Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of ischemic conditions. In particular, the present invention relates to a method of treating an ischemic condition in a subject in need thereof comprising administering the subject with a polypeptide comprising an amino acid sequence having at least 70% of identity with the amino acid sequence ranging from the amino acid residue at position 186 to the amino acid residue at position 406 in SEQ ID NO: 1.

Abstract: A device for local temperature measurement that is suitable for taking temperature measurements of an immediate vicinity of said device. The device comprises: a cell comprising a heat-conductive base and at least one first material having a predetermined fixed state-change temperature and arranged in said base; a heat-energy transfer device thermally connected to said base and said at least one first material; a local temperature measurement probe received in said base and in thermal contact with said at least one first material, the heat-energy transfer device being suitable for causing a change of state of said first material in order to carry out at least one metrological verification of the local temperature measurement probe. An associated cell and method for use are also provided.

Abstract: An active rectifier of a rotary electric machine, in particular an active rectifier for alternators, for example for rectifying alternating currents (AC) to direct currents (DC) for charging batteries on vehicles, is disclosed. The active rectifier may include a plurality of power MOSFET transistors and a detecting and driving circuitry all mounted on a single substrate to form a half-bridge module. A number of at least two and up to N modules may be connected together to serve as a two and up to N-phase rectifier. Each module is connected in a way to rectify currents from one phase of the electric machine and has an individual power supply for the detecting and driving circuitry. The power supply may receive the power from the phase which is being rectified and operates independently of the alternator's voltage regulator.

Abstract: The invention relates to a wiper arm (10; 10a-10d) for cleaning a vehicle window, with a carrier element (11), which is able to be connected at a first end region at least indirectly with a drive shaft and at another end region with a wiper blade (1), and with an additional element (30) connected with the carrier element (11), which additional element (30) extends in longitudinal direction of the wiper arm. It is provided according to the invention that the additional element (30) has at least one air guide section (166, 167), extending in longitudinal direction of the wiper arm (10; 10a-10d), which at least one air guide section (166, 167) projects beyond the underside (168) of the carrier element (11) on the side facing the vehicle window.

Abstract: The present invention relates to a process for the manufacture of a chocolate product involving the use of hydrated salt, hydrated sugar or hydrated sugar alcohol in the underlying chocolate mass and comprising the steps of refining, conching and optionally tempering of the chocolate mass. The invention further relates to a chocolate product comprising a chocolate mass comprising certain weight proportions of hydratable salt, hydratable sugar or hydratable sugar alcohol, as obtainable by the process of the invention.

Abstract: A displacement structure for a support frame includes a fixing member and a slide member. The fixing member includes a first fixing portion, a connecting portion and a second fixing portion which are sequentially connected. The connecting portion has two ends connected to the first and second fixing portions, respectively, the first and second fixing portions are opposite to each other and separated by a clamping space which is provided for clamping a table plate. The slide member includes a first clamping portion fixed to one end of the stationary rod, and two opposite second clamping portions opposite to the first clamping portion. The first clamping portion and the second clamping portions are fixed together by a fixing bolt, there is a slide space between the first clamping portion and the second clamping portions, the first clamping portion and the second clamping portions clamp the first fixing portion.

Abstract: A positioning device (1) for grasping and modifying the position, within a support structure (2) that includes, a set of products (3) for an industrial line that chain-handles these products (3), a device including, for at least one product (3) to move in the support structure (2), a maneuvering unit (4) including a movable block (5) interacting with the at least one product (3), and an actuator (6) defining the position of the block (5). This at least one maneuvering unit (4) also includes a pair of adjustment stops (7) between which the block (5) shuttles, under the action of the actuator (6), in such a way as to move the at least one product (3). A gripping device, a positioning process, and a transfer process are also described.

