Abstract: A method of assembling a substrate with a part is provided. The method includes a step of structuring the substrate by a pulsed laser. In one example, the substrate is metallic and the part is polymer-based. The structuring step engraves grooves into the substrate in a pattern determined by the relative motion of the beam and the substrate. The pattern is configured to provide improved adhesion between the structured substrate and a part after assembling the substrate and the part by laser welding. The method of assembling may further include a pre-treatment step of the structured surface to allow improve laser absorption during the welding assembling.

Abstract: A system for monitoring the flow of blood within an endoluminal passage is provided comprising a medical device and a sensor. The medical device is implantable within the endoluminal passage and includes a shaft and an expandable segment coupled to the shaft. The expandable segment is movable between a first state and a second state. Movement of the expandable segment is responsive to a change in the fluid pressure external to the expandable segment. The sensor is positioned on the medical device and is adapted to collect information associated with the state of the expandable segment.

Abstract: The claimed invention uses a combination of Natural Language Processing and Machine Learning as an automated data extractor to automatically extract features from unstructured medical reports in order to ensure compliance with QPP measures by using the extracted features to calculate service quality levels.

Abstract: The invention concerns a driver assistance system (1) comprising a device (2) for protecting an optical sensor (11) for a motor vehicle comprising a protective box (13) in which a housing (26) is provided that is configured to house an optical sensor (11), the device further comprising: a support (15) movably mounted on the protective box (13) and bearing a membrane (19) attached by its periphery to the support (15) and intended to be arranged opposite the optical sensor (11), the membrane (19) comprising an optically transparent material that is elastically deformable; and at least one actuator (21) borne by the protective box (13) and configured to move the support (15) bearing the membrane. The support (15), under the effect of the moving of the support (15) by the actuator (21), is configured to deform the membrane (19) between a resting position in which the membrane (19) is in a first state of tension and an active position in which the membrane (19) is in a second state of tension.

Abstract: An optical component for transforming an input light beam having a Gaussian irradiance distribution into an output light sheet is provided. The optical component includes a first reflective surface extending around the central optical axis of the optical component and across an input light path of the input light beam, and reflects input light rays into transitional light rays defining a transitional light cone. A second reflective surface extends around the central optical axis and across a light path of the transitional light cone, reflecting the transitional light rays outwardly into output light rays defining the output light sheet. The first and second reflective surfaces are configured to distribute optical power within the output light sheet according to a Gaussian irradiance distribution transversally to the output light sheet. The output light sheet may be planar or conical.

Abstract: The present invention concerns heterocyclic naphthoquinones derivatives for use in the treatment of Cushing disease and other cancers, in particular via the inhibition of Ubiquitin Specific Proteases (USP) 8 and/or 2.

Abstract: A spectral imager, including: a photodetector including a plurality of photosensitive sites exposed on a photosensitive surface; a collimating lens including an intermediate focal plane; an array of interferometers including two main waves, each including a cavity defined by two faces; an array of microlenses arranged in a plane parallel to the photosensitive surface, each microlens paired with an interferometer to form an optical pair, including an image focal plane coinciding with the photosensitive surface and facing a section of the photosensitive surface.

Abstract: Some aspects of the present disclosure relate to systems and processes for the conversion of lithium phosphate into a low-phosphate solution containing lithium which may be suitable as feedstock for the production of saleable lithium products.

Abstract: The fully-automatic closed-loop detection method includes: comparing a SCD file of a to-be-tested substation with a device-type data template file, so as to determine whether configuration information about the to-be-tested substation is correct; when the configuration information about the to-be-tested substation is correct, parsing the SCD file of the to-be-tested substation and generating a SSD topological diagram of the to-be-tested substation; and acquiring a testing item from a predetermined testing item library in accordance with the SSD topological diagram of the to-be-tested substation, generating a testing scheme for the to-be-tested substation, performing a testing operation and outputting a testing result.

Abstract: The invention provides a compound of formula (I): or a pharmaceutically-acceptable salt thereof, that is an inhibitor of JAK kinases. The invention also provides pharmaceutical compositions comprising such compound, a crystalline form, methods of using such compound to treat inflammatory skin diseases and other diseases, and processes and intermediates useful for preparing such compound.

