Abstract: Methods, systems, and apparatuses for detecting seizure events are disclosed, including a system for identification of an increased risk of a severe neurological event. The system may include an electroencephalogram (“EEG”) monitoring unit configured to collect EEG data from the patient during at least a postictal phase of one or more seizures and a processing unit configured to receive the EEG data from the EEG monitoring unit. The processing unit is configured to detect postictal EEG suppression from the EEG data and to identify the increased risk of the severe neurological event based on the detected postictal EEG suppression. Other embodiments are described and claimed.

Abstract: A system includes a first implantable medical device configured to receive a first far field radiative signal at a first frequency from an external transmitter to charge a first charge storage device. The first implantable medical device includes a first therapy delivery unit powered by the first charge storage device. The first therapy delivery unit delivers a first therapy to a first target tissue of a patient. The system also includes a second implantable medical device configured to receive a second far field radiative signal at a second frequency from the external transmitter to charge a second charge storage device. The second implantable medical device includes a second therapy delivery unit powered by the second charge storage device. The second therapy delivery unit delivers a second therapy to a second target tissue of the patient.

Abstract: A method of treating a patient with at least one substance addiction, which comprises directly stimulating a cranial nerve, such as the vagus nerve, of a patient with an electrical pulse signal defined by a plurality of parameters to provide a therapy regimen for alleviating a symptom associated with the substance addiction.

Abstract: An isolated circuit including a RF input configured to receive a far field radiative powering signal and a rectified voltage output configured to provide a rectified voltage based on the received far field radiative powering signal. The isolated circuit also includes a first power assembly comprising a first impedance coupled to the RF input where the first impedance is provided, at least in part, by activating a first switch in response to the rectified voltage satisfying a first voltage threshold. The isolated circuit also includes a second power assembly comprising a second impedance coupled to the RF input where the second impedance is provided, at least in part, by activating the first switch and a second switch in response to the rectified voltage satisfying the first voltage threshold and a second voltage threshold, respectively.

Abstract: A method of treating a medical condition in a patient using an implantable medical device, comprising providing an electrical signal generator; providing at least a first electrode operatively coupled to the electrical signal generator and to a vagus nerve of the patient; sensing cardiac data of the patient; determining at least a first cardiac parameter based upon said cardiac data; setting at least a first value; declaring an unstable brain state of a patient from said at least a first cardiac parameter and said at least a first value; and adjusting the at least a first value. Also, a computer readable program storage device encoded with instructions that, when executed by a computer, performs the method. In addition, the implantable medical device used in the method.

Abstract: We disclose a method of providing an electrical signal to a cranial nerve of a patient for treating a medical condition, comprising providing an electrical signal generator, coupling at least a first electrode to a cranial nerve of the patient and to the electrical signal generator, generating an electrical signal with the electrical signal generator, and applying the electrical signal to the cranial nerve, using the at least a first electrode, for a duration less than a cardiac period of the patient and during the cardiac period of the patient. We also disclose an implantable medical device capable of implementing the method.

Abstract: An implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring is provided. A stimulation therapy lead includes helical electrodes configured to conform to an outer diameter of a cervical vagus nerve sheath, and a set of connector pins electrically connected to the helical electrodes. A neurostimulator includes an electrical receptacle into which the connector pins are securely and electrically coupled. The neurostimulator also includes a pulse generator configured to therapeutically stimulate the vagus nerve through the helical electrodes in alternating cycles of stimuli application and stimuli inhibition that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes by triggering bi-directional action potentials.

Abstract: A particular implantable device may include one or more antennas configured to receive a first far field radiative signal and a second far field radiative signal. The one or more antennas may be configured to receive the first far field radiative signal in a first frequency band and to receive the second far field radiative signal in a second frequency band. The implantable device may include a voltage rectifier configured to rectify the received first far field radiative signal and the received second far field radiative signal to provide a rectified voltage signal. The implantable device may further include a charge storage element operative to receive the rectified voltage signal and to store charge responsive to the rectified voltage signal. The implantable device may also include a therapy delivery unit powered by the charge storage element. The therapy delivery unit may be operative to deliver a therapy to a patient.

Abstract: A particular implantable device may include an antenna configured to receive a far field radiative signal. The implantable device may also include a voltage rectifier configured to rectify the far field radiative signal received by the antenna to provide a rectified voltage signal. The implantable device may further include a charge storage element operative to receive the rectified voltage signal and to store charge responsive to the rectified voltage signal. The implantable device may also include a therapy delivery unit powered by the charge storage element. The therapy delivery unit is operative to deliver a therapy to a patient.

