Abstract: The present invention provides certain cortexolone derivatives of formula (I), and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. Another aspect of the invention relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of said pharmaceutical compositions as antitumor medicinal products.
Abstract: The invention relates to tablet comprising granules dispersed in at least one hydrophilic compound or matrix. The granules contain an active agent, at least one amphiphilic compound and at least one lipophilic compound. The tablet may include a gastro-resistant film coating.
Type:
Grant
Filed:
December 5, 2016
Date of Patent:
September 4, 2018
Assignee:
COSMO TECHNOLOGIES LTD.
Inventors:
Roberto Villa, Massimo Pedrani, Mauro Ajani, Lorenzo Fossati
Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
Type:
Application
Filed:
April 25, 2018
Publication date:
August 23, 2018
Applicant:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi MORO, Luigi Maria LONGO, Enrico FRIMONTI, Alessandro REPICI
Abstract: The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.
Type:
Application
Filed:
January 23, 2018
Publication date:
August 2, 2018
Applicant:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi MORO, Mauro Severino AJANI, Roberto VILLA, Giuseppe CELASCO, Alessandro REPICI
Abstract: The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, said endoscopic procedure preferably comprising the administration of said pharmaceutical composition to a human. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human.
Type:
Grant
Filed:
November 18, 2014
Date of Patent:
June 5, 2018
Assignee:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi Maria Longo, Luigi Moro, Enrico Frimonti, Alessandro Repici
Abstract: The present invention relates to methods for improving the detection of pathologies in the colon and method of flagging the mucosal lesions in the colon.
Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
Type:
Grant
Filed:
October 26, 2016
Date of Patent:
May 8, 2018
Assignee:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi Moro, Luigi Maria Longo, Enrico Frimonti, Alessandro Repici
Abstract: The present invention provides certain cortexolone derivatives of formula (I) and the same for use as antitumor active ingredients for the curative or adjuvant, or neoadjuvant or palliative treatment of precancerous lesions, dysplasias, metaplasias and tumor diseases, including malignant neoplasias and metastasis. Another aspect of the invention relates to pharmaceutical compositions comprising cortexolone derivatives of formula (I) as active ingredients and at least one physiologically acceptable excipient, and to the use of said pharmaceutical compositions as antitumor medicinal products.
Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
Type:
Application
Filed:
October 26, 2016
Publication date:
February 16, 2017
Applicant:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi MORO, Luigi Maria LONGO, Enrico FRIMONTI, Alessandro REPICI
Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
Type:
Grant
Filed:
May 13, 2016
Date of Patent:
December 20, 2016
Assignee:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi Moro, Luigi Maria Longo, Enrico Frimonti, Alessandro Repici
Abstract: The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, preferably said endoscopic procedure comprising the administration of said pharmaceutical composition to a human with the aim of improving and facilitating the resection of the lesion by raising the area where the lesion is located. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human. The invention herein disclosed also provides a kit for use in an endoscopic procedure, said kit comprising a pharmaceutical composition in form of emulsion or microemulsion, an endoscopic injection needle, a syringe and instructions for use thereof.
Type:
Application
Filed:
November 18, 2014
Publication date:
October 13, 2016
Applicant:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi Maria LONGO, Luigi MORO, Enrico FRIMONTI, Alessandro REPICI
Abstract: The invention provides a pharmaceutical composition in form of emulsion or microemulsion for use in an endoscopic procedure, said endoscopic procedure preferably comprising the administration of said pharmaceutical composition to a human. The invention herein disclosed provides a method for performing an endoscopic procedure, said method preferably comprising the administration of a pharmaceutical composition in form of emulsion or microemulsion to a human.
Type:
Application
Filed:
November 18, 2014
Publication date:
October 13, 2016
Applicant:
COSMO TECHNOLOGIES LTD
Inventors:
Luigi Maria LONGO, Luigi MORO, Enrico FRIMONTI, Alessandro REPICI
Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
Type:
Application
Filed:
May 13, 2016
Publication date:
September 8, 2016
Applicant:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi MORO, Luigi Maria LONGO, Enrico FRIMONTI, Alessandro REPICI
Abstract: The present application discloses solid compositions for the oral administration of dyes, and diagnostic use thereof. Preferably, such diagnostic use is aimed at the diagnostic evaluation of the gastrointestinal tract.
Type:
Application
Filed:
March 4, 2016
Publication date:
June 30, 2016
Applicant:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi MORO, Mauro Severino AJANI, Roberto VILLA, Giuseppe CELASCO, Alessandro REPICI
Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
Type:
Grant
Filed:
November 24, 2015
Date of Patent:
June 14, 2016
Assignee:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi Moro, Luigi Maria Longo, Enrico Frimonti, Alessandro Repici
Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
Type:
Application
Filed:
November 24, 2015
Publication date:
March 17, 2016
Applicant:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi MORO, Luigi Maria LONGO, Enrico FRIMONTI, Alessandro REPICI
Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
Type:
Grant
Filed:
November 18, 2014
Date of Patent:
January 5, 2016
Assignee:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi Moro, Luigi Maria Longo, Enrico Frimonti, Alessandro Repici
Abstract: The present invention relates to a pharmaceutical composition in form of emulsion or microemulsion and the use thereof as aid during endoscopic procedures in which it is injected in a target tissue in order to form a cushion. More in details, the invention relates to a method for performing an endoscopic procedure, which comprises injecting said pharmaceutical composition in form of emulsion or microemulsion in a target tissue of a patient, in order to form a cushion, which cushion is then optionally subjected to an endoscopic surgical procedure, such as a resection.
Type:
Application
Filed:
November 18, 2014
Publication date:
May 21, 2015
Applicant:
COSMO TECHNOLOGIES LTD.
Inventors:
Luigi MORO, Luigi Maria LONGO, Enrico FRIMONTI, Alessandro REPICI
Abstract: Pharmaceutical or dietary composition containing, as active ingredients, at least one short-chain fatty acid or salt, ester and/or amide thereof, in combination with a complex sugar and/or dietary fibre. The complex sugar and/or dietary fibre is selected from inulin, pectin, dextrin, maltodextrin or derivatives thereof and with one or more pharmacologically acceptable excipients. The composition has (a) a matrix consisting of lipophilic compounds with a melting point lower than 90° C. and optionally amphiphilic compounds in which the active ingredient are at least partially incorporated, (b) an amphiphilic matrix; and (c) an outer hydrophilic matrix in which the lipophilic matrix and the amphiphilic matrix are dispersed.
Type:
Application
Filed:
September 25, 2014
Publication date:
January 8, 2015
Applicant:
COSMO TECHNOLOGIES LTD.
Inventors:
Mauro AJANI, Roberto VILLA, Giuseppe CELASCO, Luigi MORO