Abstract: A method is performed for defining optimal landing location(s) of horizontal wells for hydraulic fracturing stimulation, for improved well performance of unconventional reservoirs. The method includes evaluating one or more planes of weakness, pinch-out points, or thin rock layering in the reservoir that may impede hydraulic fracture growth or may close fractured sections during production. The method can include conducting detailed analysis on core and open hole logs, and defining the presence, density, orientation, spacing, and mechanical properties of various thin interfaces and barriers in the rock mass. The method can include classifying the barriers or thin interfaces based on their effect on hydraulic fracture growth or fracture connectivity, and on uncertainty of their effect.

Abstract: A method for locating at least one target, in an electromagnetically absorbent environment, includes: emitting at least one electromagnetic excitation signal from a source; receiving, by an acoustic sensor, an acoustic signal from emission of the excitation signal; detecting, in the received acoustic signal, a first time of receipt of a first response to the excitation signal from an acoustic disturbance caused by electromagnetic heterogeneity of the target in the environment; estimating a first distance between the target and the acoustic sensor using the first time of receipt; detecting, in the same received acoustic signal, a second time of receipt of a second response to the excitation signal from an acoustic disturbance caused by acoustic heterogeneity of the target in the environment; estimating a second distance between the source and target using the second time of receipt; obtaining a location of the target from the first and second estimated distances.

Abstract: Optical device with an optical substrate and a multi-functional layer fixed thereon, the layer including plural multi-functional areas, each said area including a first group and a second group of functional dots and disposed within a certain rectangular area, the first group having a first composition and a first functionality, the first functionality selected from an anti-reflectance, anti-scratch, anti-fog, ultraviolet absorber, and photochromic functionality; the second group having a second composition and a second functionality, the second functionality selected from the same group as above, the second group differs with respect to the first functionality, or with respect to the first composition, or wherein within at least one multi-functional area, the first group has a height H1, the second group has a height H2, where H2>k*H1, with k being at least 1.05.

Abstract: A well cap assembly is disclosed which is well suited for use with a wellhead. The well cap assembly has a port component and a cap element. The port component has a bore extending therethrough, an upper neck portion, and an upper threaded portion. The port component further has a lower threaded portion and a barb formed on the upper neck portion. The barb can receive an external flexible tube which is temporarily secured to the port component. The cap element has an internally threaded portion which engages with the upper threaded portion of the upper neck portion and seals the bore of the port component. The cap element also has a tether for securing it to the port component.

Abstract: The invention relates to a blade 1 for wiping a vehicle window, including at least one device 2 for spraying a liquid for washing the window, arranged in order to spray said washing liquid onto a first area 61 of the window wiped by the wiper blade 1, characterized by including a means 3 for spraying the washing liquid, arranged such as to spray the washing liquid onto at least one area of the window other than the first area 61, referred to as second area 62. The invention is useful in motor vehicles.

Abstract: An engine test apparatus includes a dynamometer connected to an engine through a shaft, and a control device configured to control operations of the engine and the dynamometer, and the engine test apparatus further includes a speed measuring device configured to measure a rotation speed of the output shaft of the engine and transmit the rotation speed to the control device the control device includes an engine control unit configured to control operation of the engine, and a dynamometer control unit configured to control operation of the dynamometer, the dynamometer control unit uses the rotation speed transmitted from the speed measuring device to generate a torque current command corresponding to a torque value to be generated by the dynamometer, in order to operate the engine controlled to be operated by the engine control unit in an unloaded state as if the shaft and the dynamometer are not connected.

Abstract: The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

Abstract: To provide a technology capable of changing an output characteristic of music data more efficiently with a simpler operation irrespective of whether or not the music data is being played back, an audio controller (2) identifies a usage environment of a wireless speaker (1) from picked-up image data on an installation room of the wireless speaker (1). Then, an output characteristic suitable for the identified usage environment is selected, and the selected output characteristic is set as an output characteristic of music data to be output from the wireless speaker (1).

Abstract: ‘ARAANTRED5’ is a new and distinctive variety of Anthurium plant which is characterized by the combination of a compact growth habit with an abundance of foliage and inflorescences, relatively small, durable leaves which are dark green and glossy, large, durable spathes with a broad cordate shape and a vibrant red general coloration, and the stability of all characteristics from generation to generation. The new variety is typically produced as an indoor ornamental plant.