Abstract: A particular implantable device may include an antenna configured to receive a far field radiative signal. The implantable device may also include a voltage rectifier configured to rectify the far field radiative signal received by the antenna to provide a rectified voltage signal. The implantable device may further include a charge storage element operative to receive the rectified voltage signal and to store charge responsive to the rectified voltage signal. The implantable device may also include a stimulation module powered by the charge storage element. The stimulation module may be operative to generate an electrical stimulation signal to stimulate a target nerve of a patient. The implantable medical device may further include a nerve wrap configured to house the voltage rectifier, the charge storage element, and the stimulation module. The nerve wrap may include one or more electrodes operative to deliver the electrical stimulation signal to the target nerve.

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

Abstract: An implantable medical device includes a case having a conductive housing defining an opening. A dielectric material is coupled to the conductive housing to hermetically seal the opening. A header block is coupled to the case over the dielectric material. An antenna is within the case under the dielectric material and there is no antenna feedthrough extending through the case into the header block.

Abstract: An implantable medical device includes a case having a conductive housing defining an opening. A dielectric material is coupled to the conductive housing to hermetically seal the opening. An antenna is within the case under the dielectric material. A header block is coupled to the case over the dielectric material.

Abstract: A particular method of providing power to an implantable medical device includes providing a first signal to a primary coil that is inductively coupled to a secondary coil of an implantable medical device. The method also include determining a first alignment difference between a voltage corresponding to the first signal and at least one of a current corresponding to the first signal and a component voltage at a component of a primary coil circuit. The method further includes determining a frequency sweep range based on the first alignment difference. The method also includes performing a frequency sweep over the frequency sweep range.

Abstract: Apparatus and methods for charging a power cell in an implantable medical device (“IMD”) are disclosed herein. In one embodiment, a method includes providing an electrical pulse to an inductor external to the IMD. A frequency of an oscillation signal induced in the inductor by the current pulse is measured. The inductor is driven with an oscillating signal having a frequency based on the measured frequency of the oscillation signal. The power cell is charged using current induced in the IMD by the driving of the inductor.

Abstract: A case for an implantable medical device includes a metal case portion, having an inside and an outside, configured to attach to at least one other case portion to define a biocompatible case for the implantable medical device. The metal case portion has a plurality of grooves disposed on at least one of the inside and the outside, the grooves being oriented substantially perpendicular to an expected direction of eddy currents produced by an inductive recharging coil in proximity thereto.

Abstract: Methods and systems for adjusting neighborhood widths of candidate heart beats, including being provided with a plurality of candidate heart beats, the candidate heart beats being associated with neighborhood widths in the time domain, and scaling the neighborhood widths, an amount of scaling being determined according to one or more previous heart rate statistics.

Abstract: Methods and systems for characterizing a seizure event in a patient, including determining a time of beat sequence of the patient's heart, determining a first HR measure for a first window, determining a second HR measure for a second window, wherein at least a portion of the first window occurs after the second window, determining at least one HR parameter based upon said first HR measure and said second HR measure, identifying an onset of the seizure event in response to determining that at least one HR parameter crosses an onset threshold, identifying an end of the seizure event in response to determining that at least one HR parameter crosses an offset threshold.

Abstract: Methods and systems for detecting a seizure event, including receiving heart beat data versus time for a patient, detecting an increase in the heart rate of a patient from a baseline heart rate to an elevated heart rate, detecting a decrease in heart rate from the elevated heart rate, for a time interval occurring during said decrease in heart rate, determining at least one of a) a rate of decrease in heart rate and b) a rate of change in a rate of decrease in heart rate, and detecting a seizure event in response to determining at least one of a) a rate of decrease in heart rate greater than a threshold rate of decrease, and b) a rate of change in the rate of decrease less than a threshold rate of change in a rate of decrease.

Abstract: A system and method for estimating the longevity of an implantable medical device (IMD). In one embodiment of a method for estimating a life of a power source of an implantable medical device, a first life estimate of the power source is determined based on a first open-loop value corresponding to an open-loop parameter for open-loop therapy delivery, a first closed loop value corresponding to a closed-loop parameter for closed-loop therapy delivery, and prior usage data corresponding to prior therapy delivery. The first life estimate of the power source is displayed. The first life estimate displayed includes a first open-loop portion associated with open-loop therapy delivery and a first closed-loop portion associated with closed-loop therapy delivery.