Abstract: A method for suppressing an immune response is provided. The method involves administration of isolated lymphoid tissue-derived suppressive stromal cells (LSSC) to a subject in need of such treatment in an amount effective to suppress the immune response in the subject. The invention also involves a method to isolate LSSC by digesting lymphoid tissue fragments using a combination of an enzyme mix and agitation and then collecting the LSSC. Pharmaceutical preparations comprising LSSC are also provided.
Type:
Application
Filed:
April 5, 2024
Publication date:
August 15, 2024
Applicants:
The General Hospital Corporation d/b/a Massachusetts General Hospital, Dana-Farber Cancer Institute, Inc.
Inventors:
Anne Fletcher, Shannon J. Turley, Biju Parekkadan
Abstract: The present disclosure provides a neuro-mesenchyme signaling axis that controls group 2 innate lymphoid cells (ILC2s), adipose tissue physiology, metabolism, and obesity. This signaling axis includes ILC2s with rearranged during transfection (RET) receptor, mesenchymal stromal cells (MSCs) with beta-2 adrenergic receptor (ADRB2), and high-order brain areas including the paraventricular nucleus of the hypothalamus (PVH).
Type:
Application
Filed:
June 2, 2022
Publication date:
August 15, 2024
Applicant:
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud
Inventors:
José Henrique Veiga Fernandes, Ana Filipa Ribeiro Cardoso
Abstract: A cover for collars is provided with antiparasitic means, which is characterised in that it includes an elongate tubular body (1) which allows an antiparasitic collar (2) to be inserted therein, such as to surround the external and internal face of the collar, and which is equipped with closure means (5) at the ends thereof allowing the ends to be fastened together once the collar has been inserted. The internal face (1a) of the elongate tubular body (1) of the cover is made of a material (3) provided with holes, and the external face (1b) is made of smooth material (4) without holes.
Abstract: The disclosed apparatus, systems and methods relate a failover and internet connection monitoring system featuring a cloud server running an API, a probe, a firewall and a policy routing system. The failover connection monitoring system is capable of gathering and analyzing performance data and controlling the flow of packets to and from the internet over one or more connections to optimize performance of the network.
Type:
Grant
Filed:
February 21, 2023
Date of Patent:
August 13, 2024
Assignee:
R&D Industries, Inc.
Inventors:
Christopher Van Oort, Donald Van Oort, Nathan Lafferty
Abstract: A casting device may include a microcontroller, an inertial measurement unit in communication with the microcontroller, an actuator in communication with the microcontroller, and a power source for providing power to the casting device. The casting device may also include one or more indicators that provide user feedback regarding accurate use of the device.
Abstract: This device for measuring a magnetic field comprises: a magnetic field sensor, comprising: a probe, and a pick-up coil and a feedback coil coiled around the probe, and a control circuit, comprising: a generation module comprising a probe signal generation unit, configured to generate an electrical current, a preamplification module, a buffer module, configured to deliver an output signal of the control circuit defining an output magnetic field value, a piloting module configured to pilot the probe signal generation unit to generate the electrical current in the probe. The control circuit comprises a correction module configured to control a working magnetic field, corresponding to a magnetic field maximizing the magnetic field sensitivity of the probe and minimizing the magnetic field noise of the probe.
Type:
Grant
Filed:
January 8, 2021
Date of Patent:
August 13, 2024
Assignees:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NATIONALE SUPERIEURE D INGENIEURS DE CAEN, UNIVERSITE DE CAEN NORMANDIE
Abstract: A wearable remote control device 1 for controlling a movable equipment 10 includes a wearable carrier 2 adapted for being worn on a user's hand, a control interface 3 configured for converting user's input into instructions; a communication module 4 configured for sending the instructions receivable by the movable equipment 10, an actuation interface 5, and a tracking module 6 configured for being actuated by the actuation interface 5. The actuation interface 5 includes an actuation module 51 adapted for being actuated by the user's hand, and a gesture sensing module 52 configured for detecting a predetermined hand gesture. Upon the actuation module 51 is actuated, the actuation interface 5 provides a tracking signal 61 receivable by the movable equipment 10 for determining a traveling path with respect to movements of the wearable remote control device 1.
Type:
Grant
Filed:
March 3, 2022
Date of Patent:
August 13, 2024
Assignee:
Logistics and Supply Chain MultiTech R&D Centre Limited
Inventors:
Chow Wing Leung, Wai Tik Sze, Wong Shuk Hang
Abstract: The present invention relates to a method of delivering high Sun Protection Factor (SPF) and UVA protection factor (UVAPF) to a topical surface of a body preferably the human body. The method more preferably provides for synergistic benefit of SPF and UVA PF over and above that which can be delivered through each of two individual steps carried out sequentially viz. washing off the skin with a specific cleansing composition followed by the step of applying a sunscreen composition on to the same skin surface. The specific cleansing composition comprises water soluble sunscreens but the leave-on composition could comprise any sunscreen.
