Patents Assigned to Cornell University
  • Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis
    Patent number: 10736972
    Abstract: Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall nanoparticles at multiple times over the course of treatment in combination with a nutrient-depleted environment, thereby modulating cellular metabolic pathways to induce cell death by the mechanism ferroptosis. Ferroptosis involves iron, reactive oxygen species, and a synchronous mode of cell death execution.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: August 11, 2020
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University
    Inventors: Michelle S. Bradbury, Ulrich Wiesner, Michael Overholtzer, Howard Scher, Kai Ma
  • Electro-ultrasonic devices for nerve stimulation and treatment
    Patent number: 10737124
    Abstract: Methods, systems, and devices are disclosed for acoustic nerve stimulation. In one aspect, a system for acoustic nerve stimulation is disclosed. The system comprises an ultrasonic phased array chip device deployable into a living organism, the ultrasonic phased array chip device including a substrate and an acoustic signaling module on the substrate that includes an array of acoustic transducer elements operable to generate ultrasonic beams based on electronic control signals, capable to propagate the ultrasonic beams through biological nervous tissue to affect nervous signal firing; and a transmitter device wearable on an exterior of the living organism, wirelessly couplable with the ultrasonic phased array chip device to transmit the electronic control signals.
    Type: Grant
    Filed: March 16, 2016
    Date of Patent: August 11, 2020
    Assignee: Cornell University
    Inventor: Amit Lal
  • Mesoporous oxide nanoparticles and methods of making and using same
    Patent number: 10732115
    Abstract: Mesoporous oxide nanoparticles, compositions comprising such nanoparticle, and methods of making and using such nanoparticles. The nanoparticles (e.g., compositions comprising the nanoparticles) have an average size of less than 15 nm and a narrow size distribution. The nanoparticles can be used in imaging applications and delivery of molecular cargo (e.g., a drug) to an individual.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: August 4, 2020
    Assignee: Cornell University
    Inventors: Ulrich Wiesner, Kai Ma
  • Configurable image processing system and methods for operating a configurable image processing system for multiple applications
    Patent number: 10735675
    Abstract: A configurable image processing system can process image data for multiple applications by including an image sensor capable of operating in a machine vision mode and a photography mode in response to an operating system command. When operating in machine vision mode, the image sensor may send image data to first processor for machine vision processing. When operating in photography mode, the image sensor may send image data to an image coprocessor for photography processing.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: August 4, 2020
    Assignee: Cornell University
    Inventors: Mark Buckler, Adrian Sampson, Suren Jayasuriya
  • Double targeted constructs to affect tumor kill
    Patent number: 10716772
    Abstract: The present technology is directed to compounds, compositions, medicaments, and methods related to the treatment of cancers expressing PSMA. The compounds are of Formulas I & II or pharmaceutically acceptable salts thereof. The present technology is especially well-suited for use in treating prostate cancer.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: July 21, 2020
    Assignee: Cornell University
    Inventors: John W. Babich, James M. Kelly, Alejandro Amor-Coarasa, Shashikanth Ponnala
  • Method to match organ donors to recipients for transplantation
    Patent number: 10720226
    Abstract: This invention describes an allogenomics mismatch scoring method that estimates the genomic incompatibility between potential organ donors and a transplant recipient. The allogenomics method addresses immunological concerns and compares genotype information from matched, or potential, donors and recipients. The allogenomics method uses genomic data available before transplantation and predicts kidney graft function for greater than three years after transplantation. The strength of the inverse correlation between pre-transplantation genomic mismatches and transplant organ function increases with the time after transplantation: a low allogenomics mismatch score correlates with better acceptance and function of a donor transplant over time.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: July 21, 2020
    Assignee: Cornell University
    Inventors: Fabien Campagne, Laurent Mesnard, Manikkam Suthanthiran, Thangamani Muthukumar
  • METHODS AND COMPOSITIONS FOR CANCER TREATMENT
    Publication number: 20200222452
    Abstract: A method for treating leukemia is disclosed. The method comprises administering to a subject with leukemia an effective amount of a pharmaceutical composition comprising a naked iron oxide nanoparticle, wherein the composition is not loaded with an active agent. Also disclosed is a method for treating cancer. The method comprises administering an effective amount of a pharmaceutical composition comprising a metal oxide nanoparticle comprising a polymeric coating over a metal oxide core, wherein the nanoparticle is loaded with a reactive oxygen species (ROS)-inducing agent.
    Type: Application
    Filed: September 11, 2019
    Publication date: July 16, 2020
    Applicants: Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University
    Inventors: Jan GRIMM, Monica L. GUZMAN, Charalambos KAITTANIS
  • BIOABSORBABLE IMPLANT COMBINED WITH TISSUE-ENGINEERED COMPOSITE INTERVERTEBRAL DISC
    Publication number: 20200222200
    Abstract: The present disclosure describes an intervertebral disk replacement system. The system can include a tissue-engineered intervertebral disc that is combined with a bioresorbable stabilization system for structural guidance. The system can prevent or reduce intervertebral disk implant displacement and can increase the stiffness when compared to the implantation of the intervertebral disk implant without the stabilization system.
