Abstract: A surge protective device (SPD) module includes a module housing, first and second module electrical terminals mounted on the module housing, a gas discharge tube (GDT) mounted in the module housing, and a fail-safe mechanism mounted in the module housing. The GDT includes a first GDT terminal electrically connected to the first module electrical terminal and a second GDT terminal electrically connected to the second module electrical terminal. The fail-safe mechanism includes: an electrically conductive shorting bar positioned in a ready position and repositionable to a shorting position; a biasing member applying a biasing load to the shorting bar to direct the shorting bar from the ready position to the shorting position; and a meltable member. The meltable member maintains the shorting bar in the ready position and melts in response to a prescribed temperature to permit the shorting bar to transition from the ready position to the shorting position under the biasing load of the biasing member.

Abstract: The present invention belongs to the field of fungicides, and relates to an amide compound and the preparation method and use thereof. The amide compound is as shown in general formula I: Each substituent in Formula I is defined in the description. The compound of general formula I of the present invention has an outstanding fungicidal activity, and can be used for controlling fungal diseases.

Abstract: A method of characterizing the protein O-GlcNAcylation site-specificity of an antibody. A method of detecting or quantitating the expression of site-specific O-GlcNAcylated proteins expressed in cells and biological samples. A method of diagnosing cancer in a host based on the cellular expression of site-specific O-GlcNAcylated proteins. A method of screening anti-cancer compounds according to their ability to increase a level O-GlcNAcylation of oncogene or tumor suppressor proteins. Methods of treating cancer in an animal host by administering compounds that increase a level of O-GlcNAcylated c-myc or p53 in cancer cells. A method of distinguishing subclasses of pancreatic cancer according to the sensitivity of pancreatic cancer cells to an imidazole derivative, and a method of personalized pancreatic cancer treatment delivered according to the sensitivity subclasses.

Abstract: The invention is related to an oncolytic adenovirus that comprises a sequence encoding a hyaluronidase enzyme inserted in its genome. This adenovirus spreads more efficiently in the tumour mass and therefore the oncolytic effect is increased. Injecting the oncolytic adenovirus of the invention endovenously results in tumour volume regressions. Therefore, the oncolytic adenovirus of the present invention is useful for the treatment of a cancer or a pre-malignant state of cancer.

Abstract: A method for optical proximity correction includes inputting a physical design having a plurality of shapes. Each shape has a plurality of corners, and the physical design is to be exposed on a surface of a substrate. A set of sub-resolution assist features (SRAFs) for the physical design is determined, where a plurality of SRAFs in the set of SRAFs interact. The plurality of SRAFs together provide better dimensional control of one corner of one shape in the plurality of shapes, when exposed on the substrate, compared to using a single SRAF to control a dimension of the one corner. The plurality of SRAFs includes a positive SRAF and a negative SRAF. A modified physical design is output, where the modified physical design comprises the physical design, as modified by the set of SRAFs.

Abstract: This invention is directed to a door handle which is normally hidden within the door, be it either completely flush with a door surface, or partially protruding from said door surface. If a user wants to use the handle, then the user activates the handle using convention actuating techniques to extend the handle from the recess. Should an external object be placed between the handle and the door surface after the handle is operated and the retraction process begins, the handle movement is limited in the downward direction by the extension of an elastic link between the door handle and the rest of the retraction mechanism.

Abstract: In one aspect, the invention relates to compounds having the formula XII: where Ra, Rb, R2, R7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.

Abstract: Methods, systems, and devices for determining a machining process in a CAM system where the determining is based on CNC machine capabilities, user defined process constraints, and CNC machine configurations.

Abstract: Mechanical oscillator for a horological movement, comprising: a central fixed part being configured to be fixed to a frame of the horological movement; an inertial rim coaxial with a pivoting axis of the mechanical oscillator; at least two rigid links extending radially between the central fixed part and the inertial rim and supporting the inertial rim; and at least two flexible links extending radially from the central fixed part; each flexible link comprising a first flexible element and a second flexible element substantially coplanar to the first element, the first flexible element and the second flexible element being rigidly connected at their distal extremity; the proximal extremity of the first flexible element being fixed to the fixed part and the proximal extremity of the second flexible element being fixed to one of said at least two rigid links, such that the inertial rim can oscillate around the pivoting axis.

Abstract: The invention relates to a cleaning arrangement (10; 10a) for a wiper arm (1) of a windscreen wiper system (100), wherein the cleaning arrangement (10; 10a) has at least one spray nozzle (21, 22) for a cleaning fluid, wherein the cleaning arrangement (10; 10a) is constructed to form en engagement connection (30) at the wiper arm (1), and wherein the engagement connection (30) comprises at the cleaning arrangement (10; 10a) at least one resiliently constructed engagement element (40; 40a) which is constructed to cooperate with an engagement mount (54; 54a) at the wiper arm (1). There is provision according to the invention for the cleaning arrangement (10; 10a) to have first guide means (35), which first guide means (35) are constructed to be able to rotate the cleaning arrangement (10; 10a) in a rotation axis (37) in order to establish the engagement connection (30).

