Abstract: The present technology provides compounds, as well as compositions including such compounds, useful for imaging and/or treatment of a glioma, a breast cancer, an adrenal cortical cancer, a cervical carcinoma, a vulvar carcinoma, an endometrial carcinoma, a primary ovarian carcinoma, a metastatic ovarian carcinoma, a non-small cell lung cancer, a small cell lung cancer, a bladder cancer, a colon cancer, a primary, gastric adenocarcinoma, a primary colorectal adenocarcinoma, a renal cell carcinoma, and/or a prostate cancer.

Abstract: Provided are compositions and methods that include a K. pneumoniae yidR protein or an antigenic segment of the protein, and homologous of the protein, and antigenic segments of the homologs. The compositions can be provided as vaccine formulations for use with humans and non-human animals, including but not limited to dairy cows. The compositions and methods are useful for prophylaxis and/or therapy of conditions associated with Gram negative bacteria that include K. pneumonia, E. coli, and other pathogenic Gram negative bacteria. The conditions include such bacterial infections generally, and include specifically mastitis and metritis. The compositions and methods can also improve fertility and milk production. Administration of the compositions can improve the likelihood of a first service conception.

Abstract: The present disclosure relates to a systemically administered peptide delivery platform that biodistributes to the kidney or urinary tract. The disclosure further relates to methods of treating a disease of the kidney or urinary tract in a subject in need thereof.

Abstract: The present technology provides compounds as well as compositions including such compounds useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing prostate specific membrane antigen (“PSMA”) where the compounds are represented by the following: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, wherein M1 is independently at each occurrence an alpha-emitting radionuclide. Equivalents of such compounds are also disclosed.

Abstract: Provided herein are high performance electrodes, electrode materials comprising a plurality of active electrode material-containing particles secured within one or more graphenic web, and precursors thereof. Also provided herein are processes of generating the same by an electrospray process.

Abstract: A vertical gallium oxide (Ga2O3) device having a substrate, an n-type Ga2O3 drift layer on the substrate, an, n-type semiconducting channel extending from the n-type Ga2O3 drift layer, the channel being one of fin-shaped or nanowire shaped, an n-type source layer disposed on the channel; the source layer has a higher doping concentration than the channel, a first dielectric layer on the n-type Ga2O3 drift layer and on sidewalls of the n-type semiconducting channel, a conductive gate layer deposited on the first dielectric layer and insulated from the n-type source layer, n-type semiconducting channel as well as n-type Ga2O3 drift layer, a second dielectric layer deposited over the conductive gate layer, covering completely the conductive gate layer on channel sidewalls and an ohmic source contact deposited over the n-type source layer and over at least a part of the second dielectric layer; the source contact being configured not to be in electrical contact with the conductive gate layer.

Abstract: Systems, methods, network devices, and machine-readable media disclosed herein include encoding data for storage or transmission by encoding the data according to a tamper-resistant data encoding scheme that renders the data secure against unbounded polynomial size attacks. The present disclosure further includes subsequently determining whether the data has been tampered with, and notifying a processor when the data has been modified or compromised.

Abstract: Systems, methods, network devices, and machine-readable media disclosed herein include executing a secure algorithm for computing on a plurality of machines in a cluster by receiving a large input message and dividing the large input message into a plurality of initial input messages, computing an encryption of initial input messages, and evaluating a cluster computing circuit using a homomorphic encryption scheme.

Abstract: The present disclosure provides methods of analyzing and/or purifying inorganic nanoparticles that may be functionalized with one or more dye group. Analyzing and/or purifying the inorganic nanoparticles includes utilizing liquid chromatography, such as, for example, high performance liquid chromatography (HPLC). Methods of the present disclosure may be used to determine the location of one or more dye groups on and/or in the inorganic nanoparticles. The present disclosure also provides methods of making inorganic nanoparticles and compositions of inorganic nanoparticles.

Abstract: Compositions and methods for eosinophilia in a mammal are provided. In one embodiment, the composition is a viral gene therapy vector, and a single dose of the vector reduces increased numbers of eosinophils in a mammal.

Abstract: An artificial cilium device includes a substrate and a voltage-actuated cilia-shaped structure attached at a proximal end to the substrate. The voltage-actuated cilia-shaped structure has a first layer of a first material and a second layer of a second material. The second layer of the second material includes an exposed surface that causes the cilia-shaped structure to, in a working medium, (a) change shape from a first shape to a second shape responsive to application of a first voltage and (b) change shape from the second shape to the first shape responsive to application of a second voltage different than the first voltage.

Abstract: Dysbiosis has been linked to diseases such as inflammatory bowel disease and obesity. Multi-omics studies have uncovered significant associations between microbiota genes and diseases. Many of these genes are exclusively expressed in non-model microbes such as Firmicutes/Clostridia. A pipeline for building microbial genetic manipulation systems would be a first step to manipulating these genes in vivo and causally connecting them with host diseases. The present technology relates generally to compositions and the methods of preparations thereof for genetically engineering gut-microbiota in vitro. The present technology further relates to uses of compositions in vivo.

Abstract: Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; a proximal balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the proximal balloon; a push tube slidably mounted to the sleeve; and a distal balloon secured to the distal end of the push tube, the interior of the distal balloon being in fluid communication with the push tube, wherein the distal balloon is capable of assuming a deflated condition and an inflated condition, and further wherein when the distal balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and when the distal balloon is in its inflated condition, the axial opening is closed down.

Abstract: Systems and methods are provided for incremental 3D printing, wherein wireframes are generated and printed (scheduled for print) during the design process. In another aspect, systems and methods are provided for printing arbitrary meshes. A 3D printer system is described having, for example, five degree-of-freedom (5DOF). The 5DOF printer may be used to perform any of the methods described herein and combinations of the methods.

Abstract: The present technology is directed to compounds, compositions, medicaments, and methods related to the treatment of cancers expressing PSMA. The compounds are of Formulas I & II or pharmaceutically acceptable salts thereof. The present technology is especially well-suited for use in treating prostate cancer.

Abstract: Provided are compositions, methods, and kits for CRISPR-based editing of DNA targets by Type I CRISPR-associated (Cas) enzymes.

Abstract: Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated carrier proteins. The glycosylated carrier proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated carrier proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated carrier proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.

Abstract: Methods of obtaining and kits that can be used to obtain an optical super-resolution image of a sample or a portion thereof or an individual or a portion thereof. In various examples, the individual is an individual with cancer. In various examples, a method includes contacting a sample or individual with one or more aluminosilicate nanoparticle(s) that have at least one organic fluorophore molecule covalently bonded to the aluminosilicate network of the nanoparticle(s), or a composition including the aluminosilicate nanoparticle(s); irradiating the sample or the individual, thereby exciting at least one of the fluorophore molecules of an individual aluminosilicate nanoparticle; and obtaining a fluorescence image or a sequence of fluorescence images, which can be processed to obtain a super-resolution image of the sample or the individual. In various examples, the sample is a biological sample, living or fixed tissues and/or cells, or a biopsy obtained from an individual.

Abstract: The present invention relates to an exceptionally broad and potent neutralizing antibody which may comprise cross-clade neutralizing coverage of 83% at a median IC50 of 0.003 ?g/ml, compositions containing the same and uses thereof.

Abstract: An Alstroemeria plant particularly distinguished with vibrant coral colored flowers. The flowers on this plant have coral tepals with intense yellow highlights and little flecks of brown on the base of the inner tepals. Has a good longevity as a cut flower, continuous flowering from summer through fall, and winter-hardy from USDA zone 5 as described.