Patents Assigned to Curators of the University
  • Patent number: 11753622
    Abstract: The present invention provides a novel oocyte maturation medium or/and embryo culture medium with a chemically defined supplement to produce matured oocytes at high efficiency. The inventive medium or supplement comprises three growth factors, namely, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF-1) in a synergistic combination. Methods for oocyte and embryo culture are also provided.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: September 12, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Ye Yuan, Lee D. Spate, Randall S. Prather, R. Michael Roberts
  • Publication number: 20230282826
    Abstract: Various graphite additives were incorporated into the positive battery paste composition to compare their effects on the positive active mass utilization of lead-acid batteries. The disclosure is related to battery paste composition for preparing a lead-acid battery plate comprising a graphite additive selected from the group consisting of globular natural graphite, natural flake graphite, expanded flake graphite, and combinations thereof. The disclosure is also related to a battery paste composition comprising a sodium polymethacrylate dispersant. The disclosure is further related to batteries prepared by these battery paste compositions.
    Type: Application
    Filed: March 4, 2022
    Publication date: September 7, 2023
    Applicant: The Curators of the University of Missouri
    Inventors: Fatih Dogan, Julian Kosacki
  • Patent number: 11738324
    Abstract: Carbon dioxide (CO2) capture materials comprising one or more 3D-printed zeolite monoliths for the capture and or removal of CO2 from air or gases in enclosed compartments, including gases or mixtures of gases having less than about 5% CO2. Methods for preparing 3D-printed zeolite monoliths useful as CO2 capture materials and filters, as well as methods of removing CO2 from a gas or mixture of gases in an enclosed compartment using 3D-printed zeolite monoliths are provided.
    Type: Grant
    Filed: March 8, 2022
    Date of Patent: August 29, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Fateme Rezaei, Harshul V. Thakkar
  • Patent number: 11707077
    Abstract: Provided are engineered meat products formed as a plurality of at least partially fused layers, wherein each layer comprises at least partially fused multicellular bodies comprising non-human myocytes and wherein the engineered meat is comestible. Also provided are multicellular bodies comprising a plurality of non-human myocytes that are adhered and/or cohered to one another; wherein the multicellular bodies are arranged adjacently on a nutrient-permeable support substrate and maintained in culture to allow the multicellular bodies to at least partially fuse to form a substantially planar layer for use in formation of engineered meat. Further described herein are methods of forming engineered meat utilizing said layers.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: July 25, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Gabor Forgacs, Francoise Marga, Karoly Robert Jakab
  • Patent number: 11667995
    Abstract: A cast iron alloy is provided with a composition in weight percent (wt. %) of carbon between 2.6 to 3.4 wt. %, silicon between 2.4 to 3.2 wt. %, manganese between 0.3 to 0.6 wt. %, molybdenum between 0.4 to 1.2 wt. %, nickel between 0.6 to 1.75 wt. %, magnesium between 0.01 to 0.075 wt. %, aluminum between 1.8 to 3.5 wt. %, sulfur between 0.003 to 0.025 wt. %, zirconium between 0.001 to 0.02 wt. %, cerium between 0.001 to 0.03 wt. %, lanthanum between 0.0005 to 0.02 wt. %, and a balance of iron and unavoidable trace elements. A part formed from the cast iron alloy is also provided and the part has an Ac1 temperature equal to or greater than 895° C. and a thermo-mechanical fatigue lifetime of at least 10,000 cycles when cycled between 400° C. to 800° C. with a total cyclic strain equal to 0.001 m/m.
    Type: Grant
    Filed: September 21, 2021
    Date of Patent: June 6, 2023
    Assignees: Ford Global Technologies, LLC, The Curators of the University of Missouri
    Inventors: Larry Alan Godlewski, Mei Li, Carlos Engler-Pinto, Simon Naymovich Lekakh
  • Patent number: 11660354
    Abstract: Described herein are novel conjugates containing an inhibitor (e.g., a PSMA inhibitor, e.g., a gastrin-releasing peptide receptor inhibitor) and metal chelator that are covalently attached to a macromolecule (e.g., a nanoparticle, a polymer, a protein). Such conjugates exhibit distinct properties over the free, unbound inhibitor/chelator construct.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: May 30, 2023
    Assignees: Memorial Sloan Kettering Cancer Center, Cornell University, The Curators of the University of Missouri
    Inventors: Michelle S. Bradbury, Thomas P. Quinn, Barney Yoo, Wolfgang Weber, Karim Touijer, Howard Scher, Kai Ma, Ulrich Wiesner
  • Patent number: 11648512
    Abstract: Described herein are novel emulsion liquid membranes useful for extracting pollutants from industrial wastewater and water. The emulsion liquid membranes include, in various phases, at least one of nanoparticles, an ionic liquid, and combinations of nanoparticles and ionic liquids. Use of the present emulsion liquid membranes enhances the separation and the stability of the ELM method for pollutant extraction and recovery from wastewater and water.