Abstract: Systems, methods and aspects, and embodiments thereof relate to unsupervised or semi-supervised features learning using a quantum processor. To achieve unsupervised or semi-supervised features learning, the quantum processor is programmed to achieve Hierarchal Deep Learning (referred to as HDL) over one or more data sets. Systems and methods search for, parse, and detect maximally repeating patterns in one or more data sets or across data or data sets. Embodiments and aspects regard using sparse coding to detect maximally repeating patterns in or across data. Examples of sparse coding include L0 and L1 sparse coding. Some implementations may involve appending, incorporating or attaching labels to dictionary elements, or constituent elements of one or more dictionaries. There may be a logical association between label and the element labeled such that the process of unsupervised or semi-supervised feature learning spans both the elements and the incorporated, attached or appended label.

Abstract: We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.

Abstract: The present invention relates to methods for selecting binders by phage display and masked selection. More particularly, the present invention relates to a method for selecting a plurality of binders specific for at least one relevant target comprising screening a phage binder library of binders against the relevant target in presence of a plurality of binders obtained from a library of binders directed against at least one irrelevant target and positively selecting the binders that are specific for the at least one relevant target.

Abstract: The invention discloses a recovery assistance device for helping in rescuing victims of avalanches, earthquakes or boat capsizes. The device is capable of calculating a position from combinations of a previous position and distances to other devices. Different configurations are possible, with a basic configuration consisting of a smart phone having waveform generation capabilities, processing and GNSS receiving capabilities. The device is programmed to be used in a defined mission by an application. The device can also receive a number of add-ons as a battery add-on, a modem add-on, a sound wave generation add-on, antennas, and protection, possibly waterproof, if adequate. Devices of the same type can be carried by people to be rescued and rescuers. The device is therefore quite versatile and can increase significantly the efficiency of rescue teams in different use case scenarios.

Abstract: The present invention relates to amino alcohol compounds and to the preparation thereof from fatty esters comprising at least two carbon-carbon double bonds. In particular, the present invention relates to fatty amino alcohol compounds obtained by means of a process coupling, in a single step, a hydroaminomethylation reaction and a hydrohydroxymethylation reaction.

Abstract: A washing machine comprises: an outer drum; an inner drum rotatably disposed in the outer drum; and a rotation mechanism for driving the inner drum to rotate. A rotation shaft of the rotation mechanism extends upwardly from the bottom of the outer drum to a bottom wall of the inner drum to drive the inner drum to rotate. The washing machine further comprises: at least one pair of magnets including an outer ring-shaped magnet and an inner ring-shaped magnet which is disposed at a radial inner side of the outer ring-shaped magnet and opposite to the outer ring-shaped magnet. The inner ring-shaped magnet is disposed on the rotation shaft, and the outer ring-shaped magnet is disposed at the bottom wall of the inner drum or the outer drum, so that a magnetic force between them can reduce a magnitude of vibration of the inner drum or the outer drum.

Abstract: The invention relates to a ligand capable of binding PrP at a site within amino acid residues 131 to 153 of PrP, for use in treatment or prevention of impaired synaptic plasticity. The invention also relates to a ligand capable of binding PrP at a site within amino acid residues 131 to 153 of PrP, for use in treatment or prevention of toxicity of A? oligomers. The invention also relates to a ligand capable of binding PrP at a site within amino acid residues 131 to 153 of PrP, for use in treatment or prevention of Alzheimer's Disease. The invention also relates to methods of medical treatment.

Abstract: An optical tomography apparatus comprises: a polychromatic light source, a one-dimensional optical sensor, an interferometric microscope, a one-dimensional confocal spatial filtering system, an actuation system making it possible to perform a one-way scan depthwise of an object to be observed and a processor for reconstructing a two-dimensional image of a section of the object from a plurality of one-dimensional interferential images acquired by the image sensor during the one-way scan. An optical tomography method based on use of such an apparatus is also provided.

Abstract: A detection appliance and a method detect and evaluate a measuring signal that is indicative of breathing of a sleeping person, in connection with the observation of sleep-related breathing disorders. Instruments also detect signals that are indicative of breathing of a patient. The aim provides solutions that enable a reliable examination in terms of occurrence of sleep-related sleeping disorders, in the usual surroundings of the person concerned. In a first form, a mobile detection appliance is provided with a sensor device for detecting a nasal flow signal indicative of a nasal respiratory gas flow, and/or a respiratory flow signal indicative of an oral respiratory gas flow, in addition to an electronic data processing unit comprising a memory device and processing the signals indicative of temporal course of the nasal and oral respiration. The data processing device is configured to store data indicative of temporal course of the respiratory flow signals.