Patents Assigned to Curators of the University
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Patent number: 11518978Abstract: Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion.Type: GrantFiled: December 19, 2019Date of Patent: December 6, 2022Assignee: The Curators of the University of MissouriInventors: Gabor Forgacs, Francoise Suzanne Marga, Cyrille Norotte
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Patent number: 11515161Abstract: Doped nitride-based semiconductor materials and methods of producing these materials are described herein.Type: GrantFiled: April 17, 2020Date of Patent: November 29, 2022Assignee: The Curators of the University of MissouriInventors: Jae Wan Kwon, John Gahl, John Brockman
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Patent number: 11503823Abstract: The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.Type: GrantFiled: September 5, 2019Date of Patent: November 22, 2022Assignees: The Curators of the University of Missouri, The Trustees of Columbia UniversityInventors: James L. Cook, Clark T. Hung, Eric Lima, Aaron Stoker
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Patent number: 11474141Abstract: Methods and apparatuses for using the impedance inhomogeneity pattern (IIP) of a transmission line, or one or more segments thereof, to verify the identity of the transmission line and/or detect whether or not the transmission line has been altered or tampered with. Because the impedance inhomogeneity pattern of a transmission line is unique, unpredictable, and uncontrollable, it can be used as a physical unclonable function (PUF). The IIP can be obtained by a method such as frequency domain reflectometry or time domain reflectometry, and is then compared with a previously stored intrinsic IIP obtained from a transmission line (or segment(s)) prior to first use through the use of, for example, correlation or coherence functions. The method can be used on any transmission line, including electrical, optical and acoustic transmission lines.Type: GrantFiled: February 6, 2020Date of Patent: October 18, 2022Assignees: University of Rhode Island Board of Trustees, The Curators of the University of MissouriInventors: Tao Wei, Jie Huang
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Patent number: 11447550Abstract: This disclosure relates to synthetic ligands for detecting PD-L1 in a sample or subject. The ligand can be labeled with a variety of detectable labels allowing of visualization and quantification. The ligand provides an alternative PD-L1 binding molecule with advantages over current antibody technologies for detecting PD-L1.Type: GrantFiled: September 27, 2017Date of Patent: September 20, 2022Assignee: The Curators of the University of MissouriInventors: Raghuraman Kannan, Charles Caldwell, Jr., Vitukudi Narayanaiyengar Balaji, Govardhan Aadharsh Balaji
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Publication number: 20220280101Abstract: The present disclosure generally relates to smart bandages comprising a dressing and pressure sensor. The pressure sensor measures at least one pressure reading at a wound area while the dressing bandages the wound area. The pressure sensor includes a force sensitive film configured to generate a pressure signal based on pressure applied thereto and is operably coupled to the dressing such that pressure applied to the wound area is coupled to the force sensitive film via the dressing. A near field communication device of the pressure sensor is operably coupled to the force sensitive film for reporting the pressure signal. The smart bandage may include a user interface that is configured to display reported signals to a user for comparing the pressure at the wound area with a threshold pressure. The disclosure further provides a method of treating the wound area by applying the smart bandage to the wound area.Type: ApplicationFiled: March 4, 2022Publication date: September 8, 2022Applicant: The Curators of the University of MissouriInventors: Xueju Wang, Carolyn Crumley
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Publication number: 20220280079Abstract: Improved sensor compositions comprising a dye are provided. The compositions are generally characterized by at least partially immobilizing the dye on polymeric microparticles and dispersing in a dispersion medium. The dye may comprise an oxygen, humidity, carbon dioxide, temperature, or pH-responsive dye. Also provided is a sensor patch comprising a substrate and the sensor composition comprising a dye.Type: ApplicationFiled: March 3, 2022Publication date: September 8, 2022Applicant: The Curators of the University of MissouriInventors: Chang-Soo Kim, William Stoecker, Paul Nam, Mousumi Bose, Jason Hagerty
