Abstract: The present invention relates to compounds comprising a benzimidazole scaffold, and the use of such compounds for the treatment of viral diseases. The invention also relates to pharmaceutical compositions comprising said compounds as an active ingredient. In particular the compounds of the invention comprising a benzimidazole scaffold are used for the treatment of filoviruses or retroviruses, and preferably for the treatment of Ebola virus or HIV virus.

Abstract: A seat for a motor vehicle, the seat comprising a backrest and a seating portion, the backrest being mounted to rotate relative to the seating portion about a substantially transverse axis, a hinge being provided for adjusting a tilt of the backrest relative to the seating portion about the substantially transverse axis, the seat being provided with a plurality of means for controlling a movement of the hinge, the seat further comprising an interface for controlling said movement of the hinge, the interface comprising a central portion and a peripheral portion, the peripheral portion being arranged around the central portion, the interface further comprising a plurality of recesses shaped to receive the plurality of means for controlling the movement of said hinge.

Abstract: A particle sizing system is provided that includes an optical source generating a light beam for illuminating particles in a monitored volume, a plurality of light deflectors, each positioned to receive and deflect light scattered by the particles, and an image capture device collecting scattered light deflected by each light deflector. The image capture device outputs an image including a plurality of sub-images, each generated from the collected light deflected from a respective one of the light deflectors. Each particle is imaged as a spot in each sub-image, the plurality of spots associated with each particle corresponding to a plurality of scattering angles. The system also includes a processing unit configured to identify the spots associated with each particle in the sub-images, compute a spot parameter associated with each spot, and determine the size of each particle from its related spot parameters. A particle sizing method is also provided.

Abstract: A digital processor runs a machine learning algorithm in parallel with a sampling server. The sampling sever may continuously or intermittently draw samples for the machine learning algorithm during execution of the machine learning algorithm, for example on a given problem. The sampling server may run in parallel (e.g., concurrently, overlapping, simultaneously) with a quantum processor to draw samples from the quantum processor.

Abstract: A hybrid computing system comprising a digital and an analog processor calculates the ground energy state of a non-diagonal Hamiltonian via diagonalization of the Hamiltonian in different bases and reverse annealing. A first basis is rotated to render part of the Hamiltonian diagonal, then the quantum processor evolves backwards until a value s* of the normalized evolution coefficient. Another basis is rotated to render another part of the Hamiltonian diagonal and the quantum processor evolves backwards again until s*. The bases can be rotated via discrete Fourier transform. The quantum processor may pause for a time t after each backward evolution. The ground state energy is calculated using the final ground states.

Abstract: The disclosure is related to a system for storing and managing hierarchical relationships in a data set. The data set has a plurality of nodes, including root nodes having trees and subtrees, the tree and subtrees including parent, sibling, and child nodes. Each node in the data set has bound values and the bound values of the root nodes are fixed and of equal width. The system further includes processor on a server constructed and arranged to execute a series of steps for optimizing the data set. The processor constructed and arranged to recalculate bound values for updated nodes, sibling nodes and associated subtrees when nodes are updated.

Abstract: Provided are compounds represented by the following formulas (I), (II), (III) and (IV) having orexin type 2 receptor-activating activity, or their pharmaceutically acceptable salts.

Abstract: A telescope includes an initial telescope comprising a concave first mirror and a convex second mirror that are configured so that they form, from a light beam coming from infinity, an image called the intermediate image in a focal plane called the intermediate focal plane, the intermediate image having a largest dimension along an X-axis perpendicular to an optical axis of the telescope, a segmenting module comprising a first set of n segmenting mirrors that are placed downstream of the intermediate focal plane and that are configured to divide the intermediate image obtained from the intermediate focal plane into n sub-images, a second set of n refocusing mirrors that are configured to reimage the n sub-images into n images in a focal plane of the telescope, the images being arranged in the focal plane so as to decrease the dimension along X containing the n images, a detecting device placed in the focal plane.

Abstract: Travel pillow apparatus, storage apparatus for the travel pillow apparatus, and methods of manufacture and use. In one embodiment, the travel pillow apparatus, includes an external covering, the external covering including upper and lower support structures; an air bladder apparatus that includes an expandable open-cell foam within an interior of the air bladder apparatus. The air bladder apparatus is further shorter in length than the external covering, such that the air bladder apparatus is not intended to be positioned towards the back of a neck of a user that is utilizing the travel pillow apparatus. A storage apparatus with a one-way expulsion valve for storage of, for example, the aforementioned travel pillow apparatus. Methods of manufacturing and using the aforementioned apparatus are also disclosed.