    Type: Application
    Filed: June 29, 2018
    Publication date: July 16, 2020
    Applicant: Cornell University
    Inventors: Roger Hartl, Lawrence Bonassar, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez
  • Multiblock copolymer films, methods of making same, and uses thereof
    Patent number: 10711111
    Abstract: A method for forming an isoporous graded film comprising multiblock copolymers and isoporous graded films. The films have a surface layer and a bulk layer. The surface layer can have at least 1×1014 pores/m2 and a pore size distribution (dmax/dmin)) of less than 3. The bulk layer has an asymmetric structure. The films can be used in filtration applications.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: July 14, 2020
    Assignees: Cornell University, Yale University
    Inventors: Ulrich B. Wiesner, Rachel M. Dorin, Joerg Werner, William A. Phillip
  • Isotactic polyethers and bimetallic catalysts, methods of making same, and uses thereof
    Patent number: 10711101
    Abstract: Provided are compositions comprising isotactic polyethers. Methods of making isotactic polyethers, and uses thereof are also disclosed. Also provided are bimetallic complexes that can be used as catalyst. Methods of making isotactic polyethers and bimetallic complexes and uses thereof are also disclosed. For example, a racemic bimetallic (salalen)CrCl polymerization catalyst was prepared and used alkyl diol, PO-oligomer triols, and aPPO and PCL diols as CSAs in order to produce ?,?-hydroxy telechelic iPPO. These telechelic polymers have controlled molecular weights and are semicrystalline. Amorphous ?,?-hydroxy telechelic PPO can also be produced by increasing the reaction temperature in conjunction with the use of CSAs.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: July 14, 2020
    Assignee: Cornell University
    Inventors: Geoffrey W. Coates, Matthew Ian Childers
  • MALT1 inhibitors and uses thereof
    Patent number: 10711036
    Abstract: Provided herein are compounds of Formula (I) and pharmaceutical compositions thereof, which may be useful as MALT1 inhibitors. Also provided are for the treatment of proliferative disorders (e.g., cancer (e.g., non-Hodgkin's lymphoma, diffuse large B-cell lymphoma, MALT lymphoma), benign neoplasm, a disease associated with angiogenesis, an autoimmune disease, an inflammatory disease, an autoinflammatory disease) by administering a compound of Formula (I).
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: July 14, 2020
    Assignees: Cornell University, Dana-Farber Cancer Institute, Inc., Children's Medical Center Corporation
    Inventors: Nathanael S. Gray, David A. Scott, John Hatcher, Spandan Chennamadhavuni, Ari M. Melnick, Lorena Fontan Gabas, Hao Wu, Qi Qiao, Guangyan Du
  • EFFICIENT SYNTHESIS OF NICOTINAMIDE MONONUCLEOTIDE
    Publication number: 20200216487
    Abstract: The invention provides a process for the preparation of nicotinamide mononucleotide having formula (I): The method involves the protection of nicotinamide riboside by ketalization, followed by phosphorylation and then deprotection to provide nicotinamide mononucleotide.
    Type: Application
    Filed: March 16, 2020
    Publication date: July 9, 2020
    Applicant: Cornell University
    Inventors: Anthony Sauve, Farheen Sultana Yang Mohammed
  • Low power asynchronous GPS baseband processor
    Patent number: 10705223
    Abstract: Asynchronous Global Positioning System (GPS) baseband processor architectures with a focus on minimizing power consumption. All subsystems run at their natural frequency without clocking and all signal processing is done on-the-fly.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: July 7, 2020
    Assignee: Cornell University
    Inventors: Rajit Manohar, Benjamin Tang, Stephen Longfield, Sunil A. Bhave
  • Compounds for MALT1 degredation
    Patent number: 10689366
    Abstract: Provided herein are bifunctional compounds that inhibit MALT1 and/or promote targeted ubiquitination for the degradation of MALT1. In particular, provided are compounds that can bind MALT1, a protein whose activity is responsible for constitutive NF-KB signaling in certain cancers (e.g., activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL)), and can assist in its degradation by recruiting an E3 ubiquitin ligase (e.g., Cereblon, VHL), which can ubiquitinate MALT1, marking it for proteasome degradation. Also provided are pharmaceutical compositions comprising the bifunctional compounds, methods of treating cancer with the bifunctional compounds, methods of promoting the degradation of MALT1, and methods of binding E3 ubiquitin ligase activity in a subject by administering a compound or composition described herein.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: June 23, 2020
    Assignees: Cornell University, Dana-Farber Cancer Institute, Inc.
