Abstract: A catalyst substrate may include a ceramic base body including first and second ends, the second end being opposite to the first end, and the ceramic base body being provided with a plurality of cells each extending between the first and second ends; and a plurality of metal particles or metal fragments introduced into one or more internal spaces of one or more selected cells in the plurality of cells. Each of the plurality of metal particles or metal fragments has a size equal to or less than an opening width of the cell. The plurality of metal particles or metal fragments is configured to generate heat in accordance with varying magnetic field.

Abstract: An arrow nock may have at least two distinct string guide impressions each designed to receive a bowstring to fire an arrow from a bow. The nock may be operable when connected and aligned with the arrow to cause the bowstring to be received within at least one of the string guide impressions to fire the arrow. As it is received within the string guide impression, the bowstring may cause the arrow to rotate about its longitudinal axis.

Abstract: A series of 1,2,6,7,9,9a-hexahydropyrazino[1,2-d][1,2,4]triazin-4-one derivatives, substituted in the 8-position by an optionally substituted fused bicyclic heteroaromatic group, and in the 3-position by a range of functional groups, being selective inhibitors of phosphatidylinositol-4-kinase III? (PI4KIII?) activity, are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases and malaria; and organ and cell transplant rejection.

Abstract: A shock-absorber and/or vibration-absorber device is proposed, comprising at least one flexible element able to deform under the effect of a stress; said device being remarkable in that it includes at least one so-called dissipative layer made from a material having a shear modulus lower than the shear modulus of the flexible element, a shock-absorbing factor greater than the shock-absorbing factor of said flexible element, and at least partially secured to said flexible element such that a flexion of the flexible element, under the effect of a stress, provides shearing of the dissipative layer making it possible to dissipate at least part of the energy from said stress. A method for manufacturing said shock-absorber device is also disclosed.

Abstract: The present disclosure provides a casing windowing method and tool using coiled tubing; the windowing method comprises the steps of: a) preparing a borehole, including drifting a casing, and scraping an inner wall of the casing; b) hanging a positioning assembly in the casing, including seating the positioning assembly at a wellhead of the borehole, and after the positioning assembly is put down to a predetermined position in the casing, hanging a hanger of the positioning assembly at the inner wall of the casing; c) fixing a whipstock at a down-hole of the borehole, including seating the whipstock at the wellhead, and inserting a guiding assembly of the whipstock into the hanger so that an orientation of a window inclined plane of the guiding assembly meets a requirement of window orientation; and d) windowing the casing, including seating a tapered windowing mill at the wellhead, and after the tapered windowing mill is put down to the window inclined plane of the guiding assembly, starting the tapered windo

Abstract: A method for optical detection of residual soil on articles (such as medical instruments and equipment), after completion of a washing or a rinsing operation by a washer. A soil detection system provides an indication of soil on the articles by detecting luminescent radiation emanating from the soil in the presence of ambient light.

Abstract: A laser system includes a first laser source with a laser resonator for generating a first pulsed laser beam. The resonator has a back mirror, an outcoupling mirror and an active lasing medium in between. The system includes a second laser source for generating a second pulsed laser beam and an optical block. The optical block includes a coupling polarizer and a first polarization rotator. The optical block is movable back and forth between an active position and a passive position. In its active position the optical block is located between the outcoupling mirror and the active lasing medium such that the coupling polarizer couples the second beam into the laser resonator of the first laser source while the first rotator is positioned between the outcoupling mirror and the coupling polarizer. In the active position of the optical block a second polarization rotator is between it and the back mirror.

Abstract: Fabricating wiring layers above a Josephson junction multi-layer may include removing a part of the multilayer; depositing an insulating layer to overlie a part of the multilayer; and patterning the insulating layer to define a hole in the insulating layer. The method includes depositing a first superconducting wiring layer over a part of the insulating layer and within a portion of the hole. Further, insulating and wiring layers may be deposited and a topmost wiring layer defined. The method includes depositing a passivating layer to overlie the topmost wiring layer. Fabricating a superconducting integrated circuit comprising a hybrid dielectric system may include depositing a high-quality dielectric layer that overlies a superconducting feature. The method includes depositing a second dielectric layer that overlies at least part of the high-quality dielectric layer. The second dielectric layer can comprise a conventional dielectric material.

Abstract: The present invention relates to a viral vector for expression of the cell death-inducing PUMA protein, for use in gene therapy, for example for the treatment of rheumatoid arthritis. This vector consists in particular of a recombinant adenovirus expressing the gene encoding the PUMA protein and of a recombinant baculovirus containing a coxsackie-adenovirus receptor (CAR).

Abstract: An engine test apparatus includes a dynamometer connected to an engine through a shaft, and a control calculation device configured to control operations of the engine and the dynamometer. The shaft has one end connected to an output shaft of the engine, and the other end connected to a rotation shaft of the dynamometer, and includes a Doppler velocimeter configured to emit laser light to the one end of the shaft or the output shaft of the engine to contactlessly measure a rotation speed of the output shaft of the engine, and transmit the measured rotation speed to the control calculation device. The control calculation device uses the rotation speed transmitted from the Doppler velocimeter to control the operation of the dynamometer.

