Patents Assigned to Corixa Corporation
  • COMPOUNDS AND METHODS FOR DIAGNOSIS AND IMMUNOTHERAPY OF TUBERCULOSIS
    Publication number: 20080176798
    Abstract: Compounds and methods for diagnosing tuberculosis or for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more Mycobacterium proteins and DNA molecules encoding such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Mycobacterium infection in patients and biological samples. Antibodies directed against such polypeptides are also provided. In addition, such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against Mycobacterium infection.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 24, 2008
    Applicant: Corixa Corporation
    Inventors: Antonio Campos-Neto, Yasir Skeiky, Pamela Ovendale, Shyian Jen, Michael Lodes
  • COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER
    Publication number: 20080171048
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 17, 2008
    Applicant: CORIXA CORPORATION
    Inventors: Robert A. Henderson, Tongtong Wang, Yoshihiro Watanabe, Michael D. Kalos, Paul R. Sleath, Jeffrey C. Johnson, Marc W. Retter, Margarita Durham, Darrick Carter, Gary R. Fanger, Thomas S. Vedvick, Chaitanya S. Bangur, Andria McNabb
  • COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF LUNG CANCER
    Publication number: 20080171690
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 17, 2008
    Applicant: CORIXA CORPORATION
    Inventors: Robert A. Henderson, Tongtong Wang, Yoshihiro Watanabe, Michael D. Kalos, Paul R. Sleath, Jeffrey C. Johnson, Marc W. Retter, Margarita Durham, Darrick Carter, Gary R. Fanger, Thomas S. Vedvick, Chaitanya S. Bangur, Andria McNabb
  • Fusion proteins of Mycobacterium tuberculosis
    Publication number: 20080161263
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Application
    Filed: October 30, 2007
    Publication date: July 3, 2008
    Applicant: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Mark Alderson
  • Compounds and methods for treatment and diagnosis of Chlamydial infection
    Patent number: 7384638
    Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: June 10, 2008
    Assignee: Corixa Corporation
    Inventors: Ajay Bhatia, Peter Probst, Erika Jean Stromberg
  • PROPHYLACTIC AND THERAPEUTIC TREATMENT OF INFECTIOUS AND OTHER DISEASES WITH MONO- AND DISACCHARIDE-BASED COMPOUNDS
    Publication number: 20080119415
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
    Type: Application
    Filed: December 14, 2007
    Publication date: May 22, 2008
    Applicant: Corixa Corporation
    Inventors: David H. Persing, Richard Thomas Crane, Gary T. Elliott, J. Terry Ulrich, Michael J. Lacy, David A. Johnson, Jory R. Baldridge, Ron Wang
  • HER-2/neu fusion proteins
    Patent number: 7375091
    Abstract: The present invention is generally directed to HER-2/neu fusion proteins, nucleic acid molecules encoding HER-2/neu fusion proteins, viral vectors expressing HER-2/neu fusion proteins, and pharmaceutical compositions (e.g., vaccines) comprising the HER-2/neu fusion proteins and/or nucleic acid molecules encoding the HER-2/neu fusion proteins. The present invention is also directed to methods of treating or preventing cancer by eliciting or enhancing an immune response to the HER-2/neu protein, including for uses in the treatment of malignancies associated with the HER-2/neu oncogene.
    Type: Grant
    Filed: May 9, 2001
    Date of Patent: May 20, 2008
    Assignees: Corixa Corporation, SmithKline Beecham Biologicals s.a.
    Inventors: Martin A. Cheever, Dirk Gheysen
  • METHODS, COMPOSITIONS, AND KITS FOR THE DETECTION AND MONITORING OF COLON CANCER
    Publication number: 20080108070
    Abstract: Methods and compositions for the diagnosis and monitoring of colon cancer are disclosed.
