Patents Assigned to Consejo Superior de Investigaciones Cientificas (CSIC)
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Publication number: 20200165525Abstract: A method for recovering fibers embedded in a composite material including loading a furnace chamber with a volume of the composite material; thermolyzing the composite material in the furnace chamber, resulting in a gaseous fraction that is continuously evacuated from the furnace chamber, and a residue of fibers covered with char that is left in the furnace chamber; cracking the gaseous fraction from the thermolyzing operation, resulting in a mixture of condensable and non-condensable gases that can be recycled; injecting a stream of an oxygen-containing gas into the still hot furnace chamber after the thermolyzing is completed therein, to burn the char from the fibers in an exothermic combustion.Type: ApplicationFiled: June 1, 2018Publication date: May 28, 2020Applicants: THERMAL RECYCLING OF COMPOSITES, S.L., CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)Inventors: Roger GRAU GARCIA, Ferran GRAU GARCIA, Oriol GRAU GARCIA, Felix Antonio LOPEZ GOMEZ, Olga RODRIGUEZ LARGO
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Patent number: 10639012Abstract: The present invention relates to a method for measuring circulating cells in superficial body fluids by means of high-frequency-based device. The method can be used for detecting circulating cells in the fluids of an individual without the necessity of extracting a sample of the individual, being useful as a diagnostic tool and for monitoring the effectiveness of a treatment administered to an individual suffering from a viral, protozoal, fungal and/or bacterial disease.Type: GrantFiled: September 19, 2016Date of Patent: May 5, 2020Assignees: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), FUNDACION PARA EL CONOCIMIENTO MADRI+D, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Luis Elvira Segura, Oscar Martinez Graullera, Shiva Kant Shukla, Francisco Montero, Javier Jimenez, Ian Richard Butterworth, Brian Anthony, John Lee Haeseon, Carlos Castro Gonzalez
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Patent number: 10610538Abstract: The present invention relates to a class of novel pradimicins and analogues and derivatives thereof, including the compounds of formula A, I and 111, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof and their use to treat or prevent kinetoplastid infections and their use to manufacture a medicine to treat or prevent kinetoplastid infections, particularly infections with trypanosoma and leishmania, such as Trypanosoma brucei, Trypanosoma cruzi and Leischmania donovani. wherein Ra, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the claim 1 or as described in detail in the description of the invention. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent kinetoplastid infections.Type: GrantFiled: October 10, 2013Date of Patent: April 7, 2020Assignees: Katholieke Universiteit Leuven, Consejo Superior de Investigaciones Científicas - CSICInventors: Jan Balzarini, Dolores González Pacanowska, Luis Miguel Ruiz Pérez, Victor Castillo Acosta, Yasuhiro Igarashi
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Publication number: 20200025710Abstract: Ion sensor based on differential measurement comprising an ISFTET-REFET pair wherein the REFET is defined by a structure composed of an ISFET covered by a microreservoir where an internal reference solution is contained. The sensor comprises a first and a second ion-selective field effect transistor, an electrode, a substrate on the surface whereof are integrated the two transistors, connection tracks and the electrode and a structure adhered on the first ion-selective field effect transistor which creates a microreservoir on the gate of said first transistor, with the microreservoir having a microchannel which connects the microreservoir with the exterior and the microreservoir being filled with the reference solution.Type: ApplicationFiled: August 2, 2019Publication date: January 23, 2020Applicant: Consejo Superior de Investigaciones Cientifícas (CSIC)Inventors: Antoni BALDI COLL, Carlos DOMINGUEZ HORNA, Cecilia JIMENÉZ JORQUERA, César FERNÁNDEZ SÁNCHEZ, Andreu LLOBERA ADAN, Ángel MERLOS DOMINGO, Alfredo CADARSO BUSTO, Isabel BURDALLO BAUTISTA, Ferrán VERA GRAS
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Patent number: 10435412Abstract: The present invention relates to a family of chromenopyrazole derivatives of formula (I): which have the ability to modulate the receptor of the cannabinoid family GPR55, whereby the invention also relates to the use of these compounds for the manufacture of a medicament for the treatment of diseases in which the GPR55 receptor has a physiological role such as diabetes, Parkinson's disease, multiple sclerosis, neuropathic pain, osteoporosis and cancers such as cholangiocarcinoma, breast cancer, ovarian and prostate cancer, glioblastoma, and cutaneous carcinoma.Type: GrantFiled: April 27, 2016Date of Patent: October 8, 2019Assignees: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)Inventors: Nadine Jagerovic, Paula Morales Lazaro, Ruth Ross, Lauren Whyte
