Abstract: The invention provides compounds of formula (I): which contain a 4-membered heterocyclic amide, where the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: Insecticide composition wherein the active ingredient comprises the combination of a neonicotinoid insecticide, thiamethoxam as synthetic insecticide molecule, and at least one synergistic agent, which is chosen among the insect repellent agents such as DEET and/or IR3535® and present at a molar ratio of said synergistic agent to thiamethoxam comprised between O.OOI and 0.2 in the composition. Synergistic effect is observed at low doses. Use of the insecticide composition wherein said composition is sprayed or deposited on, or impregnated to a support, such as net, fabrics, cloth or tent, in the fight against insects which are harmful to human, to animals and/or to crops, and in particular against pyrethroid, carbanate and/or organophosphate resistant mosquitoes.

Abstract: An osmosis element comprising a central permeate tube and a membrane element, the membrane having a first part and a second part, the first part having a top edge for location adjacent the central tube, the second part being disposed at the opposite edge, the first part comprising a material to allow water to flow therethrough, the second part comprising at least two adjacent permeate spacers extending from the first part to allow water to flow therethrough, the permeate spacers having a semi-permeable membrane attached to opposed faces of the two adjacent permeate spacers, the first part comprising a barrier extending from the vicinity of the top edge, the central tube comprising an external wall and a longitudinally extending internal separator defining a first channel and a second channel each extending longitudinally of the central permeate tube, at least one first aperture extending from the first channel though the external wall and at least one second aperture extending from the second channel through

Abstract: Various irrigation fluid containment systems and components are disclosed. In some embodiments, the irrigation fluid containment system comprises a medical kit and/or an irrigation kit. In some embodiments, the irrigation fluid containment system comprises a medical basin and/or an irrigation basin. In some embodiments, the irrigation fluid containment system comprises an irrigation shield. In some embodiments, the irrigation fluid containment system comprises a suction hose.

Abstract: A compact cable connector includes an insulative block set consisting of a docking member and a terminal holder block assembly, a circuit board set including an input circuit board vertically set between the docking member and the terminal holder block assembly and an output circuit board transversely mounted on the top of the terminal holder block assembly, and a terminal set including input terminals transversely mounted in the docking member and electrically bonded to the input circuit board, output terminals vertically mounted in the terminal holder block assembly and electrically bonded to the output circuit board and connection terminals electrically connected between the input circuit board and the output circuit board.

Abstract: Clip (15) for a wiper blade (10), which clip is configured to be interposed between an end-piece (22) of the blade (10) and an aerodynamic spoiler (20) of a longitudinal cover member of the blade (10), characterized in that the said clip (15) comprises first means (25) able to collaborate by friction and/or anchorage with the end-piece (22) and second means (27) able to collaborate by friction and/or anchorage with the spoiler (20).

Abstract: An aerosol hairspray product includes a pressurisable container having a propellant and a container wall which encloses a reservoir, a hairstyling formulation having from 20 wt % to 75 wt % water, by total weight of the hairstyling formulation and propellant and from 1.0 wt % to 15 wt % hairstyling polymer, by total weight of the hairstyling formulation and propellant, and a spraying device attached to the pressurisable container and having a valve and an actuator. The reservoir is configured to store the hairstyling formulation. The valve has a spring means, a valve body having a stem, a restricted tail piece (RTP) having a first diameter of from 0.1 mm to 2.5 mm, and a vapour phase tap (VPT) having a second diameter of from 0.1 mm to 1.5 mm. The actuator has a main spray channel and communicates with an insert.

Abstract: A wireless communication device (alternatively, device, WDEV, etc.) includes at least one processing circuitry configured to support communications with other WDEV(s) and to generate and process signals for such communications. In one example, the circuitry is configured to generate a null data packet (NDP), transmit at least a portion of the NDP to another wireless communication device via fewer than all of a plurality of sub-channels of a communication channel, and receive feedback from the another wireless communication device that is based on the another wireless communication processing the at least the portion of the NDP that is received via the fewer than all of the plurality of sub-channels of the communication channel. In one example, the generated NDP includes at least one signal field (SIG) field therein that includes information to specify a preamble puncturing option or the information is transmitted in a previous packet.

Abstract: The invention relates to modulating epileptogenicity in a brain of an epileptic patient. The method according to the invention comprises the steps of: providing a virtual brain; providing a model of an epileptogenic and of a propagation zones and loading said models in the virtual brain to create a virtual epileptic brain; acquiring data of the brain of the epileptic patient; identifying, in said data, a location of at least one possible epileptogenic zone; fitting the virtual epileptic brain against the data acquired from the epileptic patient and parametrizing said at least one possible epileptogenic zone in the virtual epileptic brain as an epileptogenic zone; and simulating, within the virtual epileptic brain, the effect of a network modulation mimicking a clinical intervention of the brain of the patient.