    Type: Application
    Filed: September 6, 2007
    Publication date: May 8, 2008
    Applicant: CORIXA CORPORATION
    Inventors: Jiangchun Xu, Gordon King, Madeleine Braun, Ruth Chenault, Heather Secrist, Susan Harlocker, Siqing Wang
  • Compositions and methods for WT1 specific immunotherapy
    Patent number: 7368119
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Grant
    Filed: September 28, 2006
    Date of Patent: May 6, 2008
    Assignees: Corixa Corporation, University of Washington
    Inventors: Alexander Gaiger, Martin A. Cheever
  • Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
    Patent number: 7361733
    Abstract: Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: April 22, 2008
    Assignee: Corixa Corporation
    Inventors: Robert M. Hershberg, Nancy Ann Hosken, Michael J. Lodes, Raodoh Mohamath
  • Fusion proteins of antigens and their uses
    Patent number: 7335369
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: February 26, 2008
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. Skeiky, Davin C. Dillon, Mark Alderson, Antonio Campos-Neto
  • Compositions and method for WT1 specific immunotherapy
    Patent number: 7329410
    Abstract: A method for enhancing or inducing an immune response to WT1 is disclosed. In particular, the method comprises administering to a patient an immunogenic composition comprising an isolated polypeptide consisting of amino acids 1-249 of WT1 and a non-specific immune response enhancer.
    Type: Grant
    Filed: October 9, 2000
    Date of Patent: February 12, 2008
    Assignees: Corixa Corporation, University of Washington
    Inventors: Alexander Gaiger, Martin A. Cheever
  • PROCESSES FOR THE PRODUCTION OF AMINOALKYL GLUCOSAMINIDE PHOSPHATE AND DISACCHARIDE IMMUNOEFFECTORS, AND INTERMEDIATES THEREFOR
    Publication number: 20080033155
    Abstract: This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.
    Type: Application
    Filed: October 4, 2007
    Publication date: February 7, 2008
    Applicant: Corixa Corporation
    Inventor: David Johnson
  • Compositions and methods for WT1 specific immunotherapy
    Patent number: 7323181
    Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: January 29, 2008
    Assignee: Corixa Corporation
    Inventors: Alexander Gaiger, Patricia D McNeill
  • Fusion proteins of mycobacterium tuberculosis
    Patent number: 7311922
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
    Type: Grant
    Filed: October 10, 2000
    Date of Patent: December 25, 2007
    Assignee: Corixa Corporation
    Inventors: Yasir Skeiky, Steven Reed, Raymond L. Houghton, Patricia D. McNeill, Davin C. Dillon, Michael J. Lodes
  • METHODS, COMPOSITIONS, AND KITS FOR THE DETECTION AND MONITORING OF KIDNEY CANCER
    Publication number: 20070264651
    Abstract: Methods and compositions for the diagnosis and monitoring of kidney cancer are disclosed.
    Type: Application
    Filed: April 5, 2007
    Publication date: November 15, 2007
    Applicant: CORIXA CORPORATION
    Inventors: Paul Algate, Brian Gordon, Jane Mannion
  • METHODS, COMPOSITIONS, AND KITS FOR THE DETECTION AND MONITORING OF BLADDER CANCER
    Publication number: 20070259361
    Abstract: Methods and compositions for the diagnosis and monitoring of bladder cancer are disclosed.
    Type: Application
    Filed: April 11, 2007
    Publication date: November 8, 2007
    Applicant: Corixa Corporation
    Inventors: Paul Algate, Jane Mannion, Brian Gordon
  • Processes for the production of aminoalkyl glucosaminide phosphate and disaccharide immunoeffectors, and intermediates therefor
    Patent number: 7288640
    Abstract: This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.
    Type: Grant
    Filed: July 21, 2004
    Date of Patent: October 30, 2007
    Assignee: Corixa Corporation
    Inventors: David A. Johnson, Craig L. Johnson, Helene G. Bazin-Lee, C. Gregory Sowell
  • Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
    Publication number: 20070238182
    Abstract: Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.
    Type: Application
    Filed: October 2, 2006
    Publication date: October 11, 2007
    Applicant: Corixa Corporation
    Inventors: Alexander Gaiger, Paul Algate, Jane Mannion, Jonathan Clapper, Arjun Wang, Nadia Ordonez, Lauren Carter, Patricia McNeill
  • Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide- based compounds
    Publication number: 20070225254
    Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.
    Type: Application
    Filed: April 4, 2007
    Publication date: September 27, 2007
    Applicant: Corixa Corporation
    Inventors: David Persing, Richard Crane, Gary Elliot, J. Ulrich, Michael Lacy, David Johnson, Jory Baldridge, Rong Wang