Abstract: The invention relates to a peptide having a length of no more than 100 amino acids and comprising at least 19 contiguous amino acids from the amino acid sequence of the human PRAME protein, wherein the peptide comprises at least one HLA class II epitope and at least one HLA class I epitope from the amino acid sequence of the human PRAME protein and to its use as such or in a composition as a medicament for the treatment and/or prevention of cancer.

Abstract: The invention relates to a wiper device (10) for cleaning vehicle windows, with a wiper arm (11) and with a wiper blade (12) able to be fastened on the wiper arm (11), with a cleaning device (25), having at least one spray nozzle (44, 45), for spraying a washing fluid, wherein the at least one spray nozzle (44, 45) is arranged in the region of the free end of the wiper arm (11) and is connected directly therewith, and with a fastening device (35) for connecting the wiper blade (12) with the wiper arm (11), wherein the wiper arm (11) has a mount (28), having an at least substantially U-shaped cross section, with two parallel side wall (17, 18) for the fastening device (35) of the wiper blade (12), and wherein the cleaning device (25) is constructed on a component (27) which is separate from the fastening device (35) for the wiper blade (12).

Abstract: An eye mask for use to wake up and/or to go to sleep provides ease of cleaning or replacement without damaging electrical or optical components; different user selectable sunrise and sunset illumination modes respectively having blue-shifted and red-shifted spectra simulating natural sunrises and sunsets to assimilate the sleep/wake cycle to the natural rhythms of day and night; sunset and/or sunrise illumination modes that oscillate with fixed period or sequentially changing periods that correspond to brainwave frequencies that respectively facilitate going to sleep and/or waking and synergistically co-operate with corresponding sunset or sunrise light fields to help the user to fall into restful sleep or to awake refreshed and alert; and audio tone programming of illumination mode and treatment time and/or duration of therapy by a remote tone control generator.

Abstract: An article presentation device (10) comprising a base (20) having at least one slot (22), at least one support (30) configured to receive at least one article and to be inserted in and extracted from the slot (22), and at least one catch (40) that is movable between a locked position in which the catch (40) is suitable for co-operating with the support (30) in order to retain it in the slot (22), and an unlocked position in which the catch (40) enables the support (30) to be extracted from the slot (22), each catch (40) being associated with a single slot (22) and being actuated by a distinct drive mechanism (50). The drive mechanism (50) is configured to drive the catch (40) in turning.

Abstract: A cartridge for preparation of a beverage comprising: a closed container defining a container volume; a filter to divide the container volume into an ingredient chamber volume and a filtrate volume; a beverage medium located in the ingredient chamber volume; and a guard element located in the filtrate volume; wherein the guard element is separately-formed from the closed container and located within the filtrate volume to define an outlet zone, the guard element being interposed between the filter and the outlet zone; wherein the guard element is configured to prevent encroachment of the filter into the outlet zone such that on piercing of a piercing surface of the cartridge by a piercing element of a beverage preparation apparatus the piercing element is enabled to be placed in fluid communication with the outlet zone without the piercing element contacting the guard element or filter. Associated methods and systems are also disclosed.

Abstract: Embodiments of a tubing anchor catcher includes a setting and a stationary sleeve each containing a set of spaced-apart cone pieces at one end that form a cone block configured to engage a set of slips. The anchor catcher, which may be designed for hydraulic or rotational setting, provides a reduced outside diameter that allows room for gas or debris bypass as well as capillary or electrical lines to be banded along the outside of the tool while providing a full open inside diameter. Because there is area available between the slips, multiple lines may be banded to the tool. In some embodiments, one of the raised slip protectors may include a line carrier sized to receive a capillary or electrical line.

Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).

Abstract: A general-purpose software-reconfigurable chemical process system useful in a wide range of applications is disclosed. Embodiments may include software control of internal processes, automated provisions for cleaning internal elements with solvents, provisions for clearing and drying gasses, and multitasking operation. In one family of embodiments, a flexible software-reconfigurable multipurpose reusable “Lab-on-a-Chip” or “embedded chemical processor” is realized that can facilitate a wide range of applications, instruments, and appliances. Through use of a general architecture, a single design can be economically manufactured in large scale and readily adapted to diverse specialized applications. Clearing and cleaning provisions may be used to facilitate reuse of the device, or may be used for decontamination prior to recycling or non-reclaimed disposal.

Abstract: Various techniques and apparatus permit fabrication of superconductive circuits and structures, for instance Josephson junctions, which may, for example be useful in quantum computers. For instance, a low magnetic flux noise trilayer structure may be fabricated having a dielectric structure or layer interposed between two elements or layers capable of superconducting. A superconducting via may directly overlie a Josephson junction. A structure, for instance a Josephson junction, may be carried on a planarized dielectric layer. A fin may be employed to remove heat from the structure. A via capable of superconducting may have a width that is less than about 1 micrometer. The structure may be coupled to a resistor, for example by vias and/or a strap connector.