Patents Assigned to D
  • TRANSPARENT NANOEMULSIONS COMPRISING LAURIC OIL
    Publication number: 20210077367
    Abstract: The invention relates to oil-in-water emulsion in which specific oils (e.g., lauric oils) are used in the oil phase while surprisingly maintaining excellent transparency. In one aspect, said emulsions comprise fatty acid in oil phase. In a separate co-pending application, the invention comprises an energy efficient process for making said fatty acid containing transparent nanoemulsions.
    Type: Application
    Filed: January 21, 2019
    Publication date: March 18, 2021
    Applicant: Conopco, Inc., d/b/a UNILEVER
    Inventor: Congling QUAN
  • Means and Methods for Treating Bacterial Infections
    Publication number: 20210077563
    Abstract: The present invention relates to non-naturally occurring anti-bacterial peptides. More specifically the peptides can be used to treat multi-drug resistant bacterial infections. In addition, the present invention provides methods for producing anti-bacterial peptides.
    Type: Application
    Filed: May 9, 2018
    Publication date: March 18, 2021
    Applicants: VIB VZW, Katholieke Universiteit Leuven, K.U. Leuven R&D
    Inventors: Joost Schymkowitz, Frederic Rousseau
  • BONE GRAFT DELIVERY SYSTEM AND METHOD FOR USING SAME
    Publication number: 20210077275
    Abstract: The present invention relates to an apparatus and method for near-simultaneous and integrated delivery of bone graft material during the placement of surgical cages or other medical implants in a patient's spine. The integrated fusion cage and graft delivery device according to various embodiments delivers and disperses biologic material through a fusion cage to a disc space and, without withdrawal from the surgical site, may selectively detach the fusion cage for deposit to the same disc space. The integrated fusion cage and graft delivery device is formed such that a hollow tube and plunger selectively and controllably place bone graft material and a fusion cage in or adjacent to the bone graft receiving area. In one embodiment, the integrated fusion cage is an expandable integrated fusion cage. In another embodiment, the bone graft material is loaded into a breech area in the hollow tube.
    Type: Application
    Filed: September 15, 2020
    Publication date: March 18, 2021
    Applicant: Spinal Surgical Strategies, Inc., D/B/A Kleiner Devices Labs
    Inventors: Michael J. Milella, JR., Jeffrey Kleiner, Edward J. Grimberg, JR., Gregory Causey, Alan Burkholder
  • CAPACITIVE TOUCH SENSOR APPARATUS HAVING BRANCHING ELECTRODES
    Publication number: 20210081076
    Abstract: A capacitive touch sensor comprises a plurality of electrodes on a substrate, and a position of a finger touching the sensor is determined by monitoring output signal changes caused by changes in capacitance caused by the present of the finger over or near the electrodes. The disclosure provides a capacitive touch sensor apparatus comprising a substrate and a plurality of touch sensor electrodes arranged on the substrate. Each of the electrodes comprises a respective primary electrode strip and a respective one or more electrode strip branches extending from the primary electrode strip.
    Type: Application
    Filed: December 21, 2018
    Publication date: March 18, 2021
    Applicant: 1004335 ONTARIO INC. CARRYING ON BUSINESS AS A D METRO
    Inventors: Robert Donald MCCULLOCH, Guy Michael Amyon Farquharson DUXBURY, Albert M. DAVID, Gueorgui PAVLOV
  • Memory Device Having Variable Impedance Memory Cells and Time-To-Transition Sensing of Data Stored Therein
    Publication number: 20210082490
    Abstract: The present disclosure relates to circuits, systems, and methods of operation for a memory device. In an example, a memory device includes a memory array including a plurality of memory cells, each memory cell having an impedance that varies in accordance with a respective data value stored therein; and a tracking memory cell having an impedance based on a tracking data value stored therein; and a read circuit coupled to the memory array, the read circuit configured to determine an impedance of a selected memory cells with respect to the impedance of the tracking memory cell; read a data value stored within the selected memory cell based upon a voltage change of a signal node voltage corresponding to the impedance of the selected memory cell.
