Patents Assigned to Cordis Corporation
  • Patent number: 7803182
    Abstract: A vascular or cardiovascular medical device for placement at a site in a patient's body and for controlling pH levels at the site in the patient's body includes one or more structural components made of a biodegradable and/or bioabsorbable material, or alternatively, a coating thereon made of a biodegradable and/or bioabsorbable material. A buffering agent is provided on or in the biodegradable and/or bioabsorbable material and the buffering agent is dispersed from the biodegradable and/or bioabsorbable material in response to hydrolysis of the biodegradable and/or bioabsorbable material. Additionally, the vascular or cardiovascular medical device can include a drug that is included with the biodegradable and/or bioabsorbable material. The vascular or cardiovascular medical device can also be a stent or a valve.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: September 28, 2010
    Assignee: Cordis Corporation
    Inventors: Vipul Bhupendra Davé, George Landau, Premal Patel
  • Publication number: 20100239636
    Abstract: Methods of preparing devices for delivering at least one therapeutic agent to a target vessel in a mammal, the devices prepared by such methods, and uses of such devices for delivering a therapeutic agent, such as an antiproliferative agent, to a target vessel.
    Type: Application
    Filed: June 2, 2010
    Publication date: September 23, 2010
    Applicant: CORDIS CORPORATION
    Inventors: Carol Wright, Gerard H. Llanos, Ronald Rakos, Kristen King
  • Patent number: 7799367
    Abstract: Medical catheters are often coated, fully or partially. The present invention relates to systems and methods for coating some portion or all of a medical catheter or one or more of its components.
    Type: Grant
    Filed: October 13, 2006
    Date of Patent: September 21, 2010
    Assignee: Cordis Corporation
    Inventors: Ryan P. Merritt, Dina E. Agrapides, Vicente J. Fuillerat
  • Patent number: 7794487
    Abstract: A reduced deployment force delivery apparatus having an outer sheath with two layers that move relative to one another so as to reduce the deployment force necessary for deploying a stent, stent graft or other intraluminal device.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: September 14, 2010
    Assignee: Cordis Corporation
    Inventors: David C. Majercak, Jin S. Park, Diana M. Sanchez
  • Patent number: 7794493
    Abstract: A biocompatible solid-solution alloy may be formed into any number of implantable medical devices. The solid-solution alloy comprises a combination of elements in specific ratios that make it magnetic resonance imaging compatible while retaining the characteristics required for implantable medical devices. The biocompatible solid-solution alloy is a cobalt-chromium alloy having substantially reduced iron, silicon, phosphorus and sulfur content.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: September 14, 2010
    Assignee: Cordis Corporation
    Inventors: Robert Burgermeister, Volker Niermann, Yuchen Qiu, Theresa Scheuble
  • Patent number: 7785615
    Abstract: A medical device for placement at a site in a patient's body and for controlling pH levels at the site in the patient's body includes one or more structural components made of a first biodegradable and/or bioabsorbable material or, alternatively, one or more structural components having a coating thereon made of a first biodegradable and/or bioabsorbable material. The device also includes a buffering agent and at least one second biodegradable and/or bioabsorbable material on or in the one or more structural components, or alternatively, on or in the coating on the one or more structural components. The at least one second biodegradable and/or bioabsorbable material encapsulates the buffering agent and the buffering agent is dispersed from the at least one second biodegradable and/or bioabsorbable material in response to hydrolysis of the first biodegradable and/or bioabsorbable material.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: August 31, 2010
    Assignee: Cordis Corporation
    Inventors: Vipul Bhupendra Davé, George Landau, Premal Patel
  • Patent number: 7780714
    Abstract: An apparatus for delivering an implant within a lumen or passageway is provided. The apparatus comprises a flexible, hollow outer member having an elongated section that is inserted into and navigated through the lumen of passageway. The implant is mounted within the distal end of the elongated section. An elongated fluid chamber is defined within the outer member between two valves or seals. The valves or seals permit fluid flow in a pre-determined direction during loading of fluid into the chamber, but prevent fluid to exit the chamber during deployment of the implant. A shaft is in contact with the proximal end of the fluid column. During deployment, the shaft is held in a fixed position and the outer member actuated in a proximal direction. The implant exerts compressive forces on the outer member as it is actuated proximally. These forces are transmitted to the fluid column which resists buckling.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: August 24, 2010
