Abstract: An apparatus (1) for cooling containers, in particular vials, comprising at least one first cooling zone (200) for receiving containers, with a cooling zone base and a cooling zone wall (201), and a cooling device (300) for cooling air, and a first duct (113) for conducting the cooled air from the cooling device (300) into the cooling zone (200), wherein an outlet of the first duct (113) is spaced apart from the cooling zone base.

Abstract: A release mechanism generates a force on a cable to operate an adjustment mechanism or the like in a seat or other device. The release mechanism includes a rotor, a housing, a spring, and a cover that attaches to the housing. The spring generates a torque, and the spring also axially biases the rotor into engagement with the cover to prevent rattling.

Abstract: In a process for thermally desorbing a phase material (20), in particular for conditioning a fiber for carrying out a solid-phase microextraction, the phase material (20) is heated along a temperature curve. The temperature curve of the phase material (20) during desorption includes at least one low point.

Abstract: The present invention provides a pharmaceutical formulation comprising clomipramine or its pharmaceutically acceptable salt (preferably, clomipramine hydrochloride) as the first active ingredient, and sildenafil or its pharmaceutically acceptable salt (preferably, sildenafil citrate) as the second active ingredient, wherein stability of clomipramine is improved, and a method for manufacturing this pharmaceutical formulation. In particular, the present invention provides a pharmaceutical formulation comprising the above two active ingredients and manufactured by using a wet granulation method, wherein stability of clomipramine is improved, and a method for manufacturing this pharmaceutical formulation.

Abstract: A device for activating a screw cap of a container comprises a first holding device for holding the screw cap, and a drive for activating the first holding device, wherein the first holding device is movable in a plane. The first holding device comprises a coupling device for the coupling of an external drive, and therefore the first holding device is movable in the plane.

Abstract: An industrial process using kestose hydrolases to enable the use of sugar mixtures containing 1-kestose in the industrial production of sucrose (as crystallized sugar) by providing a method for the conversion of 1-kestose into sucrose and fructose in a sugar solution, containing kestose and more than 10 mM sucrose (3 g/L), and comprising the enzymatic hydrolysis (preferably using 1-FEH enzymes—EC 3.2.1.153) of 1-kestose. The process further provides a method of producing a polypeptide having 1-kestose hydrolase activity and a composition comprising the polypeptide.

Abstract: The present invention relates to a pharmaceutical composition for treating, preventing or improving premature ejaculation, which is taken on demand prior to sexual activity, the composition comprising clomipramine hydrochloride in an amount of 14 to 16 mg, preferably about 15 mg, as an active ingredient. More preferably, the composition of the present invention further comprises pregelatinized starch and sodium starch glycolate. The pharmaceutical composition of the present invention can provide rapid onset of efficacy, reduce a dissolution (absorption) deviation according to the patient's gastrointestinal pH conditions and minimize side effects.

Abstract: The present invention relates to a pharmaceutical preparation for oral administration comprising, as an active ingredient, clomipramine or a pharmaceutically acceptable salt thereof; and a cation exchange resin and an anion polymer as a taste masking agent, wherein the pharmaceutical preparation can be orally administered even while comprising a pharmaceutically effective amount of clomipramine because the unique tastes of clomipramine, particularly, all of the bitter taste, spicy taste and burning taste are effectively masked, and thus the convenience of drug intake and portability is improved, and a method for manufacturing thereof.

Abstract: The present invention relates to a purgative composition containing polyethylene glycol and sodium picosulfate, wherein the stability of sodium picosulfate is improved by adding a pH controller. According to the present invention, the purgative composition ensures the stability of medicinal ingredients and has a great advantage of having a small dose even while showing a bowel cleansing rate greater than or equal to a commercial preparation, which should be taken in a large dose. In addition, according to the present invention, the composition has high compliance due to a good taste.

Abstract: The present application relates to a device for extracting volatile components from a sample received in a sample vessel, wherein the sample vessel is closed in a gas-tight manner. The device moreover has a discharge line and a supply line, which protrude into the sample vessel. The supply line comprises a first valve with which a flow of gas through the supply line can be throttled and/or interrupted. A suction opening of a pump is fluidically connected to the discharge line via a first fluid line, such that the pressure conditions in the device can be controlled by the capacity of the pump and by the setting of the first valve. A second fluid line fluidically connects the supply line to an output opening of the pump, such that sample vessel, supply line, discharge line and pump form a closed gas circuit. A trap element with at least one sorption material is fluidically connected to the first fluid line or the second fluid line.

Abstract: The present invention provides a pharmaceutical formulation comprising clomipramine or its pharmaceutically acceptable salt (preferably, clomipramine hydrochloride) as the first active ingredient, and sildenafil or its pharmaceutically acceptable salt (preferably, sildenafil citrate) as the second active ingredient, wherein stability of clomipramine is improved, and a method for manufacturing this pharmaceutical formulation. In particular, the present invention provides a pharmaceutical formulation comprising the above two active ingredients and manufactured by using a wet granulation method, wherein stability of clomipramine is improved, and a method for manufacturing this pharmaceutical formulation.

