Abstract: The invention relates to the field of biomedicine, in particular to the use of annexin A5 in the treatment of cerebral stroke. The invention provides a method for treating cerebral stroke and a drug combination containing annexin A5. The method can reduce cerebral infarction, improve symptoms of neurobehavioral deficits in the brain and treating stroke.

Abstract: A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

Abstract: The present disclosure provides a global shutter CMOS pixel circuit and its image capturing method. The global shutter CMOS pixel circuit comprising a power supply unit, a pixel signal generating unit, a signal sampling and holding unit and a signal outputting unit. An output of the pixel signal generating unit is connected to an input of the signal sampling and holding unit. An output of the signal sampling and holding unit is connected to an input of the signal outputting unit. The output signal of the pixel and the photo-generated current are set to a logarithmic relationship, which effectively increases the signal dynamic range. Therefore, image signal transmission with high speed and high dynamic range can be achieved simultaneously. Furthermore, the pixels in the present disclosure can eliminate the process variations, which increases the consistency of the pixels.

Abstract: This system (40) for dynamically determining maximum electric current carrying capacities comprises: means (44) for storing a model (54) of a network portion (10), a thermal equilibrium relationship (56), operating limit temperatures and conduction parameters; and a receiver (46) for wind speed values measured by wind measurement stations (24, 26, 28, 30). It further comprises a computer (48) programmed (62, 64, 66, 68) to: apply a model (60) of wind propagation from at least one selected station towards singular points of the model (54) of the network portion, in order to estimate a wind speed value at each singular point; and calculate at least one maximum capacity value at each singular point on the basis of the thermal equilibrium relationship (56), of each operating limit temperature, of each conduction parameter and of weather parameters (58), taking into account said wind speed value estimated at each singular point in the thermal equilibrium relationship (56).

Abstract: The present invention is directed to pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: The invention relates to a novel organic solubilisation and/or extraction solvent comprising at least one compound selected from the group of saturated monocyclic terpenoids, to an extraction method using said solvent, and to extracts obtained by said method. More particularly, the invention relates to a novel use of para-menthane, a saturated terpenoid compound, as a solvent derived from natural substances, and also to a solvent comprising para-menthane.

Abstract: A circuit includes a field effect transistor having a gate driven via a drive signal. The field effect transistor has a drain-source voltage drop indicative of the intensity of a current flowing in the current path through the field effect transistor. The circuit also includes a pair of sensing transistors that include a first sensing field effect transistor arranged with its drain and gate coupled with the drain and the gate of the field effect transistor, respectively, and a second sensing field effect transistor having a gate configured for receiving a replica of the drive signal. The second sensing field effect transistor is arranged with its current path in series with the current path of the first sensing field effect transistor. A sensing signal at a sensing node is indicative of the current intensity flowing in the current path of the field effect transistor.

Abstract: Method for manufacturing porous products consisting essentially of titanium suboxide(s) of general formula TiOx, the value of x being between 1.6 and 1.9, the method including a) mixing the raw materials including at least one source of titanium dioxide, a reducing agent comprising carbon, b) forming the product, c) optionally, in particular when organic products are used during step a), thermal treatment under air or an oxidizing atmosphere, d) sintering, for example at a temperature above 1150° C. but not exceeding 1430° C., under a neutral or reducing atmosphere, in which the source of titanium dioxide consists of at least 55 wt % of anatase.

Abstract: A superconducting input and/or output system employs at least one microwave superconducting resonator. The microwave superconducting resonator(s) may be communicatively coupled to a microwave transmission line. Each microwave superconducting resonator may include a first and a second DC SQUID, in series with one another and with an inductance (e.g., inductor), and a capacitance in parallel with the first and second DC SQUIDs and inductance. Respective inductive interfaces are operable to apply flux bias to control the DC SQUIDs. The second DC SQUID may be coupled to a Quantum Flux Parametron (QFP), for example as a final element in a shift register. A superconducting parallel plate capacitor structure and method of fabricating such are also taught.

