Abstract: The present invention relates to a self-locking pushbutton for unlocking of a lock for a vehicle door, hood, covering or hatch, in particular of an agricultural vehicle, e.g. of a tractor, or of a construction machine.

Abstract: Existing content such as books are reorganized and condensed as electronic books for display on a mobile computing device. The electronic books have a hierarchical structure. A user interacts with the content of the book by way of a touch screen of the mobile computing device. The navigation may be non-linear in nature and the book is reconstructed as a set of primary ideas, supporting ideas, stacks of cards for the supporting ideas, and individual cards comprising elements and commentary from or about the book.

Abstract: Disclosed is a method of fabricating a construction element. The method may include assembling a mold on a rotational casting machine; rotating the mold around at least two axes at a predetermined speed; providing a first portion of magnesium silico-phosphate cement (MSPC) mix, having an altered hardening rate, to the mold while rotating the mold until at least a portion of the molds walls is covered by a first layer of the MSPC mix; and rotating the mold until the MSPC mix is hardened to a predetermined degree.

Abstract: The invention is directed to a bispecific chimeric antigen receptor, comprising: (a) at least two antigen-specific targeting regions; (b) an extracellular spacer domain; (c) a transmembrane domain; (d) at least one co-stimulatory domain; and (e) an intracellular signaling domain, wherein each antigen-specific targeting region comprises an antigen-specific single chain Fv (scFv) fragment, and binds a different antigen, and wherein the bispecific chimeric antigen receptor is co-expressed with a therapeutic control. The invention also provides methods and uses of the bispecific chimeric antigen receptors.

Abstract: The invention is a foldable protective canopy for attachment to a bed, the canopy comprising at least first, second and third generally U-shaped frames including respective ends joined at first and second hinges removably attachable to a bed, the canopy having a deployed position wherein the first and second U-shaped frames extend upwardly and the third U-shaped frame extends horizontally from the first and second hinges, a flexible sheet is secured to the first, second and third U-shaped frames, the sheet forming a top wall and side walls over the patient, the first U-shaped frame defining an opening into the canopy to permit room air to enter the canopy, the canopy including a folded position wherein the first and second U-shaped frames are rotatable about the first and second hinges toward the third U-shaped frame to expose the head of a patient.

Abstract: A touch sensor system includes a sensing area having a periphery and a plurality of light sources and a plurality of analog optical detectors arranged about the periphery of the sensing area. The system further includes addressing circuitry that selectively drives each of the plurality of light sources with a modulated signal and selectively activates the plurality of analog optical detectors, and a controller that receives a collective detector output from the plurality of analog optical detectors. The outputs from the analog optical detectors may be a time multiplexed to provide the collective detector output. Each optical detector may include a photodiode; a first transistor coupled to the photodiode in a current amplifier configuration that generates an amplified current output as a function of a photodiode current; and enable circuitry to enable and disable the optical detector as a function of an enable input signal.

Abstract: A system for supplying power to a portable battery pack including a battery enclosed by a wearable and replaceable pouch or skin using at least one solar panel is disclosed, wherein the pouch or skin can be provided in different colors and/or patterns. Further, the pouch or skin can be MOLLE-compatible. The battery comprises a battery element housed between a battery cover and a back plate, wherein the battery element, battery cover, and back plate have a slight curvature or contour. Further, the battery comprises flexible leads.

Abstract: The invention features soluble fibroblast growth factor receptor 3 (sFGFR3) polypeptides. The invention also features methods of using sFGFR3 polypeptides to treat skeletal growth regardation disorders, such as achondroplasia.

Abstract: A safety catheter needle having a cannula removably inserted in a catheter and associated with a cannula holder is provided. The cannula has a proximal extremity attached to the cannula holder and a distal extremity close to a deformed part, with provision for a protection device associated with the catheter holder movably containing the cannula and moving within the catheter holder when the cannula is drawn out from the catheter. The protection device has a principal body containing a moving body rotating about an axis (M) at right angles to a longitudinal axis (W) of the cannula and capable of interacting with a fixed part of the catheter holder—while the cannula is being drawn out, bringing about rotation of the rotating moving body within the principal body and immobilizing the distal extremity of the cannula within the former.

