Patents Assigned to Corixa Corporation
  • Compounds for immunodiagnosis of prostate cancer and methods for their use
    Patent number: 7270980
    Abstract: Compounds and methods for diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate tumor protein. The inventive polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: September 18, 2007
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer Lynn Mitcham
  • Fusion proteins of mycobacterium tuberculosis
    Patent number: 7261897
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: August 28, 2007
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Patent number: 7258860
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: August 21, 2007
    Assignee: Corixa Corporation
    Inventors: Tongtong Wang, David W Peckham, Marc W Retter, Gary R Fanger
  • Fusion proteins of Mycobacterium tuberculosis
    Publication number: 20070184074
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: January 26, 2006
    Publication date: August 9, 2007
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Jeff Guderian, Steven Reed
  • COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF COLON CANCER
    Publication number: 20070161034
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Application
    Filed: February 8, 2007
    Publication date: July 12, 2007
    Applicant: CORIXA CORPORATION
    Inventors: Yuqiu Jiang, Susan Harlocker, Heather Secrist, Aijun Wang, John Stolk
  • Compositions and methods for the therapy and diagnosis of breast cancer
    Patent number: 7241876
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: July 10, 2007
    Assignee: Corixa Corporation
    Inventors: Tony N. Frudakis, Steven G. Reed, John M. Smith, Lynda E. Misher, Davin C. Dillon, Marc W. Retter, Aijun Wang, Yasir A. W. Skeiky, Susan L. Harlocker, Craig H. Day, Samuel X. Li, Ta Deng
  • Compositions and methods for the therapy and diagnosis of lung cancer
    Publication number: 20070154488
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: November 22, 2006
    Publication date: July 5, 2007
    Applicant: Corixa Corporation
    Inventors: Tongtong Wang, Robert Henderson, Teresa Foy, Patricia McNeill, Yoshihiro Watanabe, Michael Kalos, Gary Fanger, Chaitanya Bangur
  • Compounds and methods for immunotherapy and diagnosis of tuberculosis
    Patent number: 7238358
    Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: July 3, 2007
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel R. Twardzik, Michael J. Lodes, Ronald C. Hendrickson
  • Compounds and methods for diagnosis of tuberculosis
    Publication number: 20070141087
    Abstract: Compounds and methods for diagnosing tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of one or more M. tuberculosis proteins, and DNA sequences encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of M. tuberculosis infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
    Type: Application
    Filed: August 16, 2006
    Publication date: June 21, 2007
    Applicant: Corixa Corporation
    Inventors: Steven Reed, Yasir Skeiky, Davin Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas Vedvick, Daniel Twardzik, Michael Lodes, Ronald Hendrickson
  • Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors and intermediates therefor
    Patent number: 7232900
    Abstract: This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.