    Assignee: Cordis Corporation
    Inventors: Clifford Dwyer, Michael V. Williamson, Jr., Craig Bonsignore
  • Patent number: 7771705
    Abstract: The present invention discloses a radiographic contrasting agent containing multiple aromatic groups, each of which is substituted with at least three halogen atoms. The radiographic contrasting agent can initiate a polymerization process. The present invention also discloses a radio-opaque polymeric material that comprises a biodegradable polymer having at least one radiographic contrasting moiety covalently attached thereto. The radio-opaque polymeric material provides enhanced contrasting intensity in radiographic imaging. The radio-opaque polymeric material can be applied on at least a portion of one surface of a medical device. The radio-opaque polymeric material can also be used to construct a medical device, a component thereof, or a portion of a component thereof.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: August 10, 2010
    Assignee: cordis Corporation
    Inventor: Jonathon Z. Zhao
  • Patent number: 7758632
    Abstract: The present invention relates to a medical device, and in particular, to a stent-based valve. The valve includes a radially expandable structural frame comprising a proximal and distal anchors formed from a lattice of interconnected elements, and having a substantially cylindrical configuration with first and second open ends and a longitudinal axis extending there between. One or more cantilevered valve struts are attached directly or indirectly to the proximal anchor. The stent based valve also comprises one or more connecting members attached between the proximal and distal anchors. A biocompatible valve assembly is coaxially disposed and attached to the proximal anchor and extends in the longitudinal direction along the one or more connecting members.
    Type: Grant
    Filed: May 9, 2003
    Date of Patent: July 20, 2010
    Assignee: Cordis Corporation
    Inventors: Hikmat Hojeibane, David Christopher Majercak
  • Patent number: 7704488
    Abstract: In accordance with the present invention, a high intensity radiopaque contrast agent is disclosed. The agent may be coated on or incorporated within bulk materials, which may then be subsequently utilized to fabricate a radiopaque medical device. Primary effects through chemistry include higher radiopaque concentrations per unit weight of the radiopaque element or agent. Secondary effects include selective placement of the radiopaque elements which may further enhance the radiopacity of the device with reduced requirements of the radiopaque agent. Such a radiopaque contrast agent may be produced in various forms such as a dendrimer and/or incorporated as the end groups of polymeric chain. In addition one can incorporate biological and/or pharmaceutical agents in combination with the present invention.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: April 27, 2010
    Assignee: Cordis Corporation
    Inventor: Jonathon Z. Zhao
  • Patent number: 7695731
    Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
    Type: Grant
    Filed: March 22, 2004
    Date of Patent: April 13, 2010
    Assignee: Cordis Corporation
    Inventors: Robert Falotico, Tom Jay Parry, Jonathon Z. Zhao
  • Patent number: 7678103
    Abstract: An orifice device for delivering a drug includes an inner member having a proximal end and a distal end. A winding is helically wound around the inner member. The winding and the inner member define a first channel for carrying a drug therethrough. An inlet is at the proximal end of the winding and an outlet is at the distal end of the winding.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: March 16, 2010
    Assignee: Cordis Corporation
    Inventor: Scott M. Russell
  • Patent number: 7670311
    Abstract: Methods and devices for reducing the mineral content of a region of non-intimal vascular tissue are provided. In the subject methods, an isolated local environment that includes the region to be demineralized is produced. The pH of the local environment is then reduced to a subphysiologic level, e.g. by flushing with an acidic dissolution fluid, for a period of time sufficient for the mineral content of the region to be reduced. The devices of the subject invention are characterized by comprising a means for producing an isolated local environment that includes a non-intimal region of vascular tissue. Also provided are kits for practicing the subject methods.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: March 2, 2010
    Assignee: Cordis Corporation
    Inventor: Brent R. Constantz