Abstract: A kappa light chain-binding polypeptide comprising or consisting essentially of one or more mutated binding domains of Peptostreptococcus Protein L.

Abstract: Quantum annealers as analog or quantum processors can find paths in problem graphs embedded in a hardware graph of the processor, for example finding valid paths, shortest paths or longest paths. A set of input, for example nucleic acid reads, can be used to set up a graph with edges between nodes denoting overlap (i.e., common base pairs) between the reads with constraints applied to perform sequence alignment or sequencing of a nucleic acid (e.g., DNA) strand or sequence, finding a solution that has a ground state energy. At least a portion of the described approaches can be applied to other problems, for instance resource allocations problems, e.g., job scheduling problems, traveling salesperson problems, and other NP-complete problems.

Abstract: The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A (SpA), as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 9 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of said polypeptide, as well as separation matrices comprising the multimers or polypeptides.

Abstract: The present disclosure provides methods and systems for synchronizing motion data with an audio/video stream. An audio/video stream, which comprises at least one timing marker, is obtained. The audio/video stream is processed to detect the at least one timing marker. Motion data associated with the audio/video stream and timing information for the motion data are obtained, the timing information including timing information regarding the at least one timing marker. The audio/video stream, with the at least one timing marker detected, and the motion data, are output with the timing information.

Abstract: The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.

Abstract: Provided herein are conjugated immunoglobulins and methods for generating conjugated immunoglobulins using a microbial transglutaminase.

Abstract: A joint assembly between a first component and a second component comprises a ball portion configured to be connected to the first component. A socket is configured to be connected to the second component or ground and comprises a socket base, a socket cover, and a spherical joint cavity within the assembled socket base and socket cover to receive the ball portion to form a spherical joint. At least one biasing member is in the joint assembly. A clamp clamps the socket base to the socket cover such that the at least one biasing member biases the socket base and the socket cover toward one another.

Abstract: A collapsible telescoping pole assembly provided comprising at least first, second and third elongated tubular members, the second and third tubular members being slidably received within the first and second tubular member, respectively, between retracted and extended positions. A first locking mechanism is associated with the distal end of the first tubular member for releasably securing the second tubular member within the first tubular member in its extended position. The first locking member is biased to a locked position and movable to an unlocked position by rotating the first locking mechanism relative to the first tubular member, causing the first locking mechanism to move axially in a distal direction to permit the second tubular member to slide freely within the first in tubular member. A second locking mechanism is associated with the distal end of the second tubular member for releasably securing the third tubular member within the second tubular member in its extended position.

Abstract: Apparatus for a drill powered wire puller are disclosed. In an embodiment the drill powered wire puller includes a center plate, a cradle plate, a housing, a support, the support including a receiver, and a capstan. The center plate is coupled with the cradle plate at a proximal end. The cradle plate includes a U-shaped notch and two hooks or catches which are configured to couple the cradle plate with a powered rotary tool, such as a drill. The right side of the center plate is coupled with a housing, the left side of the center plate is coupled with a support. The left side of the support is coupled with a capstan. The outer perimeter of the capstan includes notches that define at least one “cleat” shape in the outer perimeter.

Abstract: Provided is an anti-EphA4 antibody that can bind to EphA4 and enhance the cleavage of EphA4, as well as a pharmaceutical composition comprising the antibody as the active ingredient. A mouse anti-EphA4 antibody that has binding affinity towards EphA4 and can enhance the cleavage of EphA4 was obtained, and the sequence of the complementarity-determining region (CDR) of the mouse anti-EphA4 antibody was identified. Subsequently, the anti-EphA4 antibody of interest was obtained by producing a humanized antibody of the mouse anti-EphA4 antibody.