Patents Assigned to Cornel University
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Publication number: 20240424726Abstract: Implanted medical devices need a mechanism of immobilization to surrounding tissues, which minimizes tissue damage while providing reliable long-term anchoring. This disclosure relates to techniques for patterning arbitrarily shaped 3D objects and to patterned balloon devices having micro-or nano-patterning on an outer surface of an inflatable balloon. The external pattern can provide enhanced friction and anchoring in an aqueous environment. Examples of these types of patterns are hexagonal arrays inspired by tree frogs, corrugated patterns, and microneedle patterns. The patterned balloon devices can be disposed between an implant and surrounding tissues to facilitate anchoring of the implant.Type: ApplicationFiled: July 9, 2024Publication date: December 26, 2024Applicant: Cornell UniversityInventors: Seyedhamidreza Alaie, Simon Dunham, Bobak Mosadegh, James K. Min, Amir Ali Amiri Moghadam
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Patent number: 12176572Abstract: Provided are compositions including one or more cyclic ether(s), one or more salt(s), which may be one or more lithium salt(s), one or more sodium salt(s), or a combination thereof, and, optionally, one or more ring-opening polymerization initiator(s). The compositions may be used to form solid-state electrolytes. Also provided are methods for forming solid-state electrolytes using the compositions and devices comprising one or more composition(s) or one or more solid-state electrolyte(s) using the compositions.Type: GrantFiled: January 6, 2020Date of Patent: December 24, 2024Assignee: Cornell UniversityInventors: Lynden A. Archer, Qing Zhao, Kasim Khan, Xiaotun Liu
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Patent number: 12161734Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer. The nanoparticle has a range of diameters including between about 0.1 nm and about 100 nm, between about 0.5 nm and about 50 nm, between about 1 nm and about 25 nm, between about 1 nm and about 15 nm, or between about 1 nm and about 8 nm. The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound. The nanoparticle also exhibits high biostability and biocompatibility. To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as poly(ethylene glycol) (PEG). The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo.Type: GrantFiled: July 5, 2022Date of Patent: December 10, 2024Assignees: Sloan-Kettering Institute for Cancer Research, Cornell UniversityInventors: Michelle S. Bradbury, Ulrich Wiesner, Oula Penate Medina, Andrew Burns, Jason S. Lewis, Steven M. Larson
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Patent number: 12161052Abstract: Solid-state devices including a layer of a superconductor material epitaxially grown on a crystalline high thermal conductivity substrate, the superconductor material being one of TiNx, ZrNx, HfNx, VNx, NbNx, TaNx, MoNx, WNx, or alloys thereof, and one or more layers of a semiconducting or insulating or metallic material epitaxially grown on the layer of superconductor material, the semiconducting or insulating material being one of a Group III N material or alloys thereof or a Group 4b N material or SiC or ScN or alloys thereof.Type: GrantFiled: March 6, 2019Date of Patent: December 3, 2024Assignees: Cornell University, Govmt. of U.S.—NavyInventors: Rusen Yan, Guru Bahadur Singh Khalsa, John Wright, H. Grace Xing, Debdeep Jena, D. Scott Katzer, Neeraj Nepal, Brian P. Downey, David J. Meyer
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Publication number: 20240390334Abstract: Specifically, the invention relates to compositions and methods for treating liver ailments, such as compositions and methods for attenuating or ameliorating the development of alcoholic liver disease (ALD), hepatic steatosis, liver oxidative stress and/or hepatic lipogenesis associated with alcohol consumption in a subject by administering a retinoic acid receptor-beta (RAR?) agonist.Type: ApplicationFiled: September 14, 2022Publication date: November 28, 2024Applicants: Research Foundation of the City University of New York, Cornell UniversityInventors: STEVEN TRASINO, LORRAINE GUDAS, XIAO-HAN TANG, MARTA MELIS
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Publication number: 20240393465Abstract: A digital image detection apparatus and method of use are disclosed. The apparatus may include an array of photon detectors, configured to receive photons reflected from a target scene and a plurality of first arrival differential (FAD) units, where each FAD units is configured to receive a first input from a first photon detector in the array and a second input from a second photon detector. Each FAD unit may include a set-reset (“SR”) latch, configured to receive the first input and the second input and to determine which of the first input and the second input arrives earlier in time, and a counter control unit, configured to receive an output from the SR latch and increment a differential count based on the output.Type: ApplicationFiled: May 28, 2024Publication date: November 28, 2024Applicants: William Marsh Rice University, Cornell UniversityInventors: Ashok Veeraraghavan, Al Molnar, Mel White, Tianyi Zhang, Akshat Dave, Ankit Raghuram, Shahaboddin Ghajari