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Patent number: 11426357Abstract: A method for forming encapsulated gold nanoparticles mixes mangiferin into a liquid medium to form a reducing agent solution. Gold salts are mixed into the reducing agent solution. Reaction of the gold salts is permitted, in the absence of any other reducing agent, to form a nanoparticle solution of stabilized, biocompatible gold nanoparticles coated with mangiferin. The gold salts can consist of AuCl4, or can consist of radioactive gold salts. A cancer therapy method injects a solution of mangiferin encapsulated gold nanoparticles directly into a solid tumor. A solution consisting of an aqueous or alcoholic medium and mangiferin encapsulated gold nanoparticles is provided. The mangiferin encapsulated gold nanoparticles can have core sizes of ˜5-20 nm and total sizes of ˜20-120 nm.Type: GrantFiled: October 3, 2017Date of Patent: August 30, 2022Assignee: The Curators of the University of MissouriInventors: Kattesh Katti, Cathy Cutler, Menka Khoobchandani, Kavita Katti
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Patent number: 11422134Abstract: Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.Type: GrantFiled: April 29, 2019Date of Patent: August 23, 2022Assignee: The Curators of the University of MissouriInventors: Mahmoud Almasri, Shibajyoti Ghosh Dastider, Shuping Zhang, Majed El Dweik, Nuh Sadi Yuksek, Ibrahem Jasim, Jiayu Liu
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Patent number: 11401498Abstract: Herein a Bacillus exosporium antigen delivery (BEAD) system that provides a means to introduce recombinant proteins or small molecules into the exosporium of members of the B. cereus family of bacteria, i.e. B. anthracis, B. cereus, and B. thuringiensis, is disclosed. The system results in the surface display of recombinant proteins or small molecules such that they can stimulate an immune response. In addition, methods of making and using the system are described.Type: GrantFiled: April 27, 2018Date of Patent: August 2, 2022Assignee: The Curators of the University of MissouriInventors: George C. Stewart, Brian Matthew Thompson
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Patent number: 11352379Abstract: The present disclosure provides a new series of compounds exhibiting high fluorescence quantum yields in the solid state. In one embodiment, the compounds include a series of 2,3,4,5-tetraphenylgermoles with the same or different 1,1-substituents. In another embodiment, substituted germafluorenes, germa-fluoresceins/rhodamines, and germapins are described. These germanium heterocycles possess ideal photophysical and thermostability properties, which makes them excellent candidates for chemical or biological sensors, host materials for electroluminescent devices and solar cells, and emissive and/or electron-transport layer components in organic light emitting diode devices.Type: GrantFiled: March 29, 2019Date of Patent: June 7, 2022Assignee: The Curators Of The University Of MissouriInventors: Janet Braddock-Wilking, Teresa Lynn Bandrowsky, James Bryan Carroll, II
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Patent number: 11338036Abstract: The disclosure relates generally to methods and compositions of treating or preventing diabetes mellitus by administering to a subject a composition comprising an amount of stem and/or progenitor cells and at least one antigen-specific therapy.Type: GrantFiled: March 10, 2014Date of Patent: May 24, 2022Assignee: The Curators of the University of MissouriInventor: Habib Zaghouani
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Patent number: 11334824Abstract: A resource optimization system is offered for use in managing large scale projects. The resource optimization system has a resource optimization tool configured to receive a plurality of inputs. The plurality of inputs represent at least one task associated with the large scale project and are inputted into a resource optimization tool for a data processing procedure. An optimization module is contained within the resource optimization tool and configured to perform the data processing procedure on each of the plurality of inputs as well as exogenous disturbances inputted into the optimization module. The optimization module returns an optimization result based on the data processing procedure to reflect the management and progress of the project under evaluation.Type: GrantFiled: February 1, 2018Date of Patent: May 17, 2022Assignee: The Curators of the University of MissouriInventors: Haitao Li, Ceki Halmen, Liu Yang
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Patent number: 11314096Abstract: A system and method for performing Optical Coherence Tomography on a sample utilizes collimated, phase modulated beams of light in an interferometer. At least one of the beams of light utilized exists as an Airy beam for at least a portion of the procedure, obviating any deleterious impact caused by the Gaussian beam diffraction. The system may incorporate a light source, polarization beam splitter, delay line, non-polarization beam splitters, lenses, phase masks, waveplates, and mirrors, any or all of which may be controlled by a computing element.Type: GrantFiled: June 20, 2019Date of Patent: April 26, 2022Assignee: The Curators of the University of MissouriInventors: Ping Yu, Lixin Ma
