Abstract: In one aspect, the invention relates to compounds having the formula: where X, Ra, Rb, R2, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.

Abstract: An image capturing device captures an image of the periphery of a vehicle and outputs the captured image to a display control device. The display control device generates a display image in which a predetermined guide line overlaps the image captured by the image capturing device. A display device displays the display image generated by the display control device. The display control device generates a display image in which a plurality of points having a color different from that of the guide line are arranged at intervals along the guide line.

Abstract: A compensation device for compensating PVT variations of an analog and/or digital circuit. The compensation device includes a transistor having a first terminal, a second terminal, a third terminal, and a fourth terminal allowing to modify a threshold voltage of the transistor. The transistor is configured to be in saturation region. The voltage at the third terminal has a predetermined value and the difference between the voltage at the second terminal and the voltage at the third terminal has a predetermined value. A current generation module is configured to generate a current of a predetermined value. A compensation module is configured to force this current to flow between the first terminal and the third terminal by adjusting the voltage of the fourth terminal.

Abstract: An imaging device images surroundings of a vehicle. The display control device generates a display image having a distance guidance line indicating a position away from the vehicle by a predetermined distance and an auxiliary line to be added along the distance guidance line and having an appearance different from the distance guidance line superimposed on the image of the vehicle surroundings captured by the imaging device. The display device displays the display image generated by the display control device. The display control device generates a display image in which the mode of combination of the distance guidance line and the auxiliary line is changed in at least one position.

Abstract: Device for airing blankets comprising a crosspiece connected to a bed frame, at least two tubular profiles connected to each which can pivot. A spring element arranged inside each tubular profile passing through at least one second tubular profile for one first pipe profile and connects the second pipe profile to a first pipe profile wherein the second pipe profiles are connected to a support surface for a blanket and can be pivoted about an axis perpendicular to a support surface. An element is fastened to the first or second tubular profiles forming a receptacle for the pipe profile to be fastened, which fastens the first tubular profiles to the second tubular profiles. The first tubular profiles are arranged laterally in contact with each other and the second tubular profiles contact each other laterally wherein the first tubular profiles are vertically aligned with the respective second tubular profiles.

Abstract: The present invention is directed to methods for treating ebola virus infections or Marburg virus infections comprising administering to a subject an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: A device for dispensing liquid onto a target area of a vehicle surface is described, and includes a mixing valve that is in communication with a pressurized fluidic supply system via a fluidic distribution system, and a controller. The mixing valve includes an outlet orifice that is disposed proximal to the target area, and the mixing valve includes first and second valve conduits that are fluidly connected to the outlet orifice via a mixing portion. The first valve conduit includes a first control valve, and the second valve conduit includes a second control valve. The fluidic distribution system includes a first fluidic conduit and a second fluidic conduit. The controller is operatively connected to the fluidic supply system, and the first and second control valves.

Abstract: Disclosed embodiments include flexible tube assemblies, flexible needle assemblies, systems, methods of fabricating a flexible tube, and methods of fabricating a flexible needle.

Abstract: The invention relates to methods of treating ocular diseases and certain respiratory diseases using the compound 5-ethyl-2-fluoro-4-(3-(5-(1-methylpiperidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-2-yl)-1H-indazol-6-yl)phenol or a pharmaceutically-acceptable salt thereof.

Abstract: A system for providing mobile content to a mobile communication device includes a first computing system including one or more servers to provide, via a communications network, a graphical user interface at a second computing system, the graphical user interface (i) enabling the user of the second computing system to edit a digital file to create the mobile content and (ii) prompting and enabling a user of the second computing system to provide a phone number associated with the mobile communication device, the mobile communication device being separate and remote from the first computing system and the second computing system. The first computing system receives, from the second computing system via the communications network, the mobile content and the phone number associated with the mobile communication device.

Abstract: A microfluidic transport system for transporting microdroplets in three spatial dimensions among layers of a layered microfluidic system. In an example arrangement, a first microfluidic layer for transporting microdroplets in two spatial dimensions responsive to electric fields created by electrical operation of electrodes is fluidically connected by one or more conduits to other microfluidic layers. Microdroplets can be transported through the one or more conduits so as to be moved among a plurality of layered microfluidic arrangements. The resulting layered system can be used for heat transfer, fluidic transfer, and other uses, and can be implemented using materials such as metal, glass, polymer, plastic, layered materials, fibrous materials, etc. In some applications the layered system can be implemented within a printed circuit board, integrated circuit housing.

Abstract: A system and method is provided for executing a conditional branch instruction. The system and method may include a branch predictor to predict one or more instructions that depend on the conditional branch instruction and a branch mis-prediction buffer to store correct instructions that were not predicted by the branch predictor during a branch mis-prediction.

Abstract: The present disclosure relates to an exendin-4 analog PEGylated with polyethylene glycol or a derivative thereof, a preparation method, and a pharmaceutical composition for prevention or treatment of diabetes containing the same as an active ingredient. According to the present invention, the yield of an exendin-4 analog can be increased via the selective PEGylation by using exendin-4 in which a cysteine is introduced into #40 site of the C-terminal, and treatment effect of medications can be increased, so that the exendin-4 analog can be usefully applied as a composition for prevention or treatment of diseases caused by insulin hypersecretion.

Abstract: A sewing machine includes a contact area for two superimposed material webs, which have edges and which are to be sewn together by the sewing machine, wherein, in order to align the edges of the material webs to each other, there is a bottom guide element under the contact area for the bottom material web and a top guide element for the top material web above the contact area, wherein the guide elements are each rotatably mounted about a rotation axis. The rotation axes of the guide elements are arranged extending perpendicular to the contact area.

Abstract: The present invention provides a compound represented by formula (1): or pharmaceutically acceptable salt thereof, wherein X and Y are the same or different from each other and represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 alkoxy group, wherein the C1-6 alkoxy group may be substituted with a C1-6 alkoxy group, and Z and W are the same or different from each other and represent a hydrogen atom, a halogen atom, or a C1-6 alkyl group.

Abstract: The present invention relates to a method for rapid generation of an infectious RNA virus that completely eliminates the need of constructing a full-length c DNA, which covers the entire viral genome, cloning and propagating such full length c DNA.

Abstract: The present invention relates to a brush holder assembly (100) for an electric motor (1) of a motor vehicle equipment item comprising: a plate (9) intended to hold at least one connection brush (7) against a collector (6) arranged on a rotor (6) of en electric motor (1), the plate (9) extending in a plane perpendicular to said rotor (6), at least one induction coil (19) intended to be connected to said connection brush (7), the brush holder assembly (100) also comprising at least one retaining element (27) of the at least one induction coil (18) configured to hold the induction coil (19) in a plane parallel to the plate (9).

Abstract: A method and system for providing an electronic form are described. The method and system include identifying a visible portion of the electronic form. The electronic form can include a control component at a component location of the electronic form that is operable to receive an input from a user. The method and system can then determine an accessibility state of the control component based on the component location and at least one of a display property of the display and the visible portion. The accessibility state can be a convenient state when the component location is suitable for the display but is in an inconvenient state when the component location is not suitable for the display. When it is determined that the accessibility state is the inconvenient state, the method and system involves displaying a transient control component, or a version of the control component, on the display.