Patents Assigned to Cornel University
  • Patent number: 12131527
    Abstract: An ultrasonic computation apparatus includes first and second ultrasonic transducer arrays arranged on opposing ends thereof, and further comprises first and second ultrasonic propagation regions arranged between the first and second ultrasonic transducer arrays and proximate respective ones of the first and second ultrasonic transducer arrays, and an intermediate computational structure arranged between the first and second ultrasonic propagation regions. Respective first and second input signals applied to respective ones of the first and second ultrasonic transducer arrays cause propagation of corresponding ultrasonic waves through the respective first and second ultrasonic propagation regions towards the intermediate computational structure.
    Type: Grant
    Filed: April 20, 2022
    Date of Patent: October 29, 2024
    Assignee: Cornell University
    Inventors: Amit Lal, Yutong Liu, Juneho Hwang, Justin Kuo
  • Patent number: 12121209
    Abstract: An endoscopic tissue snare system comprising: a sleeve adapted to be slid over the exterior of an endoscope; a pair of push tubes slidably mounted to the sleeve, each of the push tubes comprising a distal opening and a proximal opening; a distal balloon secured to the distal ends of the pair of push tubes; and a snare comprising a pair of free ends and an intermediate portion disposed between the pair of free ends, wherein the snare extends into the proximal opening of one push tube, up the length of the push tube, out the distal opening of that push tube, across the face of the distal balloon, into the distal opening of the other push tube, down the length of that push tube, and out the proximal opening of that push tube.
    Type: Grant
    Filed: June 16, 2022
    Date of Patent: October 22, 2024
    Assignee: Cornell University
    Inventors: Jeffrey Milsom, Sameer Sharma, Peter Johann
  • Patent number: 12122844
    Abstract: The invention provides methods to inhibit or treat brain cancers by locally inhibiting expression or activity of growth factors or growth factor receptors.
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: October 22, 2024
    Assignees: Cornell University, Memorial Sloan-Kettering Cancer Center
    Inventors: Ronald G. Crystal, Stephen M. Kaminsky, Martin J. Hicks, Viviane Tabar
  • Publication number: 20240345142
    Abstract: Time-synchronized state estimation for reconfigurable distribution systems is challenging because of limited real-time observability. A system addresses this challenge by formulating a deep learning (DL)-based approach for topology identification (TI) and unbalanced three-phase distribution system state estimation (DSSE). Two deep neural networks (DNNs) are trained for time-synchronized DNN-based TI and DSSE, respectively, for systems that are incompletely observed by synchrophasor measurement devices (SMDs) in real-time. A data-driven approach for judicious SMD placement to facilitate reliable TI and DSSE is also developed.
    Type: Application
    Filed: April 17, 2024
    Publication date: October 17, 2024
    Applicants: Arizona Board of Regents on Behalf of Arizona State University, Cornell University
    Inventors: Anamitra Pal, Behrouz Azimian, Lang Tong
  • Publication number: 20240342989
    Abstract: An additive manufacturing system includes an apparatus to facilitate production at the microscale using metal sheet as feedstock. This additive manufacturing system uses energy from a pulsed laser beam for ejection of metallic droplets to consolidate a part in a layer-by-layer manner.