    Type: Application
    Filed: November 27, 2020
    Publication date: March 18, 2021
    Applicant: R&D 3 LLC
    Inventor: Ravindraraj Ramaraju
  • LIQUID VENTILATOR AND METHOD TO INDUCE TIDAL LIQUID VENTILATION AND/OR HYPORTHERMIA
    Publication number: 20210077759
    Abstract: Liquid ventilator and methods integrating the concept of total liquid ventilation (TLV) using liquid volumes below functional residual capacity (FRC) of mammal's lungs are disclosed. Beyond the automatization of the whole process, the technology has been up-scaled to confirm that TLV at residual volumes below FRC can provide a safe procedure while enabling the full potential of TLV in a mammal such as humans or adult-sized animals. Such tidal liquid ventilation strongly differs from the previously known TLV approach, opening promising perspectives for a safer clinical translation. Also disclosed are apparatus and method for safe and fast induction of hypothermia during liquid ventilation of a mammal.
    Type: Application
    Filed: April 12, 2019
    Publication date: March 18, 2021
    Applicants: UNIVERSITE DE SHERBROOKE, ECOLE NATIONALE VETERINAIRE D'ALFORT, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
    Inventors: Philippe MICHEAU, Renaud TISSIER, Matthias KOHLHAUER, Julien MOUSSEAU, Mathieu NADEAU, Jonathan VANDAMME
  • Mobile machine
    Patent number: 10952040
    Abstract: A system for providing mobile content to a mobile communication device includes a first computing system including one or more servers to cause a graphical user interface to be displayed at a second computing system, the graphical user interface (i) enabling a user of the second computing system to edit a digital file to create the mobile content and (ii) enabling the user of the second computing system to provide a phone number associated with the mobile communication device, the mobile communication device being separate and remote from the first computing system and the second computing system. The one or more servers of the first computing system receive, from the second computing system via the communications network, the mobile content and the phone number associated with the mobile communication device.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: March 16, 2021
    Assignee: SITO Mobile R&D IP, LLC
    Inventor: Anthony G. Macaluso
  • Method and apparatus for image compression
    Patent number: 10951897
    Abstract: The invention relates to a method and apparatus for image compression, particularly to an improved block-coding apparatus and method for image compression. Image compression systems such as JPEG and JPEG2000 are known and popular standards for image compression. Many of the advantageous features of JPEG2000 derive from the use of the EBCOT algorithm (Embedded Block-Coding with Optimized Truncation). One drawback of the JPEG2000 standards is computational complexity. This application discloses a relatively fast block-coding algorithm, particularly as compared with the standard JPEG2000 EBCOT algorithm. Computational complexity is reduced.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: March 16, 2021
    Assignee: KAKADU R & D PTY LTD
    Inventors: David Scott Taubman, Reji Kuruvilla Mathew, Aous Thabit Naman
  • Methods for treating ulcerative colitis using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile
    Patent number: 10947254
    Abstract: Disclosed are methods for treating ulcerative colitis using a compound of the formula: or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: March 16, 2021
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Ryan Hudson, Jennifer Kozak, Dante D. Podesto, Xiaojun Huang, Venkat R. Thalladi
  • Methods for determining the metabolic status of lymphomas
    Patent number: 10947598
    Abstract: Provided is an in vitro method for determining the metabolic status of a lymphoma comprising a step of determining the level of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in lymphoma cells, wherein a low level of GAPDH expression is indicative of oxidative phosphorylation (OXPHOS) status. Also provided is an in vitro method for predicting the responsiveness of a patient afflicted with a lymphoma to a treatment with a metabolic inhibitor selected from the group consisting of mitochondrial metabolic inhibitors and glutamine metabolism inhibitors comprising a step of determining the level of GAPDH expression in lymphoma cells obtained from said patient, wherein a low level of GAPDH expression is predictive of a response to a treatment with a metabolic inhibitor.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: March 16, 2021
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Université Côte d'Azur, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
    Inventors: Jean-Ehrland Ricci, Johanna Chiche, Catherine Thieblemont
  • Combination of a PD-1 antagonist and eribulin for treating cancer
    Patent number: 10945990
    Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and eribulin or a pharmaceutically acceptable salt thereof, and the use of the combination therapies for the treatment of cancer.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: March 16, 2021
    Assignees: EISAI R&D MANAGEMENT CO., LTD., MERCK SHARP & DOHME CORP.
