Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a multi-RTK inhibitor, and the use of the combination therapies for the treatment of cancer. The multi-RTK inhibitor may be represented by Formula (I): wherein R1 is C1-6 alkyl or C3-8 cycloalkyl, R2 is a hydrogen atom or C1-6 alkoxy, and R3 is a hydrogen atom or a halogen atom. A tumor therapeutic agent is disclosed that combines a compound or pharmaceutically acceptable salt thereof represented by Formula I and an anti-PD-1 antibody.

Abstract: A device for handling multipath of a G.N.S.S. signal, is configured to: determine a spatial position, a clock time and measured multipath parameters comprising a relative delay and relative amplitude; communicate to a remote server the spatial position, clock time and multipath parameters; and receive processed multipath parameters as determined by the remote server. Systems comprising a plurality of such devices and their variants are described. Further aspects are described, in particular the exclusion of one or more satellites, the use of threshold schemes, pull/push modes, configurable refresh rates, quantization of positions, activation of additional sensors, filtering options, determination of merit factors for example as a function of the number of satellites in view and/or of signal-to-noise ratio, peer-to-peer schemes, as well as graphical display, audible sound or haptic feedbacks.

Abstract: The invention is directed to a reusable face mask that may be fitted with filter material from the inside, outside or both inside and outside of the mask. Any filter material can be used and easily replaced in the face mask which is washable and environmentally sustainable.

Abstract: The present disclosure describes combination therapies for breast cancer comprising an oligonucleotide toll-like receptor 9 agonist and a PD-1 antagonist. In particular, the present disclosure describes combinations of a CpG-C type oligonucleotide and an anti-PD-1 antibody for the treatment of breast cancer. The combination may further comprise a taxane chemotherapeutic agent, in the presence or absence of a corticosteroid.

Abstract: The device includes a first portion which has a leading edge and a trailing edge, the trailing edge is disposed further from the driveway than the leading edge. The embodiment also includes a second portion which has a leading edge and a trailing edge, the leading edge of the second portion is removably attached to the trailing edge of the first portion and the leading edge of the second portion is disposed further from the driveway than the trailing edge of the second portion. The second portion also includes an extension portion. The first portion and second portion are separate from each other until they are removably attached by a connection apparatus. The device also includes at least one wheel chock with a corresponding wheel-chock track.

Abstract: Disclosed is a method of determining efficacy of a cosmetic composition to inhibit an atmospheric pollutant from contacting skin, comprising the steps of: (i) filling a sample holder of known dimensions with known amount of said composition to form a layer of defined thickness therein, where said sample holder is amenable to fluorescence-based assay; (ii) depositing, on said layer, a known amount of a model fine particulate matter which resembles an atmospheric pollutant at least in size and which comprises a material responsive to fluorescence microscopy which is excitable by a wavelength (?ex) and which emits radiation (?em) where (?ex)?(?em); (iii) irradiating said composition and said model fine particulate matter by said ?ex and recording intensity of fluorescence at ?em a plurality of times for a defined period during which said model fine particulate matter interacts with said layer; and, (iv) determining, corrected intensity of fluorescence at ?em by the following equation; corrected Intensity=recorde

Abstract: A system and method for operating a communication network having one or more cable modems. Operating the communication network may include displaying one or more messages to a subscriber and making temporary changes to Cable Modem Termination Systems in order to modify the availability of network resources for one or more cable modems assigned to a subscriber without requiring a rebooting of the one or more cable modems.

Abstract: Examples of systems and methods for monitoring metabolic activity and detectors for detecting photons are disclosed. The methods can include detection in a front and a rear detector of a photon to determine a Compton cone. This Compton cone may be combined with further Compton cone, or Line of Response calculation to determine an origin of nuclear decay. In examples of the systems and methods, substantially real-time visualization of nuclear decay can be achieved.

Abstract: The invention relates to a method for providing an aseptic chromatography column, said method comprising the steps of: pre-sterilize an empty chromatography column; pre-sterilize a chromatography medium; introducing the pre-sterilized chromatography medium into the pre-sterilized chromatography column using aseptic equipment, thereby providing an aseptic chromatography column comprising chromatography medium.

