Abstract: Disclosed is a method for crystallizing molecules having a molecular weight equal to or lower than about 500 Dalton in a gravity below about 0.01 g to about 0.000001 g as well as to crystalline molecules having a molecular weight equal to, or lower than, about 500 Dalton, prepared under microgravity conditions.

Abstract: The present invention relates to a solid, particulate plant-protein-based structurant composition comprising, based on total dry matter, a) 50-95 wt. % plant derived protein, b) 5-10 wt. % xanthan gum, c) 1-30 wt. % glucono delta lactone-derived acidulant. The invention further relates to a food product comprising said structurant composition. The invention further relates to a method for the preparation of said structurant composition and to a process for preparing a food product using said structurant composition.

Abstract: The invention is directed to a composition suitable for topical application that comprises a naturally derived preservative having benzoic acid or a derivative thereof. The composition is stable when preserved with the naturally derived preservative and when at a pH that is above the natural pH of skin to as high as 7.25.

Abstract: Early detection of lysosomal storage diseases (LSDs) including Mucopolysaccharidosis Type I (MPS I) and Pompe Disease can greatly improve patient outcome as each disease can be fatal once symptoms emerge. Screening for MPS I and Pompe Disease using biological samples including dried blood spots (DBS), buccal swab, peripheral blood mononuclear cells (PBMCs), or white blood cells (WBCs) is described. The disclosed methods and assays provide a robust way to screen newborns for LSDs. The disclosed methods and assays can also allow rapid prediction of whether a patient with LSD will develop an immune response to enzyme replacement therapy (ERT), thus improving treatment for patients with LSDs. The disclosed methods and assays can also further reduce the number of false positives caused by pseudo deficiency cases of LSD, such as MPS I and Pompe Disease.

Abstract: The present invention relates to a topical composition. Particularly, the present invention relates to a topical composition that comprises degallated tea extract that comprises less than 0.2% gallic acid on dry weight basis and provides improved skin lightening.

Abstract: A dual mode face mask wherein in a first mode the mask can be used normally and in a second mode the mask can be sealed against the user's skin.

Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.

Abstract: Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

Abstract: Disclosed is a method for producing an orthodontic appliance for securing to a user's teeth in order to carry out an orthodontic treatment, the appliance having an element. The method includes a) gathering information relating to the user's set of teeth; b) using the information to determine at least first and second stable shapes of the element towards which the element should tend to deform during the first and second periods of treatment, respectively; and c) producing and programming the element in such a way that the application of a stimulus during the first period of the treatment renders the second stable shape operational. In certain aspects in step c), a retractable or expansible material is incorporated into the element.

Abstract: The invention relates to a wiping device for a motor vehicle window, comprising a windscreen wiper frame and a piezoelectric film, said piezoelectric film being mounted on the windscreen wiper frame such as to produce an electric current. The invention also relates to a warning method and a spray control method for such a wiping device.

Abstract: The invention relates to a terminal end piece (8) for a wiper blade. The terminal end piece (8) comprises a peripheral wall (20) which separates an external environment of the terminal end piece (8) from an internal space (11) of the terminal end piece (8). The terminal end piece (8) delimits a first housing (21) which is arranged in the internal space (11) and which extends primarily in a first plane (P1). A second housing (22) is interposed between the peripheral wall (20) and the first housing (21). The terminal end piece (8) comprises at least one locking member (37) which is configured to connect the terminal end piece (8) to a flexible support (6) of the wiper blade (1).

Abstract: Provided herein are methods for generating conjugated immunoglobulins, the method comprising: decapping a cysteine at amino acid position 80 (“Cys80”) in a light chain variable region of an immunoglobulin, wherein the immunoglobulin comprises a heavy chain variable region and the light chain variable region; and conjugating a thiol-reactive compound to the Cys80, wherein the thiol-reactive compound comprises a thiol-reactive group. Antigen-binding molecules and methods for generating the same, immunoglobulins as well as nucleic acid molecules encoding the immunoglobulins and host cells comprising the nucleic acid molecules, conjugated immunoglobulins, and light chain variable regions for use in a conjugated immunoglobulin are also provided.

