Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and eribulin or a pharmaceutically acceptable salt thereof, and the use of the combination therapies for the treatment of cancer.

Abstract: The invention provides a solid composition of the peripheral mu opioid antagonist axelopran and a combination dosage form of the mu opioid antagonist axelopran sulfate in an immediate release form and an opioid analgesic agent which may be in an extended release, sustained release, modified release, or controlled release form and methods of preparing such a combination dosage form.

Abstract: Sail construction comprising foldable sail supports, a crossbeam, a holder, a sail, a bottom holder, ropes and a block and tackle system. The sail can be a self-inflatable sail designed similarly to paragliders, partially or fully inflatable.

Abstract: The present invention provides a cationic lipid which is able to be used for nucleic acid delivery to the cytoplasm. A cationic lipid according to the present invention is, for example, a compound represented by formula (1) or a pharmaceutically acceptable salt thereof, wherein L1 and L2 independently represent an alkylene group having 3 to 10 carbon atoms; R1 and R2 independently represent an alkyl group having 4 to 24 carbon atoms or an alkenyl group having 4 to 24 carbon atoms; R3 represents an alkyl group having 1 to 3 carbon atoms; and X1 represents a single bond or CO—O—.

Abstract: Proposed is a decorative element containing (a) a transparent gemstone with a faceted surface comprising convex curved regions, (b) a transparent electrically conductive layer applied to said faceted surface comprising convex curved regions, (c) a wavelength-selective layer applied (c1) to the planar side opposite to the faceted curved surface, or (c2) to the photovoltaic cell (d); (d) a photovoltaic cell; and (e) a touch-sensitive electronic circuitry.

Abstract: Disclosed are methods for treating ulcerative colitis using a compound of the formula: or a pharmaceutically-acceptable salt thereof.

Abstract: The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

Abstract: The invention relates to a method and apparatus for image compression, particularly to an improved block-coding apparatus and method for image compression. Image compression systems such as JPEG and JPEG2000 are known and popular standards for image compression. Many of the advantageous features of JPEG2000 derive from the use of the EBCOT algorithm (Embedded Block-Coding with Optimized Truncation). One drawback of the JPEG2000 standards is computational complexity. This application discloses a relatively fast block-coding algorithm, particularly as compared with the standard JPEG2000 EBCOT algorithm. Computational complexity is reduced.

Abstract: The object of the present invention relates to a novel family of peptide conjugates of formula (I): A-X1-X2-Pro-Ala-X—B??(I) wherein: A represents a hydrogen atom, a C6 to C20 acyl group or a cholesterol residue; X1 represents a covalent bond, an alanine or a proline; X2 represents an arginine, a lysine, or an alanine; X represents a lysine, an alanine, or a phenylalanine; and B represents a hydroxyl or an amine; or one of its preferentially pharmaceutically, dermatologically or cosmetically acceptable salts, as well as their synthesis processes and their uses for reducing hair loss and stimulating hair growth.

Abstract: The invention provides compounds of formula (I): where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds and methods of using such compounds to treat respiratory diseases.

Abstract: A system for providing mobile content to a mobile communication device includes a first computing system including one or more servers to cause a graphical user interface to be displayed at a second computing system, the graphical user interface (i) enabling a user of the second computing system to edit a digital file to create the mobile content and (ii) enabling the user of the second computing system to provide a phone number associated with the mobile communication device, the mobile communication device being separate and remote from the first computing system and the second computing system. The one or more servers of the first computing system receive, from the second computing system via the communications network, the mobile content and the phone number associated with the mobile communication device.