Abstract: An electronic device includes a touch screen for a touch sensitive display carried by a portable housing. The electronic device is configured to operate in a high detection threshold mode to determine whether an object is in contact with the touch sensitive display, and operate in a low detection threshold mode to determine whether the object is adjacent to the touch sensitive display, based on lack of detection of the object being in contact with the touch sensitive display. The electronic device is further configured to determine whether the object s in contact with a peripheral edge of the portable housing by determining whether the object is adjacent opposite sides of the touch sensitive display, based on detection of the object being adjacent to the touch sensitive display.

Abstract: A method of detecting repetitive information in data packets communicated between a first node and a second node over a wireless network, which may include collecting samples of a data communication signal transmitted between said first node and said second node over said wireless network at a plurality of respective times; grouping said collected samples into a plurality of sequences of samples; combining said plurality of sequences of samples into at least one united signal; and based on an analysis of said at least one united signal, providing a signal indicative of repetitive information in a plurality of data packets carried by said data communication signal.

Abstract: The invention concerns a detergent composition, comprising: a) from 2 to 95 wt. %, preferably from 2.5 to 50 wt. %, more preferably from 5 to 50 wt. % of a citric acid ester derivative of a monoglyceride of the form: —wherein one of R1, R2, and R3 is selected from a C16 to C18 fatty acid chain; and one or two of R1, R2, and R3 is selected from citric acid, the remainder, if any, being OH; and, 10 b) from 0.0001 to 5 wt. %, of further laundry ingredients selected from: perfumes, protease enzymes, amylase enzymes, cellulase enzymes and preservatives; and to a domestic method of treating a textile comprising treatment of the textile with an aqueous solution of 0.15 to 20 g/L of the detergent composition of the first aspect of the invention.

Abstract: Methods of treating malaria comprising administration of compounds of Formula (I?) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. It also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin X, plasmepsin IX or plasmepsin X and IX activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.

Abstract: Methods of safely administrating a gut-selective JAK3 inhibitor by oral administration are described. Also described are methods for providing clinically proven safe treatment of gastrointestinal inflammatory diseases, such as celiac disease, by oral administration of a gut-selective JAK3 inhibitor.

Abstract: An apparatus for a drill powered wire puller is disclosed. The drill powered wire puller includes a capstan, a housing positioned including a gear mechanism disposed therein, and a trigger assembly coupled to a trigger of a handheld power drill, wherein actuation of the trigger assembly causes depression of the trigger thereby activating the handheld power drill. The drill powered wire puller further includes a cradle plate including a notch positioned at a proximal end of the cradle plate, the notch being sized and shaped to receive the handheld power drill. The drill powered wire puller further includes a foot pedal system including a foot pedal, a base, a spring, wherein when the foot pedal receives pressure, tension is created on the throttle causing actuation of the trigger assembly and activation of the handheld power drill.

Abstract: Provided is a balance with a windshield having a door to be smoothly opened and closed either manually or automatically. Provided is an electronic balance with a windshield including a balance main body including a weighing mechanism connected to a weighing pan, a windshield having doors capable of opening and closing by sliding, and configured to form a weighing chamber by covering the weighing pan, and actuators configured to open and close the doors, wherein the actuator includes a double-acting type air cylinder having two ports serving as air intake ports, an air pump-to be connected to the two ports, two valves respectively interposed between the air pump and the two ports and configured to make the ports communicate with and shut off from the atmosphere, and a control device configured to control the two valves-to make the two ports communicate with the atmosphere when the air pump is stopped.

Abstract: A sintered bead with the following crystal phases, in percentages by mass based on crystal phases: 25%?zircon, or “Z1”, ?94%; 4%?stabilized zirconia+stabilized hafnia, or “Z2”, ?61%; monoclinic zirconia+monoclinic hafnia, or “Z3”?50%; corundum?57%; crystal phases other than Z1, Z2, Z3 and corundum<10%; the following chemical composition, in percentages by mass based on oxides: 33%?ZrO2+HfO2, or “Z4”?83.4%; HfO2?2%; 10.6%?SiO2?34.7%; Al2O3?50%; 0%?Y2O3, or “Z5”; 0%?CeO2, or “Z6”; 0.3%?CeO2+Y2O3?19%, provided that (1) CeO2+3.76*Y2O3?0.128*Z, and (2) CeO2+1.3*Y2O3?0.318*Z, with Z=Z4+Z5+Z6?(0.67*Z1*(Z4+Z5+Z6)/(0.67*Z1+Z2+Z3)); MgO?5%; CaO?2%; oxides other than ZrO2, HfO2, SiO2, Al2O3, MgO, CaO, CeO2 and Y2O3<5.0%.