    Type: Application
    Filed: April 17, 2024
    Publication date: October 17, 2024
    Applicant: Cornell University
    Inventors: ATIEH MORIDI, KAUSHALENDRA K. SINGH
  • Patent number: 12116450
    Abstract: Disclosed herein are polyurethane compositions and methods for reprocessing cross-linked polyurethane compositions. The polyurethane composition comprises a network polymer and a polyurethane exchange catalyst permeated within the network polymer. The network polymer comprises a dynamic network formed from an isocyanate constitutional unit and a second constitution unit having a hydroxyl group capable of reacting with an isocyanate group of the isocyanate constitutional unit to form a urethane bond. The catalyst comprises a metal atom and a ligand coordinated to the metal atom.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: October 15, 2024
    Assignees: Northwestern University, Cornell University
    Inventors: David J. Fortman, William R. Dichtel, Daylan T. Sheppard
  • Patent number: 12114663
    Abstract: Provided are compositions and methods for use in deterring insects, such as aphids, from damaging plants. A method is provided and involves applying to one or more plants: i) bacteria that produce pyoverdine that emits fluorescent light that is detected by the insects and causes the insects to avoid the plant(s), wherein the bacteria are applied such that that there are more than 105 bacterial cells per 3 cm2 of plant surface, ii) a composition that contains at least 0.00005 mg of isolated pyoverdine that emits fluorescent light that is detected by the insects and causes the insects to avoid the plant(s), and combinations thereof. Also provided is a system for use in plant pest control in a confined space, including in structures such as greenhouses and hydroponic growing containers. The system includes one or more light sources that only emit light having a wavelength of 450-525 nm.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: October 15, 2024
    Assignee: Cornell University
    Inventor: Tory Hendry
  • Patent number: 12115231
    Abstract: An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core-shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum.
    Type: Grant
    Filed: June 28, 2022
    Date of Patent: October 15, 2024
    Assignee: Cornell University
    Inventors: Ulrich B. Wiesner, Kai Ma, Carlie Mendoza
  • Patent number: 12103952
    Abstract: The invention relates to expressing proteins in the axons of mammalian neurons. The invention provides nucleic acids that can be used to express a selected polypeptide in neuronal axons, viruses that can be used deliver nucleic acids of the invention into neuronal axons, as well as methods for doing so. Thus, the invention provides pharmaceutical compositions comprising viruses of the invention, as well as their use in methods of treating injured axons or conditions associated with aberrant axon growth or function.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: October 1, 2024
    Assignee: Cornell University
    Inventors: Samie R. Jaffrey, Ulrich Hengst
  • Publication number: 20240307517
    Abstract: The invention is directed to fentanyl analogues and a conjugate comprising same, as well as a method of inducing an immune response against fentanyl.
    Type: Application
    Filed: May 10, 2022
    Publication date: September 19, 2024
    Applicant: Cornell University
    Inventors: Ronald G. Crystal, Stephen Kaminsky, Tristan H. Lambert, Dolan Sondhi, Bishnu De, Philip L. Leopold, Andrew Thomas Holm
  • Patent number: 12083105
    Abstract: The present technology relates to methods for treating, preventing, and/or ameliorating diseases associated with ectopic iron-sulfur (Fe—S) cluster formation or ectopic iron-sulfur (Fe—S) cluster binding, such as adult-onset neuronal ceroid lipofuscinosis (ANCL or Kufs disease) comprising administering a therapeutically effective amount of an iron chelator to a subject in need thereof. Kits for use in practicing the methods are also provided.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: September 10, 2024
    Assignee: Cornell University
    Inventors: Manu Sharma, Nima N. Naseri
  • Patent number: 12085430
    Abstract: A method of determining flow speed in a low pressure environment. The method includes obtaining bi-directional acoustic data from a plurality of transducer pairs as a fluid moves relative to the plurality of transducer pairs. The method further includes measuring phase lags corresponding to the bi-directional acoustic data, and determining bi-directional flight times using the phase lags. Additionally, the method includes calculating a flow speed of the fluid corresponding to each transducer pair from the bi-directional flight times. The method includes correcting for at least one of temperature effects, pressure effects, and wake effects, using a system model. The method further includes generating a report including the flow speed of the fluid.
    Type: Grant
    Filed: January 7, 2021
    Date of Patent: September 10, 2024
    Assignees: Trustees of Tufts College, Cornell University, Vandervalk Neeson Instruments Ltd.
    Inventors: Robert White, Don Banfield, Ian Neeson
  • Patent number: 12082907
    Abstract: Presented herein is a multichannel imaging system capable of detecting and distinguishing multiple fluorescent light sources simultaneously. Also described herein are methods of using the system to image disease or cellular abnormalities, e.g., for diagnostic and/or intraoperative purposes.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: September 10, 2024
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University, Quest Medical Imaging B.V.