Abstract: An aircraft, such as a flying car, comprising a body structure, lift structures (such as wings), control structures (such as fins, elevators, and ailerons), and a motor; a propeller connected to the motor and mounted for rotation about a drive axis to provide thrust; the propeller comprising a hub having a plurality of blades connected thereto; and a plurality of blade housings adjacent the propeller and extending substantially parallel to the drive axis; wherein the blades are mounted on the hub so as to be moveable between an expanded position in which the blades project radially from the hub, and a folded position in which each blade extends axially from the hub so as to lie in a respective blade housing.

Abstract: The present disclosure relates to a method, performed by at least one apparatus (2, 4, 6, 8), the method comprising: obtaining (22) from a user cleaning related information, and determining (42) a composition or a part thereof for an individualized cleaning agent to be produced based on the obtained cleaning related information. The present disclosure also relates to an apparatus, a system, a computer program code and a computer readable storage medium.

Abstract: The subject of the invention is an adapter (100) intended to connect a wiper to a drive arm of a vehicle wiper system, the adapter (100) comprising a head (1) and a body (2) which extend in the continuation of one another in a longitudinal direction of the adapter (100), the adapter (100) comprising a means (6, 61) of rotational connection to a connector (8) attached to the wiper, the adapter (100) being formed at least by a top wall (10, 20) from which there extend at least two lateral flanks (11a, 11b, 21a) so as to delimit an internal volume (101) in which the connector (8) is able to extend, characterized in that the adapter (100) comprises at least one centering means (3) for centering it in a direction perpendicular to the top wall (10, 20) with respect to the drive arm.

Abstract: The present invention relates to an implantable sensor configured to be implanted within the body of the subject and being configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through the body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of the subject. One pair of injection electrodes is configured for injection of electrical current into the body tissue and one pair of sensing electrodes is configured to detect the resulting voltage. A detector is operatively connected to the sensing electrodes and is configured to receive the voltage detected by the sensing electrodes, wherein the detector is configured to measure the impedance of the body tissue based on the voltage detected by the pair of sensing electrodes.

Abstract: A system and method for identifying topics in unstructured data. The method includes obtaining unstructured data from at least one data source, wherein the obtained unstructured data includes at least one unstructured data object; determining, based on the obtained unstructured data, at least one set of topic identification rules; identifying, based on the at least one unstructured data object and the at least one set of topic identification rules, at least one candidate topic of the unstructured data; and analyzing the unstructured data with respect to the at least one candidate topic to determine at least one representative topic from among the at least one candidate topic, wherein each of the at least one representative topic indicates a context of at least a portion of the unstructured data.

Abstract: Disclosed are methods for determining whether a patient will achieve a response after radiation therapy, in particular a method for determining whether a patient suffering from a cancer will achieve a response after radiation therapy including the steps of i) determining the level of ceramide in a first blood sample obtained from the patient before radiation therapy, ii) determining the level of ceramide in a second blood sample obtained from the patient during or just after radiation therapy, iii) comparing the level determined at step i) with the level determined at step ii) and iv) concluding that the patient will achieve response when the level determined at step ii) is higher than the level determined at step i) or concluding that the patient will not achieve a response when the level determined at step ii) is lower than the level determined at step i).

Abstract: Synthetic aperture (SA) imaging methods and systems are assisted by three-dimensional (3D) beam scanning imaging, for example scanning lidar. The methods can include concurrently acquiring an SA image and a 3D scanning image of a target region, determining an elevation map of the target region from the 3D scanning image, and processing the SA image based on the elevation map to provide or enhance 3D imaging capabilities in the SA image. In some implementations, the SA image is a two-dimensional (2D) SA image and the elevation map is used to orthorectify the 2D SA image. In other implementations, the SA image is a phase-wrapped 3D SA image resulting from the combination of two or more 2D SA images and the elevation map is used to perform phase unwrapping on the phase-wrapped 3D SA image.

Abstract: Various examples of devices and kits for assisting in and illuminating medical procedures are disclosed. The devices may be attached to handheld medical tools. Also disclosed are various examples of medical procedures that may be carried out using the devices or kits. Also discloses are various examples for mounting auxiliary medical tools to a device mounted on a primary medical tool.

Abstract: A manufacturing method for gate-all-around structures in semiconductor IC manufacturing field includes forming a buried gate layer on the semiconductor substrate, forming an epitaxial layer in non-buried-gate-layer regions and planarizing the epitaxial layer so that the top surface of the epitaxial layer is at the same level with the top surface of the buried gate layer; forming a fin structure on the buried gate layer; forming a gate structure traversing and surrounding the fin structure. Since the gate structure wraps around four sides of the fin to effectively control the channel, the channel width is increased compared with the double-gate or triple gate structure, thereby increasing the effective area of the channel. The present invention solves the conventional problems like complex process and high cost without degrading the device performance. It has the advantages of simplicity, compatibility with the traditional IC planar process, low cost, and easy implementation.

Abstract: The invention concerns antibody formats comprising VH sequence of Camelidae, such as llamas; antibodies of various formats have anti-CEA or anti-CD16 VH sequences thereof; vectors expressing the antibody formats, and methods for producing the same.