Abstract: The present invention relates to an oil in water emulsified food composition comprising from 5 to 65 wt % of vegetable oil, starch and aquafaba.
Abstract: Systems, methods, and articles for a portable power case are disclosed. The portable power case is comprised of at least one battery and at least one PCB. The portable power case has at least one USB port and at least two access ports, at least two leads, or at least one access port and at least one lead. The portable power case is operable to supply power to an amplifier, a radio, a wearable battery, a mobile phone, and a tablet. The portable power case is operable to be charged using solar panels, vehicle batteries, AC adapters, non-rechargeable batteries, and generators. The portable power case provides for modularity that allows the user to disassemble and selectively remove the batteries installed within the portable power case housing.
Type:
Application
Filed:
March 25, 2024
Publication date:
August 8, 2024
Applicant:
LAT Enterprises, Inc., d/b/a MediPak Energy Systems
Inventors:
Laura Thiel, Giancarlo Urzi, Carlos Cid
Abstract: Systems, methods, and computer-readable storage media for protecting data. One system includes a readiness system comprising executable instructions to identify a security posture of an entity based on entity data and model the security posture and at least one security objective to generate a set of attributes of the entity. The system can further include a cybersecurity connection system comprising executable instructions to generate a cybersecurity protection plan corresponding to an attribute to protect the entity, wherein the cybersecurity protection plan is activated in response to an input by the entity. The system can further include an incident system comprising the executable instructions to model a plurality of cybersecurity protection plans between the entity and a third-party. The system can further include a remediation system comprising the executable instructions execute one or more remediation actions to mitigate a vulnerability or security gap based on the security posture of the entity.
Abstract: Systems, methods, and computer-readable storage media for protecting data. One system includes memory and one or more processing circuits configured to embed a marketplace component into a user interface of a vendor application, wherein the marketplace component includes a plurality of protection products and access user data associated with the vendor application. The one or more processing circuits further configured to determine, by utilizing the user data, a protection readiness based on a plurality of protection requirements, wherein the plurality of protection requirements includes one or more factors corresponding with the user data. The one or more processing circuits further configured to generate a protection product based on the protection readiness and provide, via the marketplace component, the protection product to the user interface of the vendor application.
Abstract: Disclosed is a skin care composition comprising retinoid, a first modified starch and a second modified starch, wherein the weight ratio of the total modified starches to the retinoid is at least 7:1.
Abstract: The present description relates according to a first aspect to a method for measurement of optical properties of at least one particle in a sample (10) and permits, for example, quantitative determination of the complex dipolar polarizability of at least one particle present in a sample. The optical characterization method comprises the illumination of said sample (10) using a light beam, the sample (10) being positioned in the object space of an optical system (120); the acquisition of at least one phase image and at least one intensity image of said at least one particle illuminated by the light beam, the acquisition being carried out in an analysis plane arranged in the image space of the optical system (120); and the determination of at least one optical property of said at least one particle from said at least one phase image and at least one intensity image.
Type:
Grant
Filed:
August 26, 2020
Date of Patent:
August 6, 2024
Assignees:
Centre national de la recherche scientifique, Université d'Aix-Marseille, CENTRALE MARSEILLE
Abstract: A monolithic component for a timepiece, in particular for a mechanical timepiece, comprising at least one rigid portion and an elastically flexible portion and designed to transmit the movement of an actuator of the timepiece to a driven part of the timepiece. The monolithic component comprises a rigid frame, a first rigid driving member, and a first elastically flexible structure connecting said frame to said first driving member. The first elastically flexible structure is configured in a manner such as to provide a displacement of said first driving member with at least two degrees of freedom, said displacement being caused as a result of the actuator coming into contact with said first driving member.
Type:
Grant
Filed:
December 19, 2017
Date of Patent:
August 6, 2024
Assignee:
MANUFACTURE D'HORLOGERIE AUDEMARS PIGUET SA
Abstract: The invention relates to a wiper motor having a housing element connected to an electrical line that has an elastically deformable spring element in an end region projecting out of the housing element, wherein the spring element, in order to form an electrically conductive connection with a counterpart element on the housing element, is movable, with respect to a first, relaxed position of the spring element, into a second, elastically deformed position generating a contact force on the counterpart element.
Abstract: In an embodiment a method for detecting a presence of at least one object in a field of view of a time of flight sensor includes successively generating, by the time of flight sensor, histograms, each histogram comprising several classes associating a number of photons detected at a given acquisition period, adding several successively generated histograms so as to obtain a summed histogram and analyzing the summed histogram to detect the presence of at least one object in the field of view of the time of flight sensor.
Abstract: An object of the present invention is to provide a pharmaceutical composition for treating or preventing lower gastrointestinal diseases such as inflammatory bowel disease. The present invention provides a pharmaceutical composition containing a specific self-assembling peptide RADA16 for treating or preventing lower gastrointestinal diseases such as inflammatory bowel disease.