Abstract: The present invention relates to non-stoichiometric crystalline hydrates of 1-(?-D-glucopyranosyl)-4-methyl-3-[5-(4-fluorophenyl)-2-thienylmethyl]benzene, processes for their preparation, and their use as medicaments. In addition the present invention relates to pharmaceutical compositions comprising an effective amount of the novel crystalline hydrates.

Abstract: According to an embodiment of the present disclosure, a method of labeling a plurality of products includes coating a pressure sensitive adhesive to a roll of face stock, the roll of face stock configured to be converted to a plurality of individual labels aligned in a single lane; singulating an individual label from the roll of face stock; and applying the individual label to a product of the plurality of products, wherein the coating, singulating and applying are conducted sequentially in a single continuous operation with a single continuous web of material.

Abstract: A GNSS receiver comprising a circuit configured to receive a positioning signal comprising a carrier modulated by a subcarrier and a PRN code; a subcarrier and code tracking loop, comprising a first discrimination circuit, configured to calculate a first pseudo range from said received positioning signal and a first reference signal; a code tracking loop, comprising a second discrimination circuit, configured to calculate a second pseudo range from said received positioning signal and a second reference signal; and a calculation circuit configured to evaluate a difference between said first pseudo range and said second pseudo range, and to modify the output of the first discrimination circuit accordingly. The invention further addresses a method for calculating a pseudo-range in such a GNSS receiver.

Abstract: A method comprising: (a) identifying a subject in need of treatment for cataract and/or nevus and/or tumor lesion; and (b) topically administering to the eye an amount of dipyridamole which is physiologically effective in treatment of cataract and/or nevus and/or melanoma.

Abstract: The invention relates to a method for fabrication of a balance spring of a predetermined stiffness comprising the steps of fabricating a balance spring in dimensions to obtain a deliberately lower stiffness, determining the stiffness of the balance spring formed in step a) in order to compensate for said missing thickness of material required to obtain the balance spring having the dimensions necessary for said predetermined stiffness.

Abstract: In some embodiments, a contactless communication device includes an antenna, and a driving stage having a power supply terminal configured to receive a power supply voltage, where the driving stage is configured to deliver a current to the antenna. The device further includes a monitoring circuit configured to monitor the power transmitted by the antenna. The monitoring circuit is configured, in the presence of a request for a reduction in a current level of transmitted power, to reduce the power supply voltage of the driving stage down to a target value corresponding to a new level of the transmitted power less than the current level.

Abstract: An active noise cancelling device including a sensor configured to convert acoustic signals into first audio signals and a speaker acoustically coupled to the sensor A control stage is configured to control the speaker based on the first audio signals to cause the speaker to produce cancelling acoustic waves that tend to suppress acoustic noise components in the acoustic signals. The control stage includes sigma-delta modulator digital filters.

Abstract: Linker toxins and antibody-drug conjugates that bind to human oncology antigen targets such as folate receptor alpha and/or provide anti-tubulin drug activity are disclosed. The linker toxins and antibody-drug conjugates comprise an eribulin drug moiety and can be internalized into target antigen-expressing cells. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering the antibody-drug conjugates provided herein.

Abstract: Systems and methods for magnetic shielding are described. A magnetic shield formed of a material having a high magnetic permeability may be degaussed using a toroidal degaussing coil. The toroidal degaussing coil may enclose at least a portion of the shield. Magnetic field gradients may be actively compensated using multiple magnetic field sensors and local compensation coils. Trapped fluxons may be removed by an application of Lorentz force wherein an electrical current is passed through a superconducting plane.

Abstract: A longitudinal member for retaining a stiffening spine and holding a wiper blade for a windscreen wiper of a window of a motor vehicle is disclosed. The member defines at least one longitudinal housing for receiving the spine and at least one longitudinal housing for receiving a heel of the wiper blade, at least one of the housings being delimited at least partly by a bottom wall and two side walls linked to the bottom wall, where the side walls have planar inner faces converging towards one another away from the bottom wall.

Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.