Abstract: The present invention relates to a pharmaceutical preparation comprising entecavir as an active ingredient, wherein an antioxidizing agent is added to enhance stability of entecavir, and a method for preparing the same. According to the present invention, the invention has an effect that entecavir can be stably maintained in a pharmaceutical preparation containing a certain amount or more of moisture by adding the antioxidizing agent, thereby a pharmaceutical preparation can be provided as a formulation containing a certain amount or more of moisture, for example, an orally disintegrating film formulation.

Abstract: In a method for performing a solid-phase micro-extraction, a holding device connected to an extraction device and secured on an adapter is held, while an actuating device connected to a guide device is moved. A device for performing a solid-phase microextraction comprises an actuating device connected to a guide device, and a holding device connected to an extraction device, wherein the extraction device is guided at least partially in the guide device, and wherein the extraction device is movable relative to the guide device by means of an actuation of the actuating device.

Abstract: A device for collecting a sample and for depositing the sample in a sample-receiving port of a measuring apparatus comprises a first connection element (8) with three connections for fluid, and a second connection element (7), and a hollow needle (5) for collecting and depositing the sample. A first feed line (9) for a first washing liquid is connected via a first pump to a first connection for fluid of the first connection element (8). A second feed line (10) for a second washing liquid is connected via a second pump to a second connection for fluid of the first connection element (8). A connection for fluid of the second connection element (7) is connected to the third connection for fluid of the first connection element (8), and the second connection element (7) is connected to a dosing device (1) and to the hollow needle (5). A valve (2) is arranged between the third connection for fluid of the first connection element (8) and the second connection element (7).

Abstract: The present invention relates to a novel Lactobacillus brevis G-101 strain capable of decomposing monosodium L-glutamate (MSG), and a functional health food, a pharmaceutical composition, or a food product comprising the same as an active ingredient. More specifically, the strain is effective in reducing in vivo blood MSG levels of animals and attenuating MSG Symptom Complex, and thus can be used in a functional health food, a pharmaceutical composition, or a food product aiming to prevent in vivo absorption of MSG, which is known to be harmful, and improve the MSG Symptom Complex.

Abstract: A device (1) for extracting an extraction material, in particular for solid-phase micro-extraction, comprises an extractor (130) and a tip (100) for penetrating a separating layer, wherein the extractor (130) is connected to the tip (100). In a method for extracting an extraction material from a container with an extraction device (1), a separating layer of the container is penetrated by a tip (100) of an extractor (130), and the extraction material is extracted.

Abstract: The present invention provides a method for preparing a film comprising a high amount of a sildenafil free base uniformly dispersed therein and having a suitable thickness and size, as well as flexibility providing good handling stability and being not prone to breaking. The present invention also provides a sildenafil free base-containing film prepared from the method.

Abstract: A round module opener for use with a round module of cotton disposed within a wrap, including a frame, an unload conveyor assembly that is supported by the frame and moves the round module of cotton in a first direction that is parallel to a longitudinal center axis of the round module opener, a slitter assembly that is secured to the frame and slices through the wrap along its entire length as the round module of cotton moves in the first direction, and a picker assembly including a plurality of projections, the picker assembly being rotatable so that the plurality of projections first pierce a first portion of the wrap and are subsequently withdrawn from the first portion of the wrap, thereby separating the first portion of the wrap from the round cotton module.

Abstract: The present application relates to a method for operating a dosing device with a control unit and a dosing unit. The dosing unit has a cannula with a first volume and a tip, and also a sampling container fluidically connected to the cannula. In a first step, the dosing unit is moved linearly at a predetermined speed in a first direction along an axis, such that the cannula is moved into a vessel containing at least one liquid. At the same time, fluid is aspirated constantly through the cannula with a predetermined volumetric flow by a pump device. At least one optical parameter of the aspirated fluid is measured by at least one optical sensor, which is arranged between the cannula and the sampling container. When a change of the at least one optical parameter is detected, a first position of the dosing unit on the axis is stored by the control unit and the movement of the dosing unit is interrupted.

Abstract: The present application relates to an actuation device for a piston of a syringe. The actuation device comprises a holder for a barrel of the syringe, a coupling which is linearly movable relative to the holder and has a seat into which the piston of the syringe can be inserted, at least one securing element with which the piston can be secured releasably in the seat, and a linear drive for the coupling. The coupling has at least two electrically conductive contact elements which are arranged inside the seat in order to come into contact with corresponding electrically conductive contact faces of the piston when the piston is inserted into the seat. The present application further relates to a sampling system with an actuation device and with at least one syringe, and also to a syringe suitable for the sampling system.