    Inventors: Michelle S. Bradbury, Ulrich Wiesner, Richard J. C. Meester, Snehal G. Patel, Nadeem R. Abu-Rustum, Mohan Pauliah
  • Publication number: 20240287615
    Abstract: The present invention provides an in vitro method, and in vitro assay, for staging, classification, screening, monitoring, stratification, selecting treatment for, ascertaining whether treatment is working in, and/or prognostication of cancer in a subject comprising determining allelic imbalance and copy number of target gene-regions in tumor DNA from a subject as set out in the application. The present invention also provides a set of oligonucleotide probes and kits for use in the method, and assay, of the present invention.
    Type: Application
    Filed: June 9, 2022
    Publication date: August 29, 2024
    Applicants: University College London, Università degli Studi di Trento, Cornell University, The University of British Columbia
    Inventors: Gerhardt Attard, Francesca Demichelis, Alessandro Romanel, Francesco Orlando, Mark Rubin, Himisha Beltran, Alexander Wyatt
  • Patent number: 12072403
    Abstract: Exemplary methods for quantitative mapping of physical properties, systems and computer-accessible medium can be provided to generate images of tissue magnetic susceptibility, transport parameters and oxygen consumption from magnetic resonance imaging data using the Bayesian inference approach, which minimizes a data fidelity term under a constraint of a structure prior knowledge. The data fidelity term is constructed directly from the magnetic resonance imaging data. The structure prior knowledge can be characterized from known anatomic images using image feature extraction operation or artificial neural network. Thus, according to the exemplary embodiment, system, method and computer-accessible medium can be provided for determining physical properties associated with at least one structure.
    Type: Grant
    Filed: September 25, 2023
    Date of Patent: August 27, 2024
    Assignee: Cornell University
    Inventors: Yi Wang, Zhe Liu, Jinwei Zhang, Qihao Zhang, Junghun Cho, Pascal Spincemaille
  • Patent number: 12071489
    Abstract: Crosslinked nucleotide polymers. A crosslinked nucleotide polymer may be formed by reaction of a biomass comprising DNA and/or RNA with one or more crosslinker(s). A crosslinked nucleotide polymers may be formed by a crosslinking reaction including an aza-Michael addition reaction. Crosslinked nucleotide polymers may be present in various forms and compositions and form various articles of manufacture. Crosslinked nucleotide polymers may be used in therapeutic methods, coating methods, and cell-free protein production methods.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: August 27, 2024
    Assignee: Cornell University
    Inventors: Dan Luo, Dong Wang
  • Patent number: 12071424
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Grant
    Filed: February 28, 2023
    Date of Patent: August 27, 2024
    Assignee: Cornell University
    Inventors: Joseph P. Vacca, Dansu Li, Sarah Elizabeth Bettigole
  • Patent number: 12071426
    Abstract: Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: August 27, 2024
    Assignee: Cornell University
    Inventors: Joseph P. Vacca, Sarah Elizabeth Bettigole
  • Patent number: 12064336
    Abstract: An implant can include a flexible body made of a non-bioresorbable hydrogel material. The implant can also include a radiopaque marker located within the flexible body, where the body and the radiopaque marker can be implanted in a body cavity to mark the cavity in a radiographic image of the cavity.
    Type: Grant
    Filed: August 3, 2022
    Date of Patent: August 20, 2024
    Assignee: Cornell University
    Inventor: Rache Simmons
  • Patent number: 12066740
    Abstract: A meta-optical device, which imparts a phase delay to incident light of a wavelength band, includes: a first electrode and a second electrode spaced apart from each other; a liquid crystal layer between the first electrode and the second electrode; a meta-surface layer located within the liquid crystal layer and including a plurality of nanostructures each having a shape dimension smaller than a center wavelength of the wavelength band; and a voltage device configured to apply a voltage between the first electrode and the second electrode. The meta-optical device may exhibit an electrically controlled variable focal length.
    Type: Grant
    Filed: December 15, 2021
    Date of Patent: August 20, 2024
    Assignees: SAMSUNG ELECTRONICS CO., LTD., Cornell University
    Inventors: Kanghee Won, Maxim Radikovich Shcherbakov, Hongseok Lee, Melissa Bosch, Gennady Shvets