  • Patent number: 7666222
    Abstract: Methods of preparing intravascular stents with a polymeric coating containing macrocyclic lactone (such as rapamycin or its analogs), stents and stent graphs with such coatings, and methods of treating a coronary artery with such devices. The macrocyclic lactone-based polymeric coating facilitates the performance of such devices in inhibiting restenosis.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: February 23, 2010
    Assignee: Cordis Corporation
    Inventors: Carol Wright, Gerard H. Llanos, Ronald Rakos, Kristen King
  • Patent number: 7655037
    Abstract: An aneurysmal repair system that utilizes a modified apex and delivery device is designed for accurate endoprosthesis delivery and deployment. The modified apex utilizes segments that overlap and hold one another down as well as the fixation barbs attached thereto. The delivery device holds or secures at least one section of the apex and may be easily released by retraction of a hold down member.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: February 2, 2010
    Assignee: Cordis Corporation
    Inventors: James A. Fleming, III, David C. Majercak
  • Patent number: 7637933
    Abstract: A method for pre-loading an implant delivery apparatus and for delivering an implant is provided. An implant is mounted within the distal end of an elongated section of a delivery apparatus. After the implant is mounted within the elongated section, fluid is drawn into a chamber within the delivery apparatus that is proximal to the implant. This is accomplished by drawing fluid, such as a biocompatible liquid, into the chamber by applying pressure to a port. The fluid is trapped inside the chamber forming a liquid column. The elongated section is advanced through a lumen or passageway delivering the implant to a desired location. A shaft, which is in communication with the fluid column, is held stationary and the elongated section retracted deploying the implant. As the elongated section is retracted, the implant exerts forces upon the elongated section that are transmitted to the fluid column which resists buckling.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: December 29, 2009
    Assignee: Cordis Corporation
    Inventors: Clifford Dwyer, Michael V. Williamson, Jr., Craig Bonsignore
  • Patent number: 7622477
    Abstract: Isomers and 42-epimers of rapamycin alkyl ether analogs and pharmaceutically acceptable salts or prodrugs thereof, are immunomodulatory agents and are useful in the treatment of restenosis and immune and autoimmune diseases. Also disclosed are cancer-, fungal growth-, restenosis-, post-transplant tissue rejection- and immune- and autoimmune disease-inhibiting compositions and a method of inhibiting cancer, fungal growth, restenosis, post-transplant tissue rejection, and immune and autoimmune disease in a mammal. One particular preferred application of such isomers and 42-epimers of rapamycin alkyl ether analogs is in medicated devices and local vascular delivery wherein the stability and lipid solubility and subsequently diffusion through tissue and cell membranes are essential to the success of rapamycin containing combination devices.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: November 24, 2009
    Assignee: Cordis Corporation
    Inventor: Jonathon Z. Zhao
  • Patent number: 7622145
    Abstract: Processes for coating implantable medical devices that improve the stability of therapeutic agents contained within the coating.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: November 24, 2009
    Assignee: Cordis Corporation
    Inventors: Eugena A. Akerman, Dirk Cleeren, Gerard Llanos, Cynthia A. Maryanoff, Georgios Papandreou, William Rion, Karel Six, Thomas L. Todd
  • Patent number: 7594927
    Abstract: A stent provides a folded strut section that provides both structural rigidity and reduction in foreshortening of the stent mechanism. A flexible section provides flexibility for delivery of the stent mechanism. In a second embodiment, flexible section columns are angled with respect to each other, and to the longitudinal axis of the stent. These relatively flexible sections are oppositely phased in order to negate any torsion along their length. In yet another embodiment, the flexible connector can take on an undulating shape (like an “N”), but such that the longitudinal axis of the connector is not parallel with the longitudinal axis of the stent. Finally, a new method is disclosed for making stents.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: September 29, 2009
    Assignee: Cordis Corporation
    Inventors: David C. Majercak, Hikmat Hojeibane, Robert Burgermeister
  • Patent number: 7591844
    Abstract: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: September 22, 2009
    Assignees: Cordis Corporation, Wyeth
    Inventors: Gerard H. Llanos, Mark B. Roller, Angelo George Scopelianos, Robert Falotico