Patents Assigned to Cornell University
  • Patent number: 10517626
    Abstract: Devices, systems, and techniques are disclosed for intelligent semiconductor based medical tweezers and instrumentation including microscale sensors, actuators and circuitry for tissue detection and characterization. In one aspect, a tweezer device includes a hinge structure to enable tweezing motion of the device for clamping a sample, two leg components coupled to the hinge structure, a plurality of microprobes configured on both of the two leg components, and an electronic circuit electrically coupled to the microprobes to process and/or transmit the electronic signals. The microprobes include sensors in a sensing tip structured to penetrate into the sample when the device clamps the sample and produce electronic signals from the sensors of a property of the sample, the sensors of the sensing tip including at least one of an electrode to measure an electrical potential, an electrical permittivity sensor to measure electrical permittivity, or a strain gauge to measure mechanical compliance.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: December 31, 2019
    Assignee: Cornell University
    Inventors: Amit Lal, Fabrizio Michelassi, Po-Cheng Chen, Connie Wu
  • Patent number: 10517839
    Abstract: This application discloses methods for treating or preventing an ophthalmic retinal vascular permeability, angiogenic or fibroproliferative disease, disorder or condition that involve administering to a patient in need thereof a composition that can inhibit mast cell migration into the vitreous or the retina, mast cell proliferation in the vitreous or the retina, or mast cell secretion into the vitreous or the retina.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: December 31, 2019
    Assignee: Cornell University
    Inventors: Randi B. Silver, Nathan O'Connor
  • Publication number: 20190389904
    Abstract: Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT, lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).
    Type: Application
    Filed: August 26, 2016
    Publication date: December 26, 2019
    Applicants: Cornell University, Dana-Farber Cancer Institute, Inc., Children's Medical Center Corporation
    Inventors: Nathanael S. Gray, David A. Scott, John Hatcher, Spandan Chennamadhavuni, Ari M. Melnick, Lorena Fontan Gabas, Hao Wu, Qi Qiao, Guangyan Du
  • Publication number: 20190382650
    Abstract: A stabilized emulsified acid composition for deep carbonate formation stimulation is provided. The stabilized acid emulsion composition includes a petroleum operable to provide a barrier between an acid and a reservoir rock, the acid operable to react with the reservoir rock to dissolve the reservoir rock and produce a wormhole, a functional framework operable to stabilize the stabilized acid emulsion, an emulsifier operable to stabilize the stabilized acid emulsion, and a corrosion inhibitor operable to provide protection against corrosion for the metal components of a well. The petroleum can be diesel. The acid can be hydrochloric acid. The functional framework can be selected from the group comprising surface-modified clay-based material, zeolites, hybrid organic-inorganic materials, covalent-organic framework materials, and boron nitride nanotubes, and combinations thereof. The functional framework can be a surface-modified clay material selected from an organoclay.
    Type: Application
    Filed: June 3, 2019
    Publication date: December 19, 2019
    Applicants: Saudi Arabian Oil Company, Cornell University
    Inventors: Amy J. Cairns, Ghaithan A. Al-Muntasheri, Mohammed Sayed, Liling Fu, Genggeng Qi, Emmanuel P. Giannelis
  • Publication number: 20190382436
    Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
    Type: Application
    Filed: August 26, 2019
    Publication date: December 19, 2019
    Applicant: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Mohammed, Yue Yang
  • Patent number: 10504021
    Abstract: An event-driven neural network includes a plurality of interconnected core circuits is provided. Each core circuit includes an electronic synapse array has multiple digital synapses interconnecting a plurality of digital electronic neurons. A synapse interconnects an axon of a pre-synaptic neuron with a dendrite of a post-synaptic neuron. A neuron integrates input spikes and generates a spike event in response to the integrated input spikes exceeding a threshold. Each core circuit also has a scheduler that receives a spike event and delivers the spike event to a selected axon in the synapse array based on a schedule for deterministic event delivery.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: December 10, 2019
    Assignees: International Business Machines Corporation, Cornell University
    Inventors: Filipp Akopyan, John V. Arthur, Rajit Manohar, Paul A. Merolla, Dharmendra S. Modha, Alyosha Molnar, William P. Risk, III
  • Patent number: 10501581
    Abstract: Methods of making sequence-defined polymers and sequence-defined polymers. The methods are based on the orthogonal reactivity of monomers having at least two different functional groups. The sequence-defined polymers can be used in various applications. For example, the SDPs (e.g., pH sensitive SDPs) are used in cell lysis methods or as molecular vehicles to transport drug cargo into cells.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: December 10, 2019
    Assignee: Cornell University
    Inventors: Christopher Akinleye Alabi, Mintu Porel
  • Patent number: 10500253
    Abstract: The present disclosure provides compositions and methods for improving reproductive health of mammals and increasing milk production from female mammals. The methods involve administering an effective amount of IL-8 to a female mammal such that the reproductive health of the mammal is improved, or milk production from the mammal is increased, or the fat content of the milk is increased. In another aspect the disclosure includes prophylaxis and/or therapy of uterine conditions by administering IL-8 to a female mammal.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: December 10, 2019
    Assignee: Cornell University
    Inventor: Rodrigo Carvalho Bicalho
  • Publication number: 20190368057
    Abstract: Provided is an electrochemical reaction method that includes: immersing an anode and a cathode into a solution that includes azide ion (N3?), an alkene, and a transition metal catalyst; passing a current through the anode; and forming a diazide from the alkene. Related systems are also provided.