    Type: Grant
    Filed: October 29, 2020
    Date of Patent: May 16, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Muthanna Al-Dahhan, Qusay Al-Obaidi
  • Patent number: 11647864
    Abstract: A heat loss protection lid for a thermal liquid container system, wherein the heat loss protection lid comprises a central body, a liquid ingress opening formed within the central body, a liquid dispensing opening formed within one of a peripheral edge of the central body or a lip formed around the peripheral edge of the central body. and a concealed air intake hole.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: May 16, 2023
    Assignee: The Curators of the University of Missouri
    Inventor: Hongbin Ma
  • Publication number: 20230096442
    Abstract: A method for manufacturing a metal alloy component. The method comprises heating a shaped metal component and an alloying element source of vapor-phase transportable alloying element species in a reactor in the presence of a vapor-phase transport agent, wherein the heating is conducted under conditions which cause the vapor-phase transportable alloying element species to diffuse into the shaped metal component; and forming a metal alloy component alloyed with element species from the alloying element source.
    Type: Application
    Filed: September 26, 2022
    Publication date: March 30, 2023
    Applicant: The Curators of the University of Missouri
    Inventors: David W. Lipke, Andrew S. King, Ryan D. Dempsey
  • Patent number: 11613807
    Abstract: A method of depositing a nanoscale-thin film onto a substrate is disclosed. The method generally comprises depositing a layer of a solid or gaseous state functionalizing molecule onto or adjacent to the first surface of the substrate and exposing the first surface to a source of ionizing radiation, thereby functionalizing the first surface of the substrate. Once the layer of functionalizing molecule is removed, a nanoscale-thin film is then deposited onto the functionalized first surface of the substrate.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: March 28, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Matthew R. Maschmann, Matthias J. Young
  • Publication number: 20230085990
    Abstract: A cast iron alloy is provided with a composition in weight percent (wt.%) of carbon between 2.6 to 3.4 wt.%, silicon between 2.4 to 3.2 wt.%, manganese between 0.3 to 0.6 wt.%, molybdenum between 0.4 to 1.2 wt.%, nickel between 0.6 to 1.75 wt.%, magnesium between 0.01 to 0.075 wt.%, aluminum between 1.8 to 3.5 wt.%, sulfur between 0.003 to 0.025 wt.%, zirconium between 0.001 to 0.02 wt.%, cerium between 0.001 to 0.03 wt.%, lanthanum between 0.0005 to 0.02 wt.%, and a balance of iron and unavoidable trace elements. A part formed from the cast iron alloy is also provided and the part has an Ac1 temperature equal to or greater than 895° C. and a thermo-mechanical fatigue lifetime of at least 10,000.00 cycles when cycled between 400° C. to 800° C. with a total cyclic strain equal to 0.001 m/m.
    Type: Application
    Filed: September 21, 2021
    Publication date: March 23, 2023
    Applicants: Ford Global Technologies, LLC, The Curators of the University of Missouri
    Inventors: Larry Alan Godlewski, Mei Li, Carlos Engler-Pinto, Simon Naymovich Lekakh
  • Publication number: 20230072201
    Abstract: A mobile robot system and method for determining the stiffness of a human arm while moving with a user during overground interaction as the user holds the robot's handle and exchanges forces with it. A mobile base moves with the user, a robot arm interacts with the user, and a controller determines the stiffness. The robot arm includes servomotors driving a linkage mechanism, an end effector including the handle supported by the linkage mechanism, and a force transducer measuring a force applied by the user to the handle. The controller causes the robot arm to generate a force perturbation at the handle, measure a peak velocity achieved by the human arm, determine the stiffness of the human arm as a function of force and displacement, and control operation of the system based on the determined stiffness. A robot body may allow for adjusting the height of the robot arm.
    Type: Application
    Filed: September 7, 2022
    Publication date: March 9, 2023
    Applicant: The Curators of the University of Missouri
    Inventors: Sambad Regmi, Yun Seong Song
  • Publication number: 20230070476
    Abstract: The present invention is directed to processes for ionizing one or more lanthanide isotopes, processes for separating lanthanide isotopes, various apparatus and systems useful for these processes, and compositions prepared from these processes.