Abstract: Disclosed are a yttrium-doped barium fluoride crystal and a preparation method and the use thereof, wherein the yttrium-doped barium fluoride crystal has a chemical composition of Ba(1?x)YxF2+x, in which 0.01?x?0.50. The yttrium-doped BaF2 crystal of the present invention has improved scintillation performance. The yttrium doping may greatly suppress the slow luminescence component of the BaF2 crystal and has an excellent fast/slow scintillation component ratio. The doped crystal is coupled to an optical detector to obtain a scintillation probe which is applicable to the fields of high time resolved measurement radiation such as high-energy physics, nuclear physics, ultrafast imaging and nuclear medicine imaging.

Abstract: A foot for a household appliance includes a hydraulic plate, a sheath connected with the hydraulic plate, an adjustable foot arranged in the sheath and axially moveable relative to the sheath, and a device for communicating the flow of a hydraulic medium between at least two feet of the household appliance. An accommodating chamber is formed by the hydraulic plate, the sheath and the adjustable foot; the hydraulic medium is arranged in the accommodating chamber, and the hydraulic medium is compressed or expanded along with the change of pressure to drive the adjustable foot to move axially in the sheath for leveling. A control device for turning on/off the flow of the hydraulic medium is provided on the communicating device, a better leveling support effect is achieved by controlling the on/off of the communicating device.

Abstract: An anthraquinone compound and the use thereof in preparing anti-allergic drugs. The anthraquinone compound has a structure according to formula (I) and can be used to prepare anti-allergic drugs.

Abstract: A detection system (1) intended to equip a motor vehicle comprises at least one optical sensor (2) delimited by at least one curved optical surface (20). It also comprises at least one cleaning device (3) for cleaning the optical surface (20) that comprises a delivery ramp (4) for delivering at least one cleaning and/or drying fluid. According to the invention, the delivery ramp (4) has a curved shape, the curvature (C?) of which is substantially equal to the curvature (C) of at least a portion (201, 202) of the optical surface (20).

Abstract: The present invention relates to an extruded soap bar composition. It more particularly relates to a soap bar composition which delivers the enhanced antimicrobial benefit to skin while ensuring that the soap bar is easy to extrude. This is achieved by including free fatty acids in the soap bar composition while ensuring that part of the free fatty acid is hydroxy stearic acid.

Abstract: Optical touch sensors may be adversely affected by noise, such as modulated sunlight incident on the touch sensor. An analog optical detector is provided that includes a frequency dependent emitter feedback circuitry that does not substantially reduce the gain for a first modulation frequency range of the photodiode current and provides, for a second modulation frequency range of the photodiode current, a current feedback to reduce the gain of the first transistor. The second modulation frequency may include one or more expected noise modulation frequencies. A touch sensor device including a plurality of such optical detectors is also provided. Also provided is a touch sensor device comprising sampling disable circuitry operable to disable sampling of the output from the optical detectors for a duration of time.

Abstract: A method for cleaning a firearm suppressor having firing residue deposits on inner surfaces thereof, includes: providing a hydraulic system including a cleaning chamber, a turbulence-inducing nozzle, and a non-petroleum-based cleaning solution; installing a used firearm suppressor onto the turbulence-inducing nozzle; placing the used firearm suppressor into the cleaning chamber; tempering the non-petroleum-based cleaning solution to a temperature between about 120° F. and about 180° F.; and flowing the non-petroleum-based cleaning solution through the turbulence-inducing nozzle and the used firearm suppressor at a predetermined pressure and flow rate during a predetermined period of time. An apparatus for cleaning a firearm suppressor having internal baffles and expansion chambers is also described.

Abstract: The present invention relates to a self-locking pushbutton for unlocking of a lock for a vehicle door, hood, covering or hatch, in particular of an agricultural vehicle, e.g. of a tractor, or of a construction machine.