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Publication number: 20220123346Abstract: A multi-cell electrochemical reaction cell structure for a flow battery or fuel cell having a plurality of cells electrically connected in series or parallel. A first housing has a pair of mating end plates assembled together, each forming a plurality of recesses in which one of the cells is received. One of the end plates has a projection along its perimeter and the other one of the end plates has a groove along its perimeter. The projection is configured to fit within the groove in a mating relationship to seal the housing when the end plates are engaged with each other. A second housing is a tubular shell in which a plurality of tubular flow cell units electrically connected in parallel are housed. Catholyte flows in the tubular flow cell units and anolyte flows in the tubular shell.Type: ApplicationFiled: October 20, 2021Publication date: April 21, 2022Applicant: The Curators of the University of MissouriInventors: Jonghyun Park, Hiep Pham, Ian Wolf
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Patent number: 11298675Abstract: Carbon dioxide (CO2) capture materials comprising one or more 3D-printed zeolite monoliths for the capture and or removal of CO2 from air or gases in enclosed compartments, including gases or mixtures of gases having less than about 5% CO2. Methods for preparing 3D-printed zeolite monoliths useful as CO2 capture materials and filters, as well as methods of removing CO2 from a gas or mixture of gases in an enclosed compartment using 3D-printed zeolite monoliths are provided.Type: GrantFiled: September 20, 2018Date of Patent: April 12, 2022Assignee: The Curators of the University of MissouriInventors: Fateme Rezaei, Harshul V. Thakkar
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Patent number: 11241353Abstract: The present invention is an apparatus and method for use in a treatment for prevention of arthrofibrosis that includes a first and a second substantially L-shaped frames, each L-shaped frame having a first member and a second member extending from the first member in a substantially perpendicular direction and terminating in a first end, a fixed plate extending between the first members of the L-shaped frames, the fixed plate being parallel with the first members of the L-shaped frames, a movable plate pivotally coupled to the first ends of the first members of the L-shaped frames with, a pneumatic piston coupled to the movable plate and the fixed plate, a hand operated valve operatively coupled to the pneumatic piston and a goniometer coupled to the movable plate and one of the L-shaped frames, the goniometer adapted and configured to indicate the angle between the movable plate and the fixed plate.Type: GrantFiled: November 5, 2018Date of Patent: February 8, 2022Assignee: The Curators of the University of MissouriInventors: James L. Cook, Cory Crecelius, Trent Guess, Kylee Rucinski, Jonathan Williams
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Publication number: 20220013118Abstract: Methods and system for testing a voice-enabled device. A signal generator generates a carrier signal having a variable resonant frequency, and a frequency mixer mixes an audible voice command signal with the carrier signal to generate an inaudible amplitude-modulated test signal. An antenna transmits the amplitude-modulated test signal at a variable attack angle to a voice-enabled device. The resonant frequency of the carrier signal and/or the attack angle of the transmitted amplitude-modulated signal are varied and at least one of a sensitive frequency and a sensitive attack angle of the voice-enabled device is identified.Type: ApplicationFiled: June 16, 2021Publication date: January 13, 2022Applicant: The Curators of the University of MissouriInventors: Chulsoon Hwang, Zhifei Xu, Jun Fan
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Patent number: 11214729Abstract: The present invention generally relates to the composition of particle gels for CO2-EOR and CO2 storage. More particularly, CO2 resistant particle gels are provided that can re-crosslink at subterranean conditions. These particle gels can be deployed to improve the conformance of CO2 flooding, CO2 huff-puff, or Water-Alternative-Gas (WAG). The applications may also involve CO2 storage, such as the blocking of CO2 leakage and similar CO2 processing.Type: GrantFiled: August 27, 2019Date of Patent: January 4, 2022Assignee: The Curators of the University of MissouriInventors: Yifu Long, Baojun Bai, Thomas P. Schuman
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Patent number: 11213512Abstract: Compositions comprising bis(tryptophan) derivatives are provided that act as antimicrobials. Also provided are methods for reversing antibiotic resistance in a bacterium, or recovering or enhancing antimicrobial activity of an antibiotic against a variety of microbes, by co-administration with a bis(tryptophan) derivative.Type: GrantFiled: June 20, 2017Date of Patent: January 4, 2022Assignee: The Curators of the University of MissouriInventors: George W Gokel, Joseph W Meisel, Mohit B Patel