Abstract: The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

Abstract: The invention relates to a peptide and saccharide hydrolysate of Theobroma cacao L. (cocoa) beans, to a method for preparing same, to cosmetic compositions containing same, and to cosmetic uses thereof particularly for protecting skin from blue light and/or for combatting the appearance of signs of aging and photoaging of the skin.

Abstract: The present invention relates to a method of capturing and stabilising volatile thiol malodour generated on the human skin, comprising steps of: i) contacting the human skin with a substrate, ii) absorbing said thiol into the substrate, and iii) reacting said thiol with a thiol-capture agent. The invention also relates to a method of quantifying said thiol, a method of assessing the deodorizing performance of a cosmetic composition on the human skin.

Abstract: Disclosed herein are methods, systems, and apparatus for treating a medical condition of a patient, involving detecting a physiological cycle or cycles of the patient and applying an electrical signal to a portion of the patient's vagus nerve through an electrode at a selected point in the physiological cycle(s). The physiological cycle can be the cardiac and/or respiratory cycle. The selected point can be a point in the cardiac cycle correlated with increased afferent conduction on the vagus nerve, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during inspiration by the patient. The selected point can be a point in the cardiac cycle when said applying increases heart rate variability, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during expiration by the patient.

Abstract: A sealing valve plug structure includes a valve plug column corresponding to the drain opening formed in the side wall of an inner drum, and a counterweight hinged to the upper end of the valve plug column. The sealing valve installation structure is installed on the side wall of the drum, and the reset spring is clamped between the sealing valve installation structure and the valve plug column. The counterweight is used to generate an action, under the action of centrifugal force, to open the drain opening, and the valve plug column is reset by the reset spring to make the valve plug block the drain opening, to thereby open and close the drain opening. A cleaning-free washing machine having an inner drum sealed by the sealing valve plug structure is also disclosed.

Abstract: The present application provides an electronic package having an optoelectronic component and a laser component disposed on a packaging unit, with the optoelectronic component and the laser component being separated from each other. Since the laser component and the optoelectronic component are separated from each other, the electronic package has a reduced fabrication difficulty and a high yield rate. A method for fabricating the electronic package and an electronic packaging module having the electronic package are also provided.

Abstract: The present invention provides an anti-APOA4 monoclonal antibody or an antibody fragment thereof capable of accurately measuring apolipoprotein A-IV (APOA4) in a specimen, a measurement method for immunologically measuring APOA4 using the antibody or the antibody fragment thereof, and a kit for measuring APOA4 containing the antibody or the antibody fragment thereof.

Abstract: A portable zero clearance circular saw including a motor frame portion with a transverse oriented drive shaft and arbor coupled to the drive shaft, a handle portion with a hand grip coupled to the motor frame portion aft end, a planar blade deck on a first lateral side, a movable blade shield rotatably mounted coaxial with the drive shaft and having a sidewall with a edge face coplanar with the blade deck, a trigger proximate the hand grip to move the blade shield, and a blade couplable to the drive shaft against the arbor, such that the blade outer surface is flush with the blade deck and blade shield sidewall. The handle portion may be rotatably coupled to the motor frame portion, and may include two laterally disposed blade shield triggers operably coupled to the blade shield via a dual pulley system.

Abstract: The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column.

Abstract: The invention relates to a method for treating oxygenated volatile organic compounds in Fischer-Tropsch synthesis reaction water. Fischer-Tropsch synthesis reaction water is subjected to (a) primary concentration and separation, (b) carbonyl compound hydrogenation, (c) carbonyl compound cutting, (d) mixed-alcohol dehydration, (e) solvent recovery, (f) ethyl alcohol separation, (g) methyl alcohol removal and separation, (h) isopropanol separation, (i) propyl alcohol cutting, (j) n-propyl alcohol separation, and (k) 2-butanol separation, so that basic organic chemicals such as ethyl alcohol, isopropanol, n-propyl alcohol, 2-butanol and mixed alcohols are obtained. Compared with the prior art, the method directly converts the concentrated Fischer-Tropsch synthesis water rich in alcohols, aldehydes, ketones, acids, and esters into a mixed-alcohol solution by hydrogenation, thus having the advantages of simple separation process and high product purity.