Abstract: In an embodiment, a power switch controller for driving a back-to-back power switch includes: an amplifier having a supply terminal configured to receive a supply voltage, an output configured to be coupled to a gate terminal of the back-to-back power switch, a first input configured to be coupled a source terminal of the back-to-back power switch, and a second input coupled to the output of the amplifier. The amplifier is configured to generate an output voltage at the output of the amplifier, the output voltage being an offset voltage higher than a voltage at the first input of the amplifier.

Abstract: Disclosed is a method for diagnosing allergy in a human or animal patient, wherein the level of species-specific lipocalin, especially lipocalin 2 in a human patient, is measured in a sample of said patient and wherein a lowered level of said lipocalin compared to the level of said lipocalin in the corresponding sample of a human or animal that has no allergy, is indicative of an allergy, as well as a kit for performing this method, and a kit for quality control of allergen molecules or extracts used for immunotherapy of allergy by determining its siderophore-iron ligand load and thus immunomodulatory potency. Further, lipocalin proteins for use in treatment or prevention of allergies are provided, preferably complexed with siderophore-iron ligands.

Abstract: The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

Abstract: The disclosed apparatus, systems and methods relate to various apparatus, systems and methods relating to associating a tangible item or asset with a specific website by way of a paired signaler and target URL. A wireless communicator and short URL may be used. The system utilizes cloud management platforms and human readable URLs. The signaler may be re-used with multiple target URLs.

Abstract: Methods for encoding data in synthetic DNA include, for an input data sequence, constructing a codebook of a number of unique codewords, of a nucleotide length, which are constructed such that, for each codeword, the codeword is formed from a selection of nucleotide pairs from a first predefined dictionary of nucleotide pairs, and, if the nucleotide length of the codeword is odd, an additional selection of a nucleotide from a second predefined dictionary of individual nucleotides. For each symbol from the input data sequence, at least one codeword is designated as associable therewith, and each symbol is coded as one codeword selected from the designated at least one codeword associable with that symbol. A code is formed from the codewords, arranged in corresponding order to that of their respective symbols in the input data sequence. A DNA sequence is synthetized with nucleotides ordered to match the code.

Abstract: Travel pillow apparatus, storage apparatus for the travel pillow apparatus, and methods of manufacture and use. In one embodiment, the travel pillow apparatus, includes an external covering, the external covering including upper and lower support structures; an air bladder apparatus that includes an expandable open-cell foam within an interior of the air bladder apparatus. The air bladder apparatus is further shorter in length than the external covering, such that the air bladder apparatus is not intended to be positioned towards the back of a neck of a user that is utilizing the travel pillow apparatus. A storage apparatus with a one-way expulsion valve for storage of, for example, the aforementioned travel pillow apparatus. Methods of manufacturing and using the aforementioned apparatus are also disclosed.

Abstract: A handheld clamp work light is disclosed having a light member, a housing member for movement of the light member, a handle member having a handle housing and a clamp member, and the handle housing and the clamp member include feet members which pivot and may be attached to an object.

Abstract: This invention relates to an antimicrobial composition, especially one which provides synergistic anti-dandruff or anti-acne efficacy. This is achieved through a judicious combination of select essential oil actives chosen from thymol, or terpineol and certain antimicrobial lipids selected from sapienic acid, palmitoleic acid, sphingosine, dihydrosphingosine, phytosphingosine, and 6-hydroxysphingosine. These compositions can be delivered through very many different types of personal care products e.g. shampoo, conditioner; face wash or hand wash product; or a leave on cream/lotion.

Abstract: The invention relates to glucuronide prodrug compounds of Janus kinase (JAK) inhibitors having formula I: where W1, R1 and A1 are as defined. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds to treat gastrointestinal inflammatory diseases; and processes and intermediates for preparing such compounds.

Abstract: The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases.

Abstract: A computer-implemented method for verifying identity of a speaker is proposed. A low dimensional p-vector based on a speech of the speaker is extracted from the generated high dimensional speaker model and is then compared with the stored specific speaker's p-vector obtained previously during the enrollment process. The resulting biometric score is then used to determine whether to verify the speaker, or not.

Abstract: A digital-to-analog converter (DAC) and a method for operating the DAC are disclosed. The DAC receives, over a first channel, a control signal that is transmitted in accordance with a binary protocol. The DAC also receives, over a second channel different than the first channel, data that is transmitted in accordance with a multilevel communication protocol that is different than the binary protocol. The DAC determines a plurality of first and second voltages based on the received data and identifies, based on the control signal, a time when data transmission or reception is switched between first and second antennas. In response to identifying, based on the control signal, the time when data transmission or reception is switched, the DAC outputs the determined plurality of first voltages to a first antenna tuning circuit or the determined plurality of second voltages to a second antenna tuning circuit.

Abstract: A radio frequency communication guiding device comprising: a generally elongated body having an elongated cavity therein arranged to house a communication circuit, wherein the communication circuit is supported within the cavity by a substrate layer arranged to place within the cavity so as to support the communication circuit within the cavity.

Abstract: Systems and methods for controlling shelf display units and for graphically presenting information on shelf display units are disclosed. A system includes one or more display units configured to be coupled to shelves of a modular shelving system, one or more processors communicatively coupled to the one or more display units, one or more memory components communicatively coupled to the one or more processors, and machine readable instructions stored in the one or more memory components. When executed by the one or more processors, the machine readable instructions cause the system to determine a product identifier corresponding to a product, identify one or more display units to update in response to determining the product identifier corresponding to the product, and update a graphical output of the one or more display units identified to be updated in response to identifying the one or more display units to update.

Abstract: Disclosed herein is a method for treating tumor, comprising administering a liposomal composition comprising eribulin or a pharmaceutically acceptable salt thereof and a PD-1 antagonist to a patient in need thereof

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: The invention pertains to a method for manufacture and use of pesticides or agricultural spray adjuvants that counteracts the effects of hard water cat ions on anionic pesticides when applied in water spray solutions. The disclosed agricultural spray adjuvants include glyphosate compositions comprising a strong mineral acid, such as sulfuric acid, and a polyamine surfactant, such as tallow amine or coco amine.

Abstract: The present description relates to heptane obtained from a plant source, wherein the plant source comprises Commiphora wildii. Uses of said heptane in perfumery, cosmetics and food flavoring are also described.

Abstract: The invention provides novel 8-azabicyclo[3.2.1]octane compounds of formula (I): wherein R1, R2, R3, A, and G are defined in the specification, or a pharmaceutically-acceptable salt or solvate thereof, that are antagonists at the mu opioid receptor. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat conditions associated with mu opioid receptor activity, and processes and intermediates useful for preparing such compounds.