    Type: Application
    Filed: June 4, 2019
    Publication date: December 5, 2019
    Applicant: Cornell University
    Inventors: Song LIN, Niankai FU, Gregory Stuart SAUER
  • Publication number: 20190371892
    Abstract: Provided are a superlattice structure including a two-dimensional material and a device including the superlattice structure. The superlattice structure may include at least two different two-dimensional (2D) materials bonded to each other in a lateral direction, and an interfacial region of the at least two 2D materials may be strained. The superlattice structure may have a bandgap adjusted by the interfacial region that is strained. The at least two 2D materials may include first and second 2D materials. The first 2D material may have a first bandgap in an intrinsic state thereof. The second 2D material may have a second bandgap in an intrinsic state thereof. An interfacial region of the first and second 2D materials and an adjacent region may have a third bandgap between the first bandgap and the second bandgap.
    Type: Application
    Filed: May 31, 2019
    Publication date: December 5, 2019
    Applicants: Samsung Electronics Co., Ltd., THE UNIVERSITY OF CHICAGO, Center for Technology Licensing at Cornell University
    Inventors: Minhyun LEE, Jiwoong PARK, Saien XIE, Jinseong HEO, Hyeonjin SHIN
  • Patent number: 10494365
    Abstract: Embodiments of the present invention are directed to small molecule inhibitors of PHGDH. Other embodiments of the present invention relate to methods of treating cancers using the small molecule inhibitors of PHGDH disclosed herein. Still other embodiments of the present invention relate to methods for using the small molecule inhibitors of PHGDH to study serine metabolism.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: December 3, 2019
    Assignees: Cornell University, The Scripps Research Institute
    Inventors: Lewis C. Cantley, Edouard Mullarky, Costas Lyssiotis, Luke L. Lairson, Natasha Lucki
  • Patent number: 10495624
    Abstract: Provided are nanowire-coated fibers and compositions comprising one or more nanowire-coated fibers and methods of making the fibers and compositions. The fibers can be organic or inorganic fibers. The nanowires can be metallic or semiconducting nanowires. The nanowires are disposed on at least a portion of a surface of a fiber or fibers. The fibers and compositions can be used as barcodes (e.g., for anti-counterfeiting methods). The fibers and compositions also can be used as photodetectors (e.g., methods of detecting electromagnetic radiation).