    Type: Application
    Filed: January 31, 2022
    Publication date: March 9, 2023
    Applicant: The Curators of the University of Missouri
    Inventors: John Gahl, John David Robertson, Peter Norgard, Brad Jeffries, Valentina O'Donnell
  • Patent number: 11558036
    Abstract: A class of design topologies in the field of nonlinear networks (NLN) or nonlinear transmission lines (NLTL) that re-utilize direct current (DC) and low-frequency (LF) signal content reflected from a load or an output filter to yield increased pulse to radio frequency conversion efficiency and increased overall system efficiency. A nonlinear transmission line topology comprises a plurality of series inductive elements and a plurality of nonlinear capacitive elements. The inductive elements and the capacitive elements are arranged in a periodic structure forming a nonlinear network. An output coupling circuit connected across an output of the nonlinear network is configured to transmit high-frequency content to a load and to reflect back direct current and low-frequency content into the nonlinear network.
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: January 17, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Plamen Doynov, Anthony Caruso
  • Patent number: 11549048
    Abstract: This invention is broadly concerned with compositions and processes for oilfield applications. More specifically, this invention relates to novel polymer constructed packages that, when pumped into a petroleum well, provide tunable characteristics of transformation and delayed self-assembly with each other under reservoir conditions to yield strong, elastic, bulk gel materials. The compositions comprise a polymer, assembling agents, and optional additives used for the re-assembly stage are uniformly-distributed within the initial gel particles. The polymer particle packages absorb water and swell upon exposure to water, thus exposing the “assembling agents” that enable re-assembly. Both swelling and re-assembly are proportionally controlled via compositions to be tunable to allow functional dispersion and subsequent self-assembly under various reservoir conditions.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: January 10, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Jingyang Pu, Baojun Bai, Thomas Schuman
  • Patent number: 11551932
    Abstract: The present invention relates to various high quality n-type and p-type doped gallium-based semiconductor materials, electronic components incorporating these materials, and processes of producing these materials. In particular, The present invention relates processes to achieve high quality, uniform doping of a whole wafer or a thin layer of gallium-based semiconductor materials for various applications such as a vertical power transistor or diode.
    Type: Grant
    Filed: June 18, 2020
    Date of Patent: January 10, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Jae Wan Kwon, Quang Nguyen
  • Patent number: 11547720
    Abstract: Ayurvedic encapsulated gold nanoparticles, methods of fabrication and methods of treatment are provided. A method of fabrication includes mixing dried gooseberry product or mango peel product or phytochemical existent therein, into a liquid medium to form a reducing agent solution. Gold salts are mixed into the reducing agent solution. Reaction of the gold salts proceeds, in the absence of any other reducing agent, to form a nanoparticle solution of stabilized, biocompatible Ayurvedic encapsulated gold nanoparticles. An Ayurvedic medicine consists of a non-radioactive gold nanoparticle encapsulated with phytochemical existent in mango peal or gooseberry in a capsule with curcumin extract and gum Arabic.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: January 10, 2023
    Assignee: The Curators of the University of Missouri
    Inventors: Kattesh Katti, Menka Khoobchandani, Kavita Katti, Alsam Khan, Chintamani Joshi, Vinay Mutalik
  • Publication number: 20220412422
    Abstract: An elastic wave cloaking lattice-based metamaterial for cloaking an object within a void includes a lattice of connected unit cells arranged to form a void, each unit cell comprising a mass and a plurality of connecting springs, the mass coupled by the plurality of connecting springs to masses in adjacent unit cells, the plurality of connecting springs comprising at least two large springs of a first length and at least two short springs of a second length, the first length greater than the second length, the springs and masses having relational and mechanical characteristics to facilitate elastic wave cloaking in the totality of the lattice. The lattice as a whole has metamaterial properties resulting from the positional relationship and mechanical properties of masses and connecting springs of the unit cells such that the lattice at least partially cloaks an object or material portioned within the void from elastic waves.
    Type: Application
    Filed: February 24, 2022
    Publication date: December 29, 2022
    Applicant: The Curators of the University of Missouri
    Inventors: Guoliang Huang, Hussein Nassar, Yangyang Chen, Xianchen Xu
  • Patent number: 11529328
    Abstract: A method for forming crystalline solid dispersions (CSDs) of a pharmaceutical agent with low water solubility is described. The properties of the CSDs are described. Also described is the enhancement of bioavailability of the pharmaceutical agent resulting from formation of the CSD.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: December 20, 2022
    Assignee: The Curators of the University of Missouri
    Inventors: Albert N. Ngo, Bi Botti Youan
  • Patent number: 11524907
    Abstract: One aspect of the present invention is directed to a granular filter media for removing contaminants from water or other liquids. The media comprise granular materials comprising aggregate and remediation materials. Other aspects of the invention are directed to methods of making and using the granular filter media of the invention.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: December 13, 2022
    Assignee: The Curators of the University of Missouri
    Inventors: John T. Kevern, Megan L. Hart