOR-SPECIFIC GENE REGULATORY ELEMENTS FOR THE TREATMENT OF PAIN
    Publication number: 20250009906
    Abstract: Aspects of the disclosure provide nucleic acids and compositions comprising gene regulatory elements (GREs) for specific expression in nociceptor cells. Other aspects of the disclosure relate to the use of vectors and compositions comprising the gene regulatory elements for treating or managing pain and other neurological diseases in a subject in need thereof.
    Type: Application
    Filed: November 18, 2022
    Publication date: January 9, 2025
    Applicants: President and Fellows of Harvard College, The Brigham and Women's Hospital, Inc.
    Inventors: William Renthal, Sinisa Hrvatin, Mark Aurel Nagy, Eric C. Griffith, Michael E. Greenberg
  • ENGINEERED IMMUNE CELLS AND METHODS FOR USE
    Publication number: 20250009798
    Abstract: Disclosed herein, in some aspects, are immune cells comprising one or more engineered antigen receptors and one or more non-canonical CD6 isoforms and/or canonical CD6. Also disclosed are methods for cancer treatment comprising administering such immune cells to a subject in need thereof. Further disclosed are nucleic acids encoding a chimeric antigen receptor and a non-canonical CD6 isoform, and cells harboring same.
    Type: Application
    Filed: November 7, 2022
    Publication date: January 9, 2025
    Applicant: Baylor College of Medicine
    Inventors: Nabil M. Ahmed, Jessica Morris, Ahmed Gad, Sujith Joseph
  • SODIUM/LITHIUM PHOSPHOROTHIOATES AS NOVEL SOLID-STATE ELECTROLYTE FOR SODIUM/LITHIUM BATTERY
    Publication number: 20250015364
    Abstract: The disclosure relates to solid-phase and molten metal phosphorothioates useful as electrolytes, batteries comprising solid-phase and molten metal phosphorothioates, and methods of making solid-phase and molten metal phosphorothioates.
    Type: Application
    Filed: November 11, 2022
    Publication date: January 9, 2025
    Applicant: Trustees of Dartmouth College
    Inventors: Chuanlong Wang, Yiwen Zhang, Weiyang Li