Abstract: A machine to manufacture cartridges for electronic cigarettes comprising a casing made of plastic material inside which a quantity of powdered tobacco is contained; the machine is provided with a drum which receives an orderly mass of empty casings, and feeds them to a filling station in which a quantity of powdered tobacco is inserted into each empty casing and a filling unit which is arranged in correspondence to the filling station for feeding a quantity of powdered tobacco inside each empty casing from above; the filling unit is provided with a first hopper for the collection of powdered tobacco and a plurality of discs among which a first disc defining a bottom wall of the first hopper; wherein, between the first disc and a second disc a plurality of compartments is defined, each designed to contain the quantity of powdered tobacco to be inserted into a respective casing from above; and wherein the first disc and the second disc are mobile relative to one another, so as to vary the volume of the compartm

Abstract: A rigid package for tobacco articles with a hinged lid and having: at least one group of tobacco articles; at least one wrap, which encloses the group of tobacco articles and has a tobacco article extraction opening closed by a re-stick sealing flap; an outer container, which houses the wrap; a lid having a rear wall, which is hinged to the rear wall of the outer container so as to allow the lid to rotate relative to the outer container; an inner container, which houses the wrap and is arranged inside the outer container in a sliding manner; and a lifting mechanism, which moves the inner container relative to the outer container, using the rotation movement of the lid, between a lowered position, in which the inner container is completely inserted into the outer container, and an extracted position, in which the inner container is partially extracted from the outer container.

Abstract: An insert is provided for use in a cooking apparatus that alters the pressure profile, air velocity profile, and airflow pattern within said cooking apparatus in order to achieve a cyclonic air profile around food to be cooked. The insert includes a ring-shaped insert body formed by a continuous sidewall. The sidewall has an external surface and an internal surface, and a top end and a bottom end. The insert also includes a deflection plate.

Abstract: Apparatus and methods are described including placing a sample into a sample carrier that comprises a plurality of regions having upper and lower surfaces, having respective heights that are different from each other, and being configured such that cells form a monolayer, the monolayer within respective regions of the sample carrier having respective, different densities from each other, due to the respective regions of the sample carrier having respective heights that are different from each other. Microscopic images are acquired of each of the plurality of regions. Measurements are performed upon cell types that have a relatively high density upon microscopic images of a region of the sample chamber having a relatively low height, and measurements are performed upon cell types that have a relatively low density upon microscopic images of a region of the sample chamber having a relatively great height. Other applications are also described.

Abstract: Apparatus and methods for determining a property of a bodily sample using a microscope are described. A sample carrier includes a plurality of microscopy sample chambers configured to receive a least a portion of the bodily sample, while the sample is imaged by the microscope. Each of the microscopy sample chambers has an upper and a lower surface, and the microscopy sample chambers have respective heights between the upper and lower surfaces that are different from each other. The sample carrier defines a microscopy sample chamber inlet hole, that is fluid communication with all of the microscopy sample chambers, such as to facilitate filling of all of the microscopy sample chambers with the portion of the bodily sample, via the microscopy sample chamber inlet hole. Other applications are also described.

Abstract: An inner drum of a washing machine has a plurality of hollow lifting ribs arranged on the side wall of the drum that communicate with the interior of the drum. At least one drainage port communicating with the hollow portions of the lifting ribs is formed in the side wall of the drum. A sealing valve is located inside each lifting rib at each drainage port. During high-speed rotation of the drum, valve bodies of the sealing valves move along a radial center direction of the drum under a centrifugal force, to open the drainage ports. Through this arrangement, discharging water flow in the drum to the outside from the hidden drainage ports is achieved. Meanwhile, centrifugal force during the high-speed rotation of the drum is used to control valve cores of the sealing valves such that the drainage ports are automatically opened for drainage from the drum.

Abstract: The invention relates to a phaco driver system for controlling operation of an ophthalmic surgical phacoemulsification device. The phaco driver system comprises a resonant output circuit for generating a transducer voltage for driving an ultrasonic transducer of the ophthalmic surgical phacoemulsification device. Further, the phaco driver system includes a bridge unit for generating a bridge output signal for feeding the resonant output circuit, the bridge output signal being based on a composition of the first and second phase signals having a fixed mutual phase difference.

Abstract: The present invention is directed to a sensor having continuous and discontinuous regions of conductive metallic nanoparticles capped with an organic coating which enables the detection of volatile organic compounds and/or water vapor. Continuous regions may exhibit a positive response upon exposure to volatile organic compounds and to water vapor, while discontinuous regions exhibit a positive response upon exposure to volatile organic compounds and a negative response upon exposure to water vapor.