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Patent number: 10362788Abstract: Two new Helicoverpa armigera single nucleopolyhedrovirus genotypes, HearSNPV, HearSNPV-SP1B and HearSNPV-LB6, each originating from mixtures of genotypes obtained from different locations and crops, are described. Each exhibits specific insecticidal activity against H. armigera larvae comparable to that of commonly used commercial insecticides. Further, mixing the two genotypes, especially in the ratio of 1:1, within co-occluded virions of the mixed genotypes, is capable of controlling H. armigera infestations of tomato crops and is as efficacious as commonly used chemical and biological insecticides. Their use as bioinsecticides is safe for vertebrates, in that they specifically target arthropods. In addition, they are easy to produce and good yields can be obtained by orally inoculating H. armigera larvae with HearSNPV occlusion bodies.Type: GrantFiled: June 24, 2015Date of Patent: July 30, 2019Assignees: UNIVERSIDAD PÚBLICA DE NAVARRA, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), INSTITUTO DE ECOLOGÍA, A.C.Inventors: Maite Arrizubieta, Oihane Simón, Primitivo Caballero Murillo, Trevor Williams
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Publication number: 20190177721Abstract: The present invention relates to a method for preparing cDNA infectious clones based on the genome of an attenuated Porcine Reproductive and Respiratory Syndrome virus (PRRSV) and uses thereof for preparing efficacious and safety-enhanced vaccines against PRRSV. The invention further comprises an infectious cDNA clone obtainable by such method. The invention further provides an attenuated modified PRRSV, and immunogenic compositions and vaccines comprising that attenuated PRRSV. The present invention further provides the attenuated PRRSV for use in the prophylaxis and/or the treatment of PRRSV infections, and the attenuated PRRSV for use as vaccine or medicament in the prophylaxis and/or the treatment of PRRSV infections.Type: ApplicationFiled: July 31, 2017Publication date: June 13, 2019Applicants: Hipra Scientific, S.L.U., Consejo Superior de Investigaciones Cientificas (CSIC)Inventors: Xavier GIBERT PÉREZ, Marta SITJÀ ARNAU, Maria Mar FENECH MARTÍNEZ, Santiago Francisco ELENA FITO, Susana MARTÍN GARCÍA
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Patent number: 10272128Abstract: The present invention relates to an antioxidant ingredient with low calorie content obtainable by a process that comprises the following steps: (a) selecting as raw material at least one fruit and/or plant material with high antioxidant content, greater than 6 g/100 g dry matter; (b) obtaining juice and pulp by means of grinding, squeezing and/or pressing the raw material; (c) extracting sugars from the pulp obtained in the preceding step in order to produce a pulp with low calorie content; (d) dehydrating the pulp by means of a method selected from air drying, low-temperature drying with application of vacuum and/or freeze-drying; and (e) milling the pulp in order to produce the antioxidant ingredient with low calorie content. Likewise, the invention relates to the process for obtaining said ingredient and to the use thereof for the production of functional foods.Type: GrantFiled: December 20, 2012Date of Patent: April 30, 2019Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)Inventor: Fulgencio Diego Saura Calixto
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Patent number: 10254243Abstract: The present invention concerns an ion sensor based on differential measurement, that by means of at least two ion-sensitive field-effect transistors, compares the concentration of certain ions in a solution to be measured with the concentration of certain ions in a reference solution contained in a micro-reservoir with a micro-channel. To do this, the micro-reservoir and the micro-channel cover at least the gate of one of the ion-sensitive field-effect transistors and make up a unit partially filled with a porous material that covers the entirety of the aforementioned gate and at least the base of the micro-channel.Type: GrantFiled: July 12, 2016Date of Patent: April 9, 2019Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)Inventors: Antonio Baldi Coll, César Fernández Sánchez, Alfredo Cadarso Busto
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Patent number: 10226327Abstract: The present invention describes a refractive multifocal intraocular lens with aspheric geometry on both surfaces in such a way that the map of local optical strength of the lens, combined with the cornea, has a central region of intermediate optical strength surrounded by a ring of maximum optical strength, with a smooth transition between the two, after which it alternates smoothly between rings of varying strengths.Type: GrantFiled: December 27, 2013Date of Patent: March 12, 2019Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC)Inventors: David Fernández Gutiérrez, Sergio Barbero Briones, Carlos Dorronsoro Díaz, Susana Marcos Celestino
