Patents Assigned to D
  • Mutated immunoglobulin-binding polypeptides
    Patent number: 10954309
    Abstract: An Fc-binding polypeptide of improved alkali stability, comprising a mutant of an Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO:3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO 26 or SEQ ID NO 27, wherein at least the alanine residue at the position corresponding to position 42 in SEQ ID NO:4-7 has been mutated to arginine and/or wherein at least the aspartic acid residue at the position corresponding to position 37 in SEQ ID NO:4-7 has been mutated to glutamic acid.
    Type: Grant
    Filed: November 11, 2015
    Date of Patent: March 23, 2021
    Assignee: Cytiva BioProcess R&D AB
    Inventors: Gustav Rodrigo, Tomas Bjorkman, Mats Ander
  • JAK inhibitors containing a 4-membered heterocyclic amide
    Patent number: 10954237
    Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: March 23, 2021
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Paul R. Fatheree, Gary E. L. Brandt, Cameron Smith, Steven D. E. Sullivan, Lori Jean Van Orden
  • Device for protecting an optical sensor, and associated driving assistance system and cleaning method
    Patent number: 10953855
    Abstract: The invention relates to a device (3) for protecting an optical sensor (13) for a motor vehicle. According to the invention, the protection device (3) comprises: a housing (4) which is mounted in such a way that it rotates about a rotational axis (A1) and has a receiving element (19) designed to receive the optical sensor (13) such that the optical axis (15) of the optical sensor (13) merges with the rotational axis (A1), a transparent optical element (9) constrained to rotate with the housing (4) and designed to be arranged in front of the housing (4) facing the road and such that it is centred in relation to the optical sensor (13), and an actuator (5) for rotating the housing (4), so as to clean said optical element (9) by means of a centrifugal effect. The invention also relates to a driving assistance system (1) corresponding in this way to a cleaning method implementing such a protection device (3).
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: March 23, 2021
    Assignee: Valeo Systèmes d'Essuyage
    Inventors: Frédéric Bretagnol, Giuseppe Grasso, Grégory Kolanowski, Marcel Trebouet
  • System and method for product display
    Patent number: 10956884
    Abstract: A system and method for displaying product information in a store. The system is configured to communicate with a communication network. Included is a shelf display device or digital tag positioned within the store and a physical, bib tag for a product. The digital tag has a digital display surface, a reader, and a communication device. The digital tag is configured to display information associated with a product via its display surface and configured for operative communication with the communication network via its communication device. The bib tag has product-related information displayed thereon. The bib tag also has machine readable information that is readable by the reader of the digital tag. The communication device of the digital tag is configured and arranged to transmit information, regarding the machine readable information of the bib tag, to the communication network.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: March 23, 2021
    Assignee: Sunrise R&D Holdings, LLC
    Inventors: Titus Arthur Jones, Brett Bracewell Bonner
  • Methods for manufacturing micromechanical components and method for manufacturing a mould insert component
    Patent number: 10954123
    Abstract: Method of manufacturing a micromechanical component intended to cooperate with another micromechanical component, the method comprising the steps of providing a substrate, forming a mould on said substrate, said mould defining sidewalls arranged to delimit said micromechanical component, providing particles on at least said sidewalls, depositing a metal in said mould so as to form said micromechanical component, and liberating said micromechanical component from said mould and removing said particles.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: March 23, 2021
    Assignee: CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA—RECHERCHE ET DÉVELOPPEMENT
    Inventors: Nicolas Blondiaux, Raphaël Pugin
  • ALK5 inhibitors
    Patent number: 10952996
    Abstract: The present disclosure provides inhibitors of activin receptor-like kinase 5 (ALK5). Also disclosed are methods to modulate the activity of ALK5 and methods of treatment of disorders mediated by ALK5.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: March 23, 2021
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Svitlana Kulyk, Christina Owens, Steven D. E. Sullivan, Jennifer Kozak, Adam D. Hughes
  • Macrocyclic compound and uses thereof
    Patent number: 10954249
    Abstract: The present invention provides novel Compound (1) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable and medical uses thereof.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: March 23, 2021
    Assignees: President and Fellows of Harvard College, Eisai R&D Management Co., Ltd.
    Inventors: Yoshito Kishi, Kazunobu Kira, Ken Ito
  • Means and Methods for Treating Bacterial Infections
    Publication number: 20210077563
    Abstract: The present invention relates to non-naturally occurring anti-bacterial peptides. More specifically the peptides can be used to treat multi-drug resistant bacterial infections. In addition, the present invention provides methods for producing anti-bacterial peptides.
