Abstract: Devices, systems, and techniques are disclosed for intelligent semiconductor based medical tweezers and instrumentation including microscale sensors, actuators and circuitry for tissue detection and characterization. In one aspect, a tweezer device includes a hinge structure to enable tweezing motion of the device for clamping a sample, two leg components coupled to the hinge structure, a plurality of microprobes configured on both of the two leg components, and an electronic circuit electrically coupled to the microprobes to process and/or transmit the electronic signals. The microprobes include sensors in a sensing tip structured to penetrate into the sample when the device clamps the sample and produce electronic signals from the sensors of a property of the sample, the sensors of the sensing tip including at least one of an electrode to measure an electrical potential, an electrical permittivity sensor to measure electrical permittivity, or a strain gauge to measure mechanical compliance.
Type:
Grant
Filed:
August 7, 2014
Date of Patent:
December 31, 2019
Assignee:
Cornell University
Inventors:
Amit Lal, Fabrizio Michelassi, Po-Cheng Chen, Connie Wu
Abstract: This application discloses methods for treating or preventing an ophthalmic retinal vascular permeability, angiogenic or fibroproliferative disease, disorder or condition that involve administering to a patient in need thereof a composition that can inhibit mast cell migration into the vitreous or the retina, mast cell proliferation in the vitreous or the retina, or mast cell secretion into the vitreous or the retina.
Abstract: Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT, lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).
Type:
Application
Filed:
August 26, 2016
Publication date:
December 26, 2019
Applicants:
Cornell University, Dana-Farber Cancer Institute, Inc., Children's Medical Center Corporation
Inventors:
Nathanael S. Gray, David A. Scott, John Hatcher, Spandan Chennamadhavuni, Ari M. Melnick, Lorena Fontan Gabas, Hao Wu, Qi Qiao, Guangyan Du
Abstract: A stabilized emulsified acid composition for deep carbonate formation stimulation is provided. The stabilized acid emulsion composition includes a petroleum operable to provide a barrier between an acid and a reservoir rock, the acid operable to react with the reservoir rock to dissolve the reservoir rock and produce a wormhole, a functional framework operable to stabilize the stabilized acid emulsion, an emulsifier operable to stabilize the stabilized acid emulsion, and a corrosion inhibitor operable to provide protection against corrosion for the metal components of a well. The petroleum can be diesel. The acid can be hydrochloric acid. The functional framework can be selected from the group comprising surface-modified clay-based material, zeolites, hybrid organic-inorganic materials, covalent-organic framework materials, and boron nitride nanotubes, and combinations thereof. The functional framework can be a surface-modified clay material selected from an organoclay.
Type:
Application
Filed:
June 3, 2019
Publication date:
December 19, 2019
Applicants:
Saudi Arabian Oil Company, Cornell University
Inventors:
Amy J. Cairns, Ghaithan A. Al-Muntasheri, Mohammed Sayed, Liling Fu, Genggeng Qi, Emmanuel P. Giannelis
Abstract: Disclosed is a compound of formula (I): wherein R1, R2, R3, and are as defined herein. Also disclosed are methods for increasing mammalian cell NAD+ production and improving mitochondrial cell densities comprising administering to a cell the compound or a salt thereof.
Type:
Application
Filed:
August 26, 2019
Publication date:
December 19, 2019
Applicant:
Cornell University
Inventors:
Anthony Sauve, Farheen Sultana Mohammed, Yue Yang
Abstract: An event-driven neural network includes a plurality of interconnected core circuits is provided. Each core circuit includes an electronic synapse array has multiple digital synapses interconnecting a plurality of digital electronic neurons. A synapse interconnects an axon of a pre-synaptic neuron with a dendrite of a post-synaptic neuron. A neuron integrates input spikes and generates a spike event in response to the integrated input spikes exceeding a threshold. Each core circuit also has a scheduler that receives a spike event and delivers the spike event to a selected axon in the synapse array based on a schedule for deterministic event delivery.
Type:
Grant
Filed:
January 6, 2016
Date of Patent:
December 10, 2019
Assignees:
International Business Machines Corporation, Cornell University
Inventors:
Filipp Akopyan, John V. Arthur, Rajit Manohar, Paul A. Merolla, Dharmendra S. Modha, Alyosha Molnar, William P. Risk, III
Abstract: Methods of making sequence-defined polymers and sequence-defined polymers. The methods are based on the orthogonal reactivity of monomers having at least two different functional groups. The sequence-defined polymers can be used in various applications. For example, the SDPs (e.g., pH sensitive SDPs) are used in cell lysis methods or as molecular vehicles to transport drug cargo into cells.