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Patent number: 10228471Abstract: This disclosure describes an imaging radiation detection module with novel configuration of the scintillator sensor allowing for simultaneous optimization of the two key parameters: detection efficiency and spatial resolution, that typically cannot be achieved. The disclosed device is also improving response uniformity across the whole detector module, and especially in the edge regions. This is achieved by constructing the scintillation modules as hybrid structures with continuous (also referred to as monolithic) scintillator plate(s) and pixelated scintillator array(s) that are optically coupled to each other and to the photodetector.Type: GrantFiled: May 4, 2017Date of Patent: March 12, 2019Assignees: General Equipment for Medical Imaging S.A., West Virginia University, Consejo Superior de Investigaciones Cientificas (CSIC), Universitat Politecnica de Valencia, Bruker BioSpin AGInventors: Jose Maria Benlloch Baviera, Antonio Javier Gonzalez Martinez, Stan Majewski
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Patent number: 10227527Abstract: There are disclosed nanoemulsion optical materials, methods of making nanoemulsion optical materials and optical articles comprising nanoemulsion optical materials. A nanoemulsion optical material includes a polymer matrix and a plurality of nano-droplets, comprising an optically interactive material, directly dispersed within the polymer matrix.Type: GrantFiled: December 14, 2015Date of Patent: March 12, 2019Assignees: INDIZEN OPTICAL TECHNOLOGIES OF AMERICA, LLC, FUTURECHROMES S.L., CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), INSTITUT CATALA DE NANOCIENCIA I NANOTECHNOLOGIA (ICN2)Inventors: Claudio Roscini, Héctor Torres-Pierna, Daniel Ruiz-Molina
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Patent number: 10213735Abstract: The invention relates to a catalytic activation layer for use in oxygen-permeable membranes, which can comprise at least one porous structure formed by interconnected ceramic oxide particles that conduct oxygen ions and electronic carriers, where the surface of said particles that is exposed to the pores is covered with nanoparticles made from a catalyst, the composition of which corresponds to the following formula: A1-x-yBxCyOR where: A can be selected from Ti, Zr, Hf, lanthanide metals and combinations thereof; B and C are metals selected from Al, Ga, Y, Se, B, Nb, Ta, V, Mo, W, Re, Mn, Sn, Pr, Sm, Tb, Yb, Lu and combinations of same; and A must always be different from B. 0.01<x<0.5; 0<y<0.3.Type: GrantFiled: December 22, 2016Date of Patent: February 26, 2019Assignees: Consejo Superior de Investigaciones Cientificas (CSIC), Universitat Politecnica de ValenciaInventors: Jose Manuel Serra Alfaro, Julio Garcia Fayos, Laura Navarrete Algaba, Vicente Bernardo Vert Belenguer
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Patent number: 10213358Abstract: A miniaturised instrument for simulating simultaneous vision by generating masks is provided with a single image-forming optical channel. The instrument comprises: a mask-generating element (EGM) which generates at least two complementary masks, with a temporal frequency of alternation such that when one partially blocks the incident light, the other allows the incident light to partially pass, and vice-versa; an adjustable lens (LA) of variable optical power which generates, with said frequency of alternation, at least two different optical powers corresponding to at least two observation distances. The EGM and the LA are located in a single optical channel via which the incident light circulates, such that each mask of the EGM is temporally synchronised with a power of the LA. The combination of all the masks and optical powers produces, via high-speed temporal fusion, a pupil pattern wherein at least two optical powers corresponding to at least two observation distances are combined.Type: GrantFiled: September 27, 2016Date of Patent: February 26, 2019Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)Inventors: Carlos Dorronsoro Diaz, Susana Marcos Celestino
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Patent number: 10197651Abstract: The invention relates to a hybrid medical PET-SPECT/MR imaging device comprising at least one scintillating crystal and at least one module for detecting radiation which contains at least one matrix of photodetectors and an electronics section, such that said module has a mechanical structure, the external, internal or both surfaces of which are divided into at least two sections, of which at least one is coated in graphene, and the rest in non-ferromagnetic conductive material, or all the sections are coated in graphene, and such that the coating forms a Faraday cage. The invention also relates to a shielding against radiofrequency for a medical imaging device, comprising a graphene coating, which is continuous or in bands, on all the faces of the mechanical structure of the detection module of the device, or a graphene coating, continuous or in bands, on at least one face, combined with a coating of non-ferromagnetic conductive materials on the remaining faces, and said shielding forming a Faraday cage.Type: GrantFiled: June 29, 2017Date of Patent: February 5, 2019Assignees: General Equipment for Medical Imaging S.A., Consejo Superior de Investigaciones Cientificas (CSIC), Universitat Politecnica de Valencia, Bruker BioSpin AGInventors: Juan Pablo Rigla Perez, Antonio Javier Gonzalez Martinez, Jose Maria Benlloch Baviera
