Abstract: Provided is a controlled-release formulation of tamsulosin hydrochloride, which includes a granular core, and a drug-coating layer coated on the granular core, including the tamsulosin hydrochloride and a release-controlling agent selected from the group consisting of (a) a first copolymer of 1 part by weight of ethylacrylate, 2 parts by weight of methylmethacrylate, and 0.1 parts by weight of trimethylammonioethyl methacrylate chloride, (b) a mixture of the first copolymer and a second copolymer of 1 part by weight of ethylacrylate, 2 parts by weight of methylmethacrylate, and 0.2 parts by weight of trimethylammonioethyl methacrylate chloride, the weight ratio between the first copolymer and the second copolymer being 1: 0.05 to 0.2, and (c) polyvinylacetate. A process for preparing the controlled-release formulation of the tamsulosin hydrochloride is also provided.

Abstract: The sample injection valve for high-performance liquid chromatography (HPLC) devices comprises a stator with inlets for the sample and the mobile phase, outlets leading to the chromatography column and to a waste collector, as well as connections for both ends of a sample loop. Its rotor has the customary connection channels. An additional washing liquid inlet (7) opens into the connecting channel (9) that, in one valve position, connects the sample inlet (1) to the outlet (2) leading to the waste collector. This enables the sample inlet and the pipette or syringe located therein to be rinsed.

Abstract: A cigarette making machine of the type wherein a portion of tobacco for one cigarette is compressed into a generally cylindrical form within a compressed tobacco chamber. The tobacco is thereafter axially moved and injected by an elongated spoon member into a preformed cigarette tube. A moveable wall member is actuated by a handle exteriorly of the machine through at least two toggle joints linking the moveable wall member to framing of the machine whereby to displace the moveable wall to transfer the tobacco in the tube. A first link of each toggle joint is in pivotal connection with the moveable wall member. A second link of each toggle joint is in pivotal connection with the framing of the machine. Each first link has a substantially rounded head portion at the free end thereof in operative contact with an abutment surface of the moveable wall member, for strengthening the pivotal connection therebetween.

Abstract: A compact cigarette making machine for compacting and inserting a quantity of tobacco into a preformed cigarette tube is described. A tobacco receiving member is slidably retained within a base and movable longitudinally thereon to load tobacco into a cigarette tube secured to a nipple at its forward end. A cover is pivotally secured to the rearward end of the tobacco receiving member and slidable therewith with respect to the base. The cover is pivotally movable from an open position to a closed position overlying the tobacco receiving member. The cover is substantially of the same width as the base and has a pair of opposed inner tongues engagable under a respective elongated flange which projects inside the open channel-shaped base from opposed side walls thereof when the tobacco receiving member is retracted rearwardly over the base. Accordingly, the cigarette making machine is very compact in dimension and can be easily carried by a user person.

Abstract: A web winding apparatus includes a frame support having a horizontal track arrangement; a first mandrel rotatably mounted at a first fixed position on the frame support above the track arrangement, for removably holding a core thereon; a second mandrel rotatably mounted at a second fixed position on the frame support above the track arrangement, for removably holding a core thereon; a motor drive for rotating the first and second mandrels; a carriage movable between first and second carriage positions along the track arrangement below the first and second fixed positions, respectively, for guiding a web onto the core on the first mandrel at the first carriage position and cutting the web thereat, and for guiding a web onto the core on the second mandrel at the second carriage position and cutting the web thereat, the carriage including a first support, first guide rollers mounted to the first support for riding along the linear track arrangement, second guide rollers mounted to the first support, a second sup

Abstract: A lap splicing apparatus for lap splicing first and second webs together, with each of the first and second webs alternately constituting a running web and a new web to be spliced to the running web, includes a frame; a first spindle mounted at a first fixed position on the frame for holding a roll containing the first web at a first orientation; a second spindle mounted at a second fixed position on the frame for holding a roll containing the second web at the first orientation; a single lap splicing device immovably mounted at a fixed position on the frame for lap splicing the first and second webs together with the trailing tail end of the lap splice always being on the same side; a first transfer assembly of rollers for bringing the first web to the lap splicing device, and for turning the first web by at least one angle from the first orientation; and second transfer assembly of rollers for bringing the second web to the lap splicing device, and for turning the second web by at least one angle from the f

Abstract: A method for packing unfilled cigarette tubes into a receptacle consists of the steps of feeding tubes to a conveyor, moving the tubes along the conveyor to a holding position, and laterally moving a predetermined number of tubes to a container. The container may then be pivoted vertically to deposit the tubes into the receptacle.

Abstract: In an apparatus for the packaging of unfilled cigarette tubes into boxes, a counter counts a predetermined number of tubes and these are subsequently advanced to a holding position and then pushed laterally into a containment member having substantially the same dimensions as a box into which the tubes are to be placed. The containment member is pivotable and rotatable and adapted to have a box positioned thereon. The box is filled with cigarette tubes from the containment member on pivoting and rotation of the containment member without any handling of tubes by the operator, thus avoiding damage to the tubes.