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: December 3, 2019
    Assignees: Cornell University, University of Notre Dame du Lac
    Inventors: Juan P. Hinestroza, Masaru Kuno, Maksym Zhukovskyi
  • Patent number: 10485881
    Abstract: Described herein are nanoparticle drug conjugates (NDCs), which, in certain embodiments, comprise a non-toxic, multi-modality, clinically proven silica-based nanoparticle platform with covalently attached drug molecules/moieties. The nanoparticle drug conjugates (NDCs) demonstrate imaging capability and targeting ligands which efficiently clear through the kidneys. Furthermore, the conjugates incorporate therapeutic agents for cancer detection, prevention, and/or treatment.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: November 26, 2019
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University
    Inventors: Michelle S. Bradbury, Barney Yoo, Ulrich Wiesner, Kai Ma
  • Patent number: 10478489
    Abstract: The present invention relates to compositions and methods for the treatment and prevention of canine influenza virus (CIV) and CIV-related pathology. The present invention is based in part upon the discovery that various mutations in segment 1 and segment 2 of the CIV genome, thereby encoding mutant PB2 and PB1 protein, render the virus to be temperature-sensitive.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: November 19, 2019
    Assignees: University of Rochester, Cornell University
    Inventors: Luis Martinez-Sobrido, Aitor Nogales-Gonzalez, Colin Parrish
  • Patent number: 10474002
    Abstract: In one aspect, a method is provided for generating supercontinuum laser pulses within a continuous mid-infrared spectral range in a chalcogenide material. This method includes focusing an input laser beam of femtosecond pulses with a pulse energy higher than 10 microjoule along an optical path of the input laser beam; placing a chalcogenide material at a selected location along the optical path of the laser beam so that the laser intensity at the chalcogenide material is sufficiently high to cause nonlinear optical absorption that causes conversion of input optical energy into supercontinuum laser pulses of a pulse energy at or above a microjoule level at optical wavelengths within a broad continuous mid-infrared spectral range without damaging the chalcogenide material; and simultaneously moving the chalcogenide material laterally relative to the input laser beam to avoid damage to the chalcogenide material.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: November 12, 2019
    Assignee: Cornell University
    Inventors: Poul B. Petersen, Ashley Stingel
  • Patent number: 10472229
    Abstract: A method for fabricating a nanostructure utilizes a templated monocrystalline substrate. The templated monocrystalline substrate is energetically (i.e., preferably thermally) treated, with an optional precleaning and an optional amorphous material layer located thereupon, to form a template structured monocrystalline substrate that includes the monocrystalline substrate with a plurality of epitaxially aligned contiguous monocrystalline pillars extending therefrom. The monocrystalline substrate and the plurality of epitaxially aligned contiguous monocrystalline pillars may comprise the same or different monocrystalline materials.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: November 12, 2019
    Assignee: Cornell University—Cornell Center for Technology
    Inventors: Ulrich Wiesner, Michael Thompson, Hitesh Arora
  • Patent number: 10472679
    Abstract: Measurement of mRNAs in urinary cells offers a noninvasive means of diagnosing fibrosis in kidneys. One aspect of the invention is a method that includes: (a) measuring quantities of vimentin mRNA, NKCC2 mRNA, and E-cadherin mRNA in a test sample of cells obtained from urine; and (b) determining whether the vimentin mRNA quantity is higher, the NKCC2 mRNA quantity is lower, or the E-cadherin mRNA is higher than in healthy urinary cells; and thereby detecting that the sample is a fibrotic kidney sample. Step (a) can also include measuring the quantity of RNA expressed by a housekeeping gene (e.g., 18S rRNA). The quantities of vimentin mRNA, NKCC2 mRNA, and E-cadherin mRNA can be normalized against the quantity of housekeeping gene RNA.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: November 12, 2019
    Assignee: Cornell University
    Inventors: Manikkam Suthanthiran, Joseph E. Schwartz, Ruchuang Ding, Thangamani Muthukumar
  • Patent number: 10466571
    Abstract: Methods, systems, and devices are disclosed for implementing electro-optical modulators in which a resonating cavity structure is coupled to a transmission waveguide. In one example, the resonating structure includes a ring resonator whose coupling strength is controlled via an electrical control signal. The ring resonator is made of a capacitor comprising monolayer graphene sheets separated by a thick layer of dielectric material.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: November 5, 2019
    Assignee: Cornell University
    Inventors: Christopher Phare, Michal Lipson
  • Patent number: 10467245
    Abstract: This invention relates to a system and methods for determining the placement of an object in a distributed key-value store by mapping the object to nodes in multidimensional hyperspace. A search function supports efficient object retrieval, even when the search query requests multiple objects and specifies them through non-primary keys. In response to a search query, the search is translated into hyperregions in the hyperspace to determine the set of nodes that hold the queried data object. The number of contacted nodes and the number of scanned objects are significantly reduced in comparison to prior art techniques.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: November 5, 2019
    Assignee: Cornell University
    Inventors: Emin Sirer, Nicole L. Caruso, Bernard Wong, Robert Escriva
  • Patent number: PP31145
    Abstract: This invention relates to a new and distinctive variety of a Malus x domestica apple tree named ‘NY109’, particularly characterized by its overall superior horticultural performance and consistency, including excellent fruit quality at harvest by having firm, juicy, high sugar and high acid and flavorful fruit with great potential for marketing as both a fresh apple and as value-added processed apple products, such as for hard and sweet cider and for baking, is disclosed.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: December 3, 2019
    Assignee: Cornell University
    Inventors: Susan Brown, Kevin Maloney