    Type: Grant
    Filed: July 8, 2003
    Date of Patent: June 19, 2007
    Assignee: Corixa Corporation
    Inventors: David A. Johnson, Craig L. Johnson, Helene G. Bazin, C. Gregory Sowell
  • Her-2/neu fusion proteins
    Patent number: 7229623
    Abstract: The present invention is generally directed to Her-2/neu fusion proteins, nucleic acid molecules encoding Her-2/neu fusion proteins, viral vectors expressing Her-2/neu fusion proteins, and pharmaceutical compositions (e.g., vaccines) comprising the Her-2/neu fusion proteins and/or nucleic acid molecules encoding the Her-2/neu fusion proteins. The present invention is also directed to methods of treating or preventing cancer by eliciting or enhancing an immune response to the Her-2/neu protein, including for uses in the treatment of malignancies associated with the Her-2/neu oncogene.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: June 12, 2007
    Assignee: Corixa Corporation
    Inventors: Martin A. Cheever, Dirk Gheysen
  • Compositions and methods for the therapy and diagnosis of ovarian cancer
    Patent number: 7202334
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: April 10, 2007
    Assignee: Corixa Corporation
    Inventors: Jennifer L. Mitcham, Gordon E. King, Paul A. Algate, Steven P. Fling, Marc W. Retter, Gary R. Fanger, Steven G. Reed
  • Compositions and methods for the therapy and diagnosis of prostate cancer
    Patent number: 7202342
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: April 10, 2007
    Assignee: Corixa Corporation
    Inventors: Jiangchun Xu, Davin C. Dillon, Jennifer L. Mitcham, Susan L. Harlocker, Yuqiu Jiang, Michael D. Kalos, Gary R. Fanger, Marc W. Retter, John A. Stolk, Craig H. Day, Thomas S. Vedvick, Darrick Carter, Samuel X. Li, Aijun Wang, Yasir A. W. Skeiky, William T. Hepler
  • Compounds and methods for diagnosis and immunotherapy of tuberculosis
    Publication number: 20070054336
    Abstract: Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
    Type: Application
    Filed: June 27, 2006
    Publication date: March 8, 2007
    Applicant: Corixa Corporation
    Inventors: Antonio Campos-Neto, Yasir Skeiky, Pamela Ovendale, Shyian Jen, Michael Lodes
  • Fusion proteins of
    Patent number: 7186412
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: June 20, 2000
    Date of Patent: March 6, 2007
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Detection and monitoring of lung cancer
    Publication number: 20070042368
    Abstract: Compositions and methods for the diagnosis of lung cancer are disclosed. Such methods are useful to detect early tumors or provide adequate stage/grade information or tumor specificity. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Such compositions may be used, for example, to improve lung cancer diagnosis and prognosis and potentially differentiate between NSCLC and SCLC.
    Type: Application
    Filed: March 10, 2004
    Publication date: February 22, 2007
    Applicant: Corixa Corporation
    Inventors: Barbara Zehentner-Wilkinson, Dawn Hayes, Raymond Houghton
  • Compositions and methods for WT1 specific immunotherapy
    Publication number: 20070026008
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Application
    Filed: September 28, 2006
    Publication date: February 1, 2007
    Applicants: Corixa Corporation, University of Washington
    Inventors: Alexander Gaiger, Martin Cheever
  • New immunoeffector compounds
    Publication number: 20070004914
    Abstract: This invention provides compounds containing a 2-deoxy-2-amino-?-D-glucopyranose (glucosamine)glycosidically linked to an cyclic aminoalkyl (aglycon) group. The invention further provides methods for inducing an immune response using the compounds of the present invention in the presence or absence of an antigen. In addition, methods for treating disease with the compounds of the present invention with or without an antigen are also provided in this invention.
    Type: Application
    Filed: September 11, 2006
    Publication date: January 4, 2007
    Applicant: Corixa Corporation
    Inventors: David Johnson, Jory Baldridge, C. Sowell
  • Fusion proteins of mycobacterium tuberculosis antigens and their uses
    Publication number: 20060292169
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Application
    Filed: August 28, 2006
    Publication date: December 28, 2006
    Applicant: Corixa Corporation
    Inventors: Steven Reed, Yasir Skeiky, Davin Dillon, Mark Alderson, Antonio Campos-Neto
  • Methods, compositions and kits for the detection and monitoring of lung cancer
    Publication number: 20060292600
    Abstract: Compositions and methods for the diagnosis of lung cancer are disclosed. Such methods are useful to detect early tumors or provide adequate stage/grade information or tumor specificity. Compositions may comprise one or more lung tumor proteins, teins, immunogenic portions thereof, or polynucleotides that encode such portions. Such compositions may be used, for example, to improve lung cancer diagnosis and prognosis and potentially differentiate between NSCLC and SCLC.
    Type: Application
    Filed: March 29, 2006
    Publication date: December 28, 2006
    Applicant: Corixa Corporation
    Inventors: Barbara Zehentner-Wilkinson, Dawn Hayes, Raymond Houghton