    Inventors: Ari M. Melnick, Lorena Fontan Gabas, Nathanael S. Gray, David A. Scott, John Hatcher, Guangyan Du
  • Adjustable shoe and method for adjusting a shoe
    Patent number: 10687585
    Abstract: An adjustable shoe includes an outsole having a middle portion hingedly attached to a forefoot portion and a heel portion. A segmented driveshaft spans from the forefoot portion of the outsole to the heel portion. Rotation of a front segment of the driveshaft causes the forefoot portion of the outsole to rotate about a hinge axis thereby adjusting a forefoot angle. A first motor is connected to the driveshaft and operable to rotate the driveshaft. A processor is in communication with the first motor and programmed to operate the first motor to provide adjustment to the shoe. A method of adjusting a shoe includes receiving a signal representing a measured force on a portion of an outsole of the shoe. If the measured force exceeds a pre-determined threshold, a motor is activated to change an angle of a forefoot portion of the outsole relative to a middle portion.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: June 23, 2020
    Assignee: Cornell University
    Inventors: Mengyun Shi, John Stager, Thomas Tapen, Tianshu Liu, Huiju Park, Charles V. Beach, Jr.
  • METHODS FOR THE PREVENTION OR TREATMENT OF HEART FAILURE
    Publication number: 20200188470
    Abstract: The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Application
    Filed: February 20, 2020
    Publication date: June 18, 2020
    Applicants: Cornell University, University of Washington
    Inventors: Hazel H. Szeto, Peter S. Rabinovitch, Dao-Fu Dai
  • COMBINATION THERAPY FOR HEAD AND NECK CANCER
    Publication number: 20200179317
    Abstract: This invention relates to pharmaceutical composition and methods of using RXR agonist and/or RAR agonist for the treatment or prevention of head and neck cancer.
    Type: Application
    Filed: November 20, 2019
    Publication date: June 11, 2020
    Applicant: Cornell University
    Inventors: LORRAINE J. GUDAS, XIAO-HAN TANG, KWAME OSEI-SARFO, ALISON URVALEK
  • WAFER-BASED CHARGED PARTICLE ACCELERATOR, WAFER COMPONENTS, METHODS, AND APPLICATIONS
    Publication number: 20200187344
    Abstract: A wafer-based charged particle accelerator includes a charged particle source and at least one RF charged particle accelerator wafer sub-assembly and a power supply coupled to the at least one RF charged particle accelerator wafer sub-assembly. The wafer-based charged particle accelerator may further include a beam current-sensor. The wafer-based charged particle accelerator may further include at least a second RF charged particle accelerator wafer sub-assembly and at least one ESQ charged particle focusing wafer. Fabrication methods are disclosed for RF charged particle accelerator wafer sub-assemblies, ESQ charged particle focusing wafers, and the wafer-based charged particle accelerator.
    Type: Application
    Filed: August 12, 2019
    Publication date: June 11, 2020
    Applicant: Cornell University
    Inventors: Amit Lal, Thomas Schenkel, Arun Persaud, Qing Ji, Peter Seidl, Will Waldron, Serhan Ardanuc, Vinaya Kumar Kadayra Basavarajappa
  • Scalable terahertz phased array and method
    Patent number: 10680553
    Abstract: A device and method for terahertz signal generation are disclosed. Oscillators are arranged in a two-dimensional array, each oscillator connected to a corresponding antenna. Each oscillator is unidirectional connected to its adjacent oscillators by a phase shifter. A method for generating a steerable terahertz signal utilizes an array of oscillators connected by corresponding phase shifters. A terahertz signal having a fundamental frequency is generated using the array. The phase shift of one or more of the phase shifters is varied in order to vary the fundamental frequency and/or steer the signal generated by the array.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: June 9, 2020
    Assignee: Cornell University
    Inventors: Yahya Tousi, Ehsan Afshari
  • Nanofluidic channels with integrated charge sensors and methods based thereon
    Patent number: 10670559
    Abstract: An electrical detector is provided that comprises a nanofluidic channel with an integrated nanoscale charge sensor. The charge sensor can be an unfunctionalized nanowire, nanotube, transistor or capacitor and can be of carbon, silicon, carbon/silicon or other semiconducting material. The nanofluidic channel depth is on the order of the Debye screening length. Methods are also provided for detecting charged molecules or biological or chemical species with the electrical detector. Charged molecules or species in solution are driven through the nanofluidic channel of the electrical detector and contact the charge sensor, thereby producing a detectable signal. Methods are also provided for detecting a local solution potential of interest. A solution flowing through the nanofluidic channel of the electrical detector contacts the charge sensor, thereby producing a detectable local solution potential signal.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: June 2, 2020
    Assignee: Cornell University
    Inventors: John T. Mannion, Harold G. Craighead