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Patent number: 12154011Abstract: A wrist-mounted system for tracking hand poses includes one or more cameras mounted to a wearable band. In some examples, the one or more cameras are low profile and may be located less than 15 mm, and preferably less than 10 mm, of the wrist of the user. In some examples, a system includes a wearable band and one or more imaging sensors. The one or more imaging sensors are disposed to have a field of view that is anatomically distal when the wearable band is coupled to an arm of the user. The one or more imaging sensors each define an optical axis spaced from the wearable band of less than 15 mm, and preferably less than 10 mm. The image data may come from a single camera mounted on the back of the wrist which captures images of the surface contours of the back of the hand to infer hand poses and gestures.Type: GrantFiled: April 26, 2021Date of Patent: November 26, 2024Assignees: Cornell University, Wisconsin Alumni Research FoundationInventors: Cheng Zhang, Fang Hu, Yin Li
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Patent number: 12151432Abstract: An additive manufacturing system includes an apparatus to facilitate production at the microscale using metal sheet as feedstock. This additive manufacturing system uses energy from a pulsed laser beam for ejection of metallic droplets to consolidate a part in a layer-by-layer manner.Type: GrantFiled: April 17, 2024Date of Patent: November 26, 2024Assignee: Cornell UniversityInventors: Atieh Moridi, Kaushalendra K. Singh
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Publication number: 20240366529Abstract: Provided herein are compounds (e.g., compounds of Formula (I) and Formula (II), that modulate HCN channels, intermembrane proteins that serve as nonselective voltage-gated cation channels in the plasma membranes of heart and brain cells. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of treating HCN-related disorders (e.g., pain) with the compounds in a subject, by administering the compounds and/or compositions described herein.Type: ApplicationFiled: April 26, 2023Publication date: November 7, 2024Applicant: Cornell UniversityInventors: Gareth R. Tibbs, Peter A. Goldstein, Anthony A. Sauve, Rajendra Uprety, James David Warren, JR., Rebecca L. Joyce, Dipti N. Barman
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Patent number: 12131527Abstract: An ultrasonic computation apparatus includes first and second ultrasonic transducer arrays arranged on opposing ends thereof, and further comprises first and second ultrasonic propagation regions arranged between the first and second ultrasonic transducer arrays and proximate respective ones of the first and second ultrasonic transducer arrays, and an intermediate computational structure arranged between the first and second ultrasonic propagation regions. Respective first and second input signals applied to respective ones of the first and second ultrasonic transducer arrays cause propagation of corresponding ultrasonic waves through the respective first and second ultrasonic propagation regions towards the intermediate computational structure.Type: GrantFiled: April 20, 2022Date of Patent: October 29, 2024Assignee: Cornell UniversityInventors: Amit Lal, Yutong Liu, Juneho Hwang, Justin Kuo
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Patent number: 12121209Abstract: An endoscopic tissue snare system comprising: a sleeve adapted to be slid over the exterior of an endoscope; a pair of push tubes slidably mounted to the sleeve, each of the push tubes comprising a distal opening and a proximal opening; a distal balloon secured to the distal ends of the pair of push tubes; and a snare comprising a pair of free ends and an intermediate portion disposed between the pair of free ends, wherein the snare extends into the proximal opening of one push tube, up the length of the push tube, out the distal opening of that push tube, across the face of the distal balloon, into the distal opening of the other push tube, down the length of that push tube, and out the proximal opening of that push tube.Type: GrantFiled: June 16, 2022Date of Patent: October 22, 2024Assignee: Cornell UniversityInventors: Jeffrey Milsom, Sameer Sharma, Peter Johann
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Patent number: 12122844Abstract: The invention provides methods to inhibit or treat brain cancers by locally inhibiting expression or activity of growth factors or growth factor receptors.Type: GrantFiled: July 13, 2020Date of Patent: October 22, 2024Assignees: Cornell University, Memorial Sloan-Kettering Cancer CenterInventors: Ronald G. Crystal, Stephen M. Kaminsky, Martin J. Hicks, Viviane Tabar
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Publication number: 20240345142Abstract: Time-synchronized state estimation for reconfigurable distribution systems is challenging because of limited real-time observability. A system addresses this challenge by formulating a deep learning (DL)-based approach for topology identification (TI) and unbalanced three-phase distribution system state estimation (DSSE). Two deep neural networks (DNNs) are trained for time-synchronized DNN-based TI and DSSE, respectively, for systems that are incompletely observed by synchrophasor measurement devices (SMDs) in real-time. A data-driven approach for judicious SMD placement to facilitate reliable TI and DSSE is also developed.Type: ApplicationFiled: April 17, 2024Publication date: October 17, 2024Applicants: Arizona Board of Regents on Behalf of Arizona State University, Cornell UniversityInventors: Anamitra Pal, Behrouz Azimian, Lang Tong