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Publication number: 20190006057Abstract: The invention relates to a material comprising oligoglycine tectomers and nanowires. This material is useful as an electrode, as a conductive and transparent hybrid material, and as a pH sensor, as well as in biomedical applications.Type: ApplicationFiled: December 16, 2016Publication date: January 3, 2019Applicants: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC), UNIVERSIDAD DE ZARAGOZA, UNIVERSITY OF SURREYInventors: Edgar Manuel MUÑOZ DE MIGUEL, Rosa GARRIGA MATEO, Alan Brian DALTON, Izabela JUREWICZ
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Patent number: 10150736Abstract: The invention relates to haptens, immunogens and secondary immunoreactive agents, to the use thereof for producing wide-spectrum antibodies against quinolone-type antibiotics, to the application thereof to immunochemical analysis techniques, and to a kit enabling the detection of said antibiotics in biological samples from food products of animal origin.Type: GrantFiled: November 21, 2011Date of Patent: December 11, 2018Assignee: Consejo Superior de Investigaciones Cientificas (CSIC)Inventors: Maria Pilar Marco Colas, Francisco José Sánchez Baeza, Daniel González Pinacho
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Patent number: 10105390Abstract: Process for obtaining fluoride-doped citrate-coated amorphous calcium phosphate nanoparticles. This material has applications in biomedicine due to its biodegradability and bioactivity; it also promotes cell adhesion and osteogeneration. In dentistry, it may be used in toothpastes, mouthwashes, chewing gums, gels and fluoride varnishes as a remineralising agent of dentine and enamel. It is based on two solutions formed by calcium chloride and sodium citrate on the one hand, and by sodium monohydrogenophosphate and sodium carbonate with a fluoride compound on the other, which are mixed at room temperature. The process is eco-efficient and eco-friendly, as it does not leave any acid residue; it consists of a single stage and it is the first time that an amorphous calcium phosphate coated with citrate and doped with fluoride, which enhances its remineralising action, is obtained.Type: GrantFiled: July 21, 2015Date of Patent: October 23, 2018Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)Inventors: Jose Manuel Delgado Lopez, Jaime Gomez Morales, Raquel Fernandez Penas, Michele Iafisco, Anna Tampieri, Silvia Panseri
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Patent number: 10093984Abstract: The invention relates to a method to predict the response to treatment with radiotherapy combined with cisplatin-based chemotherapy in patients with cancer, preferably non-microcytic lung cancer, wherein said method is based on the detection of the presence of methylation in the IGFBP-3 gene. The present invention also relates to an in vitro method to design a customised treatment for an individual with said disease. The method of the invention may be quantitative or semi-quantitative. The present invention also relates to a probe designed for the quantitative detection of the methylation of the IGFBP-3 gene, to a kit that comprises it and to the use of the kit to predict the response of a subject to the aforementioned treatment.Type: GrantFiled: May 27, 2014Date of Patent: October 9, 2018Assignees: FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ, CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (CSIC), UNIVERSIDAD AUTÓNOMA DE MADRID, FUNDACIÓN HOSPITAL DE MADRIDInventors: Inmaculada Ibáñez de Cáceres, Olga Pernía Arias, Cristóbal Belda Iniesta, Rosario Perona Abellón, María Cortés Sempere
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Patent number: 10067085Abstract: Ion sensor based on differential measurement comprising an ISFTET-REFET pair wherein the REFET is defined by a structure composed of an ISFET covered by a microreservoir where an internal reference solution is contained. The sensor comprises a first and a second ion-selective field effect transistor, an electrode, a substrate on the surface whereof are integrated the two transistors, connection tracks and the electrode and a structure adhered on the first ion-selective field effect transistor which creates a microreservoir on the gate of said first transistor, with the microreservoir having a microchannel which connects the microreservoir with the exterior and the microreservoir being filled with the reference solution.Type: GrantFiled: January 29, 2015Date of Patent: September 4, 2018Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (CSIC)Inventors: Antoni Baldi Coll, Carlos Dominguez Horna, Cecilia Jimenéz Jorquera, César Fernández Sánchez, Andreu Llobera Adan, Ángel Merlos Domingo, Alfredo Cadarso Busto, Isabel Burdallo Bautista, Ferrán Vera Gras