    Inventors: Junji Matsui, Gursel Aktan, Vassiliki Karantza, RuiRong Yuan, Yasuhiro Funahashi, Erhan Berrak
  • Peptides of use in the preventive and curative treatment of alopecia
    Patent number: 10947273
    Abstract: The object of the present invention relates to a novel family of peptide conjugates of formula (I): A-X1-X2-Pro-Ala-X—B??(I) wherein: A represents a hydrogen atom, a C6 to C20 acyl group or a cholesterol residue; X1 represents a covalent bond, an alanine or a proline; X2 represents an arginine, a lysine, or an alanine; X represents a lysine, an alanine, or a phenylalanine; and B represents a hydroxyl or an amine; or one of its preferentially pharmaceutically, dermatologically or cosmetically acceptable salts, as well as their synthesis processes and their uses for reducing hair loss and stimulating hair growth.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: March 16, 2021
    Assignees: Institut European de Biologic Cellulaire, Centre de Recherches Biologiques et d'Experimentations Cutanees, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Michel Hocquaux, Stéphanie Almeida Épouse Scalvino, Elian Lati, Joanna Bakala
  • Dimethyl amino azetidine amides as JAK inhibitors
    Patent number: 10947229
    Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: March 16, 2021
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Daniel D. Long, Cameron Smith, Corbin Thompson
  • Anti-EphA4 antibody
    Patent number: 10947313
    Abstract: Provided is an anti-EphA4 antibody that can bind to EphA4 and enhance the cleavage of EphA4, as well as a pharmaceutical composition comprising the antibody as the active ingredient. A mouse anti-EphA4 antibody that has binding affinity towards EphA4 and can enhance the cleavage of EphA4 was obtained, and the sequence of the complementarity-determining region (CDR) of the mouse anti-EphA4 antibody was identified. Subsequently, the anti-EphA4 antibody of interest was obtained by producing a humanized antibody of the mouse anti-EphA4 antibody.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: March 16, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Eiji Inoue, Akio Yamada, Tomomi Kawakatsu, Toshio Imai, Maki Deguchi, Aki Nakatani
  • Decorative composite body having a transparent, electrically conductive layer and a solar cell
    Patent number: 10945499
    Abstract: Proposed is a decorative element containing (a) a transparent gemstone with a faceted surface comprising convex curved regions, (b) a transparent electrically conductive layer applied to said faceted surface comprising convex curved regions, (c) a wavelength-selective layer applied (c1) to the planar side opposite to the faceted curved surface, or (c2) to the photovoltaic cell (d); (d) a photovoltaic cell; and (e) a touch-sensitive electronic circuitry.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: March 16, 2021
    Assignee: D. Swarovski KG
    Inventors: Christof Gapp, Martin Scholz, Annemarie Leber, Mathias Mair, Franz Lexer, Ernst Altenberger
  • 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds
    Patent number: 10946007
    Abstract: The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: March 16, 2021
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Lori Jean Patterson, Eric L. Stangeland
  • Cationic lipid
    Patent number: 10947193
    Abstract: The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1) or a pharmaceutically acceptable salt thereof, wherein L1 and L2 independently represent an alkylene group having 3 to 10 carbon atoms; R1 and R2 independently represent an alkyl group having 4 to 24 carbon atoms or an alkenyl group having 4 to 24 carbon atoms; R3 represents an alkyl group having 1 to 3 carbon atoms; and X1 represents a single bond or CO—O—.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: March 16, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Yuta Suzuki, Yoshinori Takahashi
  • Combination dosage form of a mu opioid receptor antagonist and an opioid agent
    Patent number: 10946009
    Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: March 16, 2021
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Shaoling Li, Manshiu Leung, Hao Zhang, Venkat R. Thalladi, Yun Mo
  • Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound
    Patent number: 10946006
    Abstract: The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
    Type: Grant
    Filed: January 16, 2020
    Date of Patent: March 16, 2021
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Lori Jean Patterson, Robert S. Chao, Miroslav Rapta
  • Display screen with a graphical user interface
    Patent number: D913301
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: March 16, 2021
    Assignee: Teva Branded Pharmaceutical Products R&D, Inc.
    Inventor: Xinyu Liu