Abstract: The invention relates to an eye surgical lighting unit for lighting internal ocular tissue. The lighting unit comprises a fiber having a proximal end and a distal end, for guiding a light beam to the distal end. The lighting unit also comprises a manual unit, provided with a cannula and a handle having an internal passage positioned in line with the cannula. The fiber is adjustable between an intraocular operational position in which the fiber extends through the internal passage of the handle and through the cannula, and a chandelier operational position in which the fiber is uncoupled from the manual unit.

Abstract: The invention relates to glucuronide prodrug compounds of the Janus kinase (JAK) inhibitor tofacitinib having formula I: where A1 and R1 are as defined. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds to treat gastrointestinal inflammatory diseases; and processes and intermediates for preparing such compounds.

Abstract: The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: A tissue planing assembly includes a vacuum table, a gantry system, and a cutting device. The vacuum table includes a cutting surface configured to receive a tissue sample and apply a vacuum pressure to the tissue sample. The gantry system is configured to be positioned over the cutting surface of the vacuum table and includes a blade holder. The blade holder of the gantry system is configured to be adjustable in at least a lateral direction and a longitudinal direction relative to the cutting surface of the vacuum table. The cutting device is configured to be positioned within the blade holder.

Abstract: One aspect of the invention relates to a mutant polypeptide comprising the amino acid sequence of Escherichia coli tetracycline efflux pump A (TetA). Another aspect of the invention relates to a polynucleotide encoding a polypeptide of TetA, a fragment thereof, or a mutant thereof. Another aspect of the invention relates to a first expression plasmid vector comprising one or more first polynucleotides encoding a first polypeptide comprising a tetracycline efflux pump polypeptide, a fragment thereof or a mutant thereof, one or more second polynucleotides independently selected from the group consisting of a third polynucleotide encoding a third polypeptide comprising a lysine decarboxylase polypeptide, a fragment thereof or a mutant thereof, and a fourth polynucleotide encoding a fourth polypeptide comprising a lysine biosynthesis polypeptide, a fragment thereof or a mutant thereof.

Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Tubular bodies for use in frames for seats of vehicles such as aircraft are described. A tube can include a sidewall that has a variable thickness along the length of the tube. The variable thickness of the sidewalls can result in the tube having a variable inner diameter along the length of the tube. The tube may also include a variable outer diameter.

Abstract: Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-? protein.

Abstract: In one embodiment, a tissue planing assembly includes a base frame, a plurality of disassemblable components assembled to the base frame and having a ready configuration, a sample conveyor, a blade assembly configured to be coupled to the base frame, a control unit communicatively coupled to the sample conveyor, and one or more component sensors communicatively coupled to the control unit. The plurality of disassemblable components is configured to support a tissue sample. The sample conveyor is configured to convey the tissue sample through the blade assembly. The one or more components sensors are configured to output a signal indicative of at least one of the plurality of disassemblable components missing from the ready configuration, wherein the control unit prohibits operation of the sample conveyor when at least one of the plurality of disassemblable components is missing from the ready configuration.

Abstract: A modular ladder system has a rung section having two elongate lateral stile extrusions and elongate rung extrusions spanning therebetween. Each stile extrusion may define an attachment side having an attachment face which has two attachment channels which are adjacent, parallel and longitudinally arranged along the attachment face. Each attachment channel may have inward facing rails which define an elongate insertion space therebetween and a relatively wider connector head accommodation void thereunderneath. Furthermore, each rail may define a connector head engaging under edge. Each stile extrusion may further define a connection side adjacent to the attachment side which may define a splice joint extrusion accommodating void therein. In this way, the present modular ladder system may be quickly and easily constructed and various accessories quickly and easily attached thereto.

Abstract: The present invention relates to quinolin-2(1H)-one derivatives polymorph and its process thereof. Formula (I).

Abstract: Disclosed is a remote spectroscopy device of the LIDAR type including a module for generating an emission signal, an emission module for sending the emission signal toward a targeted material, a receiving module for receiving a response signal and a module for postprocessing of the response signal to determine a composition of the targeted material. The generating module includes at least two laser sources, each laser source being able to generate a laser signal at a predetermined wavelength, an upstream mixer able to mix the laser signals generated by the different laser sources, and a first modulator able to modulate the composite signal at a first modulation frequency to form the emission signal.

Abstract: A method for synchronizing an output of a motion signal with a virtual reality program being played comprises mixing a multi-channel audio output of the virtual reality program into at least one mixed audio track. A time position of the virtual reality program being played is obtained using the at least one mixed audio track. A motion signal corresponding to virtual reality program being played and synchronized with the identified time position of the virtual reality program being played is obtained, the motion signal comprising motion platform actuator-driving instructions. The motion signal is output to an actuation system of a motion platform for producing vibro-kinetic effects in the motion platform corresponding to and synchronized with the virtual reality program being played. A motion controller for synchronizing an output of a motion signal with a virtual reality program being played is also provided.

Abstract: The cloud-based access control system includes a mobile application program and a door unit. The mobile application program has a first identification code, a scanning sub-program, and a receiving sub-program. The door unit includes a camera unit and a two-dimensional code generation unit for capturing a first image and producing a two-dimensional code where a second identification code is encoded. The first image and the second identification code are transmitted to a cloud server. The second identification code may be obtained by the scanning sub-program. The first and second identification codes are transmitted by the mobile application program to a pairing unit of the cloud server for authentication. When the first and second identification codes are matched, the cloud server sends the first image and the second identification code to the receiving sub-program for visual confirmation and an electronic lock may be selectively unlocked.

Abstract: A higher degree of interactions between qubits is realizable. This disclosure generally relates to devices, and architectures for quantum instruments comprising quantum devices and techniques for operating the same. Systems and processors for creating and using higher degree interactions between qubits may be found herein. Higher order interactions include interactions among three or more qubits. Methods for creating and using higher degree interactions among three or more qubits on a quantum processor may be found herein.

Abstract: An apparatus and method for selecting, retaining or bioaugmenting solids in an activated sludge process for improving wastewater treatment using a screen device. If desired, the screen device may include a drum, and the rotating speed of the drum may be used to control the solids retained. Effluent including waste biomass may exit the screen device. No other discharge unit from the screen device may be required.

Abstract: A power battery assembly is provided. The power battery assembly comprises a battery circuit having at least one battery module and a relay. A normally open contact of the relay is connected with the battery circuit in series. The power battery assembly also comprises a controller for controlling the normally open contact of the relay. An input end and an output end of the relay are connected with the controller. The power battery assembly further comprises a fuse protector connected with the battery circuit in series.