Abstract: A method for maintaining a delivery robot, the delivery robot including a body and at least one sensor provided with at least one optical surface. The method includes positioning of the delivery robot in a parking base and cleaning the delivery robot by means for cleaning the parking base.

Abstract: A device for determining a state of wear of a wiper blade for a wiper system is disclosed. The device is configured to be fitted in a motor vehicle. The device for determining a state of wear includes an angular position sensor configured to measure at least one datum relating to a wiper blade during a wiping operation and an electronic control unit configured to determine the state of wear of the wiper blade as a function of the at least one datum measured by the angular position sensor.

Abstract: The invention is directed to a hydratable concentrated surfactant composition. The composition is pourable, easy to dilute, substantially free of sulfate and oil, comprises a C6-C14 acid, alcohol, amide or mixture thereof, anionic surfactant and an amphoteric surfactant, zwitterionic surfactant or both. The composition is in lamellar phase and thickens and transforms to an isotropic phase upon dilution. The composition comprises a mono-, di and/or tri-ester, can be used as a concentrate in small volumes and diluted as used and needed or can be diluted with water in refill packaging to ensure a reduction in plastic waste.

Abstract: An apparatus for targeted advertising based on identified missing job qualifications is presented. The apparatus includes at least a processor and a memory communicatively connected to the at least a processor. The memory contains instructions configuring the at least a processor to receive a candidate datum containing a plurality of user identifiers describing a user, assign a user weight to each user identifier of the candidate datum, compute a score for each user identifier based on the user weight using a user score classifier, generate a candidate score datum as a function of the scores, and provide a targeted data transmission based on the candidate score datum and a posting score datum, wherein the targeted data transmission includes an educational posting.

Abstract: A machining tool has a body that includes a central tubular portion forming a duct centered on a longitudinal axis. A peripheral tubular portion is coaxial with the central tubular portion and surrounds the central tubular portion. A first machining stage has a first arm and a second arm that extend on either side of the central tubular portion. The first arm and the second arm each have a machining member at the end thereof. The first arm and the second arm are each integral with the central tubular portion and the peripheral tubular portion. The machining tool body also includes a baseplate. The peripheral tubular portion has at least one linking arch connecting the first arm and the second arm and bypassing the central tubular portion.

Abstract: Disclosed is a method for diagnosing allergy in a human or animal patient, wherein the level of species-specific lipocalin, especially lipocalin 2 in a human patient, is measured in a sample of said patient and wherein a lowered level of said lipocalin compared to the level of said lipocalin in the corresponding sample of a human or animal that has no allergy, is indicative of an allergy, as well as a kit for performing this method, and a kit for quality control of allergen molecules or extracts used for immunotherapy of allergy by determining its siderophore-iron ligand load and thus immunomodulatory potency. Further, lipocalin proteins for use in treatment or prevention of allergies are provided, preferably complexed with siderophore-iron ligands.

Abstract: The present invention provides gene therapies for the treatment of Friedreich's ataxia. Specifically, the present invention provides a nucleic acid, cloning vector and transfer vector for the production of an adeno-associated virus (AAV) vector. The nucleic acid comprises (i) a nucleic acid sequence encoding frataxin, (ii) a phospho-glycerate-kinase (PGK) promoter, and (iii) a woodchuck hepatitis virus posttranscriptional regulatory element (WPRE). The present invention also provides a pharmaceutical composition which comprises the AAV vector or nucleic acid. Also, the AAV vector, nucleic acid or pharmaceutical composition can be used as a medicament, specifically as a medicament for the treatment of Friedreich's ataxia.

Abstract: Liquid ventilator and methods integrating the concept of total liquid ventilation (TLV) using liquid volumes below functional residual capacity (FRC) of mammal's lungs are disclosed. Beyond the automatization of the whole process, the technology has been up-scaled to confirm that TLV at residual volumes below FRC can provide a safe procedure while enabling the full potential of TLV in a mammal such as humans or adult-sized animals. Such tidal liquid ventilation strongly differs from the previously known TLV approach, opening promising perspectives for a safer clinical translation. Also disclosed are apparatus and method for safe and fast induction of hypothermia during liquid ventilation of a mammal.

Abstract: The present invention relates to a stator for an electric motor, comprising a plurality of separate teeth comprising a first connector and a second connector, a plurality of coils which are configured to be wound respectively around the plurality of separate teeth, a first end of the wire of the winding being configured to be positioned in the first connector and a second end of the wire of the winding being configured to be positioned in the second connector, a central module configured to receive the separate teeth, said central module comprising connecting frames comprising connecting tabs extending radially and configured to be inserted in a first connector or in a second connector of a separate tooth, the connecting frames being configured to provide electrical connections between the coils.

Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.

Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a multi-RTK inhibitor, and the use of the combination therapies for the treatment of cancer. The multi-RTK inhibitor may be represented by Formula (I): wherein R1 is C1-6 alkyl or C3-8 cycloalkyl, R2 is a hydrogen atom or C1-6 alkoxy, and R3 is a hydrogen atom or a halogen atom. A tumor therapeutic agent is disclosed that combines a compound or pharmaceutically acceptable salt thereof represented by Formula I and an anti-PD-1 antibody.

Abstract: The present disclosure generally relates to polymer-aerogel/fiber composite materials, polymer-aerogel/textile composite materials, and systems and methods for producing them. The gel material can comprise, in some embodiments, a network of polymer. The fiber and/or textile material can comprise at least one of any natural, synthetic, and/or mineral fiber. In some cases, certain combinations of materials, solvents, and/or processing steps may be synergistically employed so as to enable manufacture of materials suitable for use in apparel, soft goods, and other consumer applications which may benefit from the properties of a polymer-aerogel/fiber composite and/or the polymer-aerogel/textile composite.

Abstract: A foldable solar panel including at least two solar modules mounted to a substrate. The foldable solar panel includes hook and loop tape to secure the foldable solar panel in the folded configuration. The foldable solar panel includes at least two straps and at least two horizontal rows of webbing operable to attach the foldable solar panel to a load-bearing platform.

Abstract: The streamlined flat windscreen wiper comprises a longitudinal wiper blade, a longitudinal streamlined fairing comprising a central mounting and at least one end cap, and at least one caliper comprising claws for retaining said longitudinal wiper blade, and further comprises at least one adapter element fixed to the central mounting at a distal end thereof, a proximal end of the at least one end cap and said at least one caliper being pivotably articulated to said at least one adapter element.

Abstract: The present invention relates to an anti-CRISPR construct useful to counteract the spread of a gene-drive in an arthropod population. The invention is also concerned with a system comprising the anti-CRISPR construct and a crispr-based gene-drive construct, a method of producing a genetically modified arthropod, a genetically modified arthropod, and a method for counteracting a CRISPR-based gene-drive in an arthropod population.

Abstract: Apparatus and methods are described including a digital camera, and a computer processor configured to drive the digital camera to acquire, for each of a plurality of imaging fields of a stained bodily sample, three or more digital images. At least one of the images is a brightfield image and at least two of the images are fluorescent images, each of the fluorescent images being acquired using respective first and second filters, which are different from each other. The computer processor performs image processing on the digital images, by extracting visual classification features from each of the three or more digital images, and identifies one or more entities that are contained within the bodily sample, based upon the image processing. Other applications are also described.

Abstract: A method for verifying the operation of a cleaning device mounted on a motor vehicle, comprising at least one of the following steps: commanding a pump to inject cleaning fluid as far as at least one valve during a determined time period, the command to activate the pump being coupled with the keeping of the valve or valves in the closed state; at least one measurement of a parameter relating to the pressure of the cleaning liquid upstream of the valve or valves using at least one pressure sensor; comparing the measured parameter relating to the pressure against a predetermined expected value; and determining an operating status of the cleaning device on the basis of the result of the comparison between the measured parameter relating to the pressure and the predetermined expected value; and generating a warning signal in the event that the cleaning device is malfunctioning.

Abstract: The present invention discloses a formation method, comprising: forming a hard mask layer and a photo-lithographic pattern of a fin structure on a the semiconductor substrate; patterning the hard mask layer and the semiconductor substrate to gain the fin structure with a profile of steep sidewalls; forming a protective layer on the sidewall surface of the fin structure; etching the semiconductor substrate located below the fin structure to form isolation structure trenches; performing a modified treatment on the exposed surfaces of the isolation structure trenches to form a modified layer with a certain thickness; removing the protective layer and the modified layer simultaneously; filling a dielectric layer in the isolation structure trenches till to cover the fin structure and then planarizing the dielectric layer; performing a trench etching to the dielectric layer and forming the fin structure and an isolation structure with sloped sidewalls.

Abstract: The present invention relates to the use of the measure of anelloviral load for the determination of immunosuppression. More precisely, the present invention provides a method for characterizing the immunosuppressed or non-immunosuppressed status of a subject, comprising the steps of determining the anelloviral load from a biological sample of the said subject, and determining from the said comparison the immunosuppressed or non-immunosuppressed status. The determination of the immunosuppressed status of the subject can then be used to design or adapt a therapeutic treatment.

Abstract: A method is provided for indoor multipath ghosts recognition for a multiple-input-multiple-output radar with collocated antennas. The method includes the step of generating a two-dimensional Range-Doppler map for N number of consecutive radar data frames. The method further includes the step of applying a temporal clustering algorithm to the N number of consecutive radar data frames. Moreover, the method includes the step of applying a linear pattern extraction algorithm on the two-dimensional Range-Doppler map. In this context, the two-dimensional Range-Doppler map comprises detections from at least one target, at least one first-order ghost, and at least one second-order ghost with respect to one wall reflector.