Abstract: A heat seal splice assembly for heat splicing first and second webs together, with each web alternately constituting a running web moving in first direction and a new web to be spliced to the running web upon depletion of the running web from a roll, includes a central guide having first and second sides, with the first web being located to the first side of the central guide and the second web being located to the second side of the central guide, the central guide having a hold down assembly for holding the new web to the central guide, a rotation assembly for rotating the central guide such that the new web held to one side of the central guide can be positioned to an opposite side of the central guide at which the running web is positioned, a clamping assembly for clamping the first and second webs together, a first heat seal assembly movable toward and away from the first side of the central guide to heat seal the first and second webs together against the first side of the central guide when the first a

Abstract: A preparation for inhibiting the release of mercury or to render mercury that is released when treating amalgam dental fillings or when inserting new amalgam fillings, harmless. The preparation contains at least 0.01 percent by weight of a physiologically acceptable organic sulphur compound, which includes at least one group chosen from SH and R.sub.1,-S.sub.n,-R.sub.2, where n=1--6. The use of such a preparation in mouth washes, mouth sprays, toothpastes, dental prophylactic pastes or rinsing/cooling liquids intended for use when drilling, abrading, polishing or cleaning with the aid of dental instruments. A therapeutic treatment preparation may include cysteine for rendering Hg harmless in solution form and/or gas form in the oral cavities of human beings and animals.

Abstract: A novel manufacturing method for membrane controlled programmable trans-dermal therapeutic systems (PTTS) comprises highly stabilized supersaturated drug solid solution system and easily adjustable controlled release membrane. The features of the programmable transdermal therapeutic system are as follows:1. The PTTS release drugs continuously through the skin with long duration into the systemic blood circulating system with adequate therapeutic effect.2. The release rate of the TTS can be pre-programmed to decrease day by day according to a schedule of decreased symptoms, so side effects may be relieved greatly.

Abstract: A subsea packer system for large diameter casings where an inflatable liner is connected in a string of casing and has an inner tubular drillable insert member with a longitudinal bypass passage. A string of tubing with a releasable running tool is connected to a casing well head on the casing for transport into a well bore and has an isolation seal member for closing off inflation ports which extend through the insert member to the inflatable packer. The bore of the insert member is sized to a bore diameter less than the bore diameter of the casing well head and is less than the diameter of the casing.

Abstract: A stage valve with particular use in cementing a well bore annulus where the stage valve has pressure operated valve member for opening a flow passage in the stage valve and the valve member has differential pressure areas which maintain the valve member open while a fluid moves through the flow passage in one direction and which can be closed by fluid moving in an opposite direction. The flow passage has a choke to develop a pressure differential from the flow of fluid. Spring members can be used with the valve member to close the flow passage when the pressure differential of the fluid flow in one direction is insufficient to maintain the valve member in an open position.

Abstract: A subsea packer system for large diameter casings where an inflatable liner is connected in a string of casing and has an inner tubular drillable insert member with a longitudinal bypass passage. A string of tubing with a releasable running tool is connected to a casing well head on the casing for transport into a well bore and has an isolation seal member for closing off inflation ports which extend through the insert member to the inflatable packer. The bore of the insert member is sized to a bore diameter less than the bore diameter of the casing well head and is less than the diameter of the casing.

Abstract: A system for inflating an inflatable packer located in a well bore on a liner where the inflatable packer has an inflation valve and a latching recess. An inflation tool with inner and outer assemblies is disposable by a string of tubing to a position within the inflatable packer where cup members on the outer assembly straddle the inflation valve and friction drag block members on the outer assembly are located in an annular recess above the inflation valve.

Abstract: A stage valve with particular use in cementing a well bore annulus above an inflatable packer located in a well bore on a liner where the stage valve has pressure operated outer sleeve members for opening a flow port in the stage valve and an inner sleeve member actuated by the trailing plug behind a liquid cement slurry to close the flow port whereupon spring members act on at least one of the outer sleeve members to close off the flow port on the exterior of the stage valve.

Abstract: A process for determining suitable parameters of temperature and/or pressure to use in a cementing operation in a wellbore to obtain a positive seal of cement in an annulus between a liner and a borehole wall after the cement has set up and where the process utilizes the parameters of differential temperature in a well bore, pressure on the cement to obtain a positive borehole wall stress (and positive seal) in a cementing operation.

Abstract: A method for determining a proper inflation pressure for an elongated inflatable packer to effect a positive contact stress seal of an elastomer packer element with a borehole wall in a wellbore traversing earth formations. The temperature differential for each layer in a radial plane is determined. The final contact stress, the finite inflation pressure required to inflate the packer element and the temperature differential are functionally interrelated to one another to obtain a final contact stress or the packer element with a borehole wall.

Abstract: A well tool having an anchor device, straddle packers above and below a port and an internal valve which are operated by longitudinal motion in an inflatable packer device. The well tool anchor is armed by a hydraulic operated plug and set upon downward motion in a locating profile groove in a well bore. The tool when attached to a string of tubing can be filled with cement slurry and downward motion used to anchor the well tool in a profile groove in an inflatable packer; to set the straddle packers above and below an access port on an inflatable packer; and then to open a valve to admit cement slurry to the inflatable packer. After filling the inflatable packer with cement slurry, an upward motion is used to close the valve, unset the straddle packers and release the anchor to move to another location where the operation can be repeated. At the conclusion of operations, a circulation valve is opened by pressure to reverse out cement slurry from the tubing string.