Abstract: The present disclosure relates to the use of contact lenses for treating one or more ophthalmologic conditions. In some embodiments, the contact lenses may be used to treat presbyopia, induced myopia, computer vision syndrome (CVS), insufficient accommodation, or a condition associated with insufficient accommodation. The contact lens may include a number of regions having different geometries (e.g., curvature, width, diameter) depending on the flattest keratonomy of the cornea to achieve a suitable fit. For example, the contact lens may include an optic zone surrounded by an inner peripheral region and an outer peripheral region surrounding the inner peripheral region, each exhibiting varying degrees of curvature. The fitted contact lens may be selected based on a measured sagittal depth and/or eccentricity of the cornea. When fitted, an appropriate amount of fluid may accumulate between the cornea of the eye and the contact lens.

Abstract: The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.

Abstract: The system for a secure and verifiable measurement and data logging of electric vehicle energy balance, wherein vehicle energy balance status supervision provides basis for pre-payment accounting, energy charging allowances, excise taxation, and infrastructure investment payback schemes using predetermined intervals and micro-payment transactions using smart contracts. The system comprises a measurement and data logging device onboard a vehicle, and a decentralized and cryptographically safe database, using a method of transferring blockchain encoded multi-leveled information based on said logged data for mathematical algorithms to calculate and autonomously execute contract fund transactions like excise tax, car rental service payment, vehicle roaming, and grant greater supervision and control over fleet management and vehicle manufacturer warranty limits for example.

Abstract: Disclosed is a portable freezer module (30) for displaying and dispensing frozen edible products. The module comprises a case (32) and a duct (36). The case (32) comprises an insulated container having an interior space (33) for containing the frozen products, and an active cooling system for cooling the interior space and having a hot end (31) and a cold end (35). The duct (36) extends from the hot end (31) of the active cooling system of the case to a heat exhaust outlet (38). The module (30) is configured such that the case (32) can be removably sited in a presentation space (24) of a chill cabinet (20) with the heat exhaust (38) of the duct (36) positioned outside of the presentation space (24). The duct (36) is a hollow tube free from refrigerant conduits, electrical cables and other electrical equipment.

Abstract: A method for calculating the uncertainty of a data-based model, includes: a memory data generation step (S10); a measurement data receiving step (S20); a Euclidean distance calculation step (S30); a kernel function calculation step (S40); a weighted area-specific effective number calculation step (S50) of calculating a weighted area-specific effective number (Nn); a weighted value setting step (S60) of setting a weighted area-specific weighted value (Wn); a total effective number calculation step (S70) of calculating a total effective number (Nt) according to a weighted value; a prediction data calculation step (S80) of calculating prediction data (Xq) about measurement data (Q); a weighted standard deviation calculation step (S90) of calculating a weighted standard deviation (Sw); and an uncertainty calculation step (S100) of calculating uncertainty (U) so as to determine the reliability of prediction data by means of the calculated uncertainty (U).

Abstract: The invention relates to compositions comprising hydrophobically and non-hydrophobially modified cross-linked anionic polymers which have been found to minimally hinder deposition of moisturizers in compositions comprising cationic deposition polymers.

Abstract: A vehicle leveler which includes a first portion with a leading edge and a trailing edge, the trailing edge is disposed further from the driveway than the leading edge. The leveler also includes a second portion with a leading edge and a trailing edge, the leading edge of the second portion is disposed further from the driveway than the trailing edge of the second portion. The vehicle leveler has a door interlock system with at least one pair of photoelectric sensors with a sensor path. When a vehicle is being loaded or unloaded on the vehicle leveler, and at least one of the vehicle doors is opened, the door blocks the sensor path of the photoelectric sensors and prevents the vehicle leveler from lowering or raising.