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Publication number: 20240342989Abstract: An additive manufacturing system includes an apparatus to facilitate production at the microscale using metal sheet as feedstock. This additive manufacturing system uses energy from a pulsed laser beam for ejection of metallic droplets to consolidate a part in a layer-by-layer manner.Type: ApplicationFiled: April 17, 2024Publication date: October 17, 2024Applicant: Cornell UniversityInventors: ATIEH MORIDI, KAUSHALENDRA K. SINGH
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Patent number: 12116450Abstract: Disclosed herein are polyurethane compositions and methods for reprocessing cross-linked polyurethane compositions. The polyurethane composition comprises a network polymer and a polyurethane exchange catalyst permeated within the network polymer. The network polymer comprises a dynamic network formed from an isocyanate constitutional unit and a second constitution unit having a hydroxyl group capable of reacting with an isocyanate group of the isocyanate constitutional unit to form a urethane bond. The catalyst comprises a metal atom and a ligand coordinated to the metal atom.Type: GrantFiled: April 25, 2019Date of Patent: October 15, 2024Assignees: Northwestern University, Cornell UniversityInventors: David J. Fortman, William R. Dichtel, Daylan T. Sheppard
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Patent number: 12114663Abstract: Provided are compositions and methods for use in deterring insects, such as aphids, from damaging plants. A method is provided and involves applying to one or more plants: i) bacteria that produce pyoverdine that emits fluorescent light that is detected by the insects and causes the insects to avoid the plant(s), wherein the bacteria are applied such that that there are more than 105 bacterial cells per 3 cm2 of plant surface, ii) a composition that contains at least 0.00005 mg of isolated pyoverdine that emits fluorescent light that is detected by the insects and causes the insects to avoid the plant(s), and combinations thereof. Also provided is a system for use in plant pest control in a confined space, including in structures such as greenhouses and hydroponic growing containers. The system includes one or more light sources that only emit light having a wavelength of 450-525 nm.Type: GrantFiled: February 11, 2019Date of Patent: October 15, 2024Assignee: Cornell UniversityInventor: Tory Hendry
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Patent number: 12115231Abstract: An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum.Type: GrantFiled: June 28, 2022Date of Patent: October 15, 2024Assignee: Cornell UniversityInventors: Ulrich B. Wiesner, Kai Ma, Carlie Mendoza
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Patent number: 12103952Abstract: The invention relates to expressing proteins in the axons of mammalian neurons. The invention provides nucleic acids that can be used to express a selected polypeptide in neuronal axons, viruses that can be used deliver nucleic acids of the invention into neuronal axons, as well as methods for doing so. Thus, the invention provides pharmaceutical compositions comprising viruses of the invention, as well as their use in methods of treating injured axons or conditions associated with aberrant axon growth or function.Type: GrantFiled: February 5, 2021Date of Patent: October 1, 2024Assignee: Cornell UniversityInventors: Samie R. Jaffrey, Ulrich Hengst
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Publication number: 20240307517Abstract: The invention is directed to fentanyl analogues and a conjugate comprising same, as well as a method of inducing an immune response against fentanyl.Type: ApplicationFiled: May 10, 2022Publication date: September 19, 2024Applicant: Cornell UniversityInventors: Ronald G. Crystal, Stephen Kaminsky, Tristan H. Lambert, Dolan Sondhi, Bishnu De, Philip L. Leopold, Andrew Thomas Holm
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Patent number: 12085430Abstract: A method of determining flow speed in a low pressure environment. The method includes obtaining bi-directional acoustic data from a plurality of transducer pairs as a fluid moves relative to the plurality of transducer pairs. The method further includes measuring phase lags corresponding to the bi-directional acoustic data, and determining bi-directional flight times using the phase lags. Additionally, the method includes calculating a flow speed of the fluid corresponding to each transducer pair from the bi-directional flight times. The method includes correcting for at least one of temperature effects, pressure effects, and wake effects, using a system model. The method further includes generating a report including the flow speed of the fluid.Type: GrantFiled: January 7, 2021Date of Patent: September 10, 2024Assignees: Trustees of Tufts College, Cornell University, Vandervalk Neeson Instruments Ltd.Inventors: Robert White, Don Banfield, Ian Neeson