Type:
Grant
Filed:
August 19, 2015
Date of Patent:
December 10, 2019
Assignee:
Cornell University
Inventors:
Christopher Akinleye Alabi, Mintu Porel
Abstract: The present disclosure provides compositions and methods for improving reproductive health of mammals and increasing milk production from female mammals. The methods involve administering an effective amount of IL-8 to a female mammal such that the reproductive health of the mammal is improved, or milk production from the mammal is increased, or the fat content of the milk is increased. In another aspect the disclosure includes prophylaxis and/or therapy of uterine conditions by administering IL-8 to a female mammal.
Abstract: Provided is an electrochemical reaction method that includes: immersing an anode and a cathode into a solution that includes azide ion (N3?), an alkene, and a transition metal catalyst; passing a current through the anode; and forming a diazide from the alkene. Related systems are also provided.
Type:
Application
Filed:
June 4, 2019
Publication date:
December 5, 2019
Applicant:
Cornell University
Inventors:
Song LIN, Niankai FU, Gregory Stuart SAUER
Abstract: Provided are a superlattice structure including a two-dimensional material and a device including the superlattice structure. The superlattice structure may include at least two different two-dimensional (2D) materials bonded to each other in a lateral direction, and an interfacial region of the at least two 2D materials may be strained. The superlattice structure may have a bandgap adjusted by the interfacial region that is strained. The at least two 2D materials may include first and second 2D materials. The first 2D material may have a first bandgap in an intrinsic state thereof. The second 2D material may have a second bandgap in an intrinsic state thereof. An interfacial region of the first and second 2D materials and an adjacent region may have a third bandgap between the first bandgap and the second bandgap.
Type:
Application
Filed:
May 31, 2019
Publication date:
December 5, 2019
Applicants:
Samsung Electronics Co., Ltd., THE UNIVERSITY OF CHICAGO, Center for Technology Licensing at Cornell University
Abstract: Embodiments of the present invention are directed to small molecule inhibitors of PHGDH. Other embodiments of the present invention relate to methods of treating cancers using the small molecule inhibitors of PHGDH disclosed herein. Still other embodiments of the present invention relate to methods for using the small molecule inhibitors of PHGDH to study serine metabolism.
Type:
Grant
Filed:
December 30, 2016
Date of Patent:
December 3, 2019
Assignees:
Cornell University, The Scripps Research Institute
Inventors:
Lewis C. Cantley, Edouard Mullarky, Costas Lyssiotis, Luke L. Lairson, Natasha Lucki
Abstract: Provided are nanowire-coated fibers and compositions comprising one or more nanowire-coated fibers and methods of making the fibers and compositions. The fibers can be organic or inorganic fibers. The nanowires can be metallic or semiconducting nanowires. The nanowires are disposed on at least a portion of a surface of a fiber or fibers. The fibers and compositions can be used as barcodes (e.g., for anti-counterfeiting methods). The fibers and compositions also can be used as photodetectors (e.g., methods of detecting electromagnetic radiation).
Type:
Grant
Filed:
January 27, 2016
Date of Patent:
December 3, 2019
Assignees:
Cornell University, University of Notre Dame du Lac
Inventors:
Juan P. Hinestroza, Masaru Kuno, Maksym Zhukovskyi
Abstract: Described herein are nanoparticle drug conjugates (NDCs), which, in certain embodiments, comprise a non-toxic, multi-modality, clinically proven silica-based nanoparticle platform with covalently attached drug molecules/moieties. The nanoparticle drug conjugates (NDCs) demonstrate imaging capability and targeting ligands which efficiently clear through the kidneys. Furthermore, the conjugates incorporate therapeutic agents for cancer detection, prevention, and/or treatment.
Type:
Grant
Filed:
September 21, 2018
Date of Patent:
November 26, 2019
Assignees:
Memorial Sloan Kettering Cancer Center, Cornell University
Inventors:
Michelle S. Bradbury, Barney Yoo, Ulrich Wiesner, Kai Ma
Abstract: The present invention relates to compositions and methods for the treatment and prevention of canine influenza virus (CIV) and CIV-related pathology. The present invention is based in part upon the discovery that various mutations in segment 1 and segment 2 of the CIV genome, thereby encoding mutant PB2 and PB1 protein, render the virus to be temperature-sensitive.
