Abstract: The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and eribulin or a pharmaceutically acceptable salt thereof, and the use of the combination therapies for the treatment of urothelial cancer.

Abstract: In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and Z are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.

Abstract: The present invention relates to an antimicrobial composition comprising polyvalent metal salt of pyrithione; 0.001% to 3% by weight thymol, and 0.001% to 3% by weight terpineol; wherein, the ratio of % weight of polyvalent metal salt of pyrithione to sum of % weight of thymol and terpineol ranges from 0.005:1 to 200:1.

Abstract: A method of supplying and replenishing a laundry dosing system with one or more reservoirs providing stocks of components for laundry includes monitoring consumption of each of the components in the one or more reservoirs; automatically determining when each one or more reservoirs need replenishment from the monitoring; and replenishing one or more components in response to a monitoring result.

Abstract: Systems and methods for controlling shelf display units and for graphically presenting information on shelf display units are disclosed. A system includes one or more display units configured to be coupled to shelves of a modular shelving system, one or more processors communicatively coupled to the one or more display units, one or more memory components communicatively coupled to the one or more processors, and machine readable instructions stored in the one or more memory components. When executed by the one or more processors, the machine readable instructions cause the system to determine a product identifier corresponding to a product, identify one or more display units to update in response to determining the product identifier corresponding to the product, and update a graphical output of the one or more display units identified to be updated in response to identifying the one or more display units to update.

Abstract: It relates to compositions comprising specific amounts of a hyaluronic acid or a pharmaceutically or veterinary acceptable salt thereof, and two thermoreversible adhesive agents, one of them being a poloxamer, wherein the weight ratio between the poloxamer and the hyaluronic acid or its salt is from 60:1 to 10:1; that may be used as a drug delivery system for the local delivery of active agents to the gastrointestinal tract. It also relates to delivery devices comprising them; and to their uses in medicine, in particular, in the treatment and/or prevention of mucosal lesions; in the prevention of tumor recurrence and reduction of inflammation in the gastrointestinal tract.

Abstract: According to one aspect, the invention concerns a system (100) for the in-depth optical functionalization of a sample (10) made of semiconductor material, comprising: a source (20) for emitting a laser beam formed by pulses of effective duration between 1 ps and 100 ns, having a wavelength in the spectral transparency band of the material; a microscope objective (40) for deep focusing in the sample of the laser beam in a predetermined pattern, the light intensity per pulse in a focal volume of the laser beam being adapted for multiphoton absorption in the semiconductor material; a device (30) for measuring the real part of the refractive index of the sample at each point of the pattern; a control unit (60) for controlling the number of pulses received per pattern point as a function of said measurement of the real part of the refractive index so as to obtain, at each pattern point, a progressive modification of the real part of the refractive index of the material until a relative variation of the real par

Abstract: Systems and methods for a high speed drill cutting burr are described. The high speed drill may comprise a main body having a first section and a second section, the first section comprising a first housing configured to be operably connectable to a first cutting tip and the second section comprising a second housing configured to be operably connectable to a second cutting tip, and an electrical motor disposed inside the main body, the electrical motor may be configured to be in electrical communication with a power source. In some embodiments, a main body may be repositioned by rotating the main body 180° to switch between use of a first cutting tip and a second cutting tip. Mechanisms for limiting axial movement of a burr shank as well as transferring torque are described.

Abstract: The invention provides compounds of formula (I): or a pharmaceutically-acceptable salt thereof, wherein the variables are defined in the specification, that are inhibitors of JAK kinases, particularly JAK3. The invention also provides crystalline forms, pharmaceutical compositions comprising such compounds, methods of using such compounds to treat gastrointestinal and other inflammatory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Methods for presenting dynamic images to a user, configured to evaluate and/or improve the user's foveal and/or peripheral visual acuity. Dynamic computer games are popular, but the moving images of prior art dynamic computer games are not suitable for improving visual acuity. To overcome this restriction, embodiments of the present invention analyze user's responses to the moving images to determine a change in the user's visual acuity, and responsively adjust parameters of the moving images, such as speed, direction of motion, orientation, crowding, contrast, and spatial frequency, in order to improve the user's visual acuity.