    Type: Application
    Filed: May 9, 2018
    Publication date: March 18, 2021
    Applicants: VIB VZW, Katholieke Universiteit Leuven, K.U. Leuven R&D
    Inventors: Joost Schymkowitz, Frederic Rousseau
  • Memory Device Having Variable Impedance Memory Cells and Time-To-Transition Sensing of Data Stored Therein
    Publication number: 20210082490
    Abstract: The present disclosure relates to circuits, systems, and methods of operation for a memory device. In an example, a memory device includes a memory array including a plurality of memory cells, each memory cell having an impedance that varies in accordance with a respective data value stored therein; and a tracking memory cell having an impedance based on a tracking data value stored therein; and a read circuit coupled to the memory array, the read circuit configured to determine an impedance of a selected memory cells with respect to the impedance of the tracking memory cell; read a data value stored within the selected memory cell based upon a voltage change of a signal node voltage corresponding to the impedance of the selected memory cell.
    Type: Application
    Filed: November 27, 2020
    Publication date: March 18, 2021
    Applicant: R&D 3 LLC
    Inventor: Ravindraraj Ramaraju
  • CAPACITIVE TOUCH SENSOR APPARATUS HAVING BRANCHING ELECTRODES
    Publication number: 20210081076
    Abstract: A capacitive touch sensor comprises a plurality of electrodes on a substrate, and a position of a finger touching the sensor is determined by monitoring output signal changes caused by changes in capacitance caused by the present of the finger over or near the electrodes. The disclosure provides a capacitive touch sensor apparatus comprising a substrate and a plurality of touch sensor electrodes arranged on the substrate. Each of the electrodes comprises a respective primary electrode strip and a respective one or more electrode strip branches extending from the primary electrode strip.
    Type: Application
    Filed: December 21, 2018
    Publication date: March 18, 2021
    Applicant: 1004335 ONTARIO INC. CARRYING ON BUSINESS AS A D METRO
    Inventors: Robert Donald MCCULLOCH, Guy Michael Amyon Farquharson DUXBURY, Albert M. DAVID, Gueorgui PAVLOV
  • TRANSPARENT NANOEMULSIONS COMPRISING LAURIC OIL
    Publication number: 20210077367
    Abstract: The invention relates to oil-in-water emulsion in which specific oils (e.g., lauric oils) are used in the oil phase while surprisingly maintaining excellent transparency. In one aspect, said emulsions comprise fatty acid in oil phase. In a separate co-pending application, the invention comprises an energy efficient process for making said fatty acid containing transparent nanoemulsions.
    Type: Application
    Filed: January 21, 2019
    Publication date: March 18, 2021
    Applicant: Conopco, Inc., d/b/a UNILEVER
    Inventor: Congling QUAN
  • INTERFERING IN TIME-DIVISION DUPLEX COMMUNICATION
    Publication number: 20210084659
    Abstract: A computer readable storage medium is presented, having computer readable program instructions thereon for causing a processor to carry out the steps of: sub-dividing a time slot into consecutive time intervals, the time slot belongs to multiple time slots allocated to a first node for transmitting to a second node using a wireless time-division duplex communication link between the first node and the second node, the second node transmitting during separate time slots allocated to said second node; and disrupting communication between said first node and said second node by transmitting, using a transmitter, respective interference signals during at least some of said time intervals, each of said interference signals being transmitted on one of said frequency bands, wherein for at least two of said time intervals said interference signals are transmitted on different frequency band.
    Type: Application
    Filed: June 23, 2020
    Publication date: March 18, 2021
    Applicant: D-FEND SOLUTIONS AD LTD
    Inventors: Hanan LEIZEROVICH, Assaf Monsa Chermon
  • METHOD OF POSITIONING A PATIENT
    Publication number: 20210077325
    Abstract: The present disclosure provides a method of positioning a patient. The patient is provided on a support surface, an inflatable positioning mattress disposed between the patient and the support surface. Air flow into the inflatable positioning mattress is initiated to inflate the inflatable positioning mattress. A downward force is applied on the inflatable positioning mattress proximate to a first side of the support surface. A portion of the inflatable positioning mattress proximate to a second side of the support surface is raised. At least one wedge is positioned beneath the inflatable positioning mattress. Subsequently, the patient is lowered onto the at least one wedge.
    Type: Application
    Filed: December 21, 2018
    Publication date: March 18, 2021
    Applicant: D.T. Davis Enterprises, LTD., d/b/a Hovertech International
    Inventor: David T. Davis
  • BONE GRAFT DELIVERY SYSTEM AND METHOD FOR USING SAME
    Publication number: 20210077275
    Abstract: The present invention relates to an apparatus and method for near-simultaneous and integrated delivery of bone graft material during the placement of surgical cages or other medical implants in a patient's spine. The integrated fusion cage and graft delivery device according to various embodiments delivers and disperses biologic material through a fusion cage to a disc space and, without withdrawal from the surgical site, may selectively detach the fusion cage for deposit to the same disc space. The integrated fusion cage and graft delivery device is formed such that a hollow tube and plunger selectively and controllably place bone graft material and a fusion cage in or adjacent to the bone graft receiving area. In one embodiment, the integrated fusion cage is an expandable integrated fusion cage. In another embodiment, the bone graft material is loaded into a breech area in the hollow tube.
    Type: Application
    Filed: September 15, 2020
    Publication date: March 18, 2021
    Applicant: Spinal Surgical Strategies, Inc., D/B/A Kleiner Devices Labs
    Inventors: Michael J. Milella, JR., Jeffrey Kleiner, Edward J. Grimberg, JR., Gregory Causey, Alan Burkholder
  • NEPRILYSIN INHIBITORS
    Publication number: 20210079017
    Abstract: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
    Type: Application
    Filed: July 23, 2020
    Publication date: March 18, 2021
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Roland Gendron, Melissa Fleury, Adam D. Hughes
  • LIQUID VENTILATOR AND METHOD TO INDUCE TIDAL LIQUID VENTILATION AND/OR HYPORTHERMIA
    Publication number: 20210077759
    Abstract: Liquid ventilator and methods integrating the concept of total liquid ventilation (TLV) using liquid volumes below functional residual capacity (FRC) of mammal's lungs are disclosed. Beyond the automatization of the whole process, the technology has been up-scaled to confirm that TLV at residual volumes below FRC can provide a safe procedure while enabling the full potential of TLV in a mammal such as humans or adult-sized animals. Such tidal liquid ventilation strongly differs from the previously known TLV approach, opening promising perspectives for a safer clinical translation. Also disclosed are apparatus and method for safe and fast induction of hypothermia during liquid ventilation of a mammal.
    Type: Application
    Filed: April 12, 2019
    Publication date: March 18, 2021
    Applicants: UNIVERSITE DE SHERBROOKE, ECOLE NATIONALE VETERINAIRE D'ALFORT, INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
    Inventors: Philippe MICHEAU, Renaud TISSIER, Matthias KOHLHAUER, Julien MOUSSEAU, Mathieu NADEAU, Jonathan VANDAMME
  • Methods for determining the metabolic status of lymphomas
    Patent number: 10947598
    Abstract: Provided is an in vitro method for determining the metabolic status of a lymphoma comprising a step of determining the level of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in lymphoma cells, wherein a low level of GAPDH expression is indicative of oxidative phosphorylation (OXPHOS) status. Also provided is an in vitro method for predicting the responsiveness of a patient afflicted with a lymphoma to a treatment with a metabolic inhibitor selected from the group consisting of mitochondrial metabolic inhibitors and glutamine metabolism inhibitors comprising a step of determining the level of GAPDH expression in lymphoma cells obtained from said patient, wherein a low level of GAPDH expression is predictive of a response to a treatment with a metabolic inhibitor.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: March 16, 2021
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Université Côte d'Azur, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
    Inventors: Jean-Ehrland Ricci, Johanna Chiche, Catherine Thieblemont
  • Anti-EphA4 antibody
    Patent number: 10947313
    Abstract: Provided is an anti-EphA4 antibody that can bind to EphA4 and enhance the cleavage of EphA4, as well as a pharmaceutical composition comprising the antibody as the active ingredient. A mouse anti-EphA4 antibody that has binding affinity towards EphA4 and can enhance the cleavage of EphA4 was obtained, and the sequence of the complementarity-determining region (CDR) of the mouse anti-EphA4 antibody was identified. Subsequently, the anti-EphA4 antibody of interest was obtained by producing a humanized antibody of the mouse anti-EphA4 antibody.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: March 16, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Eiji Inoue, Akio Yamada, Tomomi Kawakatsu, Toshio Imai, Maki Deguchi, Aki Nakatani
  • Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound
    Patent number: 10946006
    Abstract: The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
    Type: Grant
    Filed: January 16, 2020
    Date of Patent: March 16, 2021
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Lori Jean Patterson, Robert S. Chao, Miroslav Rapta
  • Display screen with a graphical user interface
    Patent number: D913301
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: March 16, 2021
    Assignee: Teva Branded Pharmaceutical Products R&D, Inc.
    Inventor: Xinyu Liu