Type:
Grant
Filed:
August 19, 2016
Date of Patent:
November 19, 2019
Assignees:
University of Rochester, Cornell University
Inventors:
Luis Martinez-Sobrido, Aitor Nogales-Gonzalez, Colin Parrish
Abstract: In one aspect, a method is provided for generating supercontinuum laser pulses within a continuous mid-infrared spectral range in a chalcogenide material. This method includes focusing an input laser beam of femtosecond pulses with a pulse energy higher than 10 microjoule along an optical path of the input laser beam; placing a chalcogenide material at a selected location along the optical path of the laser beam so that the laser intensity at the chalcogenide material is sufficiently high to cause nonlinear optical absorption that causes conversion of input optical energy into supercontinuum laser pulses of a pulse energy at or above a microjoule level at optical wavelengths within a broad continuous mid-infrared spectral range without damaging the chalcogenide material; and simultaneously moving the chalcogenide material laterally relative to the input laser beam to avoid damage to the chalcogenide material.
Abstract: A method for fabricating a nanostructure utilizes a templated monocrystalline substrate. The templated monocrystalline substrate is energetically (i.e., preferably thermally) treated, with an optional precleaning and an optional amorphous material layer located thereupon, to form a template structured monocrystalline substrate that includes the monocrystalline substrate with a plurality of epitaxially aligned contiguous monocrystalline pillars extending therefrom. The monocrystalline substrate and the plurality of epitaxially aligned contiguous monocrystalline pillars may comprise the same or different monocrystalline materials.
Type:
Grant
Filed:
March 4, 2011
Date of Patent:
November 12, 2019
Assignee:
Cornell University—Cornell Center for Technology
Inventors:
Ulrich Wiesner, Michael Thompson, Hitesh Arora
Abstract: Measurement of mRNAs in urinary cells offers a noninvasive means of diagnosing fibrosis in kidneys. One aspect of the invention is a method that includes: (a) measuring quantities of vimentin mRNA, NKCC2 mRNA, and E-cadherin mRNA in a test sample of cells obtained from urine; and (b) determining whether the vimentin mRNA quantity is higher, the NKCC2 mRNA quantity is lower, or the E-cadherin mRNA is higher than in healthy urinary cells; and thereby detecting that the sample is a fibrotic kidney sample. Step (a) can also include measuring the quantity of RNA expressed by a housekeeping gene (e.g., 18S rRNA). The quantities of vimentin mRNA, NKCC2 mRNA, and E-cadherin mRNA can be normalized against the quantity of housekeeping gene RNA.
Type:
Grant
Filed:
May 15, 2013
Date of Patent:
November 12, 2019
Assignee:
Cornell University
Inventors:
Manikkam Suthanthiran, Joseph E. Schwartz, Ruchuang Ding, Thangamani Muthukumar
Abstract: Methods, systems, and devices are disclosed for implementing electro-optical modulators in which a resonating cavity structure is coupled to a transmission waveguide. In one example, the resonating structure includes a ring resonator whose coupling strength is controlled via an electrical control signal. The ring resonator is made of a capacitor comprising monolayer graphene sheets separated by a thick layer of dielectric material.
Abstract: This invention relates to a system and methods for determining the placement of an object in a distributed key-value store by mapping the object to nodes in multidimensional hyperspace. A search function supports efficient object retrieval, even when the search query requests multiple objects and specifies them through non-primary keys. In response to a search query, the search is translated into hyperregions in the hyperspace to determine the set of nodes that hold the queried data object. The number of contacted nodes and the number of scanned objects are significantly reduced in comparison to prior art techniques.
Type:
Grant
Filed:
September 21, 2015
Date of Patent:
November 5, 2019
Assignee:
Cornell University
Inventors:
Emin Sirer, Nicole L. Caruso, Bernard Wong, Robert Escriva
Abstract: This invention relates to a new and distinctive variety of a Malus x domestica apple tree named ‘NY109’, particularly characterized by its overall superior horticultural performance and consistency, including excellent fruit quality at harvest by having firm, juicy, high sugar and high acid and flavorful fruit with great potential for marketing as both a fresh apple and as value-added processed apple products, such as for hard and sweet cider and for baking, is disclosed.