Abstract: Embodiments of the present invention provide a method and an apparatus for predicting a residual, which method is applied to three-dimensional video encoding or multi-visual angle video encoding and comprises searching, when performing inter frame image prediction encoding on a prediction unit, a corresponding unit of the prediction unit in an adjacent visual angle encoded at the same time; and predicting a time domain predicted residual of the prediction unit by utilizing a time domain predicted residual of the corresponding unit in the encoded adjacent visual angle.

Abstract: Methods and systems for the controlled generation of bubbles in a medium having a liquid phase are generally provided. Laser pulses having a time-dependent pulse parameter controllable over their duration are generated. The medium is irradiated with the laser pulses with a radiant exposure sufficient to initiate microcavitation within the medium during each laser pulse. The time-dependent pulse parameter of each laser pulse is controlled according to a generally positive variation over the pulse duration such that the medium absorbs a greater quantity of energy from the laser pulse at an end of the pulse duration than at a beginning thereof. Such methods and systems may be used for various applications such as biology, medicine or material processing.

Abstract: A filter connector includes an insulative housing including a docking head and a base member, and an electrical module including a circuit board defining a first lateral side and a second lateral side, a plurality of input terminals mounted in the docking head and bonded to the first lateral side of the circuit board and a plurality of output terminals mounted in the base member and bonded to the second lateral side of the circuit board. Thus, the circuit board is vertically secured between the input terminals, ensuring that the filter connector is small in size, simple in structure, and easy to manufacture, and has a filtering function, thereby greatly improving the electric perform.

Abstract: The present invention relates to a device for recycling carbon fibers (5), which includes two metal rails (1, 2) between which the carbon fibers (5) are intended to be stretched, and a current generator (3), the terminals of which are connected or intended to be connected to the two metal rails (1, 2). The rails (1, 2) form electrodes (1, 2) in short circuit when the carbon fibers (5) are arranged on said rails (1, 2). The generator (3) is suitable for outputting at least one current pulse of a power in the order of or greater than the MW between these two rails (1, 2), which allows the separation of the fibers from their resin. A recycling method implemented with this device is also proposed.

Abstract: An apparatus including an antenna, a first split ring resonator, and a second split ring resonator disclosed. The first split ring resonator located on a first side of the antenna, wherein the first split ring resonator is magnetically coupled to the antenna. The second split ring resonator located on a second side of the antenna, wherein the second split ring resonator is magnetically coupled to the antenna.

Abstract: Tubular bodies for use in frames for seats of vehicles such as aircraft are described. A tube can include a sidewall that has a variable thickness along the length of the tube. The variable thickness of the sidewalls can result in the tube having a variable inner diameter along the length of the tube. The tube may also include a variable outer diameter.

Abstract: The invention concerns a wiper device (1) comprising: a driving arm (7) configured to transmit a wiping movement and having a longitudinal end (8), a windscreen wiper (3), a fixing device (5) disposed between the longitudinal end (8) of the arm (7) and the windscreen wiper (3), wherein the wiper (3) is equipped with at least one electrical element (23), characterized in that the longitudinal end (8) of the arm (7) is equipped with a sending coil (27) and in that the wiper (3) is equipped at the level of the fixing device (5) with a receiving coil (29), the cooperation of the sending coil (27) with the receiving coil (29) enabling supply of power to said electrical element (23) by magnetic induction.

Abstract: The present disclosure describes a system, method, and computer-readable medium for providing audio announcement of communications to a called party in a communication network. The method includes receiving communication from a calling party and performing a lookup of information relating to the calling party in a database via an Internet Protocol connection based on an identifier of at least one of the calling party and the called party. The information comprises one or more audio files. The method then provides the audio announcement to a called party based on the audio files.