Abstract: The invention relates to monoclonal antibodies, in particular against a peptide of the BAMBI protein, as well as the uses thereof and methods comprising same. Preferably, the antibodies are used for the treatment of autoimmune diseases.

Abstract: The invention relates to methods for the diagnosis of ischemia or ischemic tissue damage, methods for predicting the progression of ischemia in a patient having suffered an ischemic event, for determining the prognosis of a patient having suffered an ischemic event and for determining the risk that a patient suffering from stable coronary disease suffers a recurrent ischemic event based on the detection of the levels of glycosylated Apo J. The invention relates as well to a method for the determination of glycosylated Apo J in a sample.

Abstract: The present invention relates to a calcium-based secondary cell containing: an electrolyte arranged between the negative electrode and the positive electrode and comprising a calcium salt of a fluorine-containing anion of formula (XFn)m? wherein n is a positive integer of at most 6 and m is a positive integer of at least 1 and m<n, a positive-electrode active material at the positive electrode which is a one-dimensional structure accommodating Ca2+ ions and has the formula (1): Can+2Me1(n+1)?y?zMe2yMe3zO3n+3??(1) wherein: Me1, Me2, Me3 are different transition metals; 1?n and n is not necessarily an integer; 0?y and y is not necessarily an integer; 0?z and z is not necessarily an integer.

Abstract: An interchangeable sensor device for a functional near-infrared spectroscopy system (fNIRS) is a non-invasive device intended to detect changes in the concentration of hemoglobin species on any body surface area. The device includes a plurality of measurement units having different elastic configurations, each intended to be adapted to a specific area of the body, and a control unit for controlling any of the measurement units. Each of the measurement units is equipped with a first connector and the control unit is equipped with a second connector, which connectors allow the control unit to be interchangeably connected to any of the measurement units.

Abstract: The invention relates to a peptide comprising the amino acid sequence SEQ ID NO: 1 or a variant thereof capable of inhibiting IL13/IL13R?2 signalling. The invention also relates to a fusion protein, nanoparticle, virus-like particle and pharmaceutical composition comprising said peptide, and to their use for treating a cancer characterized by having increased expression of IL13R?2, or for treating asthma, atopic dermatitis or fibrosis, or for preventing the metastatic progression of a cancer characterized by having increased expression of IL13R?2.

Abstract: Method of making BTX compounds including benzene, toluene, and xylene, including feeding heavy reformate to a reactor containing a composite zeolite catalyst. The composite zeolite catalyst includes a mixture of layered mordenite (MOR-L) comprising a layered or rod-type morphology with a layer thickness less than 30 nm and ZSM-5. The MOR-L, the ZSM-5, or both include one or more impregnated metals. The method further includes producing the BTX compounds by simultaneously performing transalkylation and dealkylation of the heavy reformate in the reactor. The composite zeolite catalyst is able to simultaneously catalyze both the transalkylation and dealkylation reactions.

Abstract: The present invention relates to a series of substituted purine derivatives capable of inhibiting CDC7 kinase activity and, as such, suitable for use in the treatment of neurological diseases such as, inter alia, Alzheimer's disease, amyotrophic lateral sclerosis or frontotemporal dementia, involving hyperphosphorylation of TDP-43 and the subsequent formation of aggregates, induced by CDC7.

Abstract: The invention relates to a device for the detection of gamma rays coming from a source without image truncation and without image overlapping, comprising, at least, two detection cells and each of said cells comprising a detection space adapted to receive the gamma rays that penetrate through an opening, wherein said detection space comprises one or more detection assemblies, with some of said assemblies being positioned such that they stand in the way of the gamma rays coming into the overlap volume thereof.

Abstract: The invention relates to an intraocular lens with extended depth of focus including aspheric anterior and posterior optical surfaces.

Abstract: The present invention relates to SS-31 or composition comprising SS-31 for use in the treatment and/or prevention of aneurysm.

Abstract: The present application provides novel compositions and methods for treating acute myeloid leukemia (AML). Compounds of the invention are acid ceramidase inhibitors, reduce AML cell viability, inhibit AML cell proliferation, increase cell death of AML cells, and induce apoptosis in AML cells. A primary compound of the invention is SACLAC: 2-chloro-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide. The bromine analog of SACLAC (SABRAC: 2-bromo-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide) is also useful for treating AML. SACLAC has much better activity than other know drugs used to treat AML.

Abstract: The present invention refers to a method for exfoliating and transferring graphene from a doped silicon carbide substrate to another substrate, the method being based on exfoliation induced by hydrogen bubbles produced in the electrolysis of water.

Abstract: A system and method for generating ultra-short pulses intended to be inserted into a ring laser with a regulator of a pulsed signal of a certain intensity, the system includes an optical attenuator that allows the intensity of the pulsed signal to be adjusted at the input of an optical guide section, and a distributed amplification device inserted in the optical guide that make it possible to manage the power of the signal therein, so that it propagates as solitons or as self-similar pulses without suffering unwanted distortions despite the increase in the length of the laser cavity, increasing the power of the pulsed signal and making it possible to exceed the usual power limits of this type of laser.

Abstract: The present invention relates to a method and a device for estimating a full shape of a lens of an eye from measurements of the lens taken in-vivo by optical imaging techniques, the measurements comprising visible portions of the lens, the method comprises defining non-visible portions of the lens parting from the in-vivo measurements and using a geometrical model of a lens previously built from ex-vivo measurements. The full shape parameters of the crystalline lens can be estimated in the present invention from optical imaging techniques to improve the estimation of the IOL position and thus the IOL power selection.

Abstract: The present invention relates to a group of compounds derived from resveratrol having as substituents at least one silyl group which, in turn, can be substituted by different groups. The invention also relates to the therapeutic use of these compounds in inflammatory, neurological, and neurodegenerative diseases.

Abstract: An integrated mode converter and multiplexer (/demultiplexer) is disclosed, which combines a multimode interference coupler (100), at least one phase-shifter (200) and a symmetrical Y-junction (300). The dispersion of the multimode interference coupler (100) is engineered through subwavelength structures in order to achieve a very wide bandwidth. Several phase-shifter (200) topologies for further bandwidth enhancement are disclosed, as well as architectures for multiplexing a greater number of optical modes.

Abstract: The invention relates to an internal combustion engine that comprises a first Brayton cycle comprising a mixed ionic-electronic conducting (MIEC) membrane that separates the O2 from the air such that the suctioned air current is free from N2; a second Brayton cycle combined in a binary manner with the first Brayton cycle and nested with a cycle selected from an Otto cycle and a diesel cycle performed by means of oxy-combustion. The second Brayton cycle transmits mechanical energy and thermal energy from exhaust gases to the first Brayton cycle. The first Brayton cycle provides to the second Brayton cycle compressed O2 from the MIEC membrane. By means of the present engine, the NOx emission into the atmosphere is prevented by the separation of N2 in the MIEC membrane.

Abstract: A detector and a method for tracking an arrival time of single particles in an ion beam are disclosed, wherein the single particles are provided as a bunch of ions by a synchrotron. Herein, the detector comprises a detector segment comprising a scintillating material, the scintillating material being designated for generating radiation upon passing of a single particle comprised by the bunch of ions through the scintillating material, wherein the scintillating material comprises a plurality of scintillating fibers, the scintillating fibers being provided as a fiber layer, wherein the fiber layer is located perpendicularly with respect to a direction of the incident ion beam; at least one detector element, the detector element being designated for generating a detector signal from the radiation; and at least one evaluation device, the evaluation device being designated for determining information about the single particles from the detector signals provided by the at least one detector element.

Abstract: The present invention relates to a method for preparing cDNA infectious clones based on the genome of an attenuated Porcine Reproductive and Respiratory Syndrome virus (PRRSV) and uses thereof for preparing efficacious and safety-enhanced vaccines against PRRSV. The invention further comprises an infectious cDNA clone obtainable by such method. The invention further provides an attenuated modified PRRSV, and immunogenic compositions and vaccines comprising that attenuated PRRSV. The present invention further provides the attenuated PRRSV for use in the prophylaxis and/or the treatment of PRRSV infections, and the attenuated PRRSV for use as vaccine or medicament in the prophylaxis and/or the treatment of PRRSV infections.

Abstract: The invention relates to an exoskeleton for assisting human movement, which can be fitted to the user in terms of dimensions, tension and ranges of joint motion, either manually or automatically. The exoskeleton can be fitted to the user in the anteroposterior direction in the sagittal plane, with the user in a horizontal or sitting position, without requiring a functional transfer. The exoskeleton has a modular design which is compatible with human biomechanics and reproduces a natural and physiological movement in the user, with up to 7 actuated and controlled degrees of movement per